Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 23 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
Read More
8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
Read More
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
Most Useful Reviews
9
Pain relief experienced
7 people found this helpful
I was struggling with severe back pain and could barely stand, but after taking one capsule post-breakfast, the pain diminished significantly within three days. This unexpected relief makes me extremely grateful. I suspect that, along with my diabetes medication, the B12 supplement has contributed to my recovery.
Read More
9
Supports well-being
4 people found this helpful
Vegetarians, the elderly, and those with gastrointestinal issues are prone to B12 deficiency, especially if they have diabetes. This product is highly effective for my diabetic mother who is also vegetarian and in advanced age. It absorbs well and helps her maintain good energy and mood.
Read More
9
Dog regained mobility
4 people found this helpful
I use this for my older dog with diabetes. She developed type 1 diabetes, losing significant muscle mass and struggling to stand or walk. However, within weeks of starting treatment, she was jumping and playing with her younger dog pal. Now, when she sees a rabbit, she's off in a flash.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
- All Researches
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Read More
8
We investigated how gastrectomy impacts the risk of type 2 diabetes in gastric cancer survivors. Analyzing data from over 150,000 patients, we observed that those who underwent total gastrectomy had a higher chance of developing diabetes, especially if they didn't take vitamin B12 supplements. Surprisingly, patients who had subtotal gastrectomy enjoyed a lower risk of diabetes. Furthermore, B12 supplementation appeared to shield those who underwent total gastrectomy from heightened diabetes risk. This highlights the importance of monitoring and managing vitamin levels post-surgery.
Read More
8
We examined the relationship between B vitamin intake and the risk of developing type 2 diabetes (T2D) through a large study in Shanghai. Using data from nearly 45,000 adults, we found that higher consumption of B vitamins, particularly B1, B2, B6, B9, and B12, was linked to a lower risk of T2D.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Read More
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief experienced
7 people found this helpful
I was struggling with severe back pain and could barely stand, but after taking one capsule post-breakfast, the pain diminished significantly within three days. This unexpected relief makes me extremely grateful. I suspect that, along with my diabetes medication, the B12 supplement has contributed to my recovery.
Read More
9
Supports well-being
4 people found this helpful
Vegetarians, the elderly, and those with gastrointestinal issues are prone to B12 deficiency, especially if they have diabetes. This product is highly effective for my diabetic mother who is also vegetarian and in advanced age. It absorbs well and helps her maintain good energy and mood.
Read More
9
Dog regained mobility
4 people found this helpful
I use this for my older dog with diabetes. She developed type 1 diabetes, losing significant muscle mass and struggling to stand or walk. However, within weeks of starting treatment, she was jumping and playing with her younger dog pal. Now, when she sees a rabbit, she's off in a flash.
Read More
9
Improved mobility
1 people found this helpful
I was advised this drug for my cat recovering from neuropathic disorders caused by diabetes. The cat struggled to walk and jump. Following my vet's recommendation, we added this form of vitamin B12 alongside the main treatment. Remarkably, it strengthened my cat's paws, improved his gait, and he began to jump again. We administer one capsule twice daily mixed in food without any side effects.
Read More
9
Metabolism aid
This excellent vitamin B12 supplement supports metabolism, fat burning, and the nervous system, particularly for those with diabetes.
Read More
Frequently Asked Questions
9
Pain relief experienced
7 people found this helpful
I was struggling with severe back pain and could barely stand, but after taking one capsule post-breakfast, the pain diminished significantly within three days. This unexpected relief makes me extremely grateful. I suspect that, along with my diabetes medication, the B12 supplement has contributed to my recovery.
9
Supports well-being
4 people found this helpful
Vegetarians, the elderly, and those with gastrointestinal issues are prone to B12 deficiency, especially if they have diabetes. This product is highly effective for my diabetic mother who is also vegetarian and in advanced age. It absorbs well and helps her maintain good energy and mood.
7.5
Cat's neuropathy improved
3 people found this helpful
I bought methylcobalamin for my diabetic cat, who developed neuropathy. After four months of daily doses mixed into her food, I began to see improvements in her mobility. I plan to continue this treatment as the effects have been beneficial.
6
Helps with deficiency
4 people found this helpful
Vitamin B12 is essential for those with diabetes, especially if taking medication for a long time, as it can lead to depletion. This supplement addresses that deficiency. While it does not prevent diabetes, it helps replenish B12 levels effectively.
9
Recovery boost
My diabetic cat struggled to walk even after starting insulin. After adding B12 and folic acid, he now jumps on the bed. It's amazing!
7.5
Numbness alleviated
1 people found this helpful
My father has stage 2 diabetes, and he experienced leg numbness after walking. Since taking this B12 supplement, he has shown improvement.
7.5
Enhanced vitality
I bought B12 for my father-in-law, who takes medication for type 2 diabetes, as Metformin depletes B12. Since he started taking it, he seems more lively, but it's essential to monitor his iron levels.
9
Synergistic effect
It is crucial to take this alongside diabetes medication. Even a small pill is effective, and together they have a synergistic effect. I intend to use it long-term and will provide updates. I highly recommend it.
8
High B12 content
4 people found this helpful
I purchased this 500mcg methylcobalamin for my mother, who has diabetes and often depletes B12 due to her medication. This product's form ensures good absorption, and with 1500mcg per tablet, I only need to give it every two days.
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
7
We explored the relationship between high serum vitamin B12 levels and diabetes, particularly focusing on how vitamin B12 supplementation might affect this condition. In our retrospective study, we gathered data from 3,511 patients over one year who were found to have elevated B12 levels above the normal limit of 771 pg/mL.
A significant finding from our analysis was that 53.2% of patients with high B12 levels were also diagnosed with diabetes and had been using vitamin B12 as part of their treatment regimen. This suggests that there may be a potential link between vitamin B12 supplementation and diabetes management.
Furthermore, we observed a positive correlation between elevated B12 levels and specific laboratory results, indicating that patients’ age and other liver-related parameters could play a role in these outcomes. However, we did not find compelling evidence that vitamin B12 directly improves diabetes symptoms or controls blood sugar levels independently.
Overall, while high serum vitamin B12 is often associated with diabetes in those using it as a supplementary treatment, more detailed investigations are needed to fully understand the implications for diabetes management. Most notably, we found that many comorbid conditions were benign, primarily among Saudi patients aged 50-70.
A significant finding from our analysis was that 53.2% of patients with high B12 levels were also diagnosed with diabetes and had been using vitamin B12 as part of their treatment regimen. This suggests that there may be a potential link between vitamin B12 supplementation and diabetes management.
Furthermore, we observed a positive correlation between elevated B12 levels and specific laboratory results, indicating that patients’ age and other liver-related parameters could play a role in these outcomes. However, we did not find compelling evidence that vitamin B12 directly improves diabetes symptoms or controls blood sugar levels independently.
Overall, while high serum vitamin B12 is often associated with diabetes in those using it as a supplementary treatment, more detailed investigations are needed to fully understand the implications for diabetes management. Most notably, we found that many comorbid conditions were benign, primarily among Saudi patients aged 50-70.
4
We conducted a thorough examination on the prevalence of vitamin B12 deficiency among patients with type 2 diabetes who have been on metformin therapy. Our study involved 260 participants who had been using this medication for over a year. We took blood samples to measure their vitamin B12 levels and assessed various factors that might influence these levels.
Interestingly, we found that about 36.54% of patients were vitamin B12 deficient. The deficiency seemed more common in women, particularly those aged between 41 to 50 years, and in individuals with a longer history of diabetes. However, we did not find a clear connection between the dosage of metformin or the duration of treatment and vitamin B12 levels.
Therefore, while it is evident that vitamin B12 deficiency is a significant concern for more than a third of individuals taking metformin, our findings suggest that increasing the metformin dosage or extending the treatment duration does not necessarily lead to greater deficiency risks. This highlights the importance of routinely checking vitamin B12 levels in diabetic patients on metformin to prevent potential complications, ensuring they maintain a better quality of life.
Interestingly, we found that about 36.54% of patients were vitamin B12 deficient. The deficiency seemed more common in women, particularly those aged between 41 to 50 years, and in individuals with a longer history of diabetes. However, we did not find a clear connection between the dosage of metformin or the duration of treatment and vitamin B12 levels.
Therefore, while it is evident that vitamin B12 deficiency is a significant concern for more than a third of individuals taking metformin, our findings suggest that increasing the metformin dosage or extending the treatment duration does not necessarily lead to greater deficiency risks. This highlights the importance of routinely checking vitamin B12 levels in diabetic patients on metformin to prevent potential complications, ensuring they maintain a better quality of life.
References
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Kim G, Han KD, Cho SH, Oh R, Lee YB, et al. Association between gastrectomy and the risk of type 2 diabetes in gastric cancer survivors: A nationwide cohort study. Diabetes Metab. 2024;50:101569. doi:10.1016/j.diabet.2024.101569
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. doi:10.3390/nu16121901
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. doi:10.1016/j.ijpharm.2024.124250
- Hakola L, Mramba LK, Uusitalo U, Andrén Aronsson C, Hummel S, et al. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63:1329. doi:10.1007/s00394-024-03346-6
- Suryavanshi U, Angadi KK, Reddy VS, Reddy GB. Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats. Chem Biol Interact. 2024;387:110823. doi:10.1016/j.cbi.2023.110823
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
- Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
- Asghar S, Tanvir H, Riaz A, Ejaz MH, Akram M, et al. Prevalence of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus on Metformin Therapy: A Cross-Sectional Study. Cureus. 2024;16:e72184. doi:10.7759/cureus.72184
