If you are new to MSM, you should read THE MIRACLE OF MSM by Stanley Jacob, MD. He explains MSM and how it works in layman's terms. I've dealt with joint pain AND sciatic pain that was so painful I was wondering if I had cancer in both my legs! The following protocol/regimen is what has brought me to a place of being, literally, 99% pain free. It is my opinion (personal experience) that the combination of the hyaluronic acid and collagen II along with Doctor's Best MSM has just about cured me. This is by Russell Blaylock, MD Special Supplements to Repair Joints * *Hyaluronic acid The joint contains cartilage composed of complex glycosaminoglycans, which aid in joint health. One product that supplies this vital substance is hyaluronic acid. This is a component of connective tissue whose function is to cushion and lubricate. Some products contain the larger molecular form, which is not absorbed. Pure Encapsulation Company makes a product under this name. It has a lower molecular weight and is well absorbed. The dose is three capsules twice a day with or between meals. You can get Pure Encapsulation products at [...] * *MSM Also called methyl sulfonyl methane, MSM is a natural form of sulfur found in living organisms. Its main benefits are a reduction of inflammation and the ability to penetrate many tissues, including joints. Recent studies have confirmed its safety, even when used in large doses over prolonged periods of time. The dose is 500 mg. to 1,000 mg. two to three times a day with meals. It is widely available. * *Collagen type II This is a major component in cartilage, and supplementation has demonstrated benefits in reducing pain and improving joint function. The dose is three capsules twice a day on an empty stomach. It is important that you get a brand made from chicken rather than bovine. You can get this from [...] * Tart cherry extract A number of studies have shown that concentrated extracts of tart cherries improve joint function and reduce pain and swelling. You can also get this fromJuly 2006 The Blaylock Wellness Report Page 5 [...]. The dose is one to two capsules a day. * Triple stack This is a special compounded supplement containing full therapeutic doses of MSM, glucosamine, and curcumin. The dose is one capsule three times a day. It should be taken with meals. The best results are seen within three weeks. It can only be found at Specialty Pharmacy [...] Special Supplements to Reduce Inflammation Below I will discuss special plant extracts and vitamins that can reduce inflammation and free radicals within the joint. * *Curcumin This is one of the most powerful natural anti- inflammatory substances known. Its effects are comparable to steroids, without the harmful effects. All inflammatory arthritis problems arise from the activation of a special inflammation signal molecule in cartilage cells called NFkappaB, or NFKB. Curcumin powerfully inhibits this cell signal and also suppresses the destructive enzymes mentioned above (MMPs and collagenase). Curcumin is best absorbed when dissolved in an oil. I would recommend either extra virgin olive oil or fish oil. Fish oil has a significant anti-inflammatory effect all its own, so I would recommend over olive oil. The dose is 250 mg. of curcumin powder mixed with a half-tablespoon of fish oil. Mix well. Take this three times a day with meals. * *Quercetin This is also a powerful anti-inflammatory and antioxidant. When combined with curcumin, you get a powerful anti-inflammatory effect because they each act on different inflammatory biochemical pathways. It also suppresses the destructive enzymes I spoke about (MMPs and collagenase). Mix 250 mg. of quercetin into oil with the curcumin and take that three times a day. * *Borage oil Borage oil contains a high concentration of gamma-linolenic acid, which has significant anti- inflammatory properties. It also moistens mucous membranes and the skin. You can add this to the mix above. It will come in a gelatin capsule, but don't eat that -- just stick a pin into it and squeeze 1,000 mg. into the mentioned mix twice a day. Keep both the fish oil and borage oil in the refrigerator. * *Natural vitamin E (Unique-E) Vitamin E, in natural form, has significant anti- inflammatory effects. The dose is 1,000 IU a day. Unique-E is the brand I recommend. * *Buffered vitamin C (calcium/magnesium ascorbate) Vitamin C is not only a powerful antioxidant and anti-inflammatory, but it also strengthens the tissues and the ligaments surrounding the joint. * *Vitamin/mineral supplement A recent study found that selenium was significantly depleted in the joints of people with arthritis, while copper levels increased. High iron levels were found in the damaged joints of osteoarthritis sufferers. Iron is a powerful generator of inflammation and free radicals. A well-balanced supplement such as Extend Core [...]will deliver all the essential vitamins and minerals. * *Magnesium citrate or citrate/malate Magnesium supplementation has been shown to reduce inflammation, while a deficiency increases it. It not only slashes free radicals but blocks the release of inflammatory cytokines as well. The dose is two capsules twice a day between meals. A survey found that a dearth of magnesium is one of the most common mineral deficiencies seen, with 75% of the population lacking it. Chronic illness and many medications worsen magnesium loss. * Stinging nettle extract This plant extract has been shown to have powerful anti-inflammatory properties. Recent studies have found it to be very protective of the brain as well. It is often included in natural supplements used to treat chronic prostate problems for the same reason. But taking too much can produce a mucous-like Diarrhea. I would limit intake to two capsules a day with meals. These are the basic steps you will need to follow for good health. I have placed an asterisk beside the most important supplements. The closer you follow these steps the more likely you will attain success. It is important to know that curcumin and quercetin can cause your blood sugar to drop slightly. While this is beneficial to those with diabetes, it can be a problem if you have reactive hypoglycemia. For this reason, always take it with a meal