Last update
5/15/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Good
Based on 14 Reviews
8.2
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
8
We looked into how a new treatment combining hyaluronic acid with a peptide from fibroblast growth factor 2 could help combat acne. This method targets specific receptors involved in acne development, showing promise by reducing both acne lesions and excess oil production in lab tests. Importantly, our study revealed that this treatment does not encourage certain reactions that would typically hinder acne management. While the results are positive, we acknowledge that ongoing research is necessary for further confirmation of these findings.
Read More
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Read More
9
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
Most Useful Reviews
8
Dramatic skin change
11 people found this helpful
This product has made an impressive difference in my skin within just two weeks. At 42, I've had to deal with sun damage contributing to my adult acne. Typically, skincare takes months to show effects, but this product has left my skin feeling moist without any greasy residue. It's encouraging to see such rapid results, both in terms of acne control and overall skin health. I plan to continue this regimen and see if it also aids my joint health over time.
Read More
7
Skin healing noted
5 people found this helpful
My skin has notably become more elastic and healed faster from acne scars. This product has truly aided in the recovery of my skin's quality, and I appreciate the improvements observed over the duration of use.
Read More
9
Wrinkles and acne scars reduced
3 people found this helpful
Since using this product, my skin radiance has significantly improved, while acne scars and wrinkles appear almost gone. The overall tightness of my skin has revitalised my complexion, compelling me to maintain its use.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
- All Researches
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Read More
9
Promising treatment for acne scars
We examined how needle-free electronic pneumatic injections of hyaluronic acid could treat facial acne scars. In a carefully designed study, thirty Japanese participants received treatments on one side of their face, with follow-ups conducted for three months after completing three sessions.
Remarkably, 48.3% of the treated sides showed significant improvement, while none of the untreated sides did. Participants reported high satisfaction rates and the results were confirmed by imaging analysis. Overall, this treatment demonstrated promising effects on rolling acne scars with minimal side effects.
Remarkably, 48.3% of the treated sides showed significant improvement, while none of the untreated sides did. Participants reported high satisfaction rates and the results were confirmed by imaging analysis. Overall, this treatment demonstrated promising effects on rolling acne scars with minimal side effects.
Read More
9
Hyaluronic acid shows scar improvement
This study explored the effectiveness of using hyaluronic acid filler alongside subcision for treating post-acne scars.
In a controlled trial with 40 participants, we observed that both the subcision combined with hyaluronic acid and with fractional CO laser treatments showed significant improvements.
However, when comparing the two enhanced methods, neither was found to be statistically better than the other. Importantly, subcision alone still provided some improvement, even if modest. Overall, combining these treatments appears beneficial without serious side effects.
In a controlled trial with 40 participants, we observed that both the subcision combined with hyaluronic acid and with fractional CO laser treatments showed significant improvements.
However, when comparing the two enhanced methods, neither was found to be statistically better than the other. Importantly, subcision alone still provided some improvement, even if modest. Overall, combining these treatments appears beneficial without serious side effects.
Read More
9
We evaluated the impact of combining subcision with hyaluronic acid (HA) on atrophic acne scars. Forty patients received subcision treatments over three sessions, followed by either HA or threads on one side of the face, while the other side served as a control.
The results showed that after 6 months, 94.1% of patients in the HA group experienced significant improvement compared to 67.3% with subcision alone. Patient satisfaction was notably higher for those who received the combined treatment. Side effects were mild and temporary, making this combination a promising option for better scar management.
The results showed that after 6 months, 94.1% of patients in the HA group experienced significant improvement compared to 67.3% with subcision alone. Patient satisfaction was notably higher for those who received the combined treatment. Side effects were mild and temporary, making this combination a promising option for better scar management.
Read More
9
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Dramatic skin change
11 people found this helpful
This product has made an impressive difference in my skin within just two weeks. At 42, I've had to deal with sun damage contributing to my adult acne. Typically, skincare takes months to show effects, but this product has left my skin feeling moist without any greasy residue. It's encouraging to see such rapid results, both in terms of acne control and overall skin health. I plan to continue this regimen and see if it also aids my joint health over time.
Read More
7
Skin healing noted
5 people found this helpful
My skin has notably become more elastic and healed faster from acne scars. This product has truly aided in the recovery of my skin's quality, and I appreciate the improvements observed over the duration of use.
Read More
9
Wrinkles and acne scars reduced
3 people found this helpful
Since using this product, my skin radiance has significantly improved, while acne scars and wrinkles appear almost gone. The overall tightness of my skin has revitalised my complexion, compelling me to maintain its use.
Read More
8
Healthy skin restored
3 people found this helpful
This product is exceptional! It has rejuvenated my skin and visibly reduced my acne scars. After consistently taking two pills daily for two weeks, my skin now looks vibrant and healthier than it did previously.
Read More
8
Acne reduced
2 people found this helpful
I've repurchased this product three times because I cannot live without it. I've observed fewer acne breakouts and smoother skin since using it. The benefits, such as reduced wrinkles post-25, have been gradual but noteworthy. I truly appreciate its quality and ease of use.
Read More
Frequently Asked Questions
8
Healthy skin restored
3 people found this helpful
This product is exceptional! It has rejuvenated my skin and visibly reduced my acne scars. After consistently taking two pills daily for two weeks, my skin now looks vibrant and healthier than it did previously.
7
Skin healing noted
5 people found this helpful
My skin has notably become more elastic and healed faster from acne scars. This product has truly aided in the recovery of my skin's quality, and I appreciate the improvements observed over the duration of use.
7
Dramatic effect achieved
This product made a significant difference to my skin in the two months since I repurchased it! My original skin condition was quite dry with noticeable acne. After starting this, I noticed a dramatic effect, and even others commented that my skin appeared clearer and firmer! It's now much smoother to the touch!
8
No bad acne noted
Good, I guess it is working as I haven’t experienced any bad acne since using this product.
9
Skin condition improved
1 people found this helpful
This product has been fantastic for me thus far. While using acne medication that tends to dry my skin, this supplement has greatly helped. My acne seems to be improving, and I adore the glow and tautness it gives my skin. It's a delightful bonus that my knees feel much better as well!
8
Acne reduced
2 people found this helpful
I've repurchased this product three times because I cannot live without it. I've observed fewer acne breakouts and smoother skin since using it. The benefits, such as reduced wrinkles post-25, have been gradual but noteworthy. I truly appreciate its quality and ease of use.
7
Hyaluronic acid gel shows promise
We investigated a unique hyaluronic acid gel, combined with hydrogen peroxide and glycine, to treat mild to moderate acne. Over 8 weeks, 40 participants applied the gel multiple times a day and were frequently evaluated.
Although the results indicated some clinical benefits in reducing acne lesions and improving skin quality, they suggest this treatment might be best used alongside retinoids. Importantly, the product showed a good safety profile, although it may not be a standalone solution for everyone.
Although the results indicated some clinical benefits in reducing acne lesions and improving skin quality, they suggest this treatment might be best used alongside retinoids. Importantly, the product showed a good safety profile, although it may not be a standalone solution for everyone.
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
7
We aimed to evaluate the effectiveness of microneedling alone compared to microneedling combined with hyaluronic acid in treating acne scars.
After conducting treatment on 60 patients, we observed that while most experienced moderate improvement, those receiving the combination treatment reported better outcomes, including “good” and “very good” results.
This procedure is straightforward and can be performed in various settings, with hyaluronic acid significantly boosting the results of microneedling alone.
After conducting treatment on 60 patients, we observed that while most experienced moderate improvement, those receiving the combination treatment reported better outcomes, including “good” and “very good” results.
This procedure is straightforward and can be performed in various settings, with hyaluronic acid significantly boosting the results of microneedling alone.
7
We examined how well hyaluronic acid (HA)—both non-crosslinked and crosslinked—works for treating aesthetic skin issues, including acne scars. In our analysis of 115 patient records, both HA types produced notable improvements in skin appearance with minimal side effects. Patients reported high satisfaction levels and experienced improvements that averaged around 1.7 on the Global Aesthetic Improvement Scale. Interestingly, both forms of HA had a similar longevity in results, lasting around 13 months. This study highlights the promise of HA in tackling acne-related concerns, offering effective and safe treatment options.
References
- Stefancu ME, Barattini DF, Botnaru I, Vizman C, Stucchi L, et al. Performance and Safety of the Medical Device Ialuxid Gel in the Treatment of Mild-Moderate Acne Vulgaris: An Open-Label, Noncomparative Multicentre Interventional Clinical Trial. J Cosmet Dermatol. 2025;24:e70084. 10.1111/jocd.70084
- Sparavigna A, Grimolizzi F, Cigni C, Lualdi R, Bellia G. Dual-Plane Treatment With Highly Concentrated Hybrid Cooperative Complexes of Hyaluronans for Facial Atrophic Acne Scars. Dermatol Surg. 2025;51:152. 10.1097/DSS.0000000000004387
- Mohamed SH, Omar GA, Hamdy AE. Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study. Dermatol Pract Concept. 2024;14. 10.5826/dpc.1403a183
- Dastgheib M, Heidari S, Azizipour A, Kavyani M, Lajevardi V, et al. Investigating the impact of added Profhilo mesogel to subcision versus subcision monotherapy in treating acne scars; a single-blinded, split-face randomized trial. J Cosmet Dermatol. 2024;23:1992. 10.1111/jocd.16258
- Bano R, Brar BK, Kumar S. Comparative Evaluation of Therapeutic Efficacy and Safety of Microneedling Alone Versus Microneedling with Hyaluronic Acid in Post-Acne Scarring. J Cutan Aesthet Surg. 2023;16:279. 10.4103/JCAS.JCAS_6_23
- Behrangi E, Dehghani A, Sheikhzadeh F, Goodarzi A, Roohaninasab M. Evaluation and comparison of the efficacy and safety of cross-linked and non-cross-linked hyaluronic acid in combination with botulinum toxin type A in the treatment of atrophic acne scars: A double-blind randomized clinical trial. Skin Res Technol. 2024;30:e13541. 10.1111/srt.13541
- Kaminaka C, Sakata M, Nishiguchi M, Kunimoto K, Mikita N, et al. Clinical evaluation of needle-free electronic pneumatic hyaluronic acid injection treatment for facial atrophic acne scars: A prospective, randomized comparative trial. J Dermatol. 2023;50:971. 10.1111/1346-8138.16830
- Mehrabi J, Shehadeh W, Gallo ES, Artzi O, Horovitz T. Comparison of 2 Hyaluronic Acid-based Fillers for the Treatment of Acne Scars: Structural Lifting Versus Biostimulatory Effect. Dermatol Surg. 2023;49:581. 10.1097/DSS.0000000000003789
- Su Z, Zhang Y, Cao J, Sun Y, Cai Y, et al. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist. J Nanobiotechnology. 2023;21:55. 10.1186/s12951-023-01812-7
- Abdelwahab AA, Omar GAB, Hamdino M. A combined subcision approach with either fractional CO laser (10,600 nm) or cross-linked hyaluronic acid versus subcision alone in atrophic post-acne scar treatment. Lasers Med Sci. 2022;38:20. 10.1007/s10103-022-03677-y
- Mohammed GF, Al-Dhubaibi MS. Triple steps acne scar revision technique: A new combination therapeutic modality for atrophic acne scars. J Cosmet Dermatol. 2022;21:4659. 10.1111/jocd.14944
- Ebrahim HM, Nassar A, ElKashishy K, Artima AYM, Morsi HM. A combined approach of subcision with either cross-linked hyaluronic acid or threads in the treatment of atrophic acne scars. J Cosmet Dermatol. 2022;21:3334. 10.1111/jocd.14675
- MacGillis D, Vinshtok Y. High-velocity pneumatic injection of non-crosslinked hyaluronic acid for skin regeneration and scar remodeling: A retrospective analysis of 115 patients. J Cosmet Dermatol. 2021;20:1098. 10.1111/jocd.14002
- Roohaninasab M, Jafarzadeh A, Zare S, Alavi S, Zare S, et al. Evaluation of the Efficacy, Safety, and Satisfaction Rates of Platelet-Rich Plasma, Non-Cross-Linked Hyaluronic Acid, and their Combination in Patients with Acne Scars Treated with Fractional CO Laser: A Randomized, Double-Blind, Split-Face Comparative Study. Aesthetic Plast Surg. 2026;50:1277. 10.1007/s00266-025-05359-w
- Crainic D, Popescu R, Vlad CD, Serban DV, Popa D, et al. Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence. Biomedicines. 2025;13. 10.3390/biomedicines13092156
- Lee SD, Ahn HJ, Lee SJ, Suh DH, Song KY, et al. Comparison of a Single Treatment of Needleless Microsubcision With Hyaluronic Acid and Carbon Dioxide Pinhole Method for Atrophic Acne Scars. Dermatol Surg. 2026;52:260. 10.1097/DSS.0000000000004837
- Watanabe C. Skin Improvement in Japanese Patients With Inflammatory Dermatologic Conditions Using the Injectable Hyaluronic Acid VYC-12. J Cosmet Dermatol. 2025;24:e70275. 10.1111/jocd.70275
- Zhu J, Wen T, Ma Y, Zeng Q, Li P, et al. Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach. J Control Release. 2025;382:113754. 10.1016/j.jconrel.2025.113754
- Huang Y, Liu C, Fu Z, Li C, Wu Y, et al. The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway. Eur J Pharmacol. 2025;989:177233. 10.1016/j.ejphar.2024.177233
- Lyu J, Jiang L, Tang M, Zheng L, Liu S. Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation. J Cosmet Laser Ther. 2024;26:61. 10.1080/14764172.2024.2372342
- Barone M, De Bernardis R, Persichetti P. Minimally Invasive Post-Acne Scars Treatment with the Hybrid Filler HArmonyCa™. Aesthetic Plast Surg. 2024. 10.1007/s00266-024-04046-6
- Ozer K, Gunes D. Comment on "A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars". Dermatol Surg. 2024;50:693. 10.1097/DSS.0000000000004150
- El-Domyati M, Moftah NH, Ahmed AM, Ibrahim MR. Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study. Int J Dermatol. 2024;63:632. 10.1111/ijd.17006
- Khattab FM, Samir MA, El Khouly SS, Atwa EM. Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study. J Clin Aesthet Dermatol. 2023;16:33. PubMed
