We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
Most Useful Reviews
10
Best for influenza
1 people found this helpful
The best remedy for influenza.
Read More
9
Quick flu relief
1 people found this helpful
I always keep Ester-C for acute respiratory infections, flu, and colds. This ester form effectively addresses the first symptoms, helping me recover faster. I found it particularly beneficial after childbirth when sleepless nights could be taxing, as it supports tired adrenal glands.
Read More
9
Prevents flu complications
1 people found this helpful
Vitamin C is crucial for combating routine colds and flu. A doctor advised me to take it before my surgery, and it worked wonders. I truly noticed its effects when my father was undergoing chemotherapy and radiation, which weakened his immune system. We all caught colds and flu that winter except for him. When I had my heart surgery, I took Vitamin C and didn’t face any illness, even while caring for my grandchildren. Ester C is fantastic as it avoids the burning sensation often associated with other Vitamin C products.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
10
Best for influenza
1 people found this helpful
The best remedy for influenza.
Read More
9
Quick flu relief
1 people found this helpful
I always keep Ester-C for acute respiratory infections, flu, and colds. This ester form effectively addresses the first symptoms, helping me recover faster. I found it particularly beneficial after childbirth when sleepless nights could be taxing, as it supports tired adrenal glands.
Read More
9
Prevents flu complications
1 people found this helpful
Vitamin C is crucial for combating routine colds and flu. A doctor advised me to take it before my surgery, and it worked wonders. I truly noticed its effects when my father was undergoing chemotherapy and radiation, which weakened his immune system. We all caught colds and flu that winter except for him. When I had my heart surgery, I took Vitamin C and didn’t face any illness, even while caring for my grandchildren. Ester C is fantastic as it avoids the burning sensation often associated with other Vitamin C products.
Read More
9
Effective against flu
This one is exceptional! With everyone coughing and sneezing this flu season, I'm strengthening my immune health with this 1000mg Ester-C. It is notably effective and works quickly, making me a repeat buyer.
Read More
9
Effective composition
We use this for colds and flu! The drug has an excellent composition and is effective. Unlike other vitamin C forms, it does not adversely affect the gastric mucosa. The capsules might be large, but that's a minor issue!
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Ester-C is a patented form of vitamin C (ascorbic acid) that is known for its unique formulation, which includes calcium ascorbate. This makes Ester-C less acidic than standard vitamin C, making it gentler on the stomach for those who may experience gastrointestinal discomfort from regular vitamin C supplementation. One of the key features touted by manufacturers of Ester-C is that it is better absorbed by the body and stays in the immune system longer, although scientific research on these claims can be mixed.
In addition to its purported benefits, Ester-C is often marketed as a supplement that supports immune health, collagen production, and serves as an antioxidant, helping to combat free radicals and oxidative stress. It's available in various forms, including capsules, tablets, and powders, making it easy to incorporate into your daily routine. While some users report positive effects and tolerance of Ester-C, it's essential to consult with a healthcare professional before adding any new supplement to your regimen, especially if you have existing conditions or are taking other medications.
While Ester-C, a patented form of vitamin C, is often marketed for its potential immune-boosting effects, its direct impact on the flu is less clear. Vitamin C is known to play a role in the immune system, and some studies suggest that it may help reduce the duration and severity of colds. However, research specifically linking Ester-C to flu prevention or treatment is limited. Most health professionals recommend focusing on overall immune health through a balanced diet, adequate sleep, and proper hydration rather than relying solely on supplements.
If you are considering taking Ester-C to help with flu symptoms, it’s best to consult with your healthcare provider. They can offer personalized advice based on your health history and current conditions. While maintaining sufficient levels of vitamin C is important, it should not be viewed as a replacement for flu vaccines or antiviral medications that are prescribed in cases of influenza. It’s always advisable to approach flu prevention and treatment with a comprehensive strategy that includes both lifestyle choices and medical guidance.
Based on user reviews, many individuals report noticeable improvements in flu symptoms relatively quickly after starting the supplement. Users have shared experiences of feeling significantly better within just a few days of taking the product. For instance, one reviewer stated that they took two capsules daily for three days at the onset of illness and began to feel like themselves again Read Review. Others have indicated that they notice its effectiveness as soon as they begin to experience cold or flu symptoms Read Review.
Moreover, several users highlight that taking the supplement at the first sign of illness can lead to quicker recovery periods. One user shared how they found improvements in flu symptoms and overall health after consistent use Read Review. Thus, while the exact timeline for results can vary, many consumers agree that apparent benefits usually manifest within a few days of commencing the supplement.
Vitamin C has garnered attention for its potential role in managing flu symptoms and boosting immune response. A study found that vitamin C supplementation could reduce the likelihood of contracting an acute respiratory infection such as the flu by approximately 4% and shorten symptom duration by about 9% [1]. Moreover, research demonstrated that when combined with red ginseng, vitamin C enhanced the immune response in both human cells and animal models, reducing lung inflammation and viral load during influenza infections [3]. This suggests that vitamin C might be most effective when used in conjunction with other supportive compounds.
However, while vitamin C shows promise, it's essential to note that its effects on the flu virus itself are moderate. In tests examining its inhibitory effects on influenza neuraminidase activity, results indicated that vitamin C had a comparatively lower potency than established antiviral drugs [2]. Furthermore, other studies demonstrated that vitamin C combined with certain triterpenes resulted in significant anti-influenza activity, hinting at exciting avenues for further exploration in flu treatments [4]. Overall, while vitamin C may not be a standalone solution for flu prevention or treatment, existing research supports its potential role in a broader strategy for bolstering immune defenses and mitigating flu symptoms.
Based on user reviews, many individuals have reported significant improvements in their flu symptoms after starting the supplement. For example, one user shared that they took two capsules daily at the onset of their illness and felt notably better within days, saying they felt like a "human" again Read Review. Another user highlighted that consistent use helped them recover more quickly from respiratory infections, especially during stressful periods like post-childbirth Read Review. Numerous reviewers emphasized that taking the supplement at the first sign of a cold or flu often led to effective prevention or rapid alleviation of symptoms Read Review.
Users also noted that it not only supported immune health but also improved overall wellbeing, with some reporting benefits such as better sleep and enhanced vitality Read Review. While individual results can vary, many users seem to agree that incorporating this supplement into their regimen has contributed to fewer colds and milder flu symptoms when they do occur Read Review.
Based on user reviews, many individuals have reported positive experiences when combining this vitamin C supplement with other treatments for flu and cold symptoms. For instance, one user highlights the product's efficacy during flu season, recommending it as a preventive measure to strengthen immune health alongside other health support strategies Read Review. Another reviewer mentioned the supplement's performance in addressing acute respiratory infections effectively, especially when paired with self-care practices like rest and hydration Read Review.
Furthermore, some users discussed the supplement's role in their overall wellness routine, stating that it doesn’t just help combat flu symptoms but also contributes to better immune function throughout the year Read Review. It was noted that users often integrate this vitamin C into a broader strategy that may include other vitamins or herbal supplements, sharing that this combination helps enhance the supplement's overall effectiveness. As such, consumers frequently recommend layering this product with other immune-boosting supplements to promote quicker recovery during flu season Read Review.
Based on user reviews, there appears to be a consensus that Ester-C can be an effective remedy for flu symptoms, with many users noting specific dosages that they find beneficial. For instance, one reviewer reported taking 2,000 mg daily during illness, stating it rapidly eliminates flu symptoms (Read Review). Another user mentioned taking 2 capsules daily at the first signs of illness for three days, which they found significantly alleviated their symptoms (Read Review). On the other hand, some users suggested a more moderate approach of 1,000 mg, emphasizing its effectiveness for immune support and recovery from respiratory infections (Read Review).
Overall, while users recommend varying dosages—ranging from 1,000 mg to 2,000 mg or more—the general sentiment is that Ester-C is a reliable option for strengthening the immune response and alleviating flu symptoms. Many users appreciated the non-acidic nature of the supplement, highlighting that it does not upset the stomach compared to other Vitamin C formulations (Read Review). This flexibility in dosage and noticeable effects showcases Ester-C's role as a supportive ally during flu season.
7.5
Rapid relief
This is an exceptional vitamin C, known as a super remedy for colds and flu. At the onset of illness, I take 2 capsules daily for three days and feel significantly better. My symptoms ease, and I once again feel like a "human."
9
Effective against flu
This one is exceptional! With everyone coughing and sneezing this flu season, I'm strengthening my immune health with this 1000mg Ester-C. It is notably effective and works quickly, making me a repeat buyer.
9
Quick flu relief
1 people found this helpful
I always keep Ester-C for acute respiratory infections, flu, and colds. This ester form effectively addresses the first symptoms, helping me recover faster. I found it particularly beneficial after childbirth when sleepless nights could be taxing, as it supports tired adrenal glands.
7.5
Strengthens immune system
I used to get a cold monthly, but I can confidently say this supplement helps boost my immune system. I also noticed I slept better, though I’m unsure if this supplement contributed to that.
7.5
Strengthens against winter flu
Excellent for winter colds and flu in adults, providing remarkable strengthening properties.
7.5
Improved immune function
I have been using American Health, Ester-C with Citrus Bioflavonoids for a few months and noticed a marked improvement in my health. I frequently suffer from colds and flu, but since taking these vitamins, my symptoms have improved significantly, allowing for quicker recovery. I appreciate that it's vitamin C in ester form, making it easier for my body to absorb, eliminating concerns about getting adequate vitamin C. Furthermore, the capsules are easy to swallow and leave no unpleasant aftertaste. I recommend American Health, Ester-C with Citrus Bioflavonoids to anyone seeking an effective way to support their immune system and overall health.
9
Quick symptom relief
I have used it for years and find it eliminates flu symptoms swiftly. I take 2000 mg daily when I'm unwell.
9
Effective composition
We use this for colds and flu! The drug has an excellent composition and is effective. Unlike other vitamin C forms, it does not adversely affect the gastric mucosa. The capsules might be large, but that's a minor issue!
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
References
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. 10.3390/molecules25184248
Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. 10.1111/jphp.12529
Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. 10.1016/j.ejmech.2016.01.005
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. 10.1155/2015/675149