Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
9
We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Read More
7
We explored how nattokinase (NK), a naturally occurring enzyme with anti-inflammatory and fibrinolytic effects, influences diabetes in a study using diabetic rats. Specifically, we focused on its potential to mitigate the harmful effects of diabetes, particularly in relation to blood glucose levels, plasma proteins, and inflammation.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
Read More
9
We investigated the effects of a new fusion polypeptide combining glucagon-like peptide-1 (GLP-1) and nattokinase (NK) for managing diabetes and preventing blood clots. Using mice models, we found that after 15 days of treatment, this fusion polypeptide led to significant reductions in fasting blood glucose levels and effectively prevented thrombus formation.
This research lays groundwork for further drug development and understanding how this innovative treatment could benefit those with type 2 diabetes.
This research lays groundwork for further drug development and understanding how this innovative treatment could benefit those with type 2 diabetes.
Read More
Most Useful Reviews
9
Saved leg from amputation
290 people found this helpful
Saved Leg From Amputation - Along With Phototherapy. Years ago, I ran a therapy clinic focusing on electromagnetic therapies. I treated a patient with severe peripheral vascular disease who faced amputation. He had a dusky, purplish-red skin with severe tissue deprivation and 3+ pitting edema. I employed local phototherapy and liberal oral Nattokinase. Initially, his wife collected urine samples revealing oil-like material, which diminished over time. Nearly three years later, he had healthy, supple lower legs and strong pedal pulses, with no signs of Peripheral Vascular Disease. I have successfully saved four legs from amputation using this approach, including a 580lb diabetic patient whose second leg was saved. The wounds remained closed.
Read More
9
Health improvement
13 people found this helpful
After extensive research, I bought this for my 55-year-old father who has diabetes, blood pressure issues, and kidney stones. He reports that it's wonderful and his health has improved. I'm thankful for this product and IHerb’s excellent quality.
Read More
9
Lowers blood lipids
1 people found this helpful
Nattokinase effectively dissolves blood clots and has antithrombotic properties, making it ideal for individuals over 40 with diabetes, high blood pressure, and other related issues. Regular intake is recommended for those prone to thick blood.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
- All Researches
9
We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Read More
9
We investigated the effects of a new fusion polypeptide combining glucagon-like peptide-1 (GLP-1) and nattokinase (NK) for managing diabetes and preventing blood clots. Using mice models, we found that after 15 days of treatment, this fusion polypeptide led to significant reductions in fasting blood glucose levels and effectively prevented thrombus formation.
This research lays groundwork for further drug development and understanding how this innovative treatment could benefit those with type 2 diabetes.
This research lays groundwork for further drug development and understanding how this innovative treatment could benefit those with type 2 diabetes.
Read More
9
Mixed supplement improves diabetes markers
We examined how a mix of freeze-dried aronia, red ginseng, shiitake mushroom, and nattokinase influences diabetes in an animal model of type 2 diabetes. Over 12 weeks, diabetic rats received varying doses of the combination alongside a high-fat diet.
Our findings revealed that this combination enhanced insulin secretion and reduced insulin resistance, showing promise for improving glucose metabolism. The treatment also helped maintain better gut microbiome health and body composition in these diabetic rats.
While results look encouraging, we should be cautious in generalizing these findings to humans without more research.
Our findings revealed that this combination enhanced insulin secretion and reduced insulin resistance, showing promise for improving glucose metabolism. The treatment also helped maintain better gut microbiome health and body composition in these diabetic rats.
While results look encouraging, we should be cautious in generalizing these findings to humans without more research.
Read More
7
We explored how nattokinase (NK), a naturally occurring enzyme with anti-inflammatory and fibrinolytic effects, influences diabetes in a study using diabetic rats. Specifically, we focused on its potential to mitigate the harmful effects of diabetes, particularly in relation to blood glucose levels, plasma proteins, and inflammation.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Saved leg from amputation
290 people found this helpful
Saved Leg From Amputation - Along With Phototherapy. Years ago, I ran a therapy clinic focusing on electromagnetic therapies. I treated a patient with severe peripheral vascular disease who faced amputation. He had a dusky, purplish-red skin with severe tissue deprivation and 3+ pitting edema. I employed local phototherapy and liberal oral Nattokinase. Initially, his wife collected urine samples revealing oil-like material, which diminished over time. Nearly three years later, he had healthy, supple lower legs and strong pedal pulses, with no signs of Peripheral Vascular Disease. I have successfully saved four legs from amputation using this approach, including a 580lb diabetic patient whose second leg was saved. The wounds remained closed.
Read More
9
Health improvement
13 people found this helpful
After extensive research, I bought this for my 55-year-old father who has diabetes, blood pressure issues, and kidney stones. He reports that it's wonderful and his health has improved. I'm thankful for this product and IHerb’s excellent quality.
Read More
9
Lowers blood lipids
1 people found this helpful
Nattokinase effectively dissolves blood clots and has antithrombotic properties, making it ideal for individuals over 40 with diabetes, high blood pressure, and other related issues. Regular intake is recommended for those prone to thick blood.
Read More
9
Improved blood condition
1 people found this helpful
We take it at night to thin the blood; my husband's diabetes is significantly better in the morning. I've even stopped taking blood pressure medication at night, as it no longer rises. However, this is individual.
Read More
9
Preventive benefits
Nattokinase, derived from natto soybeans, helps break down fibrin and prevents blood clot formation. It lowers blood pressure, improves organ oxygen flow, strengthens blood vessel walls, and aids diabetes management. The product quality is excellent, and I’ve noticed significant health benefits.
Read More
Frequently Asked Questions
7.5
Improved blood thickness
394 people found this helpful
My father has had thick blood due to high cholesterol and blood clots for years. After taking various blood thinners following Covid and developing diabetes, I ordered this highly rated Nattokinase supplement for him. Within a month, he noticed his blood became thinner and his glucose levels improved. Most recently, his blood pressure has started to normalise. He is extremely pleased with the results and definitely recommends this excellent product.
7.5
Better circulation
1 people found this helpful
I’ve seen some improvement in my leg circulation. I have type two diabetes and face circulation issues. This supplement seems to help significantly.
7.5
Natural blood thinner
86 people found this helpful
My father has had issues with thick blood and diabetes for years. After trying many blood-thinning drugs post-Covid, I ordered him this highly rated Nattokinase supplement. It works excellently; he noticed his blood became lighter and his glucose levels improved. His blood pressure is also normalising, which is wonderful for him. He highly recommends this great product.
9
Improved blood condition
1 people found this helpful
We take it at night to thin the blood; my husband's diabetes is significantly better in the morning. I've even stopped taking blood pressure medication at night, as it no longer rises. However, this is individual.
9
Preventive benefits
Nattokinase, derived from natto soybeans, helps break down fibrin and prevents blood clot formation. It lowers blood pressure, improves organ oxygen flow, strengthens blood vessel walls, and aids diabetes management. The product quality is excellent, and I’ve noticed significant health benefits.
7.5
Good efficacy
2 people found this helpful
I bought this product because it's beneficial for diabetes. I have diabetes myself and experience numbness in my legs, but the quality and efficacy of the supplement are impressive. The nattokinase is great for blood circulation, and its size makes it easy to swallow.
7.5
Safe alternative
166 people found this helpful
Nattokinase is effective for blood thinning. I take one capsule daily. Initially, I took more, but found excessive circulation made it hard to sleep. This enzyme improves oxygen delivery and helps with blood-related issues, making it suitable for those with diabetes.
7
We explored how nattokinase (NK), a naturally occurring enzyme with anti-inflammatory and fibrinolytic effects, influences diabetes in a study using diabetic rats. Specifically, we focused on its potential to mitigate the harmful effects of diabetes, particularly in relation to blood glucose levels, plasma proteins, and inflammation.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
In our experiment, we divided STZ-induced diabetic rats into three groups: a control group on a basic diet, a low-NK diet group, and a high-NK diet group. Over 14 days, we noticed that the high-NK diet significantly reduced glycogen buildup in the renal tubules and lowered certain inflammatory markers, specifically C-reactive protein (CRP) levels, by day 14. Surprisingly, while significant improvements were noted in the inflammatory response, the high NK diet did not lead to reductions in blood glucose levels.
It seems that the beneficial effects of NK in terms of preventing additional complications in diabetes are distinct from its impact on blood sugar control. The results suggest that NK may play a crucial role in decreasing inflammation and tissue damage without directly affecting glucose levels. Yet, it's unclear whether these positive outcomes stem from the NK itself or from the breakdown products created during digestion.
9
We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.
Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.
Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
9
We investigated the effects of a new fusion polypeptide combining glucagon-like peptide-1 (GLP-1) and nattokinase (NK) for managing diabetes and preventing blood clots. Using mice models, we found that after 15 days of treatment, this fusion polypeptide led to significant reductions in fasting blood glucose levels and effectively prevented thrombus formation.
This research lays groundwork for further drug development and understanding how this innovative treatment could benefit those with type 2 diabetes.
This research lays groundwork for further drug development and understanding how this innovative treatment could benefit those with type 2 diabetes.
References
- Yamaguchi M, Fukuyama R, Fujita M. Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats. Heliyon. 2024;10:e28835. doi:10.1016/j.heliyon.2024.e28835
- Huang Z, Chu WK, Ng TK, Chen S, Liang J, et al. Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy. J Diabetes. 2023;15:866. doi:10.1111/1753-0407.13439
- Li X, Yang X, Umar M, Zhang Z, Luo W, et al. Expression of a novel dual-functional polypeptide and its pharmacological action research. Life Sci. 2021;267:118890. doi:10.1016/j.lfs.2020.118890
- Yang HJ, Kim MJ, Kwon DY, Kim DS, Zhang T, et al. Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats. Nutrients. 2018;10. doi:10.3390/nu10070948
