5/16/2025
Last update
5/16/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 36 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
8
We evaluated how nattokinase affects blood pressure in people living with pre-hypertension or stage 1 hypertension. In this randomized, double-blind, placebo-controlled trial involving 86 participants, we found that those taking nattokinase showed a significant drop in both systolic and diastolic blood pressure after 8 weeks. Specifically, systolic blood pressure decreased by an average of 5.55 mmHg, while diastolic blood pressure fell by 2.84 mmHg. Our results suggest that nattokinase could be a beneficial option in managing hypertension.
Read More
9
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Read More
9
We aimed to understand how nattokinase affects hypertension by comparing its efficacy against its non-protease fragments in spontaneously hypertensive rats.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Read More
Most Useful Reviews
9
Improved blood pressure
188 people found this helpful
I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!
Read More
9
Effective remedy
89 people found this helpful
Nattokinase works as a safer alternative to aspirin for improving blood fluidity. Long-term use has greatly alleviated my hypertension concerns. I take it in the evening and in the morning with serrapeptase, which helped me forget about my blood pressure issues!
Read More
9
Cardiovascular benefits
27 people found this helpful
Nattokinase is derived from fermented soybeans and has historically been used to combat cardiovascular issues. It offers a remedy for hypertension, stroke, varicose veins, and poor circulation, making it a valuable supplement for various health concerns.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Read More
9
We aimed to understand how nattokinase affects hypertension by comparing its efficacy against its non-protease fragments in spontaneously hypertensive rats.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Read More
8
Our exploration centered on the effectiveness of nattokinase, an enzyme produced by Bacillus subtilis VITMS 2, in managing hypertension. We focused on how this enzyme might help in reducing blood pressure by inhibiting angiotensin-converting enzyme (ACE), which plays a significant role in regulating blood pressure levels.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
Read More
8
We evaluated how nattokinase affects blood pressure in people living with pre-hypertension or stage 1 hypertension. In this randomized, double-blind, placebo-controlled trial involving 86 participants, we found that those taking nattokinase showed a significant drop in both systolic and diastolic blood pressure after 8 weeks. Specifically, systolic blood pressure decreased by an average of 5.55 mmHg, while diastolic blood pressure fell by 2.84 mmHg. Our results suggest that nattokinase could be a beneficial option in managing hypertension.
Read More
5
We examined the potential benefits of nattokinase in treating hypertension, as this compound has gained attention for its health-promoting properties found in traditional fermented soybean foods. Our review highlighted how nattokinase, alongside its bioactive brothers, might support blood pressure management by inhibiting certain enzymes linked to hypertension.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
While evidence suggests that nattokinase can be effective, it’s crucial to note that specific studies may show mixed results when isolated from other treatments. This nuance is important since the full scope of nattokinase's benefits could involve a broader context of dietary and lifestyle factors.
Overall, we found that incorporating nattokinase into a health-conscious diet could be worthwhile for those aiming to manage hypertension more naturally. However, we also recognize that more targeted research is necessary to fully understand its standalone efficacy.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved blood pressure
188 people found this helpful
I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!
Read More
9
Effective remedy
89 people found this helpful
Nattokinase works as a safer alternative to aspirin for improving blood fluidity. Long-term use has greatly alleviated my hypertension concerns. I take it in the evening and in the morning with serrapeptase, which helped me forget about my blood pressure issues!
Read More
9
Cardiovascular benefits
27 people found this helpful
Nattokinase is derived from fermented soybeans and has historically been used to combat cardiovascular issues. It offers a remedy for hypertension, stroke, varicose veins, and poor circulation, making it a valuable supplement for various health concerns.
Read More
9
Thrombosis prevention
11 people found this helpful
Nattokinase activates enzymes that dissolve blood clots and helps lower blood pressure. Compared to other medications like warfarin, it is safer and lasts longer. A study indicated that it significantly reduced hypertension after consistent use.
Read More
9
Long-term wellness
9 people found this helpful
Nattokinase is similar to plasmin, helping dissolve fibrin and preventing hypertension. It enhances blood flow, reducing the risk of clots that can lead to heart attacks and strokes. I take one capsule daily for significant health benefits.
Read More
Frequently Asked Questions
9
Cardiovascular health
1 people found this helpful
Nattokinase, a key post-COVID supplement, promotes longevity and lowers chronic disease rates. It dissolves fibrin, reducing blood viscosity and clots without the gastrointestinal bleeding associated with aspirin. I noticed its effects within a week.
7.5
Quality blood thinner
26 people found this helpful
I take nattokinase as a natural alternative to aspirin for blood thinning, helping to manage my hypertension. It has improved joint health and reduced high blood pressure, with additional benefits for my skin and overall well-being. I’ve been using it for three months.
7.5
Cholesterol improvement
8 people found this helpful
I've been using nattokinase for nearly two months, and while it took some time, it has effectively lowered my cholesterol and assisted with my severe hypertension. Unlike statins, it doesn't cause side effects, and I am pleased with the results.
9
Improved blood pressure
188 people found this helpful
I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!
9
Effective remedy
89 people found this helpful
Nattokinase works as a safer alternative to aspirin for improving blood fluidity. Long-term use has greatly alleviated my hypertension concerns. I take it in the evening and in the morning with serrapeptase, which helped me forget about my blood pressure issues!
7.5
Positive blood pressure outcomes
4 people found this helpful
After a friend's recommendation, I purchased nattokinase for my father, who has hypertension. The results have been promising; his blood pressure is now under control, and his health markers have improved significantly. I even bought ten more bottles to continue his treatment.
6
Pressure management
64 people found this helpful
I replaced aspirin with nattokinase to improve blood fluidity. I take one capsule each evening, although this dosage may cause bruising at times. I also take an extra dose before flights to prevent thrombosis. It is important not to take it with other blood thinners. Nattokinase is beneficial for hypertension and other cardiovascular issues.
7.5
Stabilises blood pressure
6 people found this helpful
I took this to help with blood clots. While the effects are not directly visible, my blood pressure seems to have lowered and stabilised. I plan to continue using it as it may replace my hypertension medication in the long run.
9
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
8
We evaluated how nattokinase affects blood pressure in people living with pre-hypertension or stage 1 hypertension. In this randomized, double-blind, placebo-controlled trial involving 86 participants, we found that those taking nattokinase showed a significant drop in both systolic and diastolic blood pressure after 8 weeks. Specifically, systolic blood pressure decreased by an average of 5.55 mmHg, while diastolic blood pressure fell by 2.84 mmHg. Our results suggest that nattokinase could be a beneficial option in managing hypertension.
8
Our exploration centered on the effectiveness of nattokinase, an enzyme produced by Bacillus subtilis VITMS 2, in managing hypertension. We focused on how this enzyme might help in reducing blood pressure by inhibiting angiotensin-converting enzyme (ACE), which plays a significant role in regulating blood pressure levels.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
References
- Li X, Long J, Gao Q, Pan M, Wang J, et al. Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Rev Cardiovasc Med. 2023;24:234. 10.31083/j.rcm2408234
- Qiao Y, Zhang K, Zhang Z, Zhang C, Sun Y, et al. Fermented soybean foods: A review of their functional components, mechanism of action and factors influencing their health benefits. Food Res Int. 2022;158:111575. 10.1016/j.foodres.2022.111575
- Keziah SM, Devi CS. Fibrinolytic and ACE Inhibitory Activity of Nattokinase Extracted from Bacillus subtilis VITMS 2: A Strain Isolated from Fermented Milk of Vigna unguiculata. Protein J. 2021;40:876. 10.1007/s10930-021-10023-8
- Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, et al. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34:1696.
- Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31:1583. 10.1291/hypres.31.1583
