Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 54 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
Read More
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Read More
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
Read More
Most Useful Reviews
9
Hydrates blood effectively
188 people found this helpful
I use nattokinase instead of aspirin for thick blood, enhancing its fluidity. High blood viscosity poses a risk for strokes, hence I take it in the evening and on an empty stomach in the morning. It helps me forget my blood pressure issues!
Read More
9
Saved from illness
108 people found this helpful
This product is excellent. After having a stroke, I experienced significant personality changes. I took a regimen of Nattokinase and Serrapeptase, alongside Niacinamide, and now my memory and personality have returned to what they were in my youth. I am truly grateful to be alive and well at 65.
Read More
9
Effective for stroke prevention
89 people found this helpful
I use nattokinase as an alternative to aspirin for my thick blood, which can lead to strokes. I take it before bed and on an empty stomach for optimal results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
- All Researches
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Read More
9
We investigated how nattokinase, an oral supplement, impacts carotid artery health and lipid levels in patients. Over 26 weeks, participants were randomly assigned to receive either nattokinase or statins. Both groups saw reductions in carotid artery thickness and plaque size, but nattokinase outperformed statins in plaque reduction.
While both treatments lowered cholesterol and triglyceride levels, statins achieved greater reductions. Interestingly, nattokinase raised good cholesterol levels, unlike statins. Our study suggests that nattokinase could be a promising alternative in managing atherosclerosis and reducing stroke risk.
While both treatments lowered cholesterol and triglyceride levels, statins achieved greater reductions. Interestingly, nattokinase raised good cholesterol levels, unlike statins. Our study suggests that nattokinase could be a promising alternative in managing atherosclerosis and reducing stroke risk.
Read More
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
Read More
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
Read More
User Reviews
USERS' SCORE
Good
Based on 54 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Hydrates blood effectively
188 people found this helpful
I use nattokinase instead of aspirin for thick blood, enhancing its fluidity. High blood viscosity poses a risk for strokes, hence I take it in the evening and on an empty stomach in the morning. It helps me forget my blood pressure issues!
Read More
9
Saved from illness
108 people found this helpful
This product is excellent. After having a stroke, I experienced significant personality changes. I took a regimen of Nattokinase and Serrapeptase, alongside Niacinamide, and now my memory and personality have returned to what they were in my youth. I am truly grateful to be alive and well at 65.
Read More
9
Effective for stroke prevention
89 people found this helpful
I use nattokinase as an alternative to aspirin for my thick blood, which can lead to strokes. I take it before bed and on an empty stomach for optimal results.
Read More
10
Long-term health investment
24 people found this helpful
Nattokinase is an ongoing investment in health, gently thinning blood to prevent strokes and improve overall well-being. My family and I have seen its positive effects.
Read More
8
Cost-effective treatment
24 people found this helpful
I started using nattokinase after a brain MRI showed clots causing minor strokes. It’s a natural alternative to aspirin that I've found economical and effective, even though I haven’t had my blood thickness checked again.
Read More
Frequently Asked Questions
9
Post-Covid benefits
1 people found this helpful
Nattokinase is highly beneficial post-Covid. It dissolves fibrin, reducing blood viscosity and clots, thereby preventing stroke and heart issues. In my experience, after taking it, a prior discomfort in my leg improved significantly within a few days. It's a safe, natural alternative to other blood thinners.
9
No side effects
9 people found this helpful
I have been using Nattokinase for three years after suffering a stroke. I replaced Warfarin with Nattokinase and have experienced no side effects and no more blood spots under my skin. It works perfectly for me.
9
Supports circulation
6 people found this helpful
I have taken Nattokinase for over ten years following my stroke. It supports normal circulation, blood flow, and blood viscosity.
9
Stops clotting issues
22 people found this helpful
After suffering a stroke, I started using nattokinase instead of aspirin and have had no clotting issues since. I take four capsules daily and feel great about this alternative.
9
Cognitive recovery support
4 people found this helpful
Nattokinase helps maintain healthy fibrin levels, crucial for preventing stroke-related risks. My mother, who suffered a stroke, improved cognitively after three daily capsules, preventing recurrence. Regular intake may help dissolve blood clots and ensure better overall health outcomes.
7.5
Natural blood thinner
9 people found this helpful
After my father’s stroke, we chose nattokinase instead of aspirin which caused bleeding issues. It’s safer, has improved his condition, and works well alongside Omega 3.
9
Stroke prevention
8 people found this helpful
I was experiencing TIA's and a minor stroke when I started taking Nattokinase several years ago. Since then, I haven't had any further incidents. I take four capsules daily, two in the morning and two in the evening.
7.5
Reduced recurrence
7 people found this helpful
I had a mini stroke five years ago. After reading about the benefits of Natto, I decided to try it and have been taking it twice a day since. I have not had a recurrence of the mini stroke and intend to continue taking it.
9
Hydrates blood effectively
188 people found this helpful
I use nattokinase instead of aspirin for thick blood, enhancing its fluidity. High blood viscosity poses a risk for strokes, hence I take it in the evening and on an empty stomach in the morning. It helps me forget my blood pressure issues!
9
Effective for stroke prevention
89 people found this helpful
I use nattokinase as an alternative to aspirin for my thick blood, which can lead to strokes. I take it before bed and on an empty stomach for optimal results.
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
References
- Yang XY, Wang SL, Xue WC, Zhang YP, Li LL, et al. Nattokinase's Neuroprotective Mechanisms in Ischemic Stroke: Targeting Inflammation, Oxidative Stress, and Coagulation. Antioxid Redox Signal. 2025;42:228. 10.1089/ars.2023.0527
- Wu H, Zhang Q, Xu P, Chen J, Duan L, et al. Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin. J Agric Food Chem. 2023;71:11418. 10.1021/acs.jafc.2c08718
- Pham PT, Han B, Hoang BX. Nattospes as Effective and Safe Functional Supplements in Management of Stroke. J Med Food. 2020;23:879. 10.1089/jmf.2019.0183
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. 10.3760/cma.j.issn.0376-2491.2017.26.005
