Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 15 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Read More
7
Annona muricata aids diabetes treatment
We explored the antidiabetic properties of Annona muricata leaf extract using a metabolomics approach on diabetes-induced rats. The study involved administering two doses of the extract to evaluate its impacts on metabolic profiles over four weeks.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Read More
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
Read More
Most Useful Reviews
9
Reduced sugar levels
5 people found this helpful
The product is wonderful, as I have diabetes. I noticed a decrease in my sugar levels by 3 or 4 points after consuming it. Originally, I bought it to support immunity, but upon measuring my sugar levels, I found that they had dropped from 13 or 12 to 9, and at times even 8. The product is of high quality, with great ingredients, and the quantity is sufficient for a month.
Read More
10
Improved mobility
This product is amazing for my diabetes and nerve damage. I can now walk and move my toes normally.
Read More
10
Annoying symptoms gone
Due to my diabetes, my body's stores of vitamins were consistently declining. After starting this supplement, all the bothersome symptoms vanished.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
- All Researches
9
Thiamine treatment aids diabetes management
We examined a rare condition known as thiamine-responsive megaloblastic anaemia (TRMA) in a young man with type 1 diabetes and unexplained pancytopenia. After thorough testing revealed genetic factors, we found that daily thiamine supplementation effectively resolved his anemia.
More importantly, this treatment not only improved his blood counts but also lowered his insulin needs. This highlights the significance of identifying genetic causes in young patients presenting with such symptoms.
More importantly, this treatment not only improved his blood counts but also lowered his insulin needs. This highlights the significance of identifying genetic causes in young patients presenting with such symptoms.
Read More
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Read More
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
Read More
8
We examined how ice plant extract and its active component, D-pinitol, influence insulin secretion and glucose levels in diabetic rats. The study found that both IPE and D-pinitol significantly boosted insulin secretion in rat insulin-secreting cells.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Read More
8
Thiamine disulfide shows promise for diabetes
We investigated whether thiamine disulfide (TD) can lower blood sugar and improve insulin resistance in rats with type 1 diabetes. By assigning rats to different treatment groups, we used various tests to measure blood sugar, insulin sensitivity, and gene expression related to diabetes.
Results showed that TD effectively reduced blood glucose levels and improved several metabolic markers. However, it didn't affect the expression of the Glut4 gene, which plays a role in glucose uptake. Overall, TD demonstrated potential as a diabetes treatment, particularly in reducing insulin resistance.
Results showed that TD effectively reduced blood glucose levels and improved several metabolic markers. However, it didn't affect the expression of the Glut4 gene, which plays a role in glucose uptake. Overall, TD demonstrated potential as a diabetes treatment, particularly in reducing insulin resistance.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced sugar levels
5 people found this helpful
The product is wonderful, as I have diabetes. I noticed a decrease in my sugar levels by 3 or 4 points after consuming it. Originally, I bought it to support immunity, but upon measuring my sugar levels, I found that they had dropped from 13 or 12 to 9, and at times even 8. The product is of high quality, with great ingredients, and the quantity is sufficient for a month.
Read More
10
Improved mobility
This product is amazing for my diabetes and nerve damage. I can now walk and move my toes normally.
Read More
10
Annoying symptoms gone
Due to my diabetes, my body's stores of vitamins were consistently declining. After starting this supplement, all the bothersome symptoms vanished.
Read More
6
Improved physical strength
3 people found this helpful
My husband, who suffers from diabetes, required a B group supplement, so I purchased this bottle for him. After observing his energy levels before and after taking it, he noted a slight improvement in his physical strength. He has also mentioned increased excitement at night and occasional insomnia, which may be useful for overtime work.
Read More
9
Tremors alleviated
I purchased Doctor Best's Vitamin B complex for my mother, who has diabetes and experienced hand and head tremors. Regular intake of B complex, including B12 and Magnesium, resolved the tremors. While blood tests for B vitamins aren't particularly informative, the quality of these vitamins is excellent and affordably priced.
Read More
Frequently Asked Questions
9
Reduced sugar levels
5 people found this helpful
The product is wonderful, as I have diabetes. I noticed a decrease in my sugar levels by 3 or 4 points after consuming it. Originally, I bought it to support immunity, but upon measuring my sugar levels, I found that they had dropped from 13 or 12 to 9, and at times even 8. The product is of high quality, with great ingredients, and the quantity is sufficient for a month.
6
Improved physical strength
3 people found this helpful
My husband, who suffers from diabetes, required a B group supplement, so I purchased this bottle for him. After observing his energy levels before and after taking it, he noted a slight improvement in his physical strength. He has also mentioned increased excitement at night and occasional insomnia, which may be useful for overtime work.
7.5
Control diabetes levels
Thanks to consistent intake of vitamin B, I felt less tired and experienced positive effects on my diabetes. My diabetes levels remained stable while using it, and I am currently trying other supplements like folic acid and zinc for blood purification.
7.5
Nerve repair hopes
My daughter has had diabetes for over a year, which has damaged her peripheral nervous system. This B complex contains essential ingredients for nerve repair, and I hope that prolonged use will improve her condition.
10
Improved mobility
This product is amazing for my diabetes and nerve damage. I can now walk and move my toes normally.
9
Tremors alleviated
I purchased Doctor Best's Vitamin B complex for my mother, who has diabetes and experienced hand and head tremors. Regular intake of B complex, including B12 and Magnesium, resolved the tremors. While blood tests for B vitamins aren't particularly informative, the quality of these vitamins is excellent and affordably priced.
7.5
Supports nerve health
I bought this compound for my parents following my research on diabetes's effects on peripheral nerves. It has significant benefits for nerve health, particularly for diabetics.
7.5
Nerve maintenance essential
Vitamin B is crucial for the nerves, particularly for those with diabetes, as medications can adversely affect them. The quality is high and reasonably priced, lasting for two months. It's well-packaged and has an acceptable taste and smell, meant to be taken after meals.
7
Annona muricata aids diabetes treatment
We explored the antidiabetic properties of Annona muricata leaf extract using a metabolomics approach on diabetes-induced rats. The study involved administering two doses of the extract to evaluate its impacts on metabolic profiles over four weeks.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
7
We reviewed data from a 2009-2010 survey to understand how vitamin B6 influences the link between type 2 diabetes and periodontitis, a serious gum disease.
Our findings revealed that individuals with diabetes have an increased risk of periodontitis. Importantly, higher levels of vitamin B6 appeared to reduce this risk.
This suggests that maintaining adequate vitamin B6 intake may benefit those with diabetes by potentially lowering their chances of developing gum disease.
Our findings revealed that individuals with diabetes have an increased risk of periodontitis. Importantly, higher levels of vitamin B6 appeared to reduce this risk.
This suggests that maintaining adequate vitamin B6 intake may benefit those with diabetes by potentially lowering their chances of developing gum disease.
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
References
- Zubaidi SN, Wong PL, Qadi WSM, Dawoud EAD, Hamezah HS, et al. Deciphering the mechanism of Annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with H-NMR-based metabolomics approach. J Pharm Biomed Anal. 2025;260:116806. doi:10.1016/j.jpba.2025.116806
- Zhu J, Xu W, Wu S, Song D. Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009-2010. BMC Oral Health. 2025;25:299. doi:10.1186/s12903-025-05597-z
- Gao J, Meng X, Yang X, Xie C, Tian C, et al. The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS. Bone. 2025;193:117411. doi:10.1016/j.bone.2025.117411
- Lee D, Kim SJ, Choi YJ, Rho YH, Kang TS, et al. The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats. Nutrients. 2025;17. doi:10.3390/nu17010193
- Brossfield AV, McMahon DJ, Fernando J, Omeragic B, Majeed R, et al. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial. J Clin Endocrinol Metab. 2025;110:961. doi:10.1210/clinem/dgae700
- Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2024-261435
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- D'Haese S, Claes L, Jaeken E, Deluyker D, Evens L, et al. Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. Int J Mol Sci. 2024;25. doi:10.3390/ijms25158508
- Rad MG, Sharifi M, Meamar R, Soltani N. Long term administration of thiamine disulfide improves FOXO1/PEPCK pathway in liver to reduce insulin resistance in type 1 diabetes rat model. Biomed Pharmacother. 2024;177:117053. doi:10.1016/j.biopha.2024.117053
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. doi:10.3390/nu16121901
- Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009
