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Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
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Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
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Frequently Asked Questions
Hypertension, commonly known as high blood pressure, is a medical condition characterized by the consistent elevation of blood pressure in the arteries. Blood pressure readings consist of two numbers: systolic pressure (the pressure in the arteries when the heart beats) over diastolic pressure (the pressure when the heart rests between beats). A normal blood pressure reading is typically around 120/80 mmHg. Hypertension is generally diagnosed when readings consistently exceed 130/80 mmHg, a level that increases the risk of serious health issues like heart disease, stroke, and kidney damage.
Since hypertension often develops silently without noticeable symptoms, regular monitoring of blood pressure is crucial, especially for those at higher risk due to factors like age, family history, obesity, or sedentary lifestyle. Effective management can significantly lower health risks and often includes lifestyle changes such as a balanced diet, regular exercise, reduced sodium intake, and, if necessary, medication prescribed by a healthcare provider. Early detection and consistent management of hypertension can lead to better health outcomes, making it important to stay informed about your blood pressure levels.
Nattokinase is an enzyme extracted from a traditional Japanese food called natto, which is made from fermented soybeans. This enzyme is thought to have potential health benefits, primarily for cardiovascular health. Nattokinase is believed to support the breakdown of fibrin in the blood, which can help improve circulation and reduce the risk of blood clot formation. As a dietary supplement, it is often marketed for its possible ability to promote healthy blood flow and cardiovascular function.
While some studies suggest that nattokinase may help reduce blood pressure and enhance overall heart health, research is still ongoing. As with any supplement, it is essential to consult with a healthcare professional before adding nattokinase to your regimen, especially if you are on blood-thinning medications or have underlying health conditions. Overall, while nattokinase might offer some intriguing health benefits, more comprehensive studies are needed to fully understand its efficacy and safety profile.
Nattokinase, an enzyme derived from fermented soybeans, has garnered attention in the health community for its potential benefits in managing hypertension and overall cardiovascular health. Some studies suggest that nattokinase may help reduce blood pressure by promoting blood circulation and preventing blood clot formation. Its ability to break down fibrin can improve circulation, which might lead to lower blood pressure levels over time. However, while the preliminary research is promising, it's important to note that more extensive clinical trials are needed to firmly establish the efficacy of nattokinase specifically for hypertension management.
Before adding nattokinase to your health regimen, it’s crucial to consult with a healthcare professional, especially if you're already on medication for hypertension or have any underlying health conditions. Nattokinase may interact with certain medications, particularly anticoagulants or blood thinners, which could increase the risk of bleeding. As always, a comprehensive approach that includes a balanced diet, regular physical activity, and lifestyle modifications remains the cornerstone of effective hypertension management.
Based on user reviews, individuals taking this supplement for hypertension can typically expect to see results within a range of a few weeks to a month. For instance, one user reported a significant reduction in blood pressure after only one month of use, achieving a reading of 120 over 80, which their doctor praised during a follow-up visit (Read Review). Another user mentioned that their hypertension had dramatically reduced after several months of consistent use (Read Review).
Furthermore, some users have experienced noticeable improvements in their overall symptoms relatively quickly. For example, a user dealing with Pulmonary Hypertension felt a positive impact in managing their condition shortly after starting the supplement, indicating effective symptom management (Read Review). This suggests that while individual experiences may vary, many users report seeing beneficial results in a relatively short time frame.
Nattokinase has emerged as a promising supplement supported by scientific research for managing hypertension. Various studies have consistently reported its potential benefits in lowering blood pressure. For instance, a systematic review involving 546 participants highlighted that nattokinase significantly reduced systolic blood pressure by an average of 3.45 mm Hg and diastolic blood pressure by 2.32 mm Hg when compared to a placebo [1]. Additionally, another trial with 86 participants demonstrated even greater reductions, showing a decrease of 5.55 mm Hg in systolic and 2.84 mm Hg in diastolic pressure after just eight weeks of supplementation [5].
Moreover, nattokinase works by inhibiting angiotensin-converting enzyme (ACE), a key player in blood pressure regulation [3]. This enzyme's action supports the idea that nattokinase may serve as a useful adjunctive therapy for those struggling with hypertension. While the evidence is encouraging, some studies indicate that its efficacy may depend on dosage and other lifestyle factors, suggesting that further targeted research is necessary to fully understand the full scope of its benefits [2]. Overall, if you're considering adding nattokinase to your routine for blood pressure management, current research seems to suggest an optimistic outlook.
Users have reported various improvements in symptoms related to hypertension and other conditions upon using this supplement. Many individuals have experienced significant reductions in their blood pressure levels, with one user noting a dramatic improvement leading to a reading of 120 over 80, which was praised by their doctor during a follow-up visit (Read Review). Another user expressed that their modest hypertension had dramatically reduced after several months of consistent use, leading to positive feedback from their healthcare provider (Read Review).
Additionally, users dealing with more specific conditions, like Pulmonary Hypertension, reported experiencing relief from symptoms such as breathing difficulties and congestion. One such user indicated that their condition, which was expected to worsen, actually improved due to the supplement, signifying effective symptom management (Read Review). Overall, while individual results may vary, the anecdotal evidence suggests that many users have experienced notable benefits in a relatively short time frame.
The optimal dose of nattokinase for treating hypertension is not definitively established, as available research suggests various outcomes based on different dosages. However, a systematic review involving 546 participants indicated that nattokinase supplementation resulted in a significant reduction of blood pressure, with systolic blood pressure decreasing by an average of 3.45 mm Hg and diastolic blood pressure by 2.32 mm Hg [1]. Another study, which focused on a randomized double-blind trial, reported a notable reduction in systolic blood pressure by 5.55 mm Hg and diastolic by 2.84 mm Hg after 8 weeks, but the specific dosage administered during this trial was not specified [5].
Overall, while nattokinase seems to show promise for hypertension management, its efficacy may vary depending on the dosage and individual health context. Given the complex interplay between dosage, blood pressure reduction, and lipid levels, further research is essential to pinpoint a precise optimal dose [1]. Therefore, consulting with healthcare professionals before starting any supplementation is highly recommended.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
References
- Li X, Long J, Gao Q, Pan M, Wang J, et al. Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Rev Cardiovasc Med. 2023;24:234. doi:10.31083/j.rcm2408234
- Qiao Y, Zhang K, Zhang Z, Zhang C, Sun Y, et al. Fermented soybean foods: A review of their functional components, mechanism of action and factors influencing their health benefits. Food Res Int. 2022;158:111575. doi:10.1016/j.foodres.2022.111575
- Keziah SM, Devi CS. Fibrinolytic and ACE Inhibitory Activity of Nattokinase Extracted from Bacillus subtilis VITMS 2: A Strain Isolated from Fermented Milk of Vigna unguiculata. Protein J. 2021;40:876. doi:10.1007/s10930-021-10023-8
- Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, et al. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34:1696.
- Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31:1583. doi:10.1291/hypres.31.1583
