Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Chloride (from glucosamine hydrochloride potassium sulfate)
170 mg
7%
Sodium (from chondroitin sulfate sodium)
120 mg
5%
Potassium (from glucosamine hydrochloride potassium sulfate)
190 mg
4%
GlucosamineHydrochloride Potassium Sulfate
1500 mg
†
Chondroitin sulfate Sodium
1200 mg
†
MSM (Methylsulfonylmethane)(OptiMSM®)
1000 mg
†
Top Medical Research Studies
8
MSM risk behaviors linked to diarrhea
We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
Read More
9.5
Human intestinal spirochetosis linked to MSM
We explored the intriguing link between human intestinal spirochetosis (HIS) and chronic diarrhea, focusing on a group of six men who have sex with men (MSM). This condition significantly affects young MSM, particularly those living with HIV. During our review, we found that five of these six patients experienced diarrhea, which was often linked to their sexual practices, including condomless anal intercourse and oro-anal sex.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Read More
Most Useful Reviews
9.5
Diarrhea resolved
My mother, who has diabetes, suffered from diarrhea and could barely move. After consulting her doctor about the ingredients, he deemed it beneficial. Thankfully, after taking it, her diarrhea resolved, and she returned to her normal self. It's important to check ingredient lists before ordering to avoid allergies and ensure health benefits.
Read More
9.5
Excellent joint relief
Initially sceptical, I ordered this supplement for potential joint health benefits as I suffered from diarrhea due to Teraflex. After trying a small amount without side effects for three months, I've experienced excellent results – no joint pain at all! My joints feel fine, and I've noticed stronger nails and reduced hair loss. I plan to continue taking it for up to six months. If you find my review helpful, please click yes.
Read More
1.3
Stopped the drug
My husband and I took it as prescribed by a doctor, but it caused terrible stomach pain along with diarrhea. Initially, I was perplexed, but we have decided to cancel the drug.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
- All Researches
9.5
Human intestinal spirochetosis linked to MSM
We explored the intriguing link between human intestinal spirochetosis (HIS) and chronic diarrhea, focusing on a group of six men who have sex with men (MSM). This condition significantly affects young MSM, particularly those living with HIV. During our review, we found that five of these six patients experienced diarrhea, which was often linked to their sexual practices, including condomless anal intercourse and oro-anal sex.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Read More
8
MSM risk behaviors linked to diarrhea
We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Diarrhea resolved
My mother, who has diabetes, suffered from diarrhea and could barely move. After consulting her doctor about the ingredients, he deemed it beneficial. Thankfully, after taking it, her diarrhea resolved, and she returned to her normal self. It's important to check ingredient lists before ordering to avoid allergies and ensure health benefits.
Read More
9.5
Excellent joint relief
Initially sceptical, I ordered this supplement for potential joint health benefits as I suffered from diarrhea due to Teraflex. After trying a small amount without side effects for three months, I've experienced excellent results – no joint pain at all! My joints feel fine, and I've noticed stronger nails and reduced hair loss. I plan to continue taking it for up to six months. If you find my review helpful, please click yes.
Read More
1.3
Stopped the drug
My husband and I took it as prescribed by a doctor, but it caused terrible stomach pain along with diarrhea. Initially, I was perplexed, but we have decided to cancel the drug.
Read More
6
Good effect despite
I took an MSM product which was effective, though it came with some side effects like diarrhea, prompting me to stop. Alternating between two products still results in some side effects, but the pain and inflammation seem reduced, making the effect quite favourable. As it's Chuseok, I'm planning to purchase it as a gift for my parents.
Read More
7
Increased energy
My mother finds that it energises her, but she must drink plenty of water alongside it to avoid potential kidney damage or diarrhea.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Pérez-Tanoira R, Tamarit MDP, Montaña AMV, Carmena D, Köster P, et al. Increased Prevalence of Symptomatic Human Intestinal Spirochetosis in MSM with High-Risk Sexual Behavior in a Cohort of 165 Individuals. Trop Med Infect Dis. 2023;8. doi:10.3390/tropicalmed8050250
- Garcia-Hernandez D, Vall-Mayans M, Coll-Estrada S, Naranjo-Hans L, Armengol P, et al. Human intestinal spirochetosis, a sexually transmissible infection? Review of six cases from two sexually transmitted infection centres in Barcelona. Int J STD AIDS. 2021;32:52. doi:10.1177/0956462420958350
