Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Magnesium (elemental) (from 2,667 mg Magnesium Citrate)
400 mg
95%

Top Medical Research Studies

We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.

To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.

Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.

In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
8
Magnesium reduces stroke risk
We explored how magnesium intake might influence the risk of stroke through a robust research design known as two-sample Mendelian randomization. This approach allows us to estimate the causal effects of nutrients on health outcomes, eliminating many confounding factors present in traditional observational studies.

Our findings suggest that higher levels of magnesium are linked to a significantly lower risk of cardioembolic stroke, a type of stroke caused by blood clots that travel to the brain. Specifically, our results showed a striking reduction in risk, indicating that magnesium could play a protective role in stroke prevention.

This study also identified other beneficial nutrients, such as vitamin C and vitamin B9, further emphasizing the importance of diet in stroke management. However, we should exercise caution regarding vitamin B6, which showed a potential association with an increased risk of large-artery stroke, as this finding requires additional investigation.

Overall, this research highlights the importance of magnesium and certain vitamins in stroke prevention. These insights can help shape public health strategies aimed at reducing stroke risk through dietary recommendations.
8
Dietary magnesium inversely affects stroke
We examined the relationship between dietary magnesium intake and the risk of stroke using data from a large-scale health study involving nearly 30,000 American adults. By analyzing responses from self-reported questionnaires and dietary recalls over an 11-year period, we aimed to uncover how much magnesium from our diets might influence stroke occurrences.

Our findings revealed an interesting trend: higher magnesium intake appeared to lower the risk of stroke. Specifically, we discovered that individuals in the highest quartile of magnesium consumption had a 44% reduced odds of experiencing a stroke compared to those in the lowest quartile. Additionally, this protective effect was particularly strong among women and in adults aged 40 to 59.

It’s noteworthy that while we found a clear link between diet and stroke risk, the study did not differentiate the effects of magnesium supplementation or treatment in a clinical setting. Therefore, our observations highlight the potential benefits of incorporating magnesium-rich foods into our diets, emphasizing its significance in stroke prevention.

Most Useful Reviews

7.5
Doctor's advice
I bought magnesium citrate for my mother, following her doctor's recommendation. Magnesium is known to lessen the risks associated with ischemic heart disease, hypertension, and stroke while normalising blood pressure and preventing muscle contractions.
7.5
Heart disease risk
I've learned that additional magnesium intake can significantly lower the risks of coronary heart disease, hypertension, and stroke. It effectively normalises blood pressure and lessens vascular spasms, as the citrate form is well absorbed in the digestive system.
7.5
Heart health
1 people found this helpful
I'm committed to continuing magnesium as it plays a vital role in regulating heart rhythm and maintaining healthy blood pressure. High blood pressure is known to support heart and circulatory health, particularly regarding stroke conditions.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
  • All Researches
9
Magnesium's role in stroke recovery
We explored the potential benefits of magnesium sulfate (MgSO) as a novel hypothermia infusion solution to aid recovery in patients experiencing acute ischemic stroke (AIS). In our investigation, we utilized rats that underwent a procedure mimicking stroke by occluding the middle cerebral artery. We compared the effectiveness of MgSO combined with hypothermia to traditional treatment methods.

The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.

Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
9
Magnesium enhances stroke therapy
We explored the effects of combining magnesium salts of salvianolic acid B and ginsenoside Rg1 as a potential treatment for ischemic stroke. The study used a well-structured approach, evaluating the impacts on infarct volume and neurological function in a model of middle cerebral artery occlusion.

Our findings revealed that the combination therapy was more effective than either treatment alone, significantly reducing the injured area of the brain and improving behavior in treated subjects. Specifically, the combined treatment not only resulted in a marked decrease in infarct volume but also supported better structural integrity of the brain tissue and an increase in neuron numbers.

We verified the synergistic benefits of this combination through thorough statistical analysis, showing that this approach could potentially enhance therapeutic outcomes for stroke patients. Notably, the mechanisms behind these improvements hinted towards mitigating cerebral metabolic disorders as a factor.

Overall, while the effect of magnesium alone is less clear, our results highlight the effectiveness of using it in combination with ginsenoside Rg1, paving the way for improved treatment strategies for those affected by stroke.
We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.

To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.

Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.

In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
We explored how magnesium, when combined with therapeutic hypothermia (TH), affects recovery from ischemic stroke. In our analysis, we examined various studies that specifically looked at this combination therapy alongside other cytoprotective medications. Our findings revealed that magnesium stands out as an effective agent, significantly enhancing the protective qualities of TH against brain injury and neurological impairment.

During the review, we noted that magnesium contributed positively to treatment outcomes across the board. It was particularly effective when coupled with TH, showing greater benefits in recovery compared to other drug combinations or no treatment at all. What’s fascinating is that using magnesium alongside TH presented the best overall results, making it a key player in future stroke therapies.

However, while magnesium's role is promising, it was primarily assessed in combination with other treatments. This means we still need to fully understand its isolated effects on stroke recovery. Overall, our analysis suggests that magnesium is a valuable addition to ischemic stroke treatment strategies, warranting further investigation to confirm its specific benefits.
8
Magnesium-Heart Health Connection
We explored the connection between serum magnesium levels and the risk of stroke among non-dialysis patients with chronic kidney disease (CKD) stages 4 and 5. By analyzing data from a cohort of 1,271 patients over a ten-year period, we focused on how varying levels of magnesium could influence mortality rates related to fatal heart failure, coronary heart disease, and stroke.

Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.

While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Doctor's advice
I bought magnesium citrate for my mother, following her doctor's recommendation. Magnesium is known to lessen the risks associated with ischemic heart disease, hypertension, and stroke while normalising blood pressure and preventing muscle contractions.
7.5
Heart disease risk
I've learned that additional magnesium intake can significantly lower the risks of coronary heart disease, hypertension, and stroke. It effectively normalises blood pressure and lessens vascular spasms, as the citrate form is well absorbed in the digestive system.
7.5
Heart health
1 people found this helpful
I'm committed to continuing magnesium as it plays a vital role in regulating heart rhythm and maintaining healthy blood pressure. High blood pressure is known to support heart and circulatory health, particularly regarding stroke conditions.
9
Anxiety relief
Magnesium has been a perfect solution for relieving anxiety. I used it for someone recovering from a stroke, and I believe it is essential for those with heart issues.
7.5
Reduced fatigue
I'm pleased to share that since incorporating protein and vitamins B, C, and E from Dr. Fujikawa's book over a year ago, I feel much better. During the warmer months, I often sweat profusely, and occasionally experience symptoms akin to heat stroke. I try to monitor my salt and water intake and use OS1 whenever I'm at work. Recently, I started taking magnesium after feeling excessively tired. Thankfully, it has improved my energy levels significantly, and I no longer face issues related to heat stroke. Additionally, taking B6 with magnesium has alleviated the pain during my periods.

Frequently Asked Questions

7.5
Heart health
1 people found this helpful
I'm committed to continuing magnesium as it plays a vital role in regulating heart rhythm and maintaining healthy blood pressure. High blood pressure is known to support heart and circulatory health, particularly regarding stroke conditions.
7.5
Reduced fatigue
I'm pleased to share that since incorporating protein and vitamins B, C, and E from Dr. Fujikawa's book over a year ago, I feel much better. During the warmer months, I often sweat profusely, and occasionally experience symptoms akin to heat stroke. I try to monitor my salt and water intake and use OS1 whenever I'm at work. Recently, I started taking magnesium after feeling excessively tired. Thankfully, it has improved my energy levels significantly, and I no longer face issues related to heat stroke. Additionally, taking B6 with magnesium has alleviated the pain during my periods.
4
Daily requirement
This magnesium is excellent! Well absorbed, I take it daily. Magnesium is essential for energy production and plays a vital role in numerous bodily functions, including reducing stroke risk and promoting heart health. It works best in conjunction with calcium and vitamin B6, which helps in stress relief.
7.5
Doctor's advice
I bought magnesium citrate for my mother, following her doctor's recommendation. Magnesium is known to lessen the risks associated with ischemic heart disease, hypertension, and stroke while normalising blood pressure and preventing muscle contractions.
7.5
Heart disease risk
I've learned that additional magnesium intake can significantly lower the risks of coronary heart disease, hypertension, and stroke. It effectively normalises blood pressure and lessens vascular spasms, as the citrate form is well absorbed in the digestive system.
9
Anxiety relief
Magnesium has been a perfect solution for relieving anxiety. I used it for someone recovering from a stroke, and I believe it is essential for those with heart issues.
7.5
Nervous system support
An additional intake of magnesium is vital as it reduces the risks of coronary heart disease, hypertension, and stroke. It balances blood pressure and acts as a natural anti-stress element, enhancing nervous system health and alleviating migraine frequency.
8
Magnesium reduces stroke risk
We explored how magnesium intake might influence the risk of stroke through a robust research design known as two-sample Mendelian randomization. This approach allows us to estimate the causal effects of nutrients on health outcomes, eliminating many confounding factors present in traditional observational studies.

Our findings suggest that higher levels of magnesium are linked to a significantly lower risk of cardioembolic stroke, a type of stroke caused by blood clots that travel to the brain. Specifically, our results showed a striking reduction in risk, indicating that magnesium could play a protective role in stroke prevention.

This study also identified other beneficial nutrients, such as vitamin C and vitamin B9, further emphasizing the importance of diet in stroke management. However, we should exercise caution regarding vitamin B6, which showed a potential association with an increased risk of large-artery stroke, as this finding requires additional investigation.

Overall, this research highlights the importance of magnesium and certain vitamins in stroke prevention. These insights can help shape public health strategies aimed at reducing stroke risk through dietary recommendations.
8
Magnesium depletion elevates stroke risk
We conducted an in-depth analysis focusing on how magnesium deficiency impacts stroke risk in individuals with chronic kidney disease (CKD). Our study utilized data from the National Health and Nutrition Examination Survey gathered between 2009 and 2016.

With a total of 3,536 CKD patients in our research, we discovered that about 8.6% had experienced a stroke. Notably, older adults and males were at a higher risk. Our findings indicated that lower dietary magnesium intake and higher Magnesium Depletion Scores (MDS) significantly correlated with increased stroke risk.

The relationship between MDS scores and stroke likelihood appeared to be dose-dependent, meaning that as magnesium deficiency worsened, so did the risk of stroke. We confirmed these results through subgroup analyses, particularly in patients with conditions like hypertension, diabetes, and obesity. Importantly, our study found that magnesium depletion is associated with a greater risk of stroke, underscoring the potential importance of maintaining adequate magnesium levels for heart and vascular health in this vulnerable population.
9
Magnesium's role in stroke recovery
We explored the potential benefits of magnesium sulfate (MgSO) as a novel hypothermia infusion solution to aid recovery in patients experiencing acute ischemic stroke (AIS). In our investigation, we utilized rats that underwent a procedure mimicking stroke by occluding the middle cerebral artery. We compared the effectiveness of MgSO combined with hypothermia to traditional treatment methods.

The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.

Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
7
Magnesium's role in stroke severity
We delved into how magnesium levels in the blood might relate to the severity of neurological disabilities in individuals suffering from acute ischemic strokes. This study took place in a medical college and hospital over a period of approximately 16 months, focusing on patients diagnosed with stroke confirmed through brain imaging.

During our research, we collected data from patients, including their age, stroke severity as measured by the NIH Stroke Scale, and serum magnesium levels. We discovered that most patients had moderate strokes, and a significant number of them suffered from hypomagnesaemia—a condition characterized by low magnesium levels.

Our findings indicated a clear relationship: lower magnesium levels were associated with more severe neurological disabilities, as evidenced by lower NIHSS scores. The analysis highlighted that magnesium levels were independently linked to disability severity, suggesting that magnesium plays a significant role in stroke outcomes.

While we observed a notable negative correlation between magnesium and stroke severity, further research is warranted to confirm these results and understand the potential benefits of magnesium treatment in stroke management.

References

  1. Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
  2. Zhang Y, Jiang M, Wei M, Wu C, Huang Y, et al. MgSO as a novel hypothermia infusion solution promotes ischemic stroke recovery through Ca regulation of neurovascular units. Theranostics. 2025;15:1896. doi:10.7150/thno.104879
  3. Feygin MS, Brenner A, Tanweer O. Magnesium sulfate in the management of acute ischemic stroke: A review of the literature and future directions. J Stroke Cerebrovasc Dis. 2025;34:108188. doi:10.1016/j.jstrokecerebrovasdis.2024.108188
  4. Shen H, Zhang Y, Shao Y, Chen S, Yin P, et al. Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke. Neuroreport. 2024;35:1041. doi:10.1097/WNR.0000000000002099
  5. Zhang Y, Zhang H, Jiang M, Cao X, Ge X, et al. Neuroprotection on ischemic brain injury by Mg/H released from endovascular Mg implant. Bioact Mater. 2024;42:124. doi:10.1016/j.bioactmat.2024.08.019
  6. Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16172818
  7. Feng C, Peng C, Li C. Association between magnesium depletion score and stroke in US adults with chronic kidney disease: A population-based study. J Stroke Cerebrovasc Dis. 2024;33:107963. doi:10.1016/j.jstrokecerebrovasdis.2024.107963
  8. Taleb S, Ji-Hyun Lee J, Asanad S, Starkman S, Hamilton S, et al. Modified Rankin Scale disability status at day 4 poststroke is an informative predictor of long-term day 90 outcome. J Stroke Cerebrovasc Dis. 2024;33:107902. doi:10.1016/j.jstrokecerebrovasdis.2024.107902
  9. Dariy V, Serikov K, Kmyta O, Rybalko T, Kolesnyk O. PERSONIFICATION OF ANTIHYPERTENSIVE THERAPY IN ISCHEMIC CEREBRAL STROKE. Georgian Med News. 2024.
  10. Suerte ACC, Liddle LJ, Abrahart A, Khiabani E, Colbourne F. A Systematic Review and Meta-Analysis of Therapeutic Hypothermia and Pharmacological Cotherapies in Animal Models of Ischemic Stroke. Ther Hypothermia Temp Manag. 2024;14:229. doi:10.1089/ther.2024.0012
  11. Khafri S, Ahmadi Ahangar A, Saadat P, Alijanpour S, Babaei M, et al. Mediatory role of the serum mineral level and discharge disability of stroke survivors. Caspian J Intern Med. 2024;15:124. doi:10.22088/cjim.15.1.14
  12. Della Rosa G, Gostynska NE, Ephraim JW, Sganga S, Panuccio G, et al. Magnesium alginate as a low-viscosity (intramolecularly cross-linked) system for the sustained and neuroprotective release of magnesium. Carbohydr Polym. 2024;331:121871. doi:10.1016/j.carbpol.2024.121871
  13. Hossain MI, Bhattacharjee M, Roy S, Hossain S, Banerjee S, et al. Association of Serum Magnesium Level with Severity of Neurological Disability in Patients with Acute Ischemic Stroke. Mymensingh Med J. 2024;33:9.
  14. Liotta EM, Maas MB, Prabhakaran S, Shkirkova K, Sanossian N, et al. Magnesium and Hematoma Expansion in Intracerebral Hemorrhage: A FAST-MAG Randomized Trial Analysis. Stroke. 2024;55:463. doi:10.1161/STROKEAHA.123.043555
  15. Sun P, Wang Z, Li B, Chen S. Association of Dietary Magnesium Intake with the Risk of Stroke among Adults. Int Heart J. 2023;64:1002. doi:10.1536/ihj.23-299
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