Overview
SCIENTIFIC SCORE
Questionable
Based on 32 Researches
6.9
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 2 Marine Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Fish Oil ConcentrateTotal Omega-3 Fatty Acids as Ethyl EstersEPA (EicosaPentaenoic Acid), min.DHA (DocosaHexaenoic Acid), min.
2000 mg1400 mg800 mg400 mg
††††
Top Medical Research Studies
8
We conducted a study to explore the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). Over the course of 12 weeks, 60 participants suffering from MDD were divided into two groups: one received 3.2 grams of EPA daily, while the other group was given a placebo, which was soybean oil.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.
Read More
7
We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.
Read More
5
Potential benefits for depression prevention
We conducted a study to explore whether eicosapentaenoic acid (a type of omega-3 fatty acid) can help prevent depression recurrence in older adults who have previously experienced late-life depression. Our research involved a rigorous 52-week double-blind, placebo-controlled trial with 39 patients who were currently stable and free from depression symptoms.
The participants were randomly assigned to either receive daily doses of eicosapentaenoic acid alongside docosahexaenoic acid or a placebo for the duration of the trial. We wanted to see if this supplementation could not only protect against future depressive episodes but also impact depressive and anxiety symptoms, as well as some inflammatory markers associated with depression.
Interestingly, our findings revealed that eicosapentaenoic acid did indeed show a protective effect against the recurrence of depression, with a significant hazard ratio suggesting that those taking the supplement were less likely to relapse compared to the placebo group. However, we didn't observe any notable improvements in current depressive or anxiety symptoms, nor in the inflammatory markers between the two groups.
While the results are promising regarding the prevention of depression recurrence, it's essential to keep in mind the modest size of our sample when interpreting these findings.
The participants were randomly assigned to either receive daily doses of eicosapentaenoic acid alongside docosahexaenoic acid or a placebo for the duration of the trial. We wanted to see if this supplementation could not only protect against future depressive episodes but also impact depressive and anxiety symptoms, as well as some inflammatory markers associated with depression.
Interestingly, our findings revealed that eicosapentaenoic acid did indeed show a protective effect against the recurrence of depression, with a significant hazard ratio suggesting that those taking the supplement were less likely to relapse compared to the placebo group. However, we didn't observe any notable improvements in current depressive or anxiety symptoms, nor in the inflammatory markers between the two groups.
While the results are promising regarding the prevention of depression recurrence, it's essential to keep in mind the modest size of our sample when interpreting these findings.
Read More
Most Useful Reviews
8.8
Combats anxiety
Omega-3 fatty acids play a crucial role in cardiovascular health by lowering cholesterol and preventing inflammation. They enhance brain function by improving memory and concentration while combating depression and anxiety. Additionally, Omega-3s contribute to healthy skin by moisturising and reducing inflammation, such as acne and eczema. Regular consumption also helps strengthen joints, minimising pain from inflammation.
Read More
8.8
Reinforces mental health
Doctor's Best Refined Pure Omega 3 Fish Oil is rich in gold omega, which offers valuable health benefits. It contains EPA and DHA that lower blood lipids and blood pressure while preventing cardiovascular diseases. This product mitigates inflammation and joint pain and enhances immunity, brain function, and cognition. It is effective in preventing depression and anxiety and is better absorbed by the body. Taking refined pure fish oil helps eliminate harmful substances like mercury, reducing potential harm to health.
Read More
8.8
Health necessity
Omega-3 fatty acids are essential fats that the body must obtain from food or supplements. The main types are EPA, DHA, and ALA. While ALA can be converted into EPA and DHA, this isn’t very efficient. Omega-3s offer numerous benefits: they support heart health by lowering the risk of heart disease and blood pressure, enhance brain function and memory, and some studies suggest that they may alleviate depression. Ensuring sufficient Omega-3 intake from sources like fatty fish, nuts, and seeds is essential. Capsules are a convenient supplement option.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 32 Researches
6.9
- All Researches
9
EPA alleviates depressive behavior
We investigated how eicosapentaenoic acid (EPA) impacts depressive-like behaviors in mice that were subject to chronic sleep deprivation. Our findings indicated that EPA is more effective than docosahexaenoic acid (DHA) in alleviating signs of depression, as evidenced by changes in preferences and behaviors observed in these mice.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Read More
9
DPA enhances depression treatment efficacy
We explored the therapeutic benefits of eicosapentaenoic acid (DPA) in treating depression, particularly in relation to exosomes derived from human umbilical cord mesenchymal stem cells. Chronic unpredictable mild stress (CUMS) was used to induce depression-like behaviors in the study, which highlighted the role of neuroinflammation and neurotransmitter deficiencies in this condition.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
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9
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
8
We investigated how eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil, can influence depression. In our study with mice, we observed that administering EPA for five weeks helped reduce stress-induced neuronal damage and improved brain synaptic functions.
Additionally, EPA demonstrated its ability to lower neuroinflammation linked to depressive behaviors. The findings highlight the potential of EPA as an effective option for managing depression related to inflammation. While further research is needed, these results are promising for its future clinical applications.
Additionally, EPA demonstrated its ability to lower neuroinflammation linked to depressive behaviors. The findings highlight the potential of EPA as an effective option for managing depression related to inflammation. While further research is needed, these results are promising for its future clinical applications.
Read More
8
We aimed to understand how omega-3 fatty acids could benefit maternal behaviors affected by chronic stress during pregnancy. Our study involved three groups of rats: a control, a stress group, and a group receiving omega-3 supplementation.
The results showed that stressed rats displayed poor maternal behaviors, but omega-3 supplementation significantly improved their care for pups. It appeared to enhance the serotonin system, reduce inflammation, and aid in restoring neuronal function.
This research suggests that omega-3 fish oil might offer a promising approach to help mothers dealing with stress-related behavioral issues.
The results showed that stressed rats displayed poor maternal behaviors, but omega-3 supplementation significantly improved their care for pups. It appeared to enhance the serotonin system, reduce inflammation, and aid in restoring neuronal function.
This research suggests that omega-3 fish oil might offer a promising approach to help mothers dealing with stress-related behavioral issues.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Combats anxiety
Omega-3 fatty acids play a crucial role in cardiovascular health by lowering cholesterol and preventing inflammation. They enhance brain function by improving memory and concentration while combating depression and anxiety. Additionally, Omega-3s contribute to healthy skin by moisturising and reducing inflammation, such as acne and eczema. Regular consumption also helps strengthen joints, minimising pain from inflammation.
Read More
8.8
Reinforces mental health
Doctor's Best Refined Pure Omega 3 Fish Oil is rich in gold omega, which offers valuable health benefits. It contains EPA and DHA that lower blood lipids and blood pressure while preventing cardiovascular diseases. This product mitigates inflammation and joint pain and enhances immunity, brain function, and cognition. It is effective in preventing depression and anxiety and is better absorbed by the body. Taking refined pure fish oil helps eliminate harmful substances like mercury, reducing potential harm to health.
Read More
8.8
Health necessity
Omega-3 fatty acids are essential fats that the body must obtain from food or supplements. The main types are EPA, DHA, and ALA. While ALA can be converted into EPA and DHA, this isn’t very efficient. Omega-3s offer numerous benefits: they support heart health by lowering the risk of heart disease and blood pressure, enhance brain function and memory, and some studies suggest that they may alleviate depression. Ensuring sufficient Omega-3 intake from sources like fatty fish, nuts, and seeds is essential. Capsules are a convenient supplement option.
Read More
8
Supports mental wellness
As a functional nutrition consultant, I find this supplement remarkably beneficial for those experiencing anxiety and depression, especially when blood tests reveal significant deficiencies.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Gong H, Su WJ, Deng SL, Luo J, Du ZL, et al. Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis. Transl Psychiatry. 2025;15:114. doi:10.1038/s41398-025-03317-3
- Yu Q, Li H, Chen M, Pan Y, Zhou L, et al. GPR120 internalization: a key mechanism for EPA in antidepressant action. Food Funct. 2025;16:2893. doi:10.1039/d5fo00252d
- Dyall SC, Malau IA, Su KP. Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials. Curr Opin Clin Nutr Metab Care. 2025;28:66. doi:10.1097/MCO.0000000000001077
- Al Sinani M, Johnson M, Crawford M, Al Maqbali M, Al-Adawi S. Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102668. doi:10.1016/j.plefa.2025.102668
- Wang B, Liu P, Gao X, Yang F, Sun J, et al. Exploring the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress. Behav Brain Res. 2025;483:115458. doi:10.1016/j.bbr.2025.115458
- Raza ML, Hassan ST, Jamil S, Fatima W, Fatima M. Nutritional interventions in depression: The role of vitamin D and omega-3 fatty acids in neuropsychiatric health. Clin Nutr. 2025;45:270. doi:10.1016/j.clnu.2025.01.009
- Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. doi:10.1016/j.plefa.2025.102664
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
- Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, et al. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. doi:10.1002/14651858.CD014803.pub2
- Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688
- Jastrzebska J, Frankowska M, Wesołowska J, Filip M, Smaga I. Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring. Curr Neuropharmacol. 2025;23:329. doi:10.2174/1570159X23666241014164940
- Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. doi:10.1016/j.freeradbiomed.2024.10.298
- Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. doi:10.1016/j.jad.2024.09.129
- Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168675
- Lam C, Han L, McIntyre RS, Teopiz KM, Cao B. Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis. J Child Adolesc Psychopharmacol. 2024;34:282. doi:10.1089/cap.2024.0017
- Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. doi:10.1038/s41398-024-02932-w
- Kong L, Zhang Q, Wang H, Xu Y, Xu C, et al. Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials. J Affect Disord. 2025. doi:10.1016/j.jad.2025.03.006
- Urata M, Sakurai H, Ueno F, Maruki T, Tada T, et al. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis. Neuropsychopharmacol Rep. 2025;45:e70008. doi:10.1002/npr2.70008
- Dyall SC, Malau IA, Su KP. Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials. Curr Opin Clin Nutr Metab Care. 2025;28:66. doi:10.1097/MCO.0000000000001077
- Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. doi:10.1016/j.plefa.2025.102664
- Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, et al. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. doi:10.1002/14651858.CD014803.pub2
- Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688
- Lin YW, Cheng SW, Liu WC, Zailani H, Wu SK, et al. Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture. Brain Behav Immun. 2025;123:771. doi:10.1016/j.bbi.2024.10.028
- Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. doi:10.1016/j.freeradbiomed.2024.10.298
- Li P, Zhang F, Huang C, Zhang C, Yang Z, et al. Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress. J Neuroimmune Pharmacol. 2024;19:55. doi:10.1007/s11481-024-10154-6
- Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. doi:10.1016/j.jad.2024.09.129
- Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168675
- Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. doi:10.3389/fneph.2024.1365809
- Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
- Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. doi:10.1038/s41398-024-02932-w
- Lou F, Luo S, Kang N, Yan L, Long H, et al. Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism. Pharmacol Res. 2024;204:107214. doi:10.1016/j.phrs.2024.107214
- Zhang C, Hou B, Xu Y, Zeng S, Luo X, et al. Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018. J Affect Disord. 2024;354:62. doi:10.1016/j.jad.2024.03.055
