Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 2 Marine Softgels
Amount Per Serving
%DV
Calories
20
 
Total Fat
2 g
3%**
Fish Oil ConcentrateTotal Omega-3 Fatty Acids as Ethyl EstersEPA (EicosaPentaenoic Acid), min.DHA (DocosaHexaenoic Acid), min.
2000 mg1400 mg800 mg400 mg
††††

Top Medical Research Studies

7
Omega-3 fatty acids show promise
We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.

Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.

Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.
Read More
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.

Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.

Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.

Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
8
Omega-3s may enhance mental health
We explored the relationship between omega-3 fatty acids and mental health using data from over 102,000 participants in the UK Biobank. Our analysis showed that higher plasma levels of omega-3s were linked to a lower risk of depression and anxiety. Specifically, those with the highest levels exhibited a significant reduction in depressive symptoms and better brain white matter microstructure. This suggests that omega-3 fatty acids may play an important role in enhancing mental well-being, supporting their use as a potential intervention for mental health issues.
Read More

Most Useful Reviews

7.5
Combats anxiety
Omega-3 fatty acids play a crucial role in cardiovascular health by lowering cholesterol and preventing inflammation. They enhance brain function by improving memory and concentration while combating depression and anxiety. Additionally, Omega-3s contribute to healthy skin by moisturising and reducing inflammation, such as acne and eczema. Regular consumption also helps strengthen joints, minimising pain from inflammation.
Read More
7.5
Reinforces mental health
Doctor's Best Refined Pure Omega 3 Fish Oil is rich in gold omega, which offers valuable health benefits. It contains EPA and DHA that lower blood lipids and blood pressure while preventing cardiovascular diseases. This product mitigates inflammation and joint pain and enhances immunity, brain function, and cognition. It is effective in preventing depression and anxiety and is better absorbed by the body. Taking refined pure fish oil helps eliminate harmful substances like mercury, reducing potential harm to health.
Read More
7.5
Health necessity
Omega-3 fatty acids are essential fats that the body must obtain from food or supplements. The main types are EPA, DHA, and ALA. While ALA can be converted into EPA and DHA, this isn’t very efficient. Omega-3s offer numerous benefits: they support heart health by lowering the risk of heart disease and blood pressure, enhance brain function and memory, and some studies suggest that they may alleviate depression. Ensuring sufficient Omega-3 intake from sources like fatty fish, nuts, and seeds is essential. Capsules are a convenient supplement option.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7
  • All Researches
9
DPA enhances depression treatment efficacy
We explored the therapeutic benefits of eicosapentaenoic acid (DPA) in treating depression, particularly in relation to exosomes derived from human umbilical cord mesenchymal stem cells. Chronic unpredictable mild stress (CUMS) was used to induce depression-like behaviors in the study, which highlighted the role of neuroinflammation and neurotransmitter deficiencies in this condition.

Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.

Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.

Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
Read More
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.

Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.

Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.

Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
We investigated how eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil, can influence depression. In our study with mice, we observed that administering EPA for five weeks helped reduce stress-induced neuronal damage and improved brain synaptic functions.

Additionally, EPA demonstrated its ability to lower neuroinflammation linked to depressive behaviors. The findings highlight the potential of EPA as an effective option for managing depression related to inflammation. While further research is needed, these results are promising for its future clinical applications.
Read More
8
Omega-3 improves maternal behavior
We aimed to understand how omega-3 fatty acids could benefit maternal behaviors affected by chronic stress during pregnancy. Our study involved three groups of rats: a control, a stress group, and a group receiving omega-3 supplementation.

The results showed that stressed rats displayed poor maternal behaviors, but omega-3 supplementation significantly improved their care for pups. It appeared to enhance the serotonin system, reduce inflammation, and aid in restoring neuronal function.

This research suggests that omega-3 fish oil might offer a promising approach to help mothers dealing with stress-related behavioral issues.
Read More
8
Omega-3s' potential in depression management
We explored how omega-3 fatty acids, alongside Vitamin D, may influence depression management. Our review included a broad search of scientific literature, focusing on studies that evaluate these nutrients' effects on mood and cognitive function.

The results indicate that omega-3 fatty acids can help reduce depressive symptoms, particularly for those with nutritional deficiencies. However, the variety in study designs and dosages makes it challenging to draw clear conclusions.

Overall, while omega-3s show potential as a supportive treatment for depression, more research is essential to solidify these findings.
Read More

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Combats anxiety
Omega-3 fatty acids play a crucial role in cardiovascular health by lowering cholesterol and preventing inflammation. They enhance brain function by improving memory and concentration while combating depression and anxiety. Additionally, Omega-3s contribute to healthy skin by moisturising and reducing inflammation, such as acne and eczema. Regular consumption also helps strengthen joints, minimising pain from inflammation.
Read More
7.5
Reinforces mental health
Doctor's Best Refined Pure Omega 3 Fish Oil is rich in gold omega, which offers valuable health benefits. It contains EPA and DHA that lower blood lipids and blood pressure while preventing cardiovascular diseases. This product mitigates inflammation and joint pain and enhances immunity, brain function, and cognition. It is effective in preventing depression and anxiety and is better absorbed by the body. Taking refined pure fish oil helps eliminate harmful substances like mercury, reducing potential harm to health.
Read More
7.5
Health necessity
Omega-3 fatty acids are essential fats that the body must obtain from food or supplements. The main types are EPA, DHA, and ALA. While ALA can be converted into EPA and DHA, this isn’t very efficient. Omega-3s offer numerous benefits: they support heart health by lowering the risk of heart disease and blood pressure, enhance brain function and memory, and some studies suggest that they may alleviate depression. Ensuring sufficient Omega-3 intake from sources like fatty fish, nuts, and seeds is essential. Capsules are a convenient supplement option.
Read More
6
Supports mental wellness
As a functional nutrition consultant, I find this supplement remarkably beneficial for those experiencing anxiety and depression, especially when blood tests reveal significant deficiencies.
Read More

Frequently Asked Questions

6
Supports mental wellness
As a functional nutrition consultant, I find this supplement remarkably beneficial for those experiencing anxiety and depression, especially when blood tests reveal significant deficiencies.
7.5
Health necessity
Omega-3 fatty acids are essential fats that the body must obtain from food or supplements. The main types are EPA, DHA, and ALA. While ALA can be converted into EPA and DHA, this isn’t very efficient. Omega-3s offer numerous benefits: they support heart health by lowering the risk of heart disease and blood pressure, enhance brain function and memory, and some studies suggest that they may alleviate depression. Ensuring sufficient Omega-3 intake from sources like fatty fish, nuts, and seeds is essential. Capsules are a convenient supplement option.
7.5
Combats anxiety
Omega-3 fatty acids play a crucial role in cardiovascular health by lowering cholesterol and preventing inflammation. They enhance brain function by improving memory and concentration while combating depression and anxiety. Additionally, Omega-3s contribute to healthy skin by moisturising and reducing inflammation, such as acne and eczema. Regular consumption also helps strengthen joints, minimising pain from inflammation.
7.5
Reinforces mental health
Doctor's Best Refined Pure Omega 3 Fish Oil is rich in gold omega, which offers valuable health benefits. It contains EPA and DHA that lower blood lipids and blood pressure while preventing cardiovascular diseases. This product mitigates inflammation and joint pain and enhances immunity, brain function, and cognition. It is effective in preventing depression and anxiety and is better absorbed by the body. Taking refined pure fish oil helps eliminate harmful substances like mercury, reducing potential harm to health.
7
Omega-3 shows potential for depression
We set out to understand how omega-3 fish oil and other anti-inflammatory treatments affect depression in older adults. This comprehensive review analyzed 31 randomized controlled trials to see if these interventions could reduce depressive symptoms. The findings showed that older adults had a moderate decrease in depression scores, particularly benefiting from omega-3 treatments. While this suggests a positive impact, it's important to note the studies had some variability in results. This calls for more focused research to pinpoint the best treatments for depression in this age group.
We examined recent clinical trials investigating omega-3 polyunsaturated fatty acids (PUFAs) to see how they might help with major depressive disorder (MDD).

The analysis focused on high doses of eicosapentaenoic acid (EPA), showing improvements especially in patients with inflammation-related depression and younger individuals.

Although results are encouraging, particularly for specific subpopulations, establishing the best doses and treatment durations requires further research.
7
Omega-3s linked to reduced depression
We explored how omega-3 fatty acids, specifically DHA and EPA, might influence mood and brain connectivity in young adults showing signs of mild depression. In a study involving 15 participants aged 18 to 29, we found that those with higher levels of omega-3 fatty acids had lower depression scores. This suggests that omega-3s may enhance connections in brain regions associated with mood regulation. While promising, further research is needed to deepen our understanding of these effects on subthreshold depression.
8
We focused on the effectiveness of eicosapentaenoic acid (EPA) as a treatment for mild depression. Comprehensive searches led us to several randomized controlled trials that examined how EPA could help those experiencing symptoms of mild depression.

Our analysis highlighted that EPA, found in certain fish oils, shows potential as a therapeutic option for individuals with mild depression. While some studies presented promising findings, we noted that rigorous research explicitly comparing EPA against placebo was limited.

Moreover, our review found that supplements like EPA may contribute positively to symptom relief. However, due to the lack of direct comparisons with antidepressants or detailed isolation of EPA's effects, we do not claim conclusive superiority over existing treatments at this time.

Overall, while there is hope regarding EPA's role in assisting with mild depression, we must call for further studies and more comprehensive research to validate these benefits fully.
We investigated the link between omega-3 fatty acids and depression using genetic data from large-scale studies. By analyzing over 115,000 participants in the UK Biobank and nearly 431,000 in the Psychiatric Genomics Consortium, we assessed the causal relationship between these fatty acids and major depressive disorder (MDD).

Our findings suggest that higher levels of omega-3s, particularly eicosapentaenoic acid (EPA), are associated with reduced odds of developing MDD. However, while the results show a significant correlation, we noted some uncertainty due to possible confounding factors.

Overall, omega-3s, especially EPA, may play a role in managing depression, but more targeted interventions could be required for clearer outcomes.
4
EPA shows potential in depression
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.

It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.

Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.

References

  1. Gong H, Su WJ, Deng SL, Luo J, Du ZL, et al. Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis. Transl Psychiatry. 2025;15:114. 10.1038/s41398-025-03317-3
  2. Yu Q, Li H, Chen M, Pan Y, Zhou L, et al. GPR120 internalization: a key mechanism for EPA in antidepressant action. Food Funct. 2025;16:2893. 10.1039/d5fo00252d
  3. Dyall SC, Malau IA, Su KP. Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials. Curr Opin Clin Nutr Metab Care. 2025;28:66. 10.1097/MCO.0000000000001077
  4. Al Sinani M, Johnson M, Crawford M, Al Maqbali M, Al-Adawi S. Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102668. 10.1016/j.plefa.2025.102668
  5. Wang B, Liu P, Gao X, Yang F, Sun J, et al. Exploring the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress. Behav Brain Res. 2025;483:115458. 10.1016/j.bbr.2025.115458
  6. Raza ML, Hassan ST, Jamil S, Fatima W, Fatima M. Nutritional interventions in depression: The role of vitamin D and omega-3 fatty acids in neuropsychiatric health. Clin Nutr. 2025;45:270. 10.1016/j.clnu.2025.01.009
  7. Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. 10.1016/j.plefa.2025.102664
  8. Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. 10.3390/nu16234065
  9. Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, et al. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. 10.1002/14651858.CD014803.pub2
  10. Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. 10.3390/nu16213688
  11. Jastrzebska J, Frankowska M, Wesołowska J, Filip M, Smaga I. Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring. Curr Neuropharmacol. 2025;23:329. 10.2174/1570159X23666241014164940
  12. Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. 10.1016/j.freeradbiomed.2024.10.298
  13. Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. 10.1016/j.jad.2024.09.129
  14. Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. 10.3390/ijms25168675
  15. Lam C, Han L, McIntyre RS, Teopiz KM, Cao B. Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis. J Child Adolesc Psychopharmacol. 2024;34:282. 10.1089/cap.2024.0017
  16. Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. 10.1038/s41398-024-02932-w
  17. Kong L, Zhang Q, Wang H, Xu Y, Xu C, et al. Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials. J Affect Disord. 2025. 10.1016/j.jad.2025.03.006
  18. Urata M, Sakurai H, Ueno F, Maruki T, Tada T, et al. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis. Neuropsychopharmacol Rep. 2025;45:e70008. 10.1002/npr2.70008
  19. Lin YW, Cheng SW, Liu WC, Zailani H, Wu SK, et al. Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture. Brain Behav Immun. 2025;123:771. 10.1016/j.bbi.2024.10.028
  20. Li P, Zhang F, Huang C, Zhang C, Yang Z, et al. Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress. J Neuroimmune Pharmacol. 2024;19:55. 10.1007/s11481-024-10154-6
  21. Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. 10.3389/fneph.2024.1365809
  22. Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. 10.1016/j.ynstr.2024.100646
  23. Lou F, Luo S, Kang N, Yan L, Long H, et al. Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism. Pharmacol Res. 2024;204:107214. 10.1016/j.phrs.2024.107214
  24. Zhang C, Hou B, Xu Y, Zeng S, Luo X, et al. Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018. J Affect Disord. 2024;354:62. 10.1016/j.jad.2024.03.055
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