Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 8 Reviews
8.3
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Calcium (from tricalcium phosphate and calcium stearate in Serratericâ„¢)
29 mg
2%
Serrapeptase Enzyme (from Serratio sp.)
40,000 SPU**
â€
Nattokinase (from fibrinase enzyme)
2,000 FU***
â€
Top Medical Research Studies
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
Read More
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Read More
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
Read More
Most Useful Reviews
9
Clot dissolved effectively
344 people found this helpful
Following several mini strokes, I was advised to take Eloquis, but I refused due to side effects and its inability to dissolve clots. Instead, I opted for Sarro/Natto, taking four daily. After six weeks, the pain in my neck resolved completely, and a CT scan showed that the clot in my carotid artery had disappeared.
Read More
9
Safe alternative to warfarin
48 people found this helpful
After experiencing issues with warfarin post-pulmonary embolism and afib, I sought herbal alternatives. Since switching to cayenne, ginger, turmeric, and Nattokinase, I’ve had no complications and feel great. A doctor even stated that I no longer have an increased risk of stroke, so I plan to take NattoSerra for life.
Read More
7.5
Effective pain relief
70 people found this helpful
Why wouldn't you try this wonder enzyme? I use this product for back pain in the lumbar spine, headaches, and other aches or pains. I give it a solid five stars as it surpasses opioids, muscle relaxants, and acetaminophen any day! There's no liver toxicity, side effects, or discomforts. Moreover, you benefit from preventing strokes and heart attacks!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
- All Researches
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Read More
9
We investigated how nattokinase, an oral supplement, impacts carotid artery health and lipid levels in patients. Over 26 weeks, participants were randomly assigned to receive either nattokinase or statins. Both groups saw reductions in carotid artery thickness and plaque size, but nattokinase outperformed statins in plaque reduction.
While both treatments lowered cholesterol and triglyceride levels, statins achieved greater reductions. Interestingly, nattokinase raised good cholesterol levels, unlike statins. Our study suggests that nattokinase could be a promising alternative in managing atherosclerosis and reducing stroke risk.
While both treatments lowered cholesterol and triglyceride levels, statins achieved greater reductions. Interestingly, nattokinase raised good cholesterol levels, unlike statins. Our study suggests that nattokinase could be a promising alternative in managing atherosclerosis and reducing stroke risk.
Read More
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
Read More
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Clot dissolved effectively
344 people found this helpful
Following several mini strokes, I was advised to take Eloquis, but I refused due to side effects and its inability to dissolve clots. Instead, I opted for Sarro/Natto, taking four daily. After six weeks, the pain in my neck resolved completely, and a CT scan showed that the clot in my carotid artery had disappeared.
Read More
9
Safe alternative to warfarin
48 people found this helpful
After experiencing issues with warfarin post-pulmonary embolism and afib, I sought herbal alternatives. Since switching to cayenne, ginger, turmeric, and Nattokinase, I’ve had no complications and feel great. A doctor even stated that I no longer have an increased risk of stroke, so I plan to take NattoSerra for life.
Read More
7.5
Effective pain relief
70 people found this helpful
Why wouldn't you try this wonder enzyme? I use this product for back pain in the lumbar spine, headaches, and other aches or pains. I give it a solid five stars as it surpasses opioids, muscle relaxants, and acetaminophen any day! There's no liver toxicity, side effects, or discomforts. Moreover, you benefit from preventing strokes and heart attacks!
Read More
0
Dangerous for AFIB patients
44 people found this helpful
Caution: I found this product harmful rather than beneficial. After just a week, it triggered constant afib when I exerted myself. Despite claims it wouldn’t affect my condition, I experienced muscle contractions and weight fluctuations due to water retention. I had to stop taking it to prevent severe health issues.
Read More
7.5
Natural alternative found
32 people found this helpful
I had a stroke in July. Instead of taking Plavix, a blood thinner, I am using Natto-Serra, a natural alternative.
Read More
Frequently Asked Questions
7.5
Successful treatment
Worth a try! I have experienced deep vein thrombosis, pulmonary embolism, and stroke. The doctors prescribed blood thinners which I took for several years. After starting this supplement, I stopped taking prescription medications and feel quite well. As my hematologist delightfully remarked, you can't argue with success!
7.5
Good for recovery
1 people found this helpful
I purchased this for my godfather. After I had a stroke previously, I checked online and found that the ingredients in this product are beneficial for individuals who have suffered a stroke. Consequently, I continued to buy this for my godfather to consume.
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
References
- Yang XY, Wang SL, Xue WC, Zhang YP, Li LL, et al. Nattokinase's Neuroprotective Mechanisms in Ischemic Stroke: Targeting Inflammation, Oxidative Stress, and Coagulation. Antioxid Redox Signal. 2025;42:228. 10.1089/ars.2023.0527
- Wu H, Zhang Q, Xu P, Chen J, Duan L, et al. Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin. J Agric Food Chem. 2023;71:11418. 10.1021/acs.jafc.2c08718
- Pham PT, Han B, Hoang BX. Nattospes as Effective and Safe Functional Supplements in Management of Stroke. J Med Food. 2020;23:879. 10.1089/jmf.2019.0183
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. 10.3760/cma.j.issn.0376-2491.2017.26.005
