This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
Read More
9
Selenium nanoparticles aid heart recovery
Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation.
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
Read More
9
Selenium's promise in atherosclerosis treatment
Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment.
We explored the potential of selenium-doped copper formate (Cuf-Se) nanozymes in treating atherosclerosis, a key contributor to cardiovascular diseases. By targeting inflammation and oxidative stress, Cuf-Se shows promise by reducing reactive oxygen species and preventing the formation of foam cells.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Read More
Most Useful Reviews
9
Promotes quick recovery
94 people found this helpful
The diet and ingredients in this supplement suit my needs perfectly. I take it at the first signs of illness. The quality is excellent and the taste in the capsules is non-existent. This supplement effectively eradicates diseases, and I've observed no allergic reactions. It's a product I highly recommend for its effectiveness.
Read More
5
Supports cardiovascular health
39 people found this helpful
NAC (N-Acetylcysteine) aids in detoxifying heavy metals, particularly cadmium, and assists liver function by combating harmful free radicals found in cigarette smoke, which contains over 4000 chemicals. It helps break down and remove sputum, stimulates glutathione production, vital for liver detoxification. Additionally, it supports cardiovascular health, protects the liver, enhances respiratory functions, and promotes detox and antiviral processes in the body. It is my favourite brand due to the excellent quality and price.
Read More
9
Vital necessity
36 people found this helpful
This NAC product is necessary for my home and travel pharmacy. It serves as a lifesaver for respiratory conditions, cleansing the chest of phlegm while boosting immunity and supporting glutathione production. I've seen it reduce white hair and enhance skin appearance, among other benefits, and hope to share my positive experience.
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
Read More
9
Selenium's promise in atherosclerosis treatment
Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment.
We explored the potential of selenium-doped copper formate (Cuf-Se) nanozymes in treating atherosclerosis, a key contributor to cardiovascular diseases. By targeting inflammation and oxidative stress, Cuf-Se shows promise by reducing reactive oxygen species and preventing the formation of foam cells.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Read More
8
Dietary antioxidants reduce mortality risk
Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease.
We evaluated how dietary antioxidants, including vitamins like C and E, affect mortality risks in individuals with cardiovascular disease (CVD). Our analysis incorporated data from nearly 1,400 participants, using advanced statistical models to determine the connections between antioxidant intake and death rates.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
Read More
8
Selenium aids heart recovery post-MI
Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy.
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
Read More
8
Selenium nanoparticles show heart benefits
Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction.
We evaluated the use of selenium-quantum-dot-loaded silica nanoparticles as a new treatment for myocardial ischemia-reperfusion injury, a serious cardiovascular issue. These nanoparticles showed impressive abilities to scavenge harmful reactive oxygen species and improve heart cell function.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
The diet and ingredients in this supplement suit my needs perfectly. I take it at the first signs of illness. The quality is excellent and the taste in the capsules is non-existent. This supplement effectively eradicates diseases, and I've observed no allergic reactions. It's a product I highly recommend for its effectiveness.
Read More
5
Supports cardiovascular health
39 people found this helpful
NAC (N-Acetylcysteine) aids in detoxifying heavy metals, particularly cadmium, and assists liver function by combating harmful free radicals found in cigarette smoke, which contains over 4000 chemicals. It helps break down and remove sputum, stimulates glutathione production, vital for liver detoxification. Additionally, it supports cardiovascular health, protects the liver, enhances respiratory functions, and promotes detox and antiviral processes in the body. It is my favourite brand due to the excellent quality and price.
Read More
9
Vital necessity
36 people found this helpful
This NAC product is necessary for my home and travel pharmacy. It serves as a lifesaver for respiratory conditions, cleansing the chest of phlegm while boosting immunity and supporting glutathione production. I've seen it reduce white hair and enhance skin appearance, among other benefits, and hope to share my positive experience.
Read More
9
Immune booster
7 people found this helpful
This NAC product is essential for my home and travel pharmacy, acting as a lifesaver during respiratory issues. It clears phlegm, boosts immunity, and stimulates glutathione production. I've also observed it restores my hair's colour and rejuvenates my skin while offering numerous other benefits.
Read More
9
Effective relief
1 people found this helpful
Fine. In short: it works brilliantly. Familiar to many, ACC is a cheaper alternative. I take it during viral illnesses, and I find myself back to normal swiftly.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
N-Acetyl Cysteine (NAC) is a modified form of the amino acid cysteine, known for its role as a powerful antioxidant and mucolytic agent. It has been widely used as a dietary supplement for various health benefits, including supporting respiratory health, detoxification, and enhancing overall immune function. NAC is particularly recognized for its ability to replenish glutathione, one of the body's most important antioxidants, which helps combat oxidative stress and protect cells from damage.
In addition to its antioxidant properties, N-Acetyl Cysteine is commonly leveraged in a clinical setting for its effectiveness in treating acetaminophen (Tylenol) overdoses, as it aids in restoring depleted glutathione levels, thus preventing liver damage. It can also be beneficial for individuals with chronic respiratory conditions, such as COPD or cystic fibrosis, as it helps in thinning mucus, making it easier to expel. While NAC is generally considered safe for most people, it’s important to consult a healthcare professional before starting any new supplement, particularly for those with pre-existing conditions or those already on medication.
Based on user reviews, the timeline for observing results from taking NAC (N-Acetylcysteine) can vary significantly depending on individual health conditions and specific health goals. Many users have reported noticeable improvements in their respiratory health and immune response quite rapidly, often within days to weeks of starting the supplement. For instance, several users highlight that they quickly feel better during viral illnesses after starting NAC, indicating its potential for fast-acting benefits during acute health situations Read Review.
Conversely, for longer-term health benefits such as enhanced cardiovascular function and liver support, users suggest that it may take more time to fully appreciate the effects. Some have noted improvements in liver detoxification and overall well-being after continued use over weeks, emphasizing that consistent use is crucial for the best results Read Review. While many users enjoy immediate relief from certain symptoms, for benefits pertaining to cardiovascular health, a sustained regimen may be necessary to see significant changes.
The supplements under investigation, especially those derived from selenium, appear to hold promise for cardiovascular health based on various scientific studies. For instance, a randomized controlled trial demonstrated that selenium supplements not only reduced inflammation in patients with atherosclerosis but also enhanced antioxidant levels, suggesting a protective role in heart health [2]. Additionally, selenium nanoparticles have shown potential in repairing heart damage post-myocardial infarction by scavenging harmful reactive oxygen species and reducing inflammation [6], which is crucial in treating heart conditions.
Furthermore, a study involving dietary antioxidants linked higher antioxidant intake, particularly selenium, with a significant reduction in cardiovascular disease mortality risks [3]. This is corroborated by another large-scale population study indicating that high antioxidant intake, including selenium, correlates with lower mortality rates among individuals with hypertension [7]. While these findings are promising, further research is needed to solidify selenium's role and efficacy in cardiovascular disease treatment. It may be worthwhile to keep an eye on upcoming studies that continue to explore these connections.
Users have reported a variety of symptom improvements after incorporating NAC (N-Acetylcysteine) into their routines. Many highlight its efficacy for respiratory health, with individuals noting that it helps clear phlegm and supports the immune system during respiratory issues or illnesses. One user referred to it as a "lifesaver" for respiratory conditions, indicating significant relief from mucus congestion and quick recovery during viral infections Read Review. Additionally, others have emphasized the supportive role of NAC in detoxification, particularly in enhancing liver function and neutralizing harmful substances, which is considered vital for overall well-being Read Review.
Besides respiratory and liver health benefits, some users have observed improvements in skin appearance and even hair color restoration, suggesting a link to its antioxidant effects on overall health. One reviewer shared their experience of seeing reduced white hair and enhanced skin condition Read Review. While these reports reflect positive outcomes, it's essential to remember that individual results can vary, and not everyone may experience the same level of improvement or benefits from using NAC.
Users have reported positive experiences when combining NAC (N-Acetylcysteine) with other supplements for managing cardiovascular disease. For instance, one user noted taking NAC alongside lipoic acid during a pandemic, which reportedly helped their family avoid infection, suggesting a strong synergistic effect between the two Read Review. Similarly, another user mentioned that NAC aids in improving cardiovascular health by lowering bad cholesterol while raising good cholesterol levels, indicating that combining it with a balanced diet or other supportive supplements could potentially enhance cardiovascular benefits Read Review.
Additionally, several users highlighted the overall health benefits of NAC, which not only supports liver and respiratory functions but also contributes to cardiovascular health by combating oxidative stress formed by free radicals Read ReviewRead Review. This multifaceted approach suggests that when used alongside other dietary supplements or lifestyle adjustments, NAC could further support cardiovascular health and enhance overall well-being.
9
Effective relief
1 people found this helpful
Fine. In short: it works brilliantly. Familiar to many, ACC is a cheaper alternative. I take it during viral illnesses, and I find myself back to normal swiftly.
7.5
Protects liver
NAC enhances liver function by aiding detoxification and safeguarding liver cells from damage. It also improves cardiovascular health, lowering bad cholesterol and increasing good cholesterol levels.
9
Vital necessity
36 people found this helpful
This NAC product is necessary for my home and travel pharmacy. It serves as a lifesaver for respiratory conditions, cleansing the chest of phlegm while boosting immunity and supporting glutathione production. I've seen it reduce white hair and enhance skin appearance, among other benefits, and hope to share my positive experience.
5
Supports cardiovascular health
39 people found this helpful
NAC (N-Acetylcysteine) aids in detoxifying heavy metals, particularly cadmium, and assists liver function by combating harmful free radicals found in cigarette smoke, which contains over 4000 chemicals. It helps break down and remove sputum, stimulates glutathione production, vital for liver detoxification. Additionally, it supports cardiovascular health, protects the liver, enhances respiratory functions, and promotes detox and antiviral processes in the body. It is my favourite brand due to the excellent quality and price.
9
Immune booster
7 people found this helpful
This NAC product is essential for my home and travel pharmacy, acting as a lifesaver during respiratory issues. It clears phlegm, boosts immunity, and stimulates glutathione production. I've also observed it restores my hair's colour and rejuvenates my skin while offering numerous other benefits.
9
Preventive use
1 people found this helpful
I bought NAC for preventive measures during the epidemic. It is reputed to prevent severe illness and aids recovery when diagnosed. My family took it alongside lipoic acid, and fortunately, we avoided infection. The packaging is airtight, ensuring safety for use during the pandemic.
6
Supports cardiovascular health
This quality product is well-sized and supports the cardiovascular system against oxidative stress and radicals. I recommend it for individuals with asthma or bronchitis.
7
Selenium's potential in heart health
Sodium selenite and Se-enriched yeast supplementation in atherosclerotic patients: Effects on the expression of pyroptosis-related genes and oxidative stress status.
We investigated the effects of daily sodium selenite and Se-enriched yeast on heart health in atherosclerosis patients. In this randomized, double-blind, placebo-controlled trial with 60 participants, we found that these supplements significantly reduced inflammation by lowering pro-inflammatory gene expressions.
We also observed enhancements in antioxidant levels, specifically glutathione peroxidases, while the harmful malondialdehyde levels decreased. Though results are promising, further research is necessary to confirm the true impact of selenium on cardiovascular disease risk.
9
Selenium nanoparticles aid heart recovery
Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation.
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
8
Dietary antioxidants reduce mortality risk
Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease.
We evaluated how dietary antioxidants, including vitamins like C and E, affect mortality risks in individuals with cardiovascular disease (CVD). Our analysis incorporated data from nearly 1,400 participants, using advanced statistical models to determine the connections between antioxidant intake and death rates.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
7
Significant links to reduced mortality
Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study.
This population-based study involved over 16,000 adults with hypertension to explore how dietary antioxidants like selenium impact mortality rates. By tracking participants for nearly eight years, we discovered that those with the highest intake of antioxidants showed a significantly lower risk of dying from any cause or cardiovascular disease.
Specifically, selenium appeared beneficial, suggesting it might play a role in improving health outcomes for those with hypertension. However, further research, particularly randomized controlled trials, is essential to confirm these valuable insights.
References
Bezerra LS, Magnani M, Pimentel TC, de Oliveira JCPL, Freire FMS, et al. Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats. Food Funct. 2022;13:5406. 10.1039/d1fo03492h
Roshanravan N, Koche Ghazi MK, Ghaffari S, Naemi M, Alamdari NM, et al. Sodium selenite and Se-enriched yeast supplementation in atherosclerotic patients: Effects on the expression of pyroptosis-related genes and oxidative stress status. Nutr Metab Cardiovasc Dis. 2022;32:1528. 10.1016/j.numecd.2022.02.014
Hu X, Zhao Z, An Q, Li Y, Wang B. Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease. BMC Public Health. 2025;25:1327. 10.1186/s12889-025-22481-1
Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. 10.1016/j.freeradbiomed.2025.03.004
Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. 10.2147/IJN.S500810
Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. 10.1016/j.biomaterials.2025.123119
Zhao S, Cao Y, Liu H, Liu A. Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study. Nutr J. 2025;24:14. 10.1186/s12937-024-01062-9
Huang X, Zhou Y, Guo Y, Yan D, Sun P, et al. Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment. Nano Lett. 2025;25:2662. 10.1021/acs.nanolett.4c05348
Li B, Liu H, Mishra D, Yuan Z, Zhang Y, et al. The association between blood metals and cardiovascular diseases: findings from National Health and Nutrition Examination Survey 2011-2020. Front Cardiovasc Med. 2024;11:1479665. 10.3389/fcvm.2024.1479665
Li X, Liu W, Jin T, Zhang T. Diet-derived circulating antioxidants and functional outcome after ischemic stroke: Evidence from genetic studies. J Stroke Cerebrovasc Dis. 2024;33:108039. 10.1016/j.jstrokecerebrovasdis.2024.108039