Doctor's Best Benfotiamine + Alpha-Lipoic Acid

We conducted a three-week randomized, placebo-controlled pilot study to see how benfotiamine could help patients with diabetic polyneuropathy.

Forty inpatients received either benfotiamine or a placebo, and we found that those taking benfotiamine experienced a significant improvement in neuropathy symptoms, particularly pain reduction.

Although some measures showed no major differences, more individuals in the benfotiamine group felt better overall.

9.5

Relief from symptoms

Most Useful Review

This is the best mixture for neuropathy (both diabetic and otherwise). I eventually increased to two a day, which made my urine smell, but it relieved 90% of my neuropathy symptoms in my feet. Be consistent and use sensible care practices to regain your feet. It’s the best and least expensive gift I’ve ever given myself.

Bone Pain details

Working quickly in the warehouse used to leave my feet hurting by the end of the day. However, since I started taking this, I am amazed that the bone pain in my feet has completely vanished. There is, however, a concern about a sweat-like smell compared to other vitamin B supplements.

Diabetes details

SCIENTIFIC SCORE

Possibly Effective

Based on 19 Researches

Benfotiamine showed no significant benefits

Bönhof GJ, Sipola G, Strom A, Herder C, Strassburger K, et al. BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy. BMJ Open. 2022;12:e057142. doi:10.1136/bmjopen-2021-057142

We conducted a comprehensive study to explore the effects of benfotiamine on diabetic sensorimotor polyneuropathy (DSPN) in type 2 diabetes patients. In a randomized double-blind trial involving 60 participants, we compared benfotiamine treatment to a placebo over 12 months.

The main focus was on changes in corneal nerve fiber length, along with various other clinical measures. Unfortunately, the results did not show significant benefits from benfotiamine treatment in improving the condition compared to the placebo.

9.5

Improved memory function

Most Useful Review

As I aged, I noticed my memory declining. Checking my thiamine levels showed they were low, especially on strict diets. Since taking Benfotiamine, I’ve experienced improvements in memory, sleep, and reduced irritability, making it easier to manage my diabetes. I suggest taking this complex as it also protects skin health.

We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.

Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.

This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.

9.5

Cleanses liver effectively

Most Useful Review

This is an incredibly useful and high-quality drug for the entire body. It is the most powerful antioxidant that cleanses and removes metals from the body, which is essential for my family as we reside in a rather polluted city. It cleanses and rejuvenates the liver.