Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
Selenium's potential in depression treatment
This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
8
Selenium compound alleviates depression symptoms
We observed the effects of a synthetic compound called 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) on mice suffering from sleep deprivation-induced depression.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
8
New selenium compound shows promise
We explored the effects of a new compound, CFSePB, to see if it could help alleviate depression-like symptoms in mice. Using several tests like the forced swimming test, we looked at how this selenium-rich compound influenced the serotonergic and noradrenergic systems.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
Most Useful Reviews
9
Super remedy confirmed
NAC is a super remedy for depression!
9
Minimises withdrawal symptoms
4 people found this helpful
Doctors are starting to recognise NAC's benefits, which are impressive for daily use—especially on an empty stomach. It's beneficial for managing depression and can even reduce symptoms of drug withdrawal!
7.5
Improved mood
We consume it for depression, aiming to enhance the interaction between the digestive system and the brain. My husband was diagnosed with depression, and we also incorporated nak and tudka into his regimen. Improvement was noticeable within a month, but we continue to work on it together. The size is convenient, and there's no taste.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
Selenium's potential in depression treatment
This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
8
We studied the connection between adherence to the Planetary Health Diet Index (PHDI) and depression using data from the National Health and Nutrition Examination Survey. Our analysis revealed a strong negative correlation between higher PHDI scores and the likelihood of experiencing depression.
Specifically, individuals in the highest quartile of PHDI showed significantly reduced depression risks. Vitamins and nutrients like Vitamin C, Fiber, and Selenium played notable roles in this relationship. Essentially, the data suggests that a diet aligned with sustainable practices may help protect mental health.
Specifically, individuals in the highest quartile of PHDI showed significantly reduced depression risks. Vitamins and nutrients like Vitamin C, Fiber, and Selenium played notable roles in this relationship. Essentially, the data suggests that a diet aligned with sustainable practices may help protect mental health.
8
Selenium compound alleviates depression symptoms
We observed the effects of a synthetic compound called 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) on mice suffering from sleep deprivation-induced depression.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
8
We examined how selenium-enriched fermented goat milk, made from Lactobacillus paracasei, impacts depression in mice exposed to chronic stress. The findings revealed that this treatment significantly reduced depressive behaviors and helped counteract inflammation and glucocorticoid resistance.
Additionally, we observed improvements in oxidative stress within critical brain areas. Changes in gut bacteria composition further supported the treatment’s potential effects. Overall, these insights lay a foundation for future probiotic supplements aimed at supporting mental health in depressed individuals.
Additionally, we observed improvements in oxidative stress within critical brain areas. Changes in gut bacteria composition further supported the treatment’s potential effects. Overall, these insights lay a foundation for future probiotic supplements aimed at supporting mental health in depressed individuals.
8
New selenium compound shows promise
We explored the effects of a new compound, CFSePB, to see if it could help alleviate depression-like symptoms in mice. Using several tests like the forced swimming test, we looked at how this selenium-rich compound influenced the serotonergic and noradrenergic systems.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Super remedy confirmed
NAC is a super remedy for depression!
9
Minimises withdrawal symptoms
4 people found this helpful
Doctors are starting to recognise NAC's benefits, which are impressive for daily use—especially on an empty stomach. It's beneficial for managing depression and can even reduce symptoms of drug withdrawal!
7.5
Improved mood
We consume it for depression, aiming to enhance the interaction between the digestive system and the brain. My husband was diagnosed with depression, and we also incorporated nak and tudka into his regimen. Improvement was noticeable within a month, but we continue to work on it together. The size is convenient, and there's no taste.
7.5
Support for psychiatric disorders
NAC appears helpful for psychiatric disorders and addictive behaviours, with research suggesting it can improve symptoms of depression and bipolar disorder. Other studies indicate that it may aid withdrawal symptoms and lower relapse risk for addiction.
Frequently Asked Questions
7.5
Improved mood
We consume it for depression, aiming to enhance the interaction between the digestive system and the brain. My husband was diagnosed with depression, and we also incorporated nak and tudka into his regimen. Improvement was noticeable within a month, but we continue to work on it together. The size is convenient, and there's no taste.
9
Minimises withdrawal symptoms
4 people found this helpful
Doctors are starting to recognise NAC's benefits, which are impressive for daily use—especially on an empty stomach. It's beneficial for managing depression and can even reduce symptoms of drug withdrawal!
7.5
Support for psychiatric disorders
NAC appears helpful for psychiatric disorders and addictive behaviours, with research suggesting it can improve symptoms of depression and bipolar disorder. Other studies indicate that it may aid withdrawal symptoms and lower relapse risk for addiction.
9
Super remedy confirmed
NAC is a super remedy for depression!
References
- Jiang C, Choi S, Gong H. From planetary health diet (PHD) to mental health: Higher PHD index protects against depression among the U.S. population. J Psychiatr Res. 2025;183:31. doi:10.1016/j.jpsychires.2025.02.006
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Gonçalves LDS, Rusch G, Alves AG, Krüger LD, Paim MP, et al. Acute 2-phenyl-3-(phenylselanyl)benzofuran treatment reverses the neurobehavioral alterations induced by sleep deprivation in mice. Biochem Pharmacol. 2024;226:116339. doi:10.1016/j.bcp.2024.116339
- Sun Y, Zhao H, Chang M, Yue T, Yuan Y, et al. Fermented goat milk by selenium-enriched Lactobacillus paracasei alleviates depressive psychological disturbance. J Food Sci. 2024;89:4480. doi:10.1111/1750-3841.17167
- Pires CS, da Rocha MJ, Presa MH, Zuge NP, Kuntz NEB, et al. N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system. Psychopharmacology (Berl). 2024;241:1663. doi:10.1007/s00213-024-06588-8
- Wang W, Shi Y, Zhang J, Wang Y, Cheteu Wabo TM, et al. Association of dietary overall antioxidant intake with all-cause and cause-specific mortality among adults with depression: evidence from NHANES 2005-2018. Food Funct. 2024;15:4603. doi:10.1039/d4fo00236a
- Wang Z, Xiao T, Qi G. The moderating effect of dietary selenium intake on the risk of infertility-associated depressive symptoms in female. J Obstet Gynaecol Res. 2024;50:899. doi:10.1111/jog.15912
- da Rocha MJ, Pires CS, Presa MH, Besckow EM, Nunes GD, et al. Involvement of the serotonergic system in the antidepressant-like effect of 1-(phenylselanyl)-2-(p-tolyl)indolizine in mice. Psychopharmacology (Berl). 2023;240:373. doi:10.1007/s00213-023-06313-x
- Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. doi:10.1016/j.jad.2022.11.072
- Xu Q, Qian X, Sun F, Liu H, Dou Z, et al. Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality. J Affect Disord. 2023;322:84. doi:10.1016/j.jad.2022.11.013
- Garcia CS, Besckow EM, da Silva Espíndola CN, D'Avila Nunes G, Zuge NP, et al. Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. ACS Chem Neurosci. 2022;13:1746. doi:10.1021/acschemneuro.2c00129
- Sajjadi SS, Foshati S, Haddadian-Khouzani S, Rouhani MH. The role of selenium in depression: a systematic review and meta-analysis of human observational and interventional studies. Sci Rep. 2022;12:1045. doi:10.1038/s41598-022-05078-1
- Yang J, Li H, Hao Z, Jing X, Zhao Y, et al. Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway. ACS Appl Mater Interfaces. 2022;14:3685. doi:10.1021/acsami.1c18417
- de Oliveira RL, Voss GT, da C Rodrigues K, Pinz MP, Biondi JV, et al. Prospecting for a quinoline containing selenium for comorbidities depression and memory impairment induced by restriction stress in mice. Psychopharmacology (Berl). 2022;239:59. doi:10.1007/s00213-021-06039-8
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
- Domingues M, Casaril AM, Smaniotto TÂ, Birmann PT, Lourenço DA, et al. Selanylimidazopyridine abolishes inflammation- and stress-induced depressive-like behaviors by modulating the oxido-nitrosative system. Eur J Pharmacol. 2022;914:174570. doi:10.1016/j.ejphar.2021.174570
