Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
USERS' SCORE
Good
Based on 99 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
8
We examined how selenium nanoparticles might help combat liver damage caused by cadmium, a dangerous environmental toxin. By studying both animal models and liver cells, we found that these nanoparticles could reduce cell injuries linked to a damaging process called ferroptosis.
Our findings indicated that achieving this protective effect involves enhancing certain liver enzyme activities and altering several protein levels associated with oxidative stress. Overall, while selenium shows promise in mitigating liver damage, particularly against cadmium toxicity, further research could better clarify its mechanisms and potential benefits.
Our findings indicated that achieving this protective effect involves enhancing certain liver enzyme activities and altering several protein levels associated with oxidative stress. Overall, while selenium shows promise in mitigating liver damage, particularly against cadmium toxicity, further research could better clarify its mechanisms and potential benefits.
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Most Useful Reviews
9
Enhances liver detoxification
301 people found this helpful
N-acetylcysteine is an excellent antioxidant that helps restore intestinal walls and removes mucus from the respiratory tract while aiding liver detoxification from toxins and heavy metals. I take it for two months on an empty stomach, as advised by my nutritionist. Our health is in our hands!
9
Helps relieve toxins
224 people found this helpful
Acetylcysteine truly is a superfood! It boosts glutathione production in the liver, aids detoxification, and helps remove toxins, including alcohol by-products. This product excellently supports all liver functions. I highly recommend it for liver health at an affordable price!
9
NAC for liver protection
202 people found this helpful
N-acetyl cysteine (NAC) is an excellent liver protector and an integral part of standard care for acetaminophen overdose. It's also effective against various health threats, including acute liver failure, making it essential for anyone concerned about liver health.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
- All Researches
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
9
We aimed to investigate the role of selenium and coenzyme Q in addressing liver damage caused by a methionine choline-deficient diet in mice. Over four weeks, mice receiving the combination treatment showed significant reductions in liver inflammation, fibrosis, and oxidative stress.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
9
Selenium enhances liver health
We set out to investigate if selenium, along with glutathione, can help reduce liver injury caused by a cancer-inducing substance in mice. Over 20 weeks, we divided male mice into different groups, some receiving selenium and others just glutathione, while monitoring their liver function.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
8
We explored the potential of an engineered yeast, S. cerevisiae-pYD1-ScFv-AFB1, in addressing liver damage caused by aflatoxin B1 (AFB1), a known cancer risk factor. Using a mouse model, we treated subjects with this specialized yeast for four weeks.
The results showed that the engineered yeast significantly reduced inflammation and cellular damage in the liver, and improved antioxidant capacity. Additionally, it helped repair the intestinal barrier disrupted by AFB1. These findings suggest it may offer a new way to combat AFB1 toxicity.
The results showed that the engineered yeast significantly reduced inflammation and cellular damage in the liver, and improved antioxidant capacity. Additionally, it helped repair the intestinal barrier disrupted by AFB1. These findings suggest it may offer a new way to combat AFB1 toxicity.
User Reviews
USERS' SCORE
Good
Based on 99 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhances liver detoxification
301 people found this helpful
N-acetylcysteine is an excellent antioxidant that helps restore intestinal walls and removes mucus from the respiratory tract while aiding liver detoxification from toxins and heavy metals. I take it for two months on an empty stomach, as advised by my nutritionist. Our health is in our hands!
9
Helps relieve toxins
224 people found this helpful
Acetylcysteine truly is a superfood! It boosts glutathione production in the liver, aids detoxification, and helps remove toxins, including alcohol by-products. This product excellently supports all liver functions. I highly recommend it for liver health at an affordable price!
9
NAC for liver protection
202 people found this helpful
N-acetyl cysteine (NAC) is an excellent liver protector and an integral part of standard care for acetaminophen overdose. It's also effective against various health threats, including acute liver failure, making it essential for anyone concerned about liver health.
10
Life-changing detox
135 people found this helpful
I was exhausted and recommend this product for liver detox. After trying various remedies with no success, this product transformed my life. After completing the box, my tests showed that everything was fine. The bile is excreted, and the liver fat is gone. Thank you.
7.5
Efficient liver maintenance
93 people found this helpful
I take NAC detox annually for liver health. The package has just enough for the course, and given my genetic predisposition to Gilbert's syndrome, this supplement is crucial for monitoring and maintaining my liver health. Under my nutritionist's guidance, I've significantly improved my health, confirmed by tests and my general well-being.
Frequently Asked Questions
9
Normal liver indicators
31 people found this helpful
I had significantly elevated liver function tests; my AST and ALT levels were much higher than normal. After deciding on an urgent detox for my liver, I noticed my levels normalised within a week. This product is indeed quality and effective, contributing positively to my liver health.
9
Cleanses liver effectively
7 people found this helpful
I recommend this for liver cleansing as my doctor advised it while managing poor test results after other medications. After three months of use, my liver function returned to normal, much to my surprise. Highly recommended for liver health!
10
NAC is effective
10 people found this helpful
NAC works wonders! After my NAFLD diagnosis 20 years ago, I learned about supplements to aid my liver condition, and NAC was highly recommended. After six months of taking NAC, my liver test results were "clean". I’m grateful for the insight I found at iHerb which led me to this supplement!
9
Enhances detox effects
4 people found this helpful
I purchased this supplement for its liver-protecting and detoxifying effects. It reduces fatigue and enhances my skin tone! I take 2-3 capsules before bedtime. It is a high-quality supplement with easily understood effects.
9
Reduces hangover symptoms
5 people found this helpful
After consuming alcohol, the liver processes it into harmful substances like acetaldehyde. It requires Glutathione to convert acetaldehyde into harmless compounds. NAC can enhance glutathione production in the body, aiding the liver's detoxification of toxins, which significantly alleviates hangover symptoms.
9
Visible liver improvement
31 people found this helpful
I’ve purchased this product multiple times from personal experience. It’s remarkable! I used it alongside milk thistle, and saw a significant decrease in liver enzymes in my tests—highly recommend it.
7.5
Helps reduce liver fat
7 people found this helpful
The high concentration of N-acetylcysteine is excellent for my needs. I chose this product primarily for its active ingredient and the synergy with selenium and molybdenum. I use it to address fatty liver issues and detox, thereby significantly reducing triglycerides in the liver.
10
Enhances liver well-being
3 people found this helpful
Outstanding NAC Detox Regulators for liver health and antioxidant support! I've been taking Doctor's Best NAC Detox Regulators with Seleno Excell for several weeks, and the results have been impressive. Each capsule delivers a potent combination of NAC and selenium, significantly supporting my liver health and detoxification process. The capsules are easy to swallow and have not caused any digestive issues. Since starting this supplement, I’ve experienced improved energy, clearer skin, and better overall well-being. I highly recommend it!
9
Remedy for hangovers
45 people found this helpful
This product is perfect for renewing and cleansing the liver of toxins and heavy metals. It's a great hangover remedy; I take 2 tablets before bed after a night out and 2 in the morning! It cleanses the liver from alcohol breakdown products and helps recovery from hangovers.
7.5
Efficient liver maintenance
93 people found this helpful
I take NAC detox annually for liver health. The package has just enough for the course, and given my genetic predisposition to Gilbert's syndrome, this supplement is crucial for monitoring and maintaining my liver health. Under my nutritionist's guidance, I've significantly improved my health, confirmed by tests and my general well-being.
9
Lowered liver enzymes
3 people found this helpful
Best NAC I've ever used! I started taking this to aid a liver and kidney problem. It's now my new best friend, as I’ve noticed my liver enzymes dropped significantly after just one month of taking two capsules a day.
8
We explored the effects of selenium-enriched FZU3103 (Lf@Se) on alcoholic liver injury in mice. The study found that Lf@Se significantly outperformed both regular selenium and Lf in easing liver damage.
By promoting healthy lipid metabolism and enhancing liver function, Lf@Se not only improved alcohol metabolism but also helped reduce oxidative damage in the liver. It also positively influenced gut health by increasing helpful bacteria and regulating liver metabolism.
However, it’s important to note that the findings are based on animal research and may not directly translate to humans.
By promoting healthy lipid metabolism and enhancing liver function, Lf@Se not only improved alcohol metabolism but also helped reduce oxidative damage in the liver. It also positively influenced gut health by increasing helpful bacteria and regulating liver metabolism.
However, it’s important to note that the findings are based on animal research and may not directly translate to humans.
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
References
- Huang H, Li Z, Qi Z, Ma L, Hu G, et al. Engineered S. cerevisiae-pYD1-ScFv-AFB1 mitigates aflatoxin B1 toxicity via bio-binding and intestinal microenvironment repair. Food Chem Toxicol. 2025;196:115232. doi:10.1016/j.fct.2024.115232
- Abdel-Latif GA, Al-Kashef AS, Nooman MU, Khattab AEA, Gebril SM, et al. The mechanistic interplay between Nrf-2, NF-κB/MAPK, caspase-dependent apoptosis, and autophagy in the hepatoprotective effects of Sophorolipids produced by microbial conversion of banana peels using Saccharomyces cerevisiae against doxorubicin-induced hepatotoxicity in rats. Food Chem Toxicol. 2023;182:114119. doi:10.1016/j.fct.2023.114119
- Abdel-Tawwab M, Khalil RH, Younis NA, Abo Selema TAM, Saad AH, et al. Saccharomyces cerevisiae supplemented diets mitigate the effects of waterborne cadmium toxicity on gilthead seabream (Sparus aurata L.): growth performance, haemato-biochemical, stress biomarkers, and histopathological investigations. Vet Res Commun. 2024;48:69. doi:10.1007/s11259-023-10176-0
- Cattaneo L, Lopreiato V, Piccioli-Cappelli F, Trevisi E, Minuti A. Effect of supplementing live Saccharomyces cerevisiae yeast on performance, rumen function, and metabolism during the transition period in Holstein dairy cows. J Dairy Sci. 2023;106:4353. doi:10.3168/jds.2022-23046
- Jiang G, Kong H, Wang Y, Wang Y, Zhou J, et al. Antioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide. Int J Biol Macromol. 2025;301:140234. doi:10.1016/j.ijbiomac.2025.140234
- Choi H, Choi J, Go Y, Chung J. Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice. Nutrients. 2025;17. doi:10.3390/nu17020229
- Guo W, Weng T, Song Y. Association of serum selenium with MASLD and liver fibrosis: A cross-sectional study. PLoS One. 2024;19:e0314780. doi:10.1371/journal.pone.0314780
- Yang Z, Lian J, Li J, Guo W, Ni L, et al. Intestinal Microbiomics and Liver Metabolomics Insights into the Ameliorative Effects of Selenium-Enriched FZU3103 on Alcohol-Induced Liver Injury in Mice. J Agric Food Chem. 2025;73:3232. doi:10.1021/acs.jafc.4c06072
- Shen Q, Liu Y, Li J, Zhou D. Nano-Selenium Modulates NF-κB/NLRP3 Pathway and Mitochondrial Dynamics to Attenuate Microplastic-Induced Liver Injury. Nutrients. 2024;16. doi:10.3390/nu16223878
- Liu Q, Bi J, Fan G, Wu M, Qin X, et al. Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults. J Trace Elem Med Biol. 2024;86:127566. doi:10.1016/j.jtemb.2024.127566
- Chen X, Lin X. Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway. Poult Sci. 2025;104:104449. doi:10.1016/j.psj.2024.104449
- Mrwad AA, El-Shafey SE, Said NM. Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis. J Trace Elem Med Biol. 2024;86:127563. doi:10.1016/j.jtemb.2024.127563
- Hsiao YF, Huang SC, Cheng SB, Hsu CC, Huang YC. Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities. Int J Mol Sci. 2024;25. doi:10.3390/ijms252111339
- Cengiz M, Gür B, Gür F, Şahintürk V, Bayrakdar A, et al. The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats. Heliyon. 2024;10:e38713. doi:10.1016/j.heliyon.2024.e38713
- Chen F, Li Q, Xu X, Wang F. Selenium Attenuates Ethanol-induced Hepatocellular Injury by Regulating Ferroptosis and Apoptosis. Turk J Gastroenterol. 2024;35:778. doi:10.5152/tjg.2024.24159
- Abdel-Wahhab KG, Ashry M, Hassan LK, El-Azma MH, Elqattan GM, et al. Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury. Sci Rep. 2024;14:21066. doi:10.1038/s41598-024-70894-6
- Shao C, Luo T, Wang S, Li Z, Yu X, et al. Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro. Chemosphere. 2024;364:143004. doi:10.1016/j.chemosphere.2024.143004
- Liu Y, Wang R. Association between serum selenium and non-alcoholic fatty liver disease: Results from NHANES: An observational study. Medicine (Baltimore). 2024;103:e38845. doi:10.1097/MD.0000000000038845
- Huertas-Abril PV, Prieto-Álamo MJ, Jurado J, Pérez J, Molina-Hernández V, et al. Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet. Food Chem Toxicol. 2024;191:114845. doi:10.1016/j.fct.2024.114845
