l-theanine shows promise for depressionl-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
Relevant study with positive findings
We investigated the effects of l-theanine added to sertraline in treating major depressive disorder (MDD). In a six-week, double-blind trial, participants took either l-theanine or a placebo alongside their medication. Results showed that those receiving l-theanine experienced a greater reduction in depression symptoms and higher remission rates compared to the placebo group. Though the study had a small sample size, the findings suggest l-theanine may be a promising adjunct therapy for improving treatment outcomes in MDD. More extensive research is needed for confirmation.
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L-theanine shows potential antidepressant effectsL-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions.
Study shows neurotransmitter modulation
We examined how L-theanine, a compound found in green tea, influences depressive behaviors in a rat model. Using specific behavioral tests, such as the open-field and forced swim tests, we observed that L-theanine improved depressive-like behaviors.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation.
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Effects of l-theanine on depressionEffects of chronic l-theanine administration in patients with major depressive disorder: an open-label study.
Study suggests potential benefits
We explored the effects of l-theanine, a natural amino acid found in green tea, on patients diagnosed with major depressive disorder (MDD) in an 8-week open-label study. We involved 20 participants who took 250 mg of l-theanine daily in addition to their regular medication.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
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L-theanine shows promise for mental healthEffects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
Relevant study on L-theanine benefits
This study focused on how L-theanine, administered over four weeks, affects stress-related symptoms and cognitive functions in healthy adults.
We found that participants who took 200 mg of L-theanine daily reported decreased depression, anxiety, and improved sleep quality compared to those on a placebo. Measures like verbal fluency and executive function showed significant improvements as well.
Our results suggest that L-theanine could be a helpful option for those facing stress and cognitive challenges, promoting better mental well-being.
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