Last update
3/30/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 3 Capsules
Serving Per Container: 120
Amount Per Serving
%DV
MSM (Methylsulfonylmethane) (OptiMSM®)
3,000 mg
†
Top Medical Research Studies
8
We explored the effectiveness of asthma rescue medication on lung function through a thorough analysis of data collected during the Fresno Asthmatic Children's Environment Study from 2000 to 2002. Our research utilized a method known as inverse probability of treatment weighting (IPTW) to evaluate treatment effects in an observational study context. This approach helps us account for various confounding factors that might influence the outcomes we observe.
In our findings, traditional regression methods suggested that there was no significant association between medication use and improved lung function. This might seem surprising, as one would intuitively expect that asthma medication helps improve breathing. However, we believed that this outcome was likely influenced by confounders, such as asthma symptoms and severity, which can muddle the clear effects of medication.
When we applied our marginal structural model approach, we discovered a causal link between medication use and a 7% improvement in pulmonary function. This suggests that when we accounted for other influences adequately, asthma rescue medication does indeed have a positive impact, contrary to previous findings.
We hope that our discussion on the importance of proper model selection and fitting procedures encourages more researchers to consider these aspects seriously when evaluating treatment effects. By understanding the subtleties of our methodologies, we can better justify our conclusions in the realm of asthma treatment.
In our findings, traditional regression methods suggested that there was no significant association between medication use and improved lung function. This might seem surprising, as one would intuitively expect that asthma medication helps improve breathing. However, we believed that this outcome was likely influenced by confounders, such as asthma symptoms and severity, which can muddle the clear effects of medication.
When we applied our marginal structural model approach, we discovered a causal link between medication use and a 7% improvement in pulmonary function. This suggests that when we accounted for other influences adequately, asthma rescue medication does indeed have a positive impact, contrary to previous findings.
We hope that our discussion on the importance of proper model selection and fitting procedures encourages more researchers to consider these aspects seriously when evaluating treatment effects. By understanding the subtleties of our methodologies, we can better justify our conclusions in the realm of asthma treatment.
Read More
9
We investigated how a combination of zinc salicylate and methylsulfonylmethane (MSM) affects airway smooth muscle cells in people with asthma. Our approach involved treating these cells with different substances, including zinc chloride and sodium salicylate, to see how they influenced cell growth and tissue remodeling related to asthma.
During our study, we observed that both zinc salicylate and the combination with MSM significantly reduced the proliferation of these cells in response to growth factors, while the other compounds showed varying results. Additionally, this reduction in cell growth was associated with increased levels of a key regulator called p21, which plays a role in inhibiting the cell cycle.
Notably, zinc salicylate, especially in combination with MSM, also appeared to limit the deposition of harmful extracellular matrix components like fibronectin and collagen type-I, which are crucial in tissue remodeling. Our findings suggest that this combination may help manage asthma by targeting important signaling pathways involved in cell behavior and tissue structure.
Overall, we believe that the inclusion of zinc salicylate with MSM represents a promising area for further research in asthma management, especially considering its potential to reduce harmful remodeling of the airways.
During our study, we observed that both zinc salicylate and the combination with MSM significantly reduced the proliferation of these cells in response to growth factors, while the other compounds showed varying results. Additionally, this reduction in cell growth was associated with increased levels of a key regulator called p21, which plays a role in inhibiting the cell cycle.
Notably, zinc salicylate, especially in combination with MSM, also appeared to limit the deposition of harmful extracellular matrix components like fibronectin and collagen type-I, which are crucial in tissue remodeling. Our findings suggest that this combination may help manage asthma by targeting important signaling pathways involved in cell behavior and tissue structure.
Overall, we believe that the inclusion of zinc salicylate with MSM represents a promising area for further research in asthma management, especially considering its potential to reduce harmful remodeling of the airways.
Read More
4
We set out to better understand how marginal structural models (MSMs) could shed light on the effectiveness of asthma treatments in the context of non-adherence and participants dropping out of the studies. By incorporating these models, we could gain insights into whether the conventional Intention to Treat (ITT) analyses, which may be skewed by these factors, still hold up.
In this study, we analyzed data involving 488 participants, observing that 36% did not stick to their assigned treatment and 17% were lost to follow-up. Through our analysis, we found that the relative risks for different asthma treatments, such as theophylline and montelukast, were very similar when comparing results from both the ITT analysis and the MSM approach.
These findings suggest that adherence issues and follow-up losses might not significantly undermine ITT analyses when it comes to evaluating asthma medications. However, we also noted a lack of existing guidelines on when to rely more on MSMs than ITT analyses. This means that performing MSMs as a supplemental check to ITT analyses may be beneficial for researchers looking at clinical trials with these common challenges.
In this study, we analyzed data involving 488 participants, observing that 36% did not stick to their assigned treatment and 17% were lost to follow-up. Through our analysis, we found that the relative risks for different asthma treatments, such as theophylline and montelukast, were very similar when comparing results from both the ITT analysis and the MSM approach.
These findings suggest that adherence issues and follow-up losses might not significantly undermine ITT analyses when it comes to evaluating asthma medications. However, we also noted a lack of existing guidelines on when to rely more on MSMs than ITT analyses. This means that performing MSMs as a supplemental check to ITT analyses may be beneficial for researchers looking at clinical trials with these common challenges.
Read More
Most Useful Reviews
9
Reduced asthma reliance
Its anti-inflammatory properties helped me with asthma; I realised I wasn’t using my asthma spray anymore. I also had ongoing neck pain, which has settled down. MSM comes highly recommended by Jason Hommel, who does "The Copper Revolution: Healing with Minerals".
Read More
7.5
Decreased asthma severity
10 people found this helpful
An irreplaceable thing for people with allergies. Surprisingly, an allergy to mould, cats, and dust in our family has decreased and, in some cases, completely gone. I hope to get rid of asthma.
Read More
6
Relieved asthma symptoms
6 people found this helpful
MSM is essentially sulphur, vital for synthesising collagen and keratin, crucial for skin, hair, and nails. Without sulphur, detoxification of the body does not occur. Sulphur can relieve severe symptoms of asthma and allergies, so don't hesitate to take MSM as a dietary source of sulphur.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
- All Researches
9
We investigated how a combination of zinc salicylate and methylsulfonylmethane (MSM) affects airway smooth muscle cells in people with asthma. Our approach involved treating these cells with different substances, including zinc chloride and sodium salicylate, to see how they influenced cell growth and tissue remodeling related to asthma.
During our study, we observed that both zinc salicylate and the combination with MSM significantly reduced the proliferation of these cells in response to growth factors, while the other compounds showed varying results. Additionally, this reduction in cell growth was associated with increased levels of a key regulator called p21, which plays a role in inhibiting the cell cycle.
Notably, zinc salicylate, especially in combination with MSM, also appeared to limit the deposition of harmful extracellular matrix components like fibronectin and collagen type-I, which are crucial in tissue remodeling. Our findings suggest that this combination may help manage asthma by targeting important signaling pathways involved in cell behavior and tissue structure.
Overall, we believe that the inclusion of zinc salicylate with MSM represents a promising area for further research in asthma management, especially considering its potential to reduce harmful remodeling of the airways.
During our study, we observed that both zinc salicylate and the combination with MSM significantly reduced the proliferation of these cells in response to growth factors, while the other compounds showed varying results. Additionally, this reduction in cell growth was associated with increased levels of a key regulator called p21, which plays a role in inhibiting the cell cycle.
Notably, zinc salicylate, especially in combination with MSM, also appeared to limit the deposition of harmful extracellular matrix components like fibronectin and collagen type-I, which are crucial in tissue remodeling. Our findings suggest that this combination may help manage asthma by targeting important signaling pathways involved in cell behavior and tissue structure.
Overall, we believe that the inclusion of zinc salicylate with MSM represents a promising area for further research in asthma management, especially considering its potential to reduce harmful remodeling of the airways.
Read More
8
We explored the effectiveness of asthma rescue medication on lung function through a thorough analysis of data collected during the Fresno Asthmatic Children's Environment Study from 2000 to 2002. Our research utilized a method known as inverse probability of treatment weighting (IPTW) to evaluate treatment effects in an observational study context. This approach helps us account for various confounding factors that might influence the outcomes we observe.
In our findings, traditional regression methods suggested that there was no significant association between medication use and improved lung function. This might seem surprising, as one would intuitively expect that asthma medication helps improve breathing. However, we believed that this outcome was likely influenced by confounders, such as asthma symptoms and severity, which can muddle the clear effects of medication.
When we applied our marginal structural model approach, we discovered a causal link between medication use and a 7% improvement in pulmonary function. This suggests that when we accounted for other influences adequately, asthma rescue medication does indeed have a positive impact, contrary to previous findings.
We hope that our discussion on the importance of proper model selection and fitting procedures encourages more researchers to consider these aspects seriously when evaluating treatment effects. By understanding the subtleties of our methodologies, we can better justify our conclusions in the realm of asthma treatment.
In our findings, traditional regression methods suggested that there was no significant association between medication use and improved lung function. This might seem surprising, as one would intuitively expect that asthma medication helps improve breathing. However, we believed that this outcome was likely influenced by confounders, such as asthma symptoms and severity, which can muddle the clear effects of medication.
When we applied our marginal structural model approach, we discovered a causal link between medication use and a 7% improvement in pulmonary function. This suggests that when we accounted for other influences adequately, asthma rescue medication does indeed have a positive impact, contrary to previous findings.
We hope that our discussion on the importance of proper model selection and fitting procedures encourages more researchers to consider these aspects seriously when evaluating treatment effects. By understanding the subtleties of our methodologies, we can better justify our conclusions in the realm of asthma treatment.
Read More
4
We set out to better understand how marginal structural models (MSMs) could shed light on the effectiveness of asthma treatments in the context of non-adherence and participants dropping out of the studies. By incorporating these models, we could gain insights into whether the conventional Intention to Treat (ITT) analyses, which may be skewed by these factors, still hold up.
In this study, we analyzed data involving 488 participants, observing that 36% did not stick to their assigned treatment and 17% were lost to follow-up. Through our analysis, we found that the relative risks for different asthma treatments, such as theophylline and montelukast, were very similar when comparing results from both the ITT analysis and the MSM approach.
These findings suggest that adherence issues and follow-up losses might not significantly undermine ITT analyses when it comes to evaluating asthma medications. However, we also noted a lack of existing guidelines on when to rely more on MSMs than ITT analyses. This means that performing MSMs as a supplemental check to ITT analyses may be beneficial for researchers looking at clinical trials with these common challenges.
In this study, we analyzed data involving 488 participants, observing that 36% did not stick to their assigned treatment and 17% were lost to follow-up. Through our analysis, we found that the relative risks for different asthma treatments, such as theophylline and montelukast, were very similar when comparing results from both the ITT analysis and the MSM approach.
These findings suggest that adherence issues and follow-up losses might not significantly undermine ITT analyses when it comes to evaluating asthma medications. However, we also noted a lack of existing guidelines on when to rely more on MSMs than ITT analyses. This means that performing MSMs as a supplemental check to ITT analyses may be beneficial for researchers looking at clinical trials with these common challenges.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced asthma reliance
Its anti-inflammatory properties helped me with asthma; I realised I wasn’t using my asthma spray anymore. I also had ongoing neck pain, which has settled down. MSM comes highly recommended by Jason Hommel, who does "The Copper Revolution: Healing with Minerals".
Read More
7.5
Decreased asthma severity
10 people found this helpful
An irreplaceable thing for people with allergies. Surprisingly, an allergy to mould, cats, and dust in our family has decreased and, in some cases, completely gone. I hope to get rid of asthma.
Read More
6
Relieved asthma symptoms
6 people found this helpful
MSM is essentially sulphur, vital for synthesising collagen and keratin, crucial for skin, hair, and nails. Without sulphur, detoxification of the body does not occur. Sulphur can relieve severe symptoms of asthma and allergies, so don't hesitate to take MSM as a dietary source of sulphur.
Read More
Frequently Asked Questions
9
Reduced asthma reliance
Its anti-inflammatory properties helped me with asthma; I realised I wasn’t using my asthma spray anymore. I also had ongoing neck pain, which has settled down. MSM comes highly recommended by Jason Hommel, who does "The Copper Revolution: Healing with Minerals".
7.5
Decreased asthma severity
10 people found this helpful
An irreplaceable thing for people with allergies. Surprisingly, an allergy to mould, cats, and dust in our family has decreased and, in some cases, completely gone. I hope to get rid of asthma.
6
Relieved asthma symptoms
6 people found this helpful
MSM is essentially sulphur, vital for synthesising collagen and keratin, crucial for skin, hair, and nails. Without sulphur, detoxification of the body does not occur. Sulphur can relieve severe symptoms of asthma and allergies, so don't hesitate to take MSM as a dietary source of sulphur.
9
We investigated how a combination of zinc salicylate and methylsulfonylmethane (MSM) affects airway smooth muscle cells in people with asthma. Our approach involved treating these cells with different substances, including zinc chloride and sodium salicylate, to see how they influenced cell growth and tissue remodeling related to asthma.
During our study, we observed that both zinc salicylate and the combination with MSM significantly reduced the proliferation of these cells in response to growth factors, while the other compounds showed varying results. Additionally, this reduction in cell growth was associated with increased levels of a key regulator called p21, which plays a role in inhibiting the cell cycle.
Notably, zinc salicylate, especially in combination with MSM, also appeared to limit the deposition of harmful extracellular matrix components like fibronectin and collagen type-I, which are crucial in tissue remodeling. Our findings suggest that this combination may help manage asthma by targeting important signaling pathways involved in cell behavior and tissue structure.
Overall, we believe that the inclusion of zinc salicylate with MSM represents a promising area for further research in asthma management, especially considering its potential to reduce harmful remodeling of the airways.
During our study, we observed that both zinc salicylate and the combination with MSM significantly reduced the proliferation of these cells in response to growth factors, while the other compounds showed varying results. Additionally, this reduction in cell growth was associated with increased levels of a key regulator called p21, which plays a role in inhibiting the cell cycle.
Notably, zinc salicylate, especially in combination with MSM, also appeared to limit the deposition of harmful extracellular matrix components like fibronectin and collagen type-I, which are crucial in tissue remodeling. Our findings suggest that this combination may help manage asthma by targeting important signaling pathways involved in cell behavior and tissue structure.
Overall, we believe that the inclusion of zinc salicylate with MSM represents a promising area for further research in asthma management, especially considering its potential to reduce harmful remodeling of the airways.
4
We set out to better understand how marginal structural models (MSMs) could shed light on the effectiveness of asthma treatments in the context of non-adherence and participants dropping out of the studies. By incorporating these models, we could gain insights into whether the conventional Intention to Treat (ITT) analyses, which may be skewed by these factors, still hold up.
In this study, we analyzed data involving 488 participants, observing that 36% did not stick to their assigned treatment and 17% were lost to follow-up. Through our analysis, we found that the relative risks for different asthma treatments, such as theophylline and montelukast, were very similar when comparing results from both the ITT analysis and the MSM approach.
These findings suggest that adherence issues and follow-up losses might not significantly undermine ITT analyses when it comes to evaluating asthma medications. However, we also noted a lack of existing guidelines on when to rely more on MSMs than ITT analyses. This means that performing MSMs as a supplemental check to ITT analyses may be beneficial for researchers looking at clinical trials with these common challenges.
In this study, we analyzed data involving 488 participants, observing that 36% did not stick to their assigned treatment and 17% were lost to follow-up. Through our analysis, we found that the relative risks for different asthma treatments, such as theophylline and montelukast, were very similar when comparing results from both the ITT analysis and the MSM approach.
These findings suggest that adherence issues and follow-up losses might not significantly undermine ITT analyses when it comes to evaluating asthma medications. However, we also noted a lack of existing guidelines on when to rely more on MSMs than ITT analyses. This means that performing MSMs as a supplemental check to ITT analyses may be beneficial for researchers looking at clinical trials with these common challenges.
References
- Lancet EA, Borrell LN, Holbrook J, Morabia A. Using marginal structural models to analyze randomized clinical trials with non-adherence and lost to follow up. Ann Epidemiol. 2021;63:22. 10.1016/j.annepidem.2021.07.001
- Fang L, Roth M, S'ng CT, Tamm M, Han B, et al. Zinc salicylate reduces airway smooth muscle cells remodelling by blocking mTOR and activating p21. J Nutr Biochem. 2021;89:108563. 10.1016/j.jnutbio.2020.108563
- Mortimer KM, Neugebauer R, van der Laan M, Tager IB. An application of model-fitting procedures for marginal structural models. Am J Epidemiol. 2005;162:382. PubMed
