The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
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Most Useful Reviews
9
No heartburn
210 people found this helpful
Ester-C is a non-acidic form of vitamin C that doesn’t irritate the stomach due to its neutral pH. It’s great for those who suffer from heartburn or indigestion when taking regular ascorbic acid. This combination of vitamin C and calcium is beneficial, providing both in a convenient tablet. I recommend taking it as advised by a doctor.
Read More
9
Sensitive stomach
2 people found this helpful
This is a fantastic product! No added sugar and, importantly, no heartburn or reflux. I have a sensitive stomach and tolerate this well. Ester-C’s calcium ascorbate is superior to other types of vitamin C I’ve tried.
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9
No unpleasant sensations
2 people found this helpful
I frequently order Vitamin C Ester-C 1000 mg. After an adrenal gland removal, my doctor advised a daily dose. I take it post-breakfast without heartburn, and I highly recommend this product.
The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.7
All Reviews
Positive Reviews
Negative Reviews
9
No heartburn
210 people found this helpful
Ester-C is a non-acidic form of vitamin C that doesn’t irritate the stomach due to its neutral pH. It’s great for those who suffer from heartburn or indigestion when taking regular ascorbic acid. This combination of vitamin C and calcium is beneficial, providing both in a convenient tablet. I recommend taking it as advised by a doctor.
Read More
9
Sensitive stomach
2 people found this helpful
This is a fantastic product! No added sugar and, importantly, no heartburn or reflux. I have a sensitive stomach and tolerate this well. Ester-C’s calcium ascorbate is superior to other types of vitamin C I’ve tried.
Read More
9
No unpleasant sensations
2 people found this helpful
I frequently order Vitamin C Ester-C 1000 mg. After an adrenal gland removal, my doctor advised a daily dose. I take it post-breakfast without heartburn, and I highly recommend this product.
Read More
10
No heartburn experienced
As Ester C is a neutralised vitamin, I don’t have heartburn even on an empty stomach, so I take it with collagen. Vitamin C is essential.
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10
Good for weak stomach
I constantly consume it. I bought this as I don't enjoy fruits and vegetables much, so this gives me a bit of relief. I have a weak stomach, but because it is Ester C, I experience no heartburn.
Heartburn is a common condition characterized by a burning sensation in the chest, often behind the breastbone. This discomfort is typically caused by acid reflux, where stomach acid flows back into the esophagus, the tube that connects the throat to the stomach. Symptoms may vary in intensity and duration, sometimes resulting in a bitter taste in the mouth, difficulty swallowing, or a sensation of food being stuck in the throat. While it can occur occasionally in healthy individuals after consuming certain foods or beverages, chronic heartburn, also known as gastroesophageal reflux disease (GERD), may require medical attention and lifestyle adjustments.
Diet plays a significant role in managing heartburn. Identifying and avoiding trigger foods—such as spicy dishes, citrus fruits, chocolate, and caffeinated drinks—can help alleviate symptoms. Over-the-counter antacids and medications can offer quick relief, while prescription options may be necessary for more severe cases. In addition to dietary changes, maintaining a healthy weight and avoiding large meals before bedtime can also promote better digestive health and reduce the frequency of heartburn. If symptoms persist or worsen, consulting a healthcare professional is advisable for a comprehensive evaluation and treatment plan.
Ester-C is a patented form of vitamin C (ascorbic acid) that is known for its unique formulation, which includes calcium ascorbate. This makes Ester-C less acidic than standard vitamin C, making it gentler on the stomach for those who may experience gastrointestinal discomfort from regular vitamin C supplementation. One of the key features touted by manufacturers of Ester-C is that it is better absorbed by the body and stays in the immune system longer, although scientific research on these claims can be mixed.
In addition to its purported benefits, Ester-C is often marketed as a supplement that supports immune health, collagen production, and serves as an antioxidant, helping to combat free radicals and oxidative stress. It's available in various forms, including capsules, tablets, and powders, making it easy to incorporate into your daily routine. While some users report positive effects and tolerance of Ester-C, it's essential to consult with a healthcare professional before adding any new supplement to your regimen, especially if you have existing conditions or are taking other medications.
Based on user reviews, the time to see results from taking Ester-C for heartburn can vary significantly. Many users report experiencing immediate relief from heartburn symptoms, stating that this non-acidic form of vitamin C does not irritate the stomach like traditional ascorbic acid. For instance, one user noted, "I have hardly any heartburn," which suggests quick results (Read Review). Another user shared that they "purchased it because it claims to prevent heartburn, and it truly does" (Read Review).
However, a few users did mention needing a bit more time to evaluate its effects fully. One stated they've only been taking it for less than a month and hadn’t yet discerned the effect but planned to continue (Read Review). Overall, while some immediate positive results are observed by many, full effectiveness might be clearer after several weeks of consistent use.
The research on using vitamin C spray for heartburn relief shows promising results, indicating a basis for its consideration as a supplementary treatment. A study with 240 participants revealed that a 2% vitamin C solution spray significantly alleviated heartburn symptoms. Specifically, 33% of those receiving the vitamin C reported relief from acid regurgitation, compared to only 15% of participants using sodium thiosulfate, another solution used for comparison [1]. This highlights the potential for vitamin C to aid in managing heartburn, particularly in a post-procedural context, like after a Lugol chromoendoscopy.
Moreover, the study demonstrated that vitamin C not only reduced heartburn symptoms but also improved patients' overall experience during the procedure, as it helped discolor iodine-stained mucosa more quickly than saline. With 21% of vitamin C users reporting relief from retrosternal pain versus just 9% with sodium thiosulfate, it seems that this supplement could be a useful addition for those suffering from heartburn after specific medical procedures [1]. However, while these findings are compelling, further research could help to establish broader effectiveness and guidelines for use in daily heartburn management.
Based on user reviews, many individuals have reported significant improvements in their gastrointestinal symptoms after switching to Ester-C. A common theme among users is the absence of heartburn and other discomforts associated with traditional vitamin C supplements. For instance, one user noted that they experienced "no heartburn" or reflux, and another exclaimed that they had "hardly any heartburn" since taking the product regularly (Read Review, Read Review). Those with more sensitive stomachs found Ester-C particularly tolerable, often stating that it did not irritate their stomachs—a frequent complaint with ascorbic acid.Read Review, Read Review.
In addition to heartburn relief, some users reported additional benefits, such as improvements in skin condition and overall health, likely owing to the product's formulation which includes calcium and other bioflavonoids (Read Review, Read Review). However, individual experiences may vary, and while many report a smoother digestion process and symptom relief, others have pointed out that they are still evaluating its effectiveness after a shorter duration of use. Thus, while Ester-C seems to offer a gentler alternative for vitamin C intake for many, results can differ based on individual health factors and duration of supplementation.
Users have reported a generally positive experience when combining Ester-C with other supplements for heartburn management. Many individuals emphasize that not only does Ester-C provide relief from heartburn on its own, but it is also well-tolerated when taken alongside other products. For instance, one user mentioned taking Ester-C with collagen and hyaluronic acid, stating that they experienced no heartburn while using these supplements together (Read Review). Similarly, another review highlights that the non-irritating nature of Ester-C enables users to consume it without issues, even on an empty stomach, further enhancing its versatility with other dietary supplements like collagen (Read Review).
Additionally, users highlight the formulation of Ester-C as a significant advantage, with several noting improvements in overall digestive comfort compared to other vitamin C sources. As one user noted, they had successfully combined it with their routine without the discomfort typically associated with traditional vitamin C, stating they have "hardly any heartburn" while taking it regularly (Read Review). Overall, many users seem to enjoy the ease of incorporating Ester-C with other supplements, allowing for both heartburn relief and additional health benefits.
Based on user reviews, many people reported that Ester C is effective in preventing heartburn, particularly when taken in doses around 1000 mg. Users found that this non-acidic form of vitamin C, which has a neutral pH, does not irritate the stomach compared to traditional ascorbic acid. For instance, one user noted, "I take it post-breakfast without heartburn" Read Review. Another user highlighted that they took it regularly without experiencing any heartburn, stating, "I have hardly any heartburn, so I take it regularly" Read Review.
Many users recommend taking Ester C in the advised dosage of 1000 mg, which several described as well-tolerated by even those with sensitive stomachs. One user mentioned, "I absolutely love this! There was no heartburn while taking it" Read Review, while another echoed that this vitamin C form helped them avoid symptoms: "I previously experienced heartburn... thankfully, this is the first Vitamin C that my body accepts without any side effects" Read Review. Overall, users seem to agree that Ester C is a solid option for those seeking relief from heartburn while still obtaining the benefits of vitamin C.
9
Casual heartburn relief
I have hardly any heartburn, so I take it regularly.
10
Effective against heartburn
I purchased it because it claims to prevent heartburn, and it truly does.
6
Minimal heartburn relief
Large capsule; it was surprisingly bigger than I expected, approximately 27 mm in length and 8 to 9 mm in diameter. I sometimes feel a bit of pain when swallowing. However, compared to other water-soluble vitamin C, I experience less heartburn. I have not yet discerned the effect as I've only been taking it for less than a month, but I plan to continue for my vitamin C deficiency.
9
Sensitive stomach
2 people found this helpful
This is a fantastic product! No added sugar and, importantly, no heartburn or reflux. I have a sensitive stomach and tolerate this well. Ester-C’s calcium ascorbate is superior to other types of vitamin C I’ve tried.
9
Pleasant experience
I absolutely love this! There was no heartburn while taking it, and it was enjoyable to consume. I recommend it to anyone with a sensitive stomach.
9
Best choice
This is my favourite Vitamin C! I previously experienced heartburn, stomach aches, and nausea with other brands. Thankfully, this is the first Vitamin C that my body accepts without any side effects, and I’m thrilled with the results.
7.5
No pain
1 people found this helpful
These large capsules do not cause heartburn after swallowing, unlike some other products. I take them for anaemia and have noticed improvements in my skin condition even when feeling under the weather.
9
Mild formulation
American Health Ester-C 1000 mg is highly absorbable and doesn’t cause heartburn, making it practical as just one tablet is required daily. The addition of citrus bioflavonoids aids immunity. I recommend it for those seeking a gentler option than regular vitamin C.
7.5
Immunity boost
3 people found this helpful
I take this with hyaluronic acid and collagen for better absorption. The capsules are large but easy to swallow. I experienced no heartburn and recovered quickly from a mild viral illness while taking these.
10
No heartburn experienced
As Ester C is a neutralised vitamin, I don’t have heartburn even on an empty stomach, so I take it with collagen. Vitamin C is essential.
9
No unpleasant sensations
2 people found this helpful
I frequently order Vitamin C Ester-C 1000 mg. After an adrenal gland removal, my doctor advised a daily dose. I take it post-breakfast without heartburn, and I highly recommend this product.
8
Vitamin C reduces heartburn symptoms
The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
References
Jin D, Wang J, Zhan Q, Huang K, Wang H, et al. The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial. Gastrointest Endosc. 2020;92:554. doi:10.1016/j.gie.2019.11.028