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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 36 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
9
Nattokinase benefits high blood pressure
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nattokinase's impact on hypertension
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Read More
8
Nattokinase shows anti-hypertensive activity
Fibrinolytic and ACE Inhibitory Activity of Nattokinase Extracted from Bacillus subtilis VITMS 2: A Strain Isolated from Fermented Milk of Vigna unguiculata.
Directly relevant to hypertension
Our exploration centered on the effectiveness of nattokinase, an enzyme produced by Bacillus subtilis VITMS 2, in managing hypertension. We focused on how this enzyme might help in reducing blood pressure by inhibiting angiotensin-converting enzyme (ACE), which plays a significant role in regulating blood pressure levels.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
Read More
5
Nattokinase's potential for hypertension
Fermented soybean foods: A review of their functional components, mechanism of action and factors influencing their health benefits.
Mixed evidence on effectiveness
We examined the potential benefits of nattokinase in treating hypertension, as this compound has gained attention for its health-promoting properties found in traditional fermented soybean foods. Our review highlighted how nattokinase, alongside its bioactive brothers, might support blood pressure management by inhibiting certain enzymes linked to hypertension.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
Read More
Most Useful Reviews
9.5
Improved blood pressure
I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!
Read More
9.5
Effective remedy
Nattokinase works as a safer alternative to aspirin for improving blood fluidity. Long-term use has greatly alleviated my hypertension concerns. I take it in the evening and in the morning with serrapeptase, which helped me forget about my blood pressure issues!
Read More
9.5
Cardiovascular benefits
Nattokinase is derived from fermented soybeans and has historically been used to combat cardiovascular issues. It offers a remedy for hypertension, stroke, varicose veins, and poor circulation, making it a valuable supplement for various health concerns.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
9
Nattokinase benefits high blood pressure
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nattokinase's impact on hypertension
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Read More
8
Nattokinase shows anti-hypertensive activity
Fibrinolytic and ACE Inhibitory Activity of Nattokinase Extracted from Bacillus subtilis VITMS 2: A Strain Isolated from Fermented Milk of Vigna unguiculata.
Directly relevant to hypertension
Our exploration centered on the effectiveness of nattokinase, an enzyme produced by Bacillus subtilis VITMS 2, in managing hypertension. We focused on how this enzyme might help in reducing blood pressure by inhibiting angiotensin-converting enzyme (ACE), which plays a significant role in regulating blood pressure levels.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
Read More
5
Nattokinase's potential for hypertension
Fermented soybean foods: A review of their functional components, mechanism of action and factors influencing their health benefits.
Mixed evidence on effectiveness
We examined the potential benefits of nattokinase in treating hypertension, as this compound has gained attention for its health-promoting properties found in traditional fermented soybean foods. Our review highlighted how nattokinase, alongside its bioactive brothers, might support blood pressure management by inhibiting certain enzymes linked to hypertension.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.7
9.5
Improved blood pressure
I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!
Read More
9.5
Effective remedy
Nattokinase works as a safer alternative to aspirin for improving blood fluidity. Long-term use has greatly alleviated my hypertension concerns. I take it in the evening and in the morning with serrapeptase, which helped me forget about my blood pressure issues!
9.5
Cardiovascular benefits
Nattokinase is derived from fermented soybeans and has historically been used to combat cardiovascular issues. It offers a remedy for hypertension, stroke, varicose veins, and poor circulation, making it a valuable supplement for various health concerns.
9.5
Thrombosis prevention
Nattokinase activates enzymes that dissolve blood clots and helps lower blood pressure. Compared to other medications like warfarin, it is safer and lasts longer. A study indicated that it significantly reduced hypertension after consistent use.
9.5
Long-term wellness
Nattokinase is similar to plasmin, helping dissolve fibrin and preventing hypertension. It enhances blood flow, reducing the risk of clots that can lead to heart attacks and strokes. I take one capsule daily for significant health benefits.
