5/11/2025
Last update
5/11/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 11 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic Acid
600 mg
†
Top Medical Research Studies
9
We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.
Read More
8
We studied the effects of alpha-lipoic acid (ALA) on migraines in patients with insulin resistance. In our exploratory study, 32 participants took 400 mg of ALA twice daily for six months while continuing their regular treatment.
We observed that by the end of the study, 69% of participants experienced at least a 50% reduction in migraine attacks. Additionally, the average number of attacks decreased significantly over the months. However, no changes in insulin resistance were seen, indicating that while ALA may help reduce migraine frequency, further research through randomized controlled trials is needed to confirm these findings.
We observed that by the end of the study, 69% of participants experienced at least a 50% reduction in migraine attacks. Additionally, the average number of attacks decreased significantly over the months. However, no changes in insulin resistance were seen, indicating that while ALA may help reduce migraine frequency, further research through randomized controlled trials is needed to confirm these findings.
Read More
7
We conducted a randomized, double-blind, placebo-controlled trial to see if alpha-lipoic acid (ALA) could help women with episodic migraines. Ninety-two participants took either 300 mg of ALA or a placebo for three months.
By the end of the study, we found that ALA significantly reduced certain inflammatory markers and improved mental health scores related to depression, anxiety, and stress. However, some measures of oxidative stress did not show a notable difference. Overall, ALA appears beneficial for migraine-related oxidative and mood-related issues.
By the end of the study, we found that ALA significantly reduced certain inflammatory markers and improved mental health scores related to depression, anxiety, and stress. However, some measures of oxidative stress did not show a notable difference. Overall, ALA appears beneficial for migraine-related oxidative and mood-related issues.
Read More
Most Useful Reviews
9
Improved migraine symptoms
1 people found this helpful
After taking thiocarnitine for three days, I felt my brain reacted quicker, and my migraine decreased. After three weeks, the recent migraines improved significantly and I felt more refreshed. I will continue taking one tablet a day to help repair damaged nerves and prevent brain degeneration.
Read More
7.5
Improved pain
My migraine pain improves when I take it daily (600).
Read More
6
Fewer migraine attacks
2 people found this helpful
I use it to prevent migraine attacks. A study published in the journal "Medical Council" No. 4 2012 recommends a dosage of 600 mg. The authors relied on clinical studies showing decreased seizure frequency and duration.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
Alpha-Lipoic Acid aids migraine prevention
We conducted a study to understand how alpha-lipoic acid (ALA) could help adolescents suffering from migraines. In this clinical trial, 60 participants were split into two groups: one received flunarizine alone, while the other received flunarizine along with ALA as an add-on treatment. This design allowed us to see if ALA made a significant difference in migraine management.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
Read More
9
We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.
Read More
8
We explored the effects of alpha-lipoic acid on migraines as part of a broader study examining dietary fatty acid supplementation. This research particularly assessed how various supplements, including omega-3 fatty acids and alpha-lipoic acid, influence migraine clinical outcomes.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
Read More
8
We studied the effects of alpha-lipoic acid (ALA) on migraines in patients with insulin resistance. In our exploratory study, 32 participants took 400 mg of ALA twice daily for six months while continuing their regular treatment.
We observed that by the end of the study, 69% of participants experienced at least a 50% reduction in migraine attacks. Additionally, the average number of attacks decreased significantly over the months. However, no changes in insulin resistance were seen, indicating that while ALA may help reduce migraine frequency, further research through randomized controlled trials is needed to confirm these findings.
We observed that by the end of the study, 69% of participants experienced at least a 50% reduction in migraine attacks. Additionally, the average number of attacks decreased significantly over the months. However, no changes in insulin resistance were seen, indicating that while ALA may help reduce migraine frequency, further research through randomized controlled trials is needed to confirm these findings.
Read More
7
Alpha-lipoic acid reduces migraine attacks
We assessed the effects of alpha-lipoic acid on migraines, focusing on its potential benefits backed by evidence from several trials. These trials provided insights into how alpha-lipoic acid influences migraine characteristics such as attack frequency and severity.
Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.
It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.
Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.
It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved migraine symptoms
1 people found this helpful
After taking thiocarnitine for three days, I felt my brain reacted quicker, and my migraine decreased. After three weeks, the recent migraines improved significantly and I felt more refreshed. I will continue taking one tablet a day to help repair damaged nerves and prevent brain degeneration.
Read More
7.5
Improved pain
My migraine pain improves when I take it daily (600).
Read More
6
Fewer migraine attacks
2 people found this helpful
I use it to prevent migraine attacks. A study published in the journal "Medical Council" No. 4 2012 recommends a dosage of 600 mg. The authors relied on clinical studies showing decreased seizure frequency and duration.
Read More
9
Reduced recurrence
Excellent! The use of alpha-lipoic acid reduces the recurrence of migraines.
Read More
7.5
Reduced headache severity
Very good. I took it based on a study that it reduces migraine effects. So far, I feel that the headache is lighter, even though I only take it during attacks. The quality is good, it is easy on the stomach, and the pill ingredients are commendable.
Read More
Frequently Asked Questions
9
Improved migraine symptoms
1 people found this helpful
After taking thiocarnitine for three days, I felt my brain reacted quicker, and my migraine decreased. After three weeks, the recent migraines improved significantly and I felt more refreshed. I will continue taking one tablet a day to help repair damaged nerves and prevent brain degeneration.
7.5
Boosted energy
A migraine doctor suggested I incorporate this into my morning routine before breakfast. I found that after the initial week, my energy levels soared, and over time, I began to experience better control over my migraines.
7.5
Decreased pain
Mumtaz, I used it with Co Q10 for migraines. After a month, the pain significantly decreased, alongside the frequency of occurrences compared to before.
7.5
Migraine head pain relief
I consider this product a powerful antioxidant. I take it in courses: first, 2 months of 300 mg, then 600 mg with plenty of water. I notice migraine-like head pains disappear, I gain more energy, and my weight stabilises. I find the price and quality correspond well.
6
Better control
My migraine pain improves when I take it daily (600).
7.5
Less frequent attacks
Excellent! I learned that Alpha Lipoic Acid with CoQ10 is effective for migraine pain. I felt that my attacks have lessened since taking them. I hope these supplements help me get rid of this nightmare.
6
Fewer migraine attacks
2 people found this helpful
I use it to prevent migraine attacks. A study published in the journal "Medical Council" No. 4 2012 recommends a dosage of 600 mg. The authors relied on clinical studies showing decreased seizure frequency and duration.
7.5
Improved pain
My migraine pain improves when I take it daily (600).
8
We explored the effects of alpha-lipoic acid on migraines as part of a broader study examining dietary fatty acid supplementation. This research particularly assessed how various supplements, including omega-3 fatty acids and alpha-lipoic acid, influence migraine clinical outcomes.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
7
Alpha-lipoic acid reduces migraine attacks
We assessed the effects of alpha-lipoic acid on migraines, focusing on its potential benefits backed by evidence from several trials. These trials provided insights into how alpha-lipoic acid influences migraine characteristics such as attack frequency and severity.
Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.
It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.
Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.
It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.
9
Alpha-Lipoic Acid aids migraine prevention
We conducted a study to understand how alpha-lipoic acid (ALA) could help adolescents suffering from migraines. In this clinical trial, 60 participants were split into two groups: one received flunarizine alone, while the other received flunarizine along with ALA as an add-on treatment. This design allowed us to see if ALA made a significant difference in migraine management.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
References
- García-Pérez-de-Sevilla G, González-de-la-Flor Á. Impact of Fatty Acid Supplementation on Migraine Outcomes: A Systematic Review and Meta-analysis. Nutr Rev. 2025. 10.1093/nutrit/nuae219
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
- Puliappadamb HM, Satpathy AK, Mishra BR, Maiti R, Jena M. Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial. J Clin Pharmacol. 2023;63:1398. 10.1002/jcph.2331
- Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep. 2022;12:271. 10.1038/s41598-021-04397-z
- Rezaei Kelishadi M, Alavi Naeini A, Askari G, Khorvash F, Heidari Z. The efficacy of alpha-lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double-blind, placebo-controlled clinical trial. Int J Clin Pract. 2021;75:e14455. 10.1111/ijcp.14455
- Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, et al. The role of nutrients in the pathogenesis and treatment of migraine headaches: Review. Biomed Pharmacother. 2018;102:317. 10.1016/j.biopha.2018.03.059
- Cavestro C, Bedogni G, Molinari F, Mandrino S, Rota E, et al. Alpha-Lipoic Acid Shows Promise to Improve Migraine in Patients with Insulin Resistance: A 6-Month Exploratory Study. J Med Food. 2018;21:269. 10.1089/jmf.2017.0068
- Magis D, Ambrosini A, Sándor P, Jacquy J, Laloux P, et al. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache. 2007;47:52.
