Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic Acid
600 mg
†
Top Medical Research Studies
9.5
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
7
We investigated the potential of alpha-lipoic acid (ALA) in treating cerebral ischemia, a condition often associated with strokes. The idea behind using ALA is its antioxidant properties, which might help mitigate damage caused during a stroke.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
Most Useful Reviews
9.5
Restores nerve damage
A wonderful product. After a stroke, I started using "Tioktatsid" and continued with tablets. The price in MSC is 1900 rubles for 30 tablets of 600 mg. The difference in cost is immediately noticeable. It must be taken on an empty stomach 30 minutes before meals for proper absorption and should not be taken with metals such as magnesium or calcium, as it binds to them. I physically feel the restoration of the affected areas from the stroke, with long numbness in my fingers and toes diminishing. My doctor recommends this remedy continuously, and I have noticed a decrease in blood sugar levels.
9.5
Stroke prevention
This health product protects the heart, aids in stroke prevention, treats stroke sequelae, and stabilises blood sugar levels. It is essential for my well-being.
9
Regenerates nerve tissue
Due to its antioxidant and hypoglycaemic properties, it is effective for treating type 2 diabetes. It improves blood vessel function and lowers cholesterol. Notably, it promotes regeneration of nerve tissue in the brain, reducing risks of stroke, dementia, and age-related diseases. If you found this review helpful, please like it.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
- All Researches
9.5
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
7
We investigated the potential of alpha-lipoic acid (ALA) in treating cerebral ischemia, a condition often associated with strokes. The idea behind using ALA is its antioxidant properties, which might help mitigate damage caused during a stroke.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Restores nerve damage
A wonderful product. After a stroke, I started using "Tioktatsid" and continued with tablets. The price in MSC is 1900 rubles for 30 tablets of 600 mg. The difference in cost is immediately noticeable. It must be taken on an empty stomach 30 minutes before meals for proper absorption and should not be taken with metals such as magnesium or calcium, as it binds to them. I physically feel the restoration of the affected areas from the stroke, with long numbness in my fingers and toes diminishing. My doctor recommends this remedy continuously, and I have noticed a decrease in blood sugar levels.
9.5
Stroke prevention
This health product protects the heart, aids in stroke prevention, treats stroke sequelae, and stabilises blood sugar levels. It is essential for my well-being.
9
Regenerates nerve tissue
Due to its antioxidant and hypoglycaemic properties, it is effective for treating type 2 diabetes. It improves blood vessel function and lowers cholesterol. Notably, it promotes regeneration of nerve tissue in the brain, reducing risks of stroke, dementia, and age-related diseases. If you found this review helpful, please like it.
8.8
Improved foot activity
After suffering a stroke a year ago, a friend recommended this remedy saying it could help repair damaged nerves. After nearly finishing a bottle, I've noticed improvements in my foot activities. I will continue using this alongside other supplements and plan to repurchase it.
8.8
Nerve healing recommendation
My doctor recommended this for healing nerves post-stroke, with the expectation of improvement.
Frequently Asked Questions
9.5
Restores nerve damage
A wonderful product. After a stroke, I started using "Tioktatsid" and continued with tablets. The price in MSC is 1900 rubles for 30 tablets of 600 mg. The difference in cost is immediately noticeable. It must be taken on an empty stomach 30 minutes before meals for proper absorption and should not be taken with metals such as magnesium or calcium, as it binds to them. I physically feel the restoration of the affected areas from the stroke, with long numbness in my fingers and toes diminishing. My doctor recommends this remedy continuously, and I have noticed a decrease in blood sugar levels.
8.8
Improved foot activity
After suffering a stroke a year ago, a friend recommended this remedy saying it could help repair damaged nerves. After nearly finishing a bottle, I've noticed improvements in my foot activities. I will continue using this alongside other supplements and plan to repurchase it.
6.8
Mixed results
I bought this alpha-lipoic acid for multiple reasons, including support after our family suffered from Covid-19 and to aid my mother after her stroke. While I noticed some positive effects post-Covid, neither my mother nor I saw significant results regarding insulin resistance, although she has shown some improvement after her stroke. I will continue using it but won't have high expectations regarding insulin resistance.
9.5
Stroke prevention
This health product protects the heart, aids in stroke prevention, treats stroke sequelae, and stabilises blood sugar levels. It is essential for my well-being.
8.8
Nerve healing recommendation
My doctor recommended this for healing nerves post-stroke, with the expectation of improvement.
References
- Mosallaei N, Malaekeh-Nikouei A, Sarraf Shirazi S, Behmadi J, Malaekeh-Nikouei B. A comprehensive review on alpha-lipoic acid delivery by nanoparticles. Bioimpacts. 2024;14:30136. doi:10.34172/bi.2024.30136
- Luo K, Wang Y, Lu E, Nie W, Yan X, et al. Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke. ACS Appl Mater Interfaces. 2024;16:49628. doi:10.1021/acsami.4c08966
- Zhu C, Wang Y, Li Y, Wang T, Ye F, et al. Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary study. Bioorg Chem. 2024;147:107339. doi:10.1016/j.bioorg.2024.107339
