Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 56 Reviews
7.5
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic Acid
600 mg
†
Top Medical Research Studies
8
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Read More
7
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Read More
8
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
Read More
Most Useful Reviews
9
Maintains healthy sugar
111 people found this helpful
I assisted a type 2 diabetic patient who had not taken medications. His cumulative score dropped from 8 to 6 within three months, thanks to adding Ceylon cinnamon and chromium while avoiding bread. With a healthy diet, this regimen can potentially reverse diabetes.
Read More
9
Less foot pain
49 people found this helpful
I'm experiencing feeling in my feet returning with less pain. I've had diabetes-related burning and numbness for a long time, but now shooting pains are rare and milder. I've switched to Doctor's Best from HEB branded Alpha-Lipoic Acid and noticed improvements; I can even feel textures on the floor again. My A1C blood sugar is maintained at 5.7-5.9, allowing my nerves time to heal.
Read More
9
Weight loss help
28 people found this helpful
The best thing ever to keep my blood sugar low while also helping me lose weight. Taking three capsules a day has kept me on track; no more diabetes issues. Shipping was fast, around three days, and I am very satisfied with the product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Read More
8
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
Read More
7
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 56 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Maintains healthy sugar
111 people found this helpful
I assisted a type 2 diabetic patient who had not taken medications. His cumulative score dropped from 8 to 6 within three months, thanks to adding Ceylon cinnamon and chromium while avoiding bread. With a healthy diet, this regimen can potentially reverse diabetes.
Read More
9
Less foot pain
49 people found this helpful
I'm experiencing feeling in my feet returning with less pain. I've had diabetes-related burning and numbness for a long time, but now shooting pains are rare and milder. I've switched to Doctor's Best from HEB branded Alpha-Lipoic Acid and noticed improvements; I can even feel textures on the floor again. My A1C blood sugar is maintained at 5.7-5.9, allowing my nerves time to heal.
Read More
9
Weight loss help
28 people found this helpful
The best thing ever to keep my blood sugar low while also helping me lose weight. Taking three capsules a day has kept me on track; no more diabetes issues. Shipping was fast, around three days, and I am very satisfied with the product.
Read More
9
Consistent benefits
16 people found this helpful
I have been taking alpha lipoic acid regularly for seven years. My mother, who has diabetes, also finds it very helpful. She consistently takes 600 mg, while I adjust my dosage. I love the Doctor Best brand due to its quality.
Read More
7.5
Reduces sugar levels
14 people found this helpful
This is a great product from a good brand at a reasonable price with optimal dosage. I take 600 mg of Lipoic acid in the morning before breakfast for 2-3 months annually. My family has type 2 diabetes, and after following the doctor’s recommendations, we observe reduced sugar levels.
Read More
Frequently Asked Questions
7.5
Relieves neuropathic pain
3 people found this helpful
I have been taking this for my type 2 diabetes for 12 years and recently experienced neuropathy in my hands. After 2 months on this drug, I felt relief, making it an excellent alternative for preventive diabetes treatment. However, it can cause a burning sensation in the stomach, so it’s best taken with meals.
9
Maintains healthy sugar
111 people found this helpful
I assisted a type 2 diabetic patient who had not taken medications. His cumulative score dropped from 8 to 6 within three months, thanks to adding Ceylon cinnamon and chromium while avoiding bread. With a healthy diet, this regimen can potentially reverse diabetes.
6
Requires effort
10 people found this helpful
This medicine is not a magic wand for diabetes. It requires a steady diet and exercise to be effective. While it aided in my management of diabetes when combined with lifestyle changes, the effects diminished when I could not maintain consistency.
7.5
Lowers sugar level
1 people found this helpful
Excellent! I have purchased it multiple times based on recommendations for individuals with diabetes, and I noticed a drop in sugar levels while taking it. Consequently, the basal sugar dose was eliminated in favour of taking alpha in the morning and evening to maintain normal levels.
9
Improved daily vitality
9 people found this helpful
My mother has been suffering from type 2 diabetes for over 15 years. She is 69 years old and regularly takes this product, which helps her remain energetic throughout the day. This acid also supports her blood vessels in combating diabetes. I recommend it and suggest purchasing the larger package for better value.
9
Reduces numbness
1 people found this helpful
Excellent and useful for nerves and numbness that diabetes may cause. For almost a year, I have taken two pills a day, and they are very effective.
9
Significant improvement
2 people found this helpful
A good thing! My boyfriend has diabetes. The doctor recommended Lipoevaya, which significantly improves his condition. His sugar levels are stable without needing other pills, just this and proper nutrition. We are pleased with the availability of 600 mg in one capsule, aligning with the doctor’s recommendation.
9
Relieves neuropathy
1 people found this helpful
This product is effective for diabetes, providing tangible results. The symptoms of neuropathy have improved noticeably since I began taking it.
7
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
8
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
8
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
References
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. doi:10.3390/biomedicines13020438
- Zoheir KMA, Ali NI, Ashour AE, Kishta MS, Othman SI, et al. Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model. J Diabetes Metab Disord. 2025;24:56. doi:10.1007/s40200-025-01559-y
- Lu Q, Tang X, Tao B, Huang K, Li K, et al. Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections. Int J Biol Macromol. 2025;296:139685. doi:10.1016/j.ijbiomac.2025.139685
