Overview
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.8
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
7
We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Read More
7
We examined how vitamin B-12 affects bone health, particularly in relation to osteoporosis, by looking at a group of 93 healthy postmenopausal Chinese-Singaporean women. The study focused on measuring bone density and strength as well as the women’s levels of vitamin B-12 and folate.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
Read More
5
We conducted a two-year study to explore how low-dose B-vitamin supplementation, particularly focusing on vitamin B12, impacts bone health in adults aged 50 and older. Our participants were divided into two groups: one received the B-vitamin combination, which included folic acid, B12, B6, and riboflavin, while the other group was given a placebo. All participants received vitamin D as well, ensuring they had the same base level of this important nutrient.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Read More
Most Useful Reviews
9
Supports general health
This product is extremely useful. It greatly benefits the body, nerves, and overall health. I use it alongside my family as it’s one of the most important vitamins for daily health. It promotes bone growth and helps prevent osteoporosis. Nutritionists emphasise the significance of vitamin B12 and its role in supporting mood and mental health.
Read More
6
Improved memory function
3 people found this helpful
I purchased iHerb's own brand of vitamin B group without B12, so I bought it separately. The nutritional supplements for vitamin B12 can be mainly categorised into two forms: methylcobalamin and cyanocobalamin. Initially confused, I finally chose methylcobalamin, a natural form obtainable through food or quality supplements. B12 protects nerve cells and aids in addressing issues like forgetfulness, inattention, gum problems, and osteoporosis. Dr Best is a reputable brand whose products are easily absorbed. The capsules are fine and easy to swallow, which suits my needs perfectly.
Read More
7.5
Effective for fatigue
This product is very good, and I’m quite satisfied. I suffer from osteoporosis and chronic fatigue, but I have noticed an improvement since I started using it. The packaging lasts for 180 days, making it extremely convenient.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.8
- All Researches
7
We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Read More
7
We examined how vitamin B-12 affects bone health, particularly in relation to osteoporosis, by looking at a group of 93 healthy postmenopausal Chinese-Singaporean women. The study focused on measuring bone density and strength as well as the women’s levels of vitamin B-12 and folate.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
Read More
5
We conducted a two-year study to explore how low-dose B-vitamin supplementation, particularly focusing on vitamin B12, impacts bone health in adults aged 50 and older. Our participants were divided into two groups: one received the B-vitamin combination, which included folic acid, B12, B6, and riboflavin, while the other group was given a placebo. All participants received vitamin D as well, ensuring they had the same base level of this important nutrient.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Read More
4
We investigated how vitamin B12 influences osteoporosis, especially in cases linked to high homocysteine levels, alongside taurine. Through molecular docking techniques and laboratory experiments, we discovered that taurine and homocysteine interact with PPARγ, a crucial protein in bone health.
Vitamin B12 showed some positive effects on bone health; however, it didn't perform as strongly as taurine. We noticed that while vitamin B12 contributes beneficially, it can't fully counteract the damaging impact of hyperhomocysteinemia on bone. The study highlighted that taurine, particularly when combined with vitamin B12, exhibited greater effectiveness against osteoporosis.
In conclusion, while vitamin B12 has its merits in promoting bone health, taurine appears to play a more significant role. This suggests that further exploration into taurine's mechanisms could be valuable for developing treatments for osteoporosis.
Vitamin B12 showed some positive effects on bone health; however, it didn't perform as strongly as taurine. We noticed that while vitamin B12 contributes beneficially, it can't fully counteract the damaging impact of hyperhomocysteinemia on bone. The study highlighted that taurine, particularly when combined with vitamin B12, exhibited greater effectiveness against osteoporosis.
In conclusion, while vitamin B12 has its merits in promoting bone health, taurine appears to play a more significant role. This suggests that further exploration into taurine's mechanisms could be valuable for developing treatments for osteoporosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports general health
This product is extremely useful. It greatly benefits the body, nerves, and overall health. I use it alongside my family as it’s one of the most important vitamins for daily health. It promotes bone growth and helps prevent osteoporosis. Nutritionists emphasise the significance of vitamin B12 and its role in supporting mood and mental health.
Read More
6
Improved memory function
3 people found this helpful
I purchased iHerb's own brand of vitamin B group without B12, so I bought it separately. The nutritional supplements for vitamin B12 can be mainly categorised into two forms: methylcobalamin and cyanocobalamin. Initially confused, I finally chose methylcobalamin, a natural form obtainable through food or quality supplements. B12 protects nerve cells and aids in addressing issues like forgetfulness, inattention, gum problems, and osteoporosis. Dr Best is a reputable brand whose products are easily absorbed. The capsules are fine and easy to swallow, which suits my needs perfectly.
Read More
7.5
Effective for fatigue
This product is very good, and I’m quite satisfied. I suffer from osteoporosis and chronic fatigue, but I have noticed an improvement since I started using it. The packaging lasts for 180 days, making it extremely convenient.
Read More
7.5
Reduces osteoporosis risk
Vitamin B12 aids in manufacturing red blood cells and preventing anaemia. It enhances bone health, lowering the risk of osteoporosis, and increases energy levels. Additionally, it helps protect the brain from dementia. The package comes with 60 tablets, is easy to transport, and the price is reasonable for such excellent quality. I found the product effective and fairly priced.
Read More
6
Needed for women
I regularly order this product; it’s excellent. As I age, my need for this vitamin has increased, particularly B12 for women. I take one capsule daily for the prevention and treatment of musculoskeletal issues, including osteoporosis and for combating age-related skin changes like pallor and dryness.
Read More
Frequently Asked Questions
7.5
Effective for fatigue
This product is very good, and I’m quite satisfied. I suffer from osteoporosis and chronic fatigue, but I have noticed an improvement since I started using it. The packaging lasts for 180 days, making it extremely convenient.
7.5
Reduces osteoporosis risk
Vitamin B12 aids in manufacturing red blood cells and preventing anaemia. It enhances bone health, lowering the risk of osteoporosis, and increases energy levels. Additionally, it helps protect the brain from dementia. The package comes with 60 tablets, is easy to transport, and the price is reasonable for such excellent quality. I found the product effective and fairly priced.
6
Improved memory function
3 people found this helpful
I purchased iHerb's own brand of vitamin B group without B12, so I bought it separately. The nutritional supplements for vitamin B12 can be mainly categorised into two forms: methylcobalamin and cyanocobalamin. Initially confused, I finally chose methylcobalamin, a natural form obtainable through food or quality supplements. B12 protects nerve cells and aids in addressing issues like forgetfulness, inattention, gum problems, and osteoporosis. Dr Best is a reputable brand whose products are easily absorbed. The capsules are fine and easy to swallow, which suits my needs perfectly.
9
Supports general health
This product is extremely useful. It greatly benefits the body, nerves, and overall health. I use it alongside my family as it’s one of the most important vitamins for daily health. It promotes bone growth and helps prevent osteoporosis. Nutritionists emphasise the significance of vitamin B12 and its role in supporting mood and mental health.
6
Needed for women
I regularly order this product; it’s excellent. As I age, my need for this vitamin has increased, particularly B12 for women. I take one capsule daily for the prevention and treatment of musculoskeletal issues, including osteoporosis and for combating age-related skin changes like pallor and dryness.
4
We investigated how vitamin B12 influences osteoporosis, especially in cases linked to high homocysteine levels, alongside taurine. Through molecular docking techniques and laboratory experiments, we discovered that taurine and homocysteine interact with PPARγ, a crucial protein in bone health.
Vitamin B12 showed some positive effects on bone health; however, it didn't perform as strongly as taurine. We noticed that while vitamin B12 contributes beneficially, it can't fully counteract the damaging impact of hyperhomocysteinemia on bone. The study highlighted that taurine, particularly when combined with vitamin B12, exhibited greater effectiveness against osteoporosis.
In conclusion, while vitamin B12 has its merits in promoting bone health, taurine appears to play a more significant role. This suggests that further exploration into taurine's mechanisms could be valuable for developing treatments for osteoporosis.
Vitamin B12 showed some positive effects on bone health; however, it didn't perform as strongly as taurine. We noticed that while vitamin B12 contributes beneficially, it can't fully counteract the damaging impact of hyperhomocysteinemia on bone. The study highlighted that taurine, particularly when combined with vitamin B12, exhibited greater effectiveness against osteoporosis.
In conclusion, while vitamin B12 has its merits in promoting bone health, taurine appears to play a more significant role. This suggests that further exploration into taurine's mechanisms could be valuable for developing treatments for osteoporosis.
7
We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
5
We conducted a two-year study to explore how low-dose B-vitamin supplementation, particularly focusing on vitamin B12, impacts bone health in adults aged 50 and older. Our participants were divided into two groups: one received the B-vitamin combination, which included folic acid, B12, B6, and riboflavin, while the other group was given a placebo. All participants received vitamin D as well, ensuring they had the same base level of this important nutrient.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
Throughout the study, we measured bone mineral density (BMD) using advanced imaging techniques. Interestingly, the overall results showed that B-vitamin supplementation did not significantly prevent bone density loss; both groups experienced a decline in BMD by about 1%. However, we found that participants with lower baseline levels of B12 experienced less bone loss when they received B-vitamin supplementation compared to those who did not. This suggests that improving B-vitamin status, particularly in individuals with lower B12, could have specific benefits for maintaining bone health.
Although the intervention did not affect BMD for everyone, the findings highlight the potential importance of B12 for those at risk. We believe this study opens doors for further research on how necessary nutrients like B12 can support bone health, especially in older adults.
7
We examined how vitamin B-12 affects bone health, particularly in relation to osteoporosis, by looking at a group of 93 healthy postmenopausal Chinese-Singaporean women. The study focused on measuring bone density and strength as well as the women’s levels of vitamin B-12 and folate.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
What we found was intriguing. Women with higher levels of circulating folate tended to have better bone mineral density (BMD), while those with greater levels of vitamin B-12 displayed stronger bones overall. This indicates a potential positive relationship between these vitamins and bone strength, particularly suggesting that vitamin B-12 could play a role in promoting bone health among postmenopausal women.
Nevertheless, while these results are promising, they also suggest more research is needed. We should explore whether improving the intake of these vitamins could help reduce the risk of osteoporosis and fractures. In our study, we didn’t find any direct intervention that confirms vitamin B-12 alone successfully treats osteoporosis, but the associations encourage further investigation into how dietary adjustments might benefit bone health.
References
- Adhish M, Manjubala I. Integrative in-silico and in-vitro analysis of taurine and vitamin B12 in modulating PPARγ and Wnt signaling in hyperhomocysteinemia-induced osteoporosis. Biol Direct. 2024;19:141. doi:10.1186/s13062-024-00581-z
- Li Z, Zheng R, Xue H, Zhu H. Vitamin B12 as a novel risk biomarker of spinal fractures. Medicine (Baltimore). 2022;101:e30796. doi:10.1097/MD.0000000000030796
- Clements M, Heffernan M, Ward M, Hoey L, Doherty LC, et al. A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status. J Bone Miner Res. 2022;37:2443. doi:10.1002/jbmr.4709
- Kalimeri M, Leek F, Wang NX, Koh HR, Roy NC, et al. Folate and Vitamin B-12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese-Singaporean Women. JBMR Plus. 2020;4:e10399. doi:10.1002/jbm4.10399
