' 
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
8
Selenium benefits Hashimoto's patients
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Directly evaluates selenium effects
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Read More
9
Selenium reduces anti-Tg antibodies
Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial.
Direct impact on thyroid treatment
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
9
Cognitive benefits of N-acetylcysteine
N‑acetylcysteine prevents hypothyroidism‑induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and BDNF in hippocampal tissues.
High relevance to hypothyroidism treatment
The study explored the effectiveness of N-acetylcysteine (often abbreviated as AC) in treating cognitive impairments associated with hypothyroidism in adolescent rats. We conducted the research with a well-structured design, where sixty male adolescent rats were divided into various groups. Some received treatment with AC while others were induced with hypothyroidism using propylthiouracil, creating a solid groundwork for comparison.
Our findings revealed that N-acetylcysteine significantly helped improve cognitive functions in hypothyroid rats. In tests designed to assess learning and memory, such as the Morris water maze and passive avoidance tests, treated rats showed remarkable improvements. They found hidden platforms faster and spent less time in dark chambers, indicating better learning and memory abilities compared to their non-treated counterparts.
On the biochemical side, AC treatment resulted in reduced harmful substances in the brain and increased protective factors. Notably, levels of brain-derived neurotrophic factor (BDNF), crucial for brain health, were significantly improved. Furthermore, AC also decreased inflammatory markers in the brain, suggesting that its benefits arise from anti-oxidative properties and enhancements in overall brain health.
Our findings revealed that N-acetylcysteine significantly helped improve cognitive functions in hypothyroid rats. In tests designed to assess learning and memory, such as the Morris water maze and passive avoidance tests, treated rats showed remarkable improvements. They found hidden platforms faster and spent less time in dark chambers, indicating better learning and memory abilities compared to their non-treated counterparts.
On the biochemical side, AC treatment resulted in reduced harmful substances in the brain and increased protective factors. Notably, levels of brain-derived neurotrophic factor (BDNF), crucial for brain health, were significantly improved. Furthermore, AC also decreased inflammatory markers in the brain, suggesting that its benefits arise from anti-oxidative properties and enhancements in overall brain health.
Read More
Most Useful Reviews
9.5
Antibodies reduced
Excellent! Doctor's Best Acetylcysteine (NAC Detox Regulators) aids the absorption of glutathione, a crucial antioxidant in healthy cells. It has been proven that N-acetylcysteine enhances glutathione production. Selenium and molybdenum are vital for this process, supporting detoxification and energy production. The capsules are medium-sized, tasteless, and easy to swallow. I took one each morning on an empty stomach. NAC helped reduce my antibodies; I have hypothyroidism and finished a few jars. I recommend it.
Read More
8.8
Effective liver support
I have a diagnosis of hypothyroidism, which causes high cholesterol and fatty liver. This condition necessitates liver support. On my doctor's recommendation, I took NAC to enhance immunity; this drug has anti-inflammatory and antioxidant properties, promotes detoxification, and helps protect the liver from toxins. It aids in achieving sufficient intercellular glutathione levels, enabling the liver to neutralise harmful substances. I recommend this quality product.
Read More
8.8
NAC strengthens immunity
I have hypothyroidism, which leads to high cholesterol and fatty liver. This condition needs liver support. On my doctor's advice, I took NAC to bolster immunity, and it has anti-inflammatory and antioxidant benefits that aid detoxification and protect the liver from harmful chemicals.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
- All Researches
9
Selenium reduces anti-Tg antibodies
Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial.
Direct impact on thyroid treatment
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
9
Selenium aids subclinical hypothyroidism
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.
Combination treatment limits isolation
We approached the intriguing question of whether selenium, when combined with myo-inositol, could help those dealing with subclinical hypothyroidism. This study involved 148 women of reproductive age, who had their thyroid stimulating hormone (TSH) levels monitored over a six-month period while taking daily supplements.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Read More
9
Cognitive benefits of N-acetylcysteine
N‑acetylcysteine prevents hypothyroidism‑induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and BDNF in hippocampal tissues.
High relevance to hypothyroidism treatment
The study explored the effectiveness of N-acetylcysteine (often abbreviated as AC) in treating cognitive impairments associated with hypothyroidism in adolescent rats. We conducted the research with a well-structured design, where sixty male adolescent rats were divided into various groups. Some received treatment with AC while others were induced with hypothyroidism using propylthiouracil, creating a solid groundwork for comparison.
Our findings revealed that N-acetylcysteine significantly helped improve cognitive functions in hypothyroid rats. In tests designed to assess learning and memory, such as the Morris water maze and passive avoidance tests, treated rats showed remarkable improvements. They found hidden platforms faster and spent less time in dark chambers, indicating better learning and memory abilities compared to their non-treated counterparts.
On the biochemical side, AC treatment resulted in reduced harmful substances in the brain and increased protective factors. Notably, levels of brain-derived neurotrophic factor (BDNF), crucial for brain health, were significantly improved. Furthermore, AC also decreased inflammatory markers in the brain, suggesting that its benefits arise from anti-oxidative properties and enhancements in overall brain health.
Our findings revealed that N-acetylcysteine significantly helped improve cognitive functions in hypothyroid rats. In tests designed to assess learning and memory, such as the Morris water maze and passive avoidance tests, treated rats showed remarkable improvements. They found hidden platforms faster and spent less time in dark chambers, indicating better learning and memory abilities compared to their non-treated counterparts.
On the biochemical side, AC treatment resulted in reduced harmful substances in the brain and increased protective factors. Notably, levels of brain-derived neurotrophic factor (BDNF), crucial for brain health, were significantly improved. Furthermore, AC also decreased inflammatory markers in the brain, suggesting that its benefits arise from anti-oxidative properties and enhancements in overall brain health.
Read More
8
Selenium and myo-inositol efficacy
Role of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.
Focus on combined treatment effects
We explored the impact of selenium supplementation on patients with autoimmune thyroiditis, particularly focusing on its effectiveness in restoring normal thyroid function. The study compared the effects of selenium alone against a combination therapy of selenium and myo-inositol (referred to as MI + Se).
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Read More
8
Selenium's mixed effects on thyroid
Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults.
Significant but complex findings
We investigated how selenium affects thyroid function in older Chinese adults, focusing particularly on its potential impact on hypothyroidism. Our study included participants aged 65 and older, who provided samples of their fingernails and whole blood for analysis. We specifically looked at hormone levels, including thyroid stimulating hormone (TSH) and various forms of thyroxine, to assess thyroid health.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Antibodies reduced
Excellent! Doctor's Best Acetylcysteine (NAC Detox Regulators) aids the absorption of glutathione, a crucial antioxidant in healthy cells. It has been proven that N-acetylcysteine enhances glutathione production. Selenium and molybdenum are vital for this process, supporting detoxification and energy production. The capsules are medium-sized, tasteless, and easy to swallow. I took one each morning on an empty stomach. NAC helped reduce my antibodies; I have hypothyroidism and finished a few jars. I recommend it.
Read More
8.8
Effective liver support
I have a diagnosis of hypothyroidism, which causes high cholesterol and fatty liver. This condition necessitates liver support. On my doctor's recommendation, I took NAC to enhance immunity; this drug has anti-inflammatory and antioxidant properties, promotes detoxification, and helps protect the liver from toxins. It aids in achieving sufficient intercellular glutathione levels, enabling the liver to neutralise harmful substances. I recommend this quality product.
Read More
8.8
NAC strengthens immunity
I have hypothyroidism, which leads to high cholesterol and fatty liver. This condition needs liver support. On my doctor's advice, I took NAC to bolster immunity, and it has anti-inflammatory and antioxidant benefits that aid detoxification and protect the liver from harmful chemicals.
Read More
8.8
Improved test results
With hypothyroidism, the endocrinologist advised me to drink it. The tests improved, but I was told to drink only after delivery and following the doctor's appointment.
8
Positive trend noticed
I see a positive trend. This is not the first time I say that I take it to cleanse the liver and to help with hypothyroidism.
