Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60 
Amount Per Serving
%DV
Vitamin K2 (from MenaQ7® Menaquinone, MK-7)
45 mcg
38%

Top Medical Research Studies

9
Vitamin K2 supports BMD in osteoporosis
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.

Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.

However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Read More
9
MK-4 enhances bone health
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.

Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.

Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More

Most Useful Reviews

7.5
Effective osteoporosis support
31 people found this helpful
Works for osteoporosis. My mother developed this condition, and after researching, I found that the combination of vitamin D and K2 is beneficial. This product helps raise vitamin D levels in the blood effectively. The capsules are small and easy to swallow.
Read More
9
Bone density improvement
14 people found this helpful
Easy to swallow and it helped my bone density improve in two areas, going from osteoporosis to osteopenia.
Read More
9
Prevents calcium misplacement
9 people found this helpful
This important supplement ensures calcium benefits bones while preventing its deposition in vessels and soft tissues. Vitamin K is widely respected in treating osteoporosis and other conditions. I appreciate its role in health care in developed nations, especially in Japan.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
  • All Researches
9
Vitamin K2 supports BMD in osteoporosis
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
9
MK-4 enhances bone health
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.

Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.

Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
9
Vitamin K2 enhances osteoporosis treatment
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).

In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.

Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.

Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
Read More
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.

Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.

These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Read More
9
Vitamin K2 promotes bone health
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.

Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.

Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.

Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 26 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Effective osteoporosis support
31 people found this helpful
Works for osteoporosis. My mother developed this condition, and after researching, I found that the combination of vitamin D and K2 is beneficial. This product helps raise vitamin D levels in the blood effectively. The capsules are small and easy to swallow.
Read More
9
Bone density improvement
14 people found this helpful
Easy to swallow and it helped my bone density improve in two areas, going from osteoporosis to osteopenia.
Read More
9
Prevents calcium misplacement
9 people found this helpful
This important supplement ensures calcium benefits bones while preventing its deposition in vessels and soft tissues. Vitamin K is widely respected in treating osteoporosis and other conditions. I appreciate its role in health care in developed nations, especially in Japan.
Read More
7.5
Addressing osteoporosis effectively
5 people found this helpful
After being prescribed a higher dosage due to early signs of osteoporosis, I take this alongside Vitamin D3. It seems effective as I experience no pain. At 73, I continue to compete as a senior trail runner, which I take pride in.
Read More
7.5
Improves bone issues
4 people found this helpful
I’ve been addressing my leaky gut and acid reflux. After adding vitamins K2 and D3, I observed reduced prominence in my varicose veins within three weeks, and I hope to see longer-term improvements for my bones and gut.
Read More

Frequently Asked Questions

7.5
Improves bone issues
4 people found this helpful
I’ve been addressing my leaky gut and acid reflux. After adding vitamins K2 and D3, I observed reduced prominence in my varicose veins within three weeks, and I hope to see longer-term improvements for my bones and gut.
6
Consistent use
I take K2 for osteoporosis. While it may not show immediate effects, consistent use is advised, and I plan to monitor changes in my test results later.
9
Improved bone density
1 people found this helpful
I purchased this product with Vitamin D3 for my mother diagnosed with osteoporosis. After three years, her vitamin D levels and bone density have improved significantly. The capsules are easy to swallow and the quality is commendable.
7.5
Addressing osteoporosis effectively
5 people found this helpful
After being prescribed a higher dosage due to early signs of osteoporosis, I take this alongside Vitamin D3. It seems effective as I experience no pain. At 73, I continue to compete as a senior trail runner, which I take pride in.
7.5
Essential for bone health
1 people found this helpful
I've found that taking vitamin K2 alongside vitamin D3, magnesium, and calcium is effective in increasing bone density and reducing fractures. Although it takes time for the benefits to appear, I believe in the necessity of vitamin K2 for osteoporosis prevention.
9
Avoids calcium-related risks
1 people found this helpful
I combine K2 and D to ensure calcium is absorbed by bones instead of settling in the arteries. This combination is effective in fighting osteoporosis, and I also take magnesium and vitamin C for better absorption without gastrointestinal discomfort.
9
Prevents calcium misplacement
9 people found this helpful
This important supplement ensures calcium benefits bones while preventing its deposition in vessels and soft tissues. Vitamin K is widely respected in treating osteoporosis and other conditions. I appreciate its role in health care in developed nations, especially in Japan.
7.5
Bone health support
Small doses of vitamin K2 are beneficial for the elderly’s bones and help prevent osteoporosis.
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.

Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.

However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
9
Vitamin K2 supports BMD in osteoporosis
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
4
Vitamin K shows modest hip geometry effects
We evaluated how vitamin K supplementation could impact fracture risk in post-menopausal women with osteoporosis, particularly when paired with bisphosphonates, calcium, and vitamin D. Although our study involved 105 women and used rigorous methods, we found no significant improvements in bone density or turnover.

Interestingly, vitamin K did show a modest effect on hip geometry, suggesting some potential benefits in this area. However, to truly understand its effectiveness, further studies are necessary to confirm these findings.
We examined how vitamin K2 impacts osteoporosis, focusing on its role in promoting strong bones. This review highlighted how various vitamins, including K2, contribute to bone health. It emphasized that while deficiencies in vitamins can lead to a higher risk of osteoporosis, maintaining a balanced intake is essential.

Vitamin K2 shows promise in preventing osteoporosis by activating matrix Gla protein, which is important for bone mineralization. This vitamin works alongside other vitamins like A, C, and E to foster the development of bone-forming cells known as osteoblasts. Interestingly, vitamin K2 helps to lower the risk of vascular calcification, which is beneficial for maintaining healthy bones.

We learned that while vitamin K2 has positive effects, careful attention to recommended dosages is crucial. Excessive intake of certain vitamins, especially vitamin A, can negatively affect bone health. Therefore, we concluded that a balanced approach to vitamin intake, including K2, may be a viable strategy for osteoporosis prevention.
9
Vitamin K2 promotes bone health
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.

Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.

Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.

Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.

References

  1. Ding F, Zhang W, Liu T, Rong X, Cui Y, et al. MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells. Drug Des Devel Ther. 2025;19:2173. doi:10.2147/DDDT.S503930
  2. Wang Q, Yu H, Kong Y. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:69. doi:10.1186/s12891-024-07173-y
  3. Öz İ, Kochai A, Avan YL, Keskin D, Çınar BM, et al. The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis. Jt Dis Relat Surg. 2023;34:356. doi:10.52312/jdrs.2023.911
  4. Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, et al. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Arch Osteoporos. 2023;18:83. doi:10.1007/s11657-023-01288-w
  5. Li C, Liang C, Kong Z, Su Y, Ren W, et al. Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism. Ann Nutr Metab. 2023;79:334. doi:10.1159/000531065
  6. Giordani C, Matacchione G, Giuliani A, Valli D, Scarpa ES, et al. Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108820
  7. Lee AS, Sung MJ, Son SJ, Han AR, Hong SM, et al. Effect of Menaquinone-4 on Receptor Activator of Nuclear Factor B Ligand-Induced Osteoclast Differentiation and Ovariectomy-Induced Bone Loss. J Med Food. 2023;26:128. doi:10.1089/jmf.2022.K.0078
  8. Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
  9. Tao X, Xu T, Liu L, Lin X, Zhang Z, et al. Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia. Front Endocrinol (Lausanne). 2022;13:961322. doi:10.3389/fendo.2022.961322
  10. Ma ML, Ma ZJ, He YL, Sun H, Yang B, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649. doi:10.3389/fpubh.2022.979649
  11. Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6
  12. Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
  13. Mandatori D, Penolazzi L, Pelusi L, Lambertini E, Michelucci F, et al. Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2. Nutrients. 2021;13. doi:10.3390/nu13082823
  14. Wang H, Zhang N, Li L, Yang P, Ma Y. Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling. Nutrients. 2021;13. doi:10.3390/nu13082570
  15. Wang B, Tang J, Weng S, Chen L, Wu Z, et al. Is vitamin K a treatment choice for atypical femoral fractures in patients with secondary osteoporosis?. J Int Med Res. 2021;49:3000605211001643. doi:10.1177/03000605211001643
  16. Solmaz I, Ozdemir MA, Unal E, Abdurrezzak U, Muhtaroglu S, et al. Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study. J Pediatr Endocrinol Metab. 2021;34:441. doi:10.1515/jpem-2020-0637
  17. Zhang Z, Xia K, Gong W, Mai R, Liu P, et al. Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis. Horm Metab Res. 2025;57:33. doi:10.1055/a-2371-1642
  18. Hirashima S, Kiyooka Y, Kaetsu S, Nakagawa K. Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice. Biochem Biophys Res Commun. 2024;702:149635. doi:10.1016/j.bbrc.2024.149635
  19. Kong M, Gao C, Luan X, Fan C, Hao M, et al. Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis. BMC Musculoskelet Disord. 2024;25:109. doi:10.1186/s12891-024-07227-1
  20. Skalny AV, Aschner M, Tsatsakis A, Rocha JBT, Santamaria A, et al. Role of vitamins beyond vitamin D in bone health and osteoporosis (Review). Int J Mol Med. 2024;53. doi:10.3892/ijmm.2023.5333
  21. Cui Y, Zhang W, Yang P, Zhu S, Luo S, et al. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Free Radic Biol Med. 2023;206:33. doi:10.1016/j.freeradbiomed.2023.06.022
  22. Wang H, Li L, Zhang N, Ma Y. Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells. Nutrients. 2022;14. doi:10.3390/nu14142934
  23. Jadhav N, Ajgaonkar S, Saha P, Gurav P, Pandey A, et al. Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front Pharmacol. 2022;13:896920. doi:10.3389/fphar.2022.896920
  24. Hu L, Ji J, Li D, Meng J, Yu B. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:592. doi:10.1186/s13018-021-02728-4
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