' 
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
Antidiabetic effects of selenium
Physicochemical properties, structural characterization, and antidiabetic activity of selenylated low molecular weight apple pectin in HFD/STZ-induced type 2 diabetic mice.
High relevance to diabetes treatment
We investigated the impact of a novel selenylated low molecular weight apple pectin on diabetes management. The study focused on mice induced with type 2 diabetes through a high-fat diet and streptozotocin treatment.
Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.
Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.
Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.
Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.
Read More
9
Selenium polysaccharides aid diabetes management
Selenium polysaccharide form sweet corn cob mediated hypoglycemic effects in vitro and untargeted metabolomics study on type 2 diabetes.
Strong focus on diabetes treatment
We explored the effects of selenium polysaccharides derived from sweet corn cob on type 2 diabetes (T2D) through a combination of laboratory tests and animal studies. The goal was to determine how this unique compound could influence blood sugar levels in those dealing with T2D.
Our findings indicated that selenium polysaccharides help regulate enzymes that break down carbohydrates, specifically α-amylase and α-glucosidase, which play a significant role in digesting sugars. By inhibiting these enzymes, the compound appears to reduce sugar absorption into the bloodstream.
In animal models, we observed that selenium polysaccharides not only curbed blood sugar spikes but also significantly altered various metabolic pathways, impacting substances like adenine and others linked to energy and lipid metabolism. Additionally, when we compared selenium polysaccharides to a common diabetes medication, metformin, we found that the polysaccharides provided more effective metabolic interventions.
Overall, our study suggests that selenium-treated polysaccharides could play a meaningful role in managing T2D and reducing its complications while improving blood glucose levels.
Our findings indicated that selenium polysaccharides help regulate enzymes that break down carbohydrates, specifically α-amylase and α-glucosidase, which play a significant role in digesting sugars. By inhibiting these enzymes, the compound appears to reduce sugar absorption into the bloodstream.
In animal models, we observed that selenium polysaccharides not only curbed blood sugar spikes but also significantly altered various metabolic pathways, impacting substances like adenine and others linked to energy and lipid metabolism. Additionally, when we compared selenium polysaccharides to a common diabetes medication, metformin, we found that the polysaccharides provided more effective metabolic interventions.
Overall, our study suggests that selenium-treated polysaccharides could play a meaningful role in managing T2D and reducing its complications while improving blood glucose levels.
Read More
8
Selenium compounds show diabetes promise
Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists.
Highly relevant to diabetes research
We looked into the potential benefits of selenium-containing compounds for managing diabetes, particularly focusing on type 2 diabetes mellitus (T2DM) and obesity. In this investigation, researchers designed new compounds that creatively utilized selenium through a specific strategy that modified a known chemical structure.
One of the key findings was that these new compounds were able to effectively activate a critical receptor in the body called the GLP-1 receptor. This activation led to a noticeable increase in cyclic adenosine monophosphate (cAMP), which is important for blood sugar regulation. In tests conducted on special mice designed to mimic human conditions, the compound not only lowered blood glucose levels but also reduced food intake.
Perhaps encouragingly, this compound demonstrated a longer-lasting effect compared to its predecessor, danuglipron, without showing significant adverse side effects during toxicity studies. This suggests that selenium may have a promising role in developing oral medications for T2DM and obesity, thus opening avenues for further research in this area.
One of the key findings was that these new compounds were able to effectively activate a critical receptor in the body called the GLP-1 receptor. This activation led to a noticeable increase in cyclic adenosine monophosphate (cAMP), which is important for blood sugar regulation. In tests conducted on special mice designed to mimic human conditions, the compound not only lowered blood glucose levels but also reduced food intake.
Perhaps encouragingly, this compound demonstrated a longer-lasting effect compared to its predecessor, danuglipron, without showing significant adverse side effects during toxicity studies. This suggests that selenium may have a promising role in developing oral medications for T2DM and obesity, thus opening avenues for further research in this area.
Read More
Most Useful Reviews
8.8
Improves nerve issues
The strongest antioxidant for diabetics and liver health. The price is reasonable with good additives. While you may not 'feel' its effects regularly unless using it for acne, it’s essential to trust the science. This product is beneficial long-term for anyone with liver disease or diabetes. As someone with type 1 diabetes, I noticed this helps with nerve issues caused by diabetic complications and improves my acne. Overall, it’s a great product.
Read More
8.8
Supports diabetes management
Doctor's Best N-Acetylcysteine (NAC) is excellent for strong immunity and offers numerous benefits, including protection against oxidative stress and assisting with diabetes. I recommend taking one capsule twice daily with meals or as advised by a healthcare professional. I personally use it for detoxification.
Read More
8.8
Improves analysis indicators
I take this on the advice of my doctor to treat diabetes, and I feel better overall. My analysis indicators have also improved!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
- All Researches
9
Selenium's role in diabetes treatment
Nanometerizing Taxifolin Into Selenized Liposomes to Ameliorate Its Hypoglycemic Effect by Optimizing Drug Release and Bioavailability.
Limited understanding of selenium's effect
We sought to understand how selenium, when combined with taxifolin, might improve treatment options for diabetes mellitus. The focus was on creating selenized liposomes, or Tax-Se@LPs, that would enhance the delivery and effectiveness of taxifolin, a natural compound known for its potential health benefits.
Through a specialized manufacturing technique, we developed these nanometric liposomes and assessed their performance in preclinical settings. Our findings indicated that Tax-Se@LPs not only improved the absorption of taxifolin in the digestive system but also significantly reduced blood glucose levels in diabetic models. With a relative bioavailability of 216.65%, the selenized formulation demonstrated a more prolonged effect compared to other delivery methods.
Despite these promising results, our study did not isolate the effectiveness of selenium on its own. The benefits observed were largely attributed to the advanced delivery system rather than the selenium content alone. Therefore, while increased bioavailability and hypoglycemic effects are evident from using Tax-Se@LPs, the specific role that selenium plays in these outcomes needs further exploration for a clearer understanding.
Through a specialized manufacturing technique, we developed these nanometric liposomes and assessed their performance in preclinical settings. Our findings indicated that Tax-Se@LPs not only improved the absorption of taxifolin in the digestive system but also significantly reduced blood glucose levels in diabetic models. With a relative bioavailability of 216.65%, the selenized formulation demonstrated a more prolonged effect compared to other delivery methods.
Despite these promising results, our study did not isolate the effectiveness of selenium on its own. The benefits observed were largely attributed to the advanced delivery system rather than the selenium content alone. Therefore, while increased bioavailability and hypoglycemic effects are evident from using Tax-Se@LPs, the specific role that selenium plays in these outcomes needs further exploration for a clearer understanding.
Read More
9
Selenium's Role in Diabetes Control
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
Assessment of peptide efficacy
We investigated how selenium-modified peptides affect the aggregation of the human islet amyloid polypeptide (hIAPP), which is known to have a role in diabetes. Our study focused on the active peptide derived from coix seed prolamins called LPFYPN (LP6) and its modified versions.
Through our experiments, we observed that both LP6 and its modified peptides, particularly the selenium-enhanced version, significantly inhibited the harmful aggregation of hIAPP. This aggregation is linked to the cytotoxic effects that can worsen diabetes conditions.
The findings showed that the selenium-modified peptide not only reduced these harmful aggregates but also helped to boost the body's autophagy processes—essentially improving how cells eliminate these damaging proteins. By doing so, it reduced cell toxicity and promoted healthier cell function.
Overall, our results suggest that selenium holds potential in developing new dietary approaches to manage type 2 diabetes and possibly other amyloid-related diseases. This could mean that including selenium-rich ingredients in our diet may provide valuable health benefits in tackling diabetes health challenges.
Through our experiments, we observed that both LP6 and its modified peptides, particularly the selenium-enhanced version, significantly inhibited the harmful aggregation of hIAPP. This aggregation is linked to the cytotoxic effects that can worsen diabetes conditions.
The findings showed that the selenium-modified peptide not only reduced these harmful aggregates but also helped to boost the body's autophagy processes—essentially improving how cells eliminate these damaging proteins. By doing so, it reduced cell toxicity and promoted healthier cell function.
Overall, our results suggest that selenium holds potential in developing new dietary approaches to manage type 2 diabetes and possibly other amyloid-related diseases. This could mean that including selenium-rich ingredients in our diet may provide valuable health benefits in tackling diabetes health challenges.
Read More
9
Antidiabetic effects of selenium
Physicochemical properties, structural characterization, and antidiabetic activity of selenylated low molecular weight apple pectin in HFD/STZ-induced type 2 diabetic mice.
High relevance to diabetes treatment
We investigated the impact of a novel selenylated low molecular weight apple pectin on diabetes management. The study focused on mice induced with type 2 diabetes through a high-fat diet and streptozotocin treatment.
Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.
Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.
Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.
Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.
Read More
9
Selenium improves liver function in diabetes
Antioxidant and Antiapoptotic Effects of Selenium And Nano Selenium-Loaded Exosomes on Hepatic Dysfunction of Type 1 Diabetic Rats.
Research confirms selenium's potential
We sought to understand how selenium could improve liver health among rats with type 1 diabetes. Our study involved groups of rats, including healthy controls and diabetic ones, with some receiving exosomes—tiny messenger particles that can carry beneficial compounds. We specifically looked at exosomes loaded with either selenium or a nano version of it to see their effects over four weeks.
The results were promising. The groups of rats that received selenium-loaded exosomes showed significant reductions in various markers of oxidative stress and inflammation in the liver. This suggests that selenium may help in combating the damaging effects associated with diabetes. At the same time, we observed an increase in antioxidant levels in the liver, which are crucial for protecting cells from damage.
Additionally, we noted improvements in liver function, including reduced levels of liver enzymes and a better overall lipid profile. Histological examinations of liver tissue revealed restored architecture in treated diabetic rats compared to those who did not receive any treatment. Notably, the group that received exosomes loaded with nano selenium achieved the best outcomes in terms of liver health and function.
The results were promising. The groups of rats that received selenium-loaded exosomes showed significant reductions in various markers of oxidative stress and inflammation in the liver. This suggests that selenium may help in combating the damaging effects associated with diabetes. At the same time, we observed an increase in antioxidant levels in the liver, which are crucial for protecting cells from damage.
Additionally, we noted improvements in liver function, including reduced levels of liver enzymes and a better overall lipid profile. Histological examinations of liver tissue revealed restored architecture in treated diabetic rats compared to those who did not receive any treatment. Notably, the group that received exosomes loaded with nano selenium achieved the best outcomes in terms of liver health and function.
Read More
9
Selenium polysaccharides aid diabetes management
Selenium polysaccharide form sweet corn cob mediated hypoglycemic effects in vitro and untargeted metabolomics study on type 2 diabetes.
Strong focus on diabetes treatment
We explored the effects of selenium polysaccharides derived from sweet corn cob on type 2 diabetes (T2D) through a combination of laboratory tests and animal studies. The goal was to determine how this unique compound could influence blood sugar levels in those dealing with T2D.
Our findings indicated that selenium polysaccharides help regulate enzymes that break down carbohydrates, specifically α-amylase and α-glucosidase, which play a significant role in digesting sugars. By inhibiting these enzymes, the compound appears to reduce sugar absorption into the bloodstream.
In animal models, we observed that selenium polysaccharides not only curbed blood sugar spikes but also significantly altered various metabolic pathways, impacting substances like adenine and others linked to energy and lipid metabolism. Additionally, when we compared selenium polysaccharides to a common diabetes medication, metformin, we found that the polysaccharides provided more effective metabolic interventions.
Overall, our study suggests that selenium-treated polysaccharides could play a meaningful role in managing T2D and reducing its complications while improving blood glucose levels.
Our findings indicated that selenium polysaccharides help regulate enzymes that break down carbohydrates, specifically α-amylase and α-glucosidase, which play a significant role in digesting sugars. By inhibiting these enzymes, the compound appears to reduce sugar absorption into the bloodstream.
In animal models, we observed that selenium polysaccharides not only curbed blood sugar spikes but also significantly altered various metabolic pathways, impacting substances like adenine and others linked to energy and lipid metabolism. Additionally, when we compared selenium polysaccharides to a common diabetes medication, metformin, we found that the polysaccharides provided more effective metabolic interventions.
Overall, our study suggests that selenium-treated polysaccharides could play a meaningful role in managing T2D and reducing its complications while improving blood glucose levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improves nerve issues
The strongest antioxidant for diabetics and liver health. The price is reasonable with good additives. While you may not 'feel' its effects regularly unless using it for acne, it’s essential to trust the science. This product is beneficial long-term for anyone with liver disease or diabetes. As someone with type 1 diabetes, I noticed this helps with nerve issues caused by diabetic complications and improves my acne. Overall, it’s a great product.
Read More
8.8
Supports diabetes management
Doctor's Best N-Acetylcysteine (NAC) is excellent for strong immunity and offers numerous benefits, including protection against oxidative stress and assisting with diabetes. I recommend taking one capsule twice daily with meals or as advised by a healthcare professional. I personally use it for detoxification.
Read More
8.8
Improves analysis indicators
I take this on the advice of my doctor to treat diabetes, and I feel better overall. My analysis indicators have also improved!
8.8
Effective for diabetes
Excellent antioxidant with top-notch price-quality ratio. This supplement may assist in treating cardiovascular issues and has been effective for diabetes management. I did not perceive any enhancement in my training endurance.
8.5
Reduced pain and fatigue
Great for candida sufferers! I have recurring candida infections due to Type 2 diabetes, leading to significant fatigue and pain in my body. After taking four capsules each morning, I quickly noticed improvements in my overall energy levels and the pain in my feet has vanished. Previous products didn't address the toxins produced by candida, but this one certainly does.
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