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SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 12 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
9
Nattokinase shows promise for DR
Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy.
Directly addresses DR treatment
We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Read More
7
Nattokinase shows promise in diabetes
Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats.
Strong relevance to diabetes research
We explored how nattokinase (NK), a naturally occurring enzyme with anti-inflammatory and fibrinolytic effects, influences diabetes in a study using diabetic rats. Specifically, we focused on its potential to mitigate the harmful effects of diabetes, particularly in relation to blood glucose levels, plasma proteins, and inflammation.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
Read More
Most Useful Reviews
9.5
Saved leg from amputation
Saved Leg From Amputation - Along With Phototherapy. Years ago, I ran a therapy clinic focusing on electromagnetic therapies. I treated a patient with severe peripheral vascular disease who faced amputation. He had a dusky, purplish-red skin with severe tissue deprivation and 3+ pitting edema. I employed local phototherapy and liberal oral Nattokinase. Initially, his wife collected urine samples revealing oil-like material, which diminished over time. Nearly three years later, he had healthy, supple lower legs and strong pedal pulses, with no signs of Peripheral Vascular Disease. I have successfully saved four legs from amputation using this approach, including a 580lb diabetic patient whose second leg was saved. The wounds remained closed.
Read More
9.5
Health improvement
After extensive research, I bought this for my 55-year-old father who has diabetes, blood pressure issues, and kidney stones. He reports that it's wonderful and his health has improved. I'm thankful for this product and IHerb’s excellent quality.
Read More
9.5
Lowers blood lipids
Nattokinase effectively dissolves blood clots and has antithrombotic properties, making it ideal for individuals over 40 with diabetes, high blood pressure, and other related issues. Regular intake is recommended for those prone to thick blood.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
9
Nattokinase shows promise for DR
Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy.
Directly addresses DR treatment
We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Read More
7
Nattokinase shows promise in diabetes
Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats.
Strong relevance to diabetes research
We explored how nattokinase (NK), a naturally occurring enzyme with anti-inflammatory and fibrinolytic effects, influences diabetes in a study using diabetic rats. Specifically, we focused on its potential to mitigate the harmful effects of diabetes, particularly in relation to blood glucose levels, plasma proteins, and inflammation.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.7
9.5
Health improvement
After extensive research, I bought this for my 55-year-old father who has diabetes, blood pressure issues, and kidney stones. He reports that it's wonderful and his health has improved. I'm thankful for this product and IHerb’s excellent quality.
9.5
Lowers blood lipids
Nattokinase effectively dissolves blood clots and has antithrombotic properties, making it ideal for individuals over 40 with diabetes, high blood pressure, and other related issues. Regular intake is recommended for those prone to thick blood.
9.5
Preventive benefits
Nattokinase, derived from natto soybeans, helps break down fibrin and prevents blood clot formation. It lowers blood pressure, improves organ oxygen flow, strengthens blood vessel walls, and aids diabetes management. The product quality is excellent, and I’ve noticed significant health benefits.
Read More
9.5
Saved leg from amputation
Saved Leg From Amputation - Along With Phototherapy. Years ago, I ran a therapy clinic focusing on electromagnetic therapies. I treated a patient with severe peripheral vascular disease who faced amputation. He had a dusky, purplish-red skin with severe tissue deprivation and 3+ pitting edema. I employed local phototherapy and liberal oral Nattokinase. Initially, his wife collected urine samples revealing oil-like material, which diminished over time. Nearly three years later, he had healthy, supple lower legs and strong pedal pulses, with no signs of Peripheral Vascular Disease. I have successfully saved four legs from amputation using this approach, including a 580lb diabetic patient whose second leg was saved. The wounds remained closed.
Read More
8.8
Improved blood thickness
My father has had thick blood due to high cholesterol and blood clots for years. After taking various blood thinners following Covid and developing diabetes, I ordered this highly rated Nattokinase supplement for him. Within a month, he noticed his blood became thinner and his glucose levels improved. Most recently, his blood pressure has started to normalise. He is extremely pleased with the results and definitely recommends this excellent product.
Read More
