Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
Read More
7
We explored the connection between vitamin B12 levels and heart rate variability (HRV) in patients who have experienced ischemic stroke. The study involved a look back at the medical records of 87 patients from January 2015 to December 2022. Each patient had their serum vitamin B12 levels measured and underwent 24-hour heart rhythm monitoring.
Our findings revealed a significant relationship between vitamin B12 status and HRV, particularly in the frequency domain, which is a crucial area for understanding autonomic function. The statistical analysis indicated that vitamin B12 levels are a substantial predictor of HRV parameters, suggesting that lower levels of this vitamin may coincide with poorer heart rate regulation in stroke patients.
This research highlights the potential impact of vitamin B12 on maintaining heart health in those who have suffered strokes. By demonstrating that vitamin B12 status could be linked to autonomic dysfunction, we provide valuable insights into how maintaining proper vitamin levels might aid recovery and improve overall cardiovascular health in these patients.
Our findings revealed a significant relationship between vitamin B12 status and HRV, particularly in the frequency domain, which is a crucial area for understanding autonomic function. The statistical analysis indicated that vitamin B12 levels are a substantial predictor of HRV parameters, suggesting that lower levels of this vitamin may coincide with poorer heart rate regulation in stroke patients.
This research highlights the potential impact of vitamin B12 on maintaining heart health in those who have suffered strokes. By demonstrating that vitamin B12 status could be linked to autonomic dysfunction, we provide valuable insights into how maintaining proper vitamin levels might aid recovery and improve overall cardiovascular health in these patients.
Read More
4
We examined whether high levels of vitamin B-12 affect the risk of stroke, with a particular focus on gender differences. Utilizing data from the Korean Genome Epidemiology Study, we assessed stroke occurrence in relation to vitamin B-12 plasma levels using various statistical methods.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
Read More
Most Useful Reviews
9
Aids stroke rehabilitation
Vitamin B12 is an excellent aid for nervous system disorders. This nutrient has a high concentration and is beneficial for serious nervous system issues. Research shows it significantly helps in stroke rehabilitation. It is essential to follow the packaging instructions and to consult with a neurologist before beginning supplementation, which I did.
Read More
9
Restores mental state
I regularly order vitamin B12 for my mother, who has had two strokes, leading to memory issues and unusual behaviour. Since she started taking this vitamin, it has lifted her spirits and restored her mental state. Consequently, we ensure she takes it twice a year. It’s an effective vitamin.
Read More
7.5
Improves post-stroke recovery
My mother was advised by her doctor to take B-12 following her ischemic stroke. Initially, she was dissatisfied with the prescribed Gabapentin. However, after starting the B-12 and researching the appropriate type, this brand has greatly helped her. She needs to continue taking it for an extended period.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
B12 deficiency mimics stroke symptoms
We examined a fascinating case involving a 53-year-old woman who showed atypical signs of vitamin B12 deficiency, resulting in gait instability that mimicked stroke symptoms. Neuroimaging confirmed spinal cord damage typical of subacute combined degeneration, while lab tests showed low B12 levels.
Despite the absence of classic symptoms, the patient responded remarkably well to immediate B12 treatment, restoring her gait stability and neurological functions. This emphasizes the importance of recognizing varied symptoms of B12 deficiency and the need for swift intervention.
Despite the absence of classic symptoms, the patient responded remarkably well to immediate B12 treatment, restoring her gait stability and neurological functions. This emphasizes the importance of recognizing varied symptoms of B12 deficiency and the need for swift intervention.
Read More
8
We explored the relationship between vitamin B12, folate, and plasma total homocysteine levels in predicting the risk of acute ischemic stroke. This study involved 259 stroke patients and an equal number of healthy control participants.
Through careful analysis, we found that vitamin B12 acted as an independent risk factor for ischemic stroke. Additionally, the model combining vitamin B12, folate, and homocysteine levels demonstrated the best diagnostic value, particularly for small vessel disease cases.
Overall, our research indicates a significant connection between vitamin B12 levels and stroke risk.
Through careful analysis, we found that vitamin B12 acted as an independent risk factor for ischemic stroke. Additionally, the model combining vitamin B12, folate, and homocysteine levels demonstrated the best diagnostic value, particularly for small vessel disease cases.
Overall, our research indicates a significant connection between vitamin B12 levels and stroke risk.
Read More
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
Read More
8
We examined how different dosages of B-vitamins, specifically folic acid, vitamin B12, and vitamin B6, affect stroke prevention. Our review included 14 studies with over 76,000 participants and assessed the risk of stroke after supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
Read More
8
We delved into the relationship between serum vitamin B levels and the risk of ischemic stroke by examining hospitalized patients at a major medical center. Our study involved over 2,200 patients and analyzed data using logistic regression, adjusting for various factors.
The results indicated that low vitamin B levels could signal an increased risk for ischemic stroke. Specifically, patients with lower serum vitamin B showed a higher prevalence of stroke, while higher levels appeared to lower that risk. These findings suggest that monitoring and supplementation of vitamin B could potentially benefit stroke outcomes.
The results indicated that low vitamin B levels could signal an increased risk for ischemic stroke. Specifically, patients with lower serum vitamin B showed a higher prevalence of stroke, while higher levels appeared to lower that risk. These findings suggest that monitoring and supplementation of vitamin B could potentially benefit stroke outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Aids stroke rehabilitation
Vitamin B12 is an excellent aid for nervous system disorders. This nutrient has a high concentration and is beneficial for serious nervous system issues. Research shows it significantly helps in stroke rehabilitation. It is essential to follow the packaging instructions and to consult with a neurologist before beginning supplementation, which I did.
Read More
9
Restores mental state
I regularly order vitamin B12 for my mother, who has had two strokes, leading to memory issues and unusual behaviour. Since she started taking this vitamin, it has lifted her spirits and restored her mental state. Consequently, we ensure she takes it twice a year. It’s an effective vitamin.
Read More
7.5
Improves post-stroke recovery
My mother was advised by her doctor to take B-12 following her ischemic stroke. Initially, she was dissatisfied with the prescribed Gabapentin. However, after starting the B-12 and researching the appropriate type, this brand has greatly helped her. She needs to continue taking it for an extended period.
Read More
6
Prevents stroke occurrence
Vitamin B12 is vital in alleviating pain and preventing pernicious anaemia, heart attacks, and stroke. It aids in treating nervous diseases, anaemia, depression, hypertension, and sclerosis.
Read More
4
Supports stroke prevention
Vitamin B12 is an essential nutrient the body requires to optimise brain, nerve and blood health. Despite its importance, many people around the world exhibit a deficiency in this crucial nutrient. Vitamin B12 performs numerous functions, such as reducing fatigue, optimising memory and sleep, promoting the production of red blood cells and brain chemicals, and improving nerve function and communication skills. It also significantly lowers the risk of heart disease and stroke, making regular intake necessary.
Read More
Frequently Asked Questions
9
Restores mental state
I regularly order vitamin B12 for my mother, who has had two strokes, leading to memory issues and unusual behaviour. Since she started taking this vitamin, it has lifted her spirits and restored her mental state. Consequently, we ensure she takes it twice a year. It’s an effective vitamin.
7.5
Improves post-stroke recovery
My mother was advised by her doctor to take B-12 following her ischemic stroke. Initially, she was dissatisfied with the prescribed Gabapentin. However, after starting the B-12 and researching the appropriate type, this brand has greatly helped her. She needs to continue taking it for an extended period.
9
Aids stroke rehabilitation
Vitamin B12 is an excellent aid for nervous system disorders. This nutrient has a high concentration and is beneficial for serious nervous system issues. Research shows it significantly helps in stroke rehabilitation. It is essential to follow the packaging instructions and to consult with a neurologist before beginning supplementation, which I did.
4
Supports stroke prevention
Vitamin B12 is an essential nutrient the body requires to optimise brain, nerve and blood health. Despite its importance, many people around the world exhibit a deficiency in this crucial nutrient. Vitamin B12 performs numerous functions, such as reducing fatigue, optimising memory and sleep, promoting the production of red blood cells and brain chemicals, and improving nerve function and communication skills. It also significantly lowers the risk of heart disease and stroke, making regular intake necessary.
7
Vitamin B12 deficiency and stroke
We focused on understanding how vitamin B12 levels relate to stroke severity and outcomes. In a study involving 75 patients with ischemic stroke and 75 matched controls, we found stroke patients had notably lower vitamin B12 levels and higher homocysteine levels than the control group.
Specifically, those with the lowest B12 levels faced more severe strokes and worse functional outcomes after discharge. Although this study shows a clear connection, further research is needed to determine if B12 supplementation can genuinely reduce stroke risk or improve recovery.
Specifically, those with the lowest B12 levels faced more severe strokes and worse functional outcomes after discharge. Although this study shows a clear connection, further research is needed to determine if B12 supplementation can genuinely reduce stroke risk or improve recovery.
4
We examined data from over 8,000 adults in the National Health and Examination Survey to understand how vitamin B levels and homocysteine relate to stroke risk.
Our findings revealed complex relationships: higher levels of homocysteine were positively associated with stroke prevalence, while vitamin B6 and folate showed L-shaped trends.
Interestingly, vitamin B12 had a U-shaped relationship with stroke, suggesting both low and high levels might be concerning. These results indicate a need for balanced vitamin levels in stroke prevention.
Our findings revealed complex relationships: higher levels of homocysteine were positively associated with stroke prevalence, while vitamin B6 and folate showed L-shaped trends.
Interestingly, vitamin B12 had a U-shaped relationship with stroke, suggesting both low and high levels might be concerning. These results indicate a need for balanced vitamin levels in stroke prevention.
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
7
We explored how vitamin B12 levels and genetic factors are linked to early-onset post-stroke depression (PSD). In a study involving 173 ischemic stroke patients, we measured serum vitamin B12 and folate levels, alongside genetic testing for specific single nucleotide polymorphisms (SNPs).
After just two weeks post-stroke, 84 patients—about 48.6%—were diagnosed with PSD. Those with depression had notably lower vitamin B12 levels compared to those who did not experience depression.
Our findings suggest that a particular genetic variant (rs1801198) may increase the risk of developing PSD, especially in individuals with lower vitamin B12 levels. This indicates that both vitamin B12 and genetic factors play a role in the development of depression following a stroke.
Overall, our research provides valuable insights into the potential role of vitamin B12 as a treatment avenue for dealing with PSD, thus improving the quality of life for stroke survivors.
After just two weeks post-stroke, 84 patients—about 48.6%—were diagnosed with PSD. Those with depression had notably lower vitamin B12 levels compared to those who did not experience depression.
Our findings suggest that a particular genetic variant (rs1801198) may increase the risk of developing PSD, especially in individuals with lower vitamin B12 levels. This indicates that both vitamin B12 and genetic factors play a role in the development of depression following a stroke.
Overall, our research provides valuable insights into the potential role of vitamin B12 as a treatment avenue for dealing with PSD, thus improving the quality of life for stroke survivors.
8
We examined how different dosages of B-vitamins, specifically folic acid, vitamin B12, and vitamin B6, affect stroke prevention. Our review included 14 studies with over 76,000 participants and assessed the risk of stroke after supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
4
We examined whether high levels of vitamin B-12 affect the risk of stroke, with a particular focus on gender differences. Utilizing data from the Korean Genome Epidemiology Study, we assessed stroke occurrence in relation to vitamin B-12 plasma levels using various statistical methods.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
References
- Saeed Z, Zehra SA, Muhammad A, Ashraf I. Atypical Motor-Predominant Presentation of Subacute Combined Degeneration of Spinal Cord Due to Vitamin B12 Deficiency: A Case Report of Stroke Mimicry in the Absence of Classic Symptoms. Cureus. 2024;16:e74697. doi:10.7759/cureus.74697
- Atam V, Srivastava S, Sharma A, Atam I, Tewari J, et al. Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study. Cureus. 2024;16:e70473. doi:10.7759/cureus.70473
- Harale M, Oommen A, Faruqi A, Mundada M, Reddy RH, et al. Study of Biochemical Predictors of Early Neurological Deterioration in Ischemic Stroke in a Tertiary Care Hospital. Cureus. 2024;16:e68183. doi:10.7759/cureus.68183
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. doi:10.1016/j.tjnut.2024.08.002
- Zhou L, Wang J, Wu H, Yu P, He Z, et al. Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study. Nutr J. 2024;23:76. doi:10.1186/s12937-024-00977-7
- Moti Wala S, AlEdani EM, Samuel EA, Ahmad K, Manongi NJ, et al. Exploring the Nexus: A Systematic Review on the Interplay of the Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Genotype, Hyperhomocysteinemia, and Spontaneous Cervical/Vertebral Artery Dissection in Young Adults. Cureus. 2024;16:e60878. doi:10.7759/cureus.60878
- Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480
- Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. doi:10.1016/j.ajcnut.2023.12.021
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Rafay A, Abdul Fatir C, Hiba HT, Jamil M, Talha Awan M. Hyperhomocysteinemia Presenting as Stroke in a Young Individual: A Case Report. Cureus. 2024;16:e52381. doi:10.7759/cureus.52381
- Zhou L, Wang J, Li M, Tan Y, Wu Y, et al. Low vitamin B levels may predict the risk of ischemic stroke: A cross-sectional study. J Clin Neurosci. 2023;117:125. doi:10.1016/j.jocn.2023.09.024
- Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141. doi:10.3389/fneur.2023.1184141
- Hu X, Jiang Y. The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol. 2024;4:1465380. doi:10.3389/fneph.2024.1465380
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Park EJ. Association between vitamin B12 status and heart rate variability in patients with ischemic stroke. Medicine (Baltimore). 2023;102:e33428. doi:10.1097/MD.0000000000033428
- Rasyid A, Mesiano T, Kurniawan M, Hidayat R, Eddy Yunus R, et al. Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient. Case Rep Dermatol Med. 2023;2023:6580971. doi:10.1155/2023/6580971
