We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
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8
Vitamin B12 levels and ASD risk
Inferring the genetic effects of serum homocysteine and vitamin B levels on autism spectral disorder through Mendelian randomization.
We explored the possible connection between serum vitamin B12 levels and autism spectrum disorder (ASD) using a genetic study design known as Mendelian randomization. This approach allowed us to sift through various genetic markers linked to these factors to see if there was a tangible link between vitamin B12 and the risk of developing ASD.
Our analysis included a significant number of genetic variants and aimed to determine if higher vitamin B12 levels could be causally connected to an increased risk of autism. We found evidence suggesting that elevated serum vitamin B12 levels might be associated with a greater risk of ASD, with our primary analysis indicating an odds ratio of 1.68, suggesting a nearly 70% increase in risk.
However, it's important to note that while our main findings pointed towards a potential link, other analytical methods didn't consistently support this association. For instance, when using different approaches, like the weighted median method, the results were not significant. Additionally, we didn’t find any direct causal relationships between ASD and levels of vitamin B6, folate, or homocysteine.
Given these mixed results, we feel that while there is an intriguing association between high vitamin B12 levels and ASD risk, further research is necessary to validate these findings and understand the underlying mechanisms before establishing treatment implications.
Read More
8
Methylcobalamin improves autism symptoms
Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration.
We examined the potential of a syrup form of methylcobalamin, a type of vitamin B12, in improving the lives of individuals with autism. Over a period of 200 days, 25 children and young adults received a daily dose of 500 µg of this treatment. Throughout this time, both parents and psychologists regularly evaluated the clinical and psychological progress of the participants.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
Read More
Most Useful Reviews
9
Improved academic skills
147 people found this helpful
I have bought this product several times and really like it. My son, who has autism and doesn't speak, was advised by a psychiatrist to take methylcobalamin to enhance his cognitive function. Since starting this medication, he has excelled in his studies, particularly in mathematics. Although he began speaking at 8, by 10, his vocabulary had expanded significantly, which I believe is partly thanks to methylcobalamin.
Read More
9
Academic improvement noted
3 people found this helpful
Once again, I am buying this product as I find it very effective. My son, who has autism and does not speak, was instructed by his psychiatrist to take methylcobalamin for better cognitive function. His skills in academics, especially mathematics, have improved markedly since he started this medication. He began speaking at 8 and by 10, his vocabulary had grown significantly, which I credit partially to methylcobalamin.
Read More
7.5
Enhanced speech development
1 people found this helpful
Excellent product! I am very pleased as my daughter, who has autism and hardly eats meat, has benefited from it. It has significantly supported her speech development with no side effects.
We explored the possible connection between serum vitamin B12 levels and autism spectrum disorder (ASD) using a genetic study design known as Mendelian randomization. This approach allowed us to sift through various genetic markers linked to these factors to see if there was a tangible link between vitamin B12 and the risk of developing ASD.
Our analysis included a significant number of genetic variants and aimed to determine if higher vitamin B12 levels could be causally connected to an increased risk of autism. We found evidence suggesting that elevated serum vitamin B12 levels might be associated with a greater risk of ASD, with our primary analysis indicating an odds ratio of 1.68, suggesting a nearly 70% increase in risk.
However, it's important to note that while our main findings pointed towards a potential link, other analytical methods didn't consistently support this association. For instance, when using different approaches, like the weighted median method, the results were not significant. Additionally, we didn’t find any direct causal relationships between ASD and levels of vitamin B6, folate, or homocysteine.
Given these mixed results, we feel that while there is an intriguing association between high vitamin B12 levels and ASD risk, further research is necessary to validate these findings and understand the underlying mechanisms before establishing treatment implications.
Read More
8
Vitamin B12's impact on autism
Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis.
We delved into the relationship between vitamin B12 levels and autism in children and adolescents by analyzing a comprehensive review of studies on this topic. The review encapsulated 56 studies, including nearly 38,000 participants, and found that those diagnosed with autism spectrum disorders (ASD) had significantly lower vitamin B12 levels compared to the control group. Specifically, the findings revealed a striking difference, with the standardized mean difference indicating a notable deficiency in individuals with ASD.
Moreover, our exploration also pointed to lower vitamin B12 intake in children with autism as compared to those without similar diagnoses. While this suggests a potential link, we noted that no significant differences in vitamin B12 intake were found when comparing children with depression to the control group. However, the study did highlight an encouraging finding: higher vitamin B12 intake appeared to correlate with a reduced risk of depression and behavioral problems.
Overall, the gathered evidence suggests that there may be beneficial effects of ensuring sufficient vitamin B12 levels in children and adolescents, particularly regarding autism and general mental health. This could mean that vitamin B12 deficiency might be a reversible factor involved in some mental health conditions among young individuals.
Read More
8
Methylcobalamin improves autism symptoms
Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration.
We examined the potential of a syrup form of methylcobalamin, a type of vitamin B12, in improving the lives of individuals with autism. Over a period of 200 days, 25 children and young adults received a daily dose of 500 µg of this treatment. Throughout this time, both parents and psychologists regularly evaluated the clinical and psychological progress of the participants.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
Read More
8
Effectiveness of Vitamin B12 in Autism
Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey.
We examined how vitamin B12, a common nutritional supplement, may impact symptoms of autism spectrum disorder (ASD). Our analysis is based on a national survey that included responses from 1,286 participants across the United States. Participants shared their experiences regarding the perceived benefits and side effects of various nutraceuticals, with vitamin B12 emerging as one of the top-rated treatments.
Interestingly, the survey revealed that nutraceuticals, including vitamin B12, were viewed as more beneficial and had fewer adverse effects compared to traditional psychiatric and seizure medications. Specifically, the overall benefit rating for nutraceuticals was 1.59, compared to 1.39 for medications, while adverse effects for nutraceuticals were rated at 0.1 versus 0.9 for medications.
These findings suggest that vitamin B12, among other nutraceuticals, may offer clinical benefits for those with ASD, particularly in addressing core symptoms and associated comorbidities. However, it's essential to approach these results with an open mind and consider the diverse experiences shared by participants in the survey.
Read More
5
Maternal B12 and autism risk
Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder.
We investigated the connection between maternal serum vitamin B12 levels during early pregnancy and the occurrence of autism spectrum disorders (ASD) in children. In this study, we looked at data from a Finnish national birth cohort, which included 1,558 children diagnosed with ASD between 1987 and 2007. Each of these cases was carefully matched with a control child based on their date of birth, sex, and place of birth.
Our findings revealed that higher levels of maternal vitamin B12, specifically those at or above the 81st percentile, were linked to an increased risk of childhood autism. The adjusted odds ratio was 1.59, indicating a significant association. However, it’s critical to note that there were no significant findings regarding the relationships between maternal vitamin B12 levels and other ASD subtypes, like Asperger's or pervasive developmental disorder (NOS).
This study underscores a potential risk factor associated with higher maternal vitamin B12 levels, yet it does not suggest that vitamin B12 treatment can effectively address autism. In fact, the findings highlight the complexity of autism development and emphasize the need for further research to understand these relationships better.
I have bought this product several times and really like it. My son, who has autism and doesn't speak, was advised by a psychiatrist to take methylcobalamin to enhance his cognitive function. Since starting this medication, he has excelled in his studies, particularly in mathematics. Although he began speaking at 8, by 10, his vocabulary had expanded significantly, which I believe is partly thanks to methylcobalamin.
Read More
9
Academic improvement noted
3 people found this helpful
Once again, I am buying this product as I find it very effective. My son, who has autism and does not speak, was instructed by his psychiatrist to take methylcobalamin for better cognitive function. His skills in academics, especially mathematics, have improved markedly since he started this medication. He began speaking at 8 and by 10, his vocabulary had grown significantly, which I credit partially to methylcobalamin.
Read More
7.5
Enhanced speech development
1 people found this helpful
Excellent product! I am very pleased as my daughter, who has autism and hardly eats meat, has benefited from it. It has significantly supported her speech development with no side effects.
Read More
7.5
Assisted temperament
This product was recommended for my nephew to aid with his autism symptoms. It has indeed helped improve his temperament.
Read More
6
Increased clarity
6 people found this helpful
Developmental grey is for slow-speaking children with autism. Since I began taking B12, my son has been making more distinct sounds and has calmed down. Perhaps this is due to time, but I will continue to give it to him. He has an unbalanced diet and doesn’t eat meat, yet he enjoys this berry-flavoured supplement. I also find it helps relieve my own neuralgia, and it refreshes my mind.
Read More
Frequently Asked Questions
Autism, also known as Autism Spectrum Disorder (ASD), is a neurodevelopmental condition characterized by a range of challenges related to social skills, repetitive behaviors, speech, and nonverbal communication. Its effects can vary widely among individuals, ranging from mild to severe. Some people with autism may have difficulty understanding social cues, while others may exhibit intense focus on specific interests or subjects. The spectrum nature of autism reflects the diversity in symptoms and abilities, meaning that no two individuals with autism experience the condition in the same way.
The exact causes of autism are not entirely understood, but research suggests a combination of genetic and environmental factors may play a role. Early diagnosis and intervention are critical, as they can greatly improve the quality of life for individuals with autism. Support can include behavioral therapies, speech therapy, and tailored educational programs, all aimed at helping individuals reach their potential. Awareness and understanding of autism have grown significantly in recent years, fostering a more inclusive environment and improved resources for those affected by the disorder.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in several vital functions in the human body. It is essential for red blood cell formation, neurological function, and DNA synthesis. Naturally occurring in animal products, the vitamin can be found in high concentrations in meat, fish, eggs, and dairy, making it particularly important for those following a vegetarian or vegan diet, as plant-based sources of B12 are limited and often require supplementation.
A deficiency in vitamin B12 can lead to serious health issues, including anemia, fatigue, memory problems, and nerve damage. Due to its significance, it's crucial for individuals, particularly those at risk of deficiency, to ensure adequate intake through diet or supplementation. For most adults, the recommended daily allowance (RDA) is around 2.4 micrograms, though pregnant or breastfeeding women may require higher amounts. If you're considering B12 supplements, it's advisable to consult with a healthcare provider to determine the best option for your specific needs and health status.
Based on user reviews, the time it takes to see results from this supplement can vary. Some users report noticeable improvements in cognitive function and speech development after a few months of consistent use. For instance, one parent observed significant progress in their son's academics and vocabulary expansion around ages 8 to 10 after starting methylcobalamin, attributing part of his success to the supplement Read Review. Another review mentioned their daughter benefiting from improved speech development with no side effects, suggesting a positive impact with continued use Read Review.
However, some users caution that results may depend on various factors, including individual circumstances and consistency of use. One parent noted improvements in their son's speech over time and acknowledged the potential influence of the supplement Read Review. As these reviews highlight a range of experiences, it's advisable to track progress over several months while consulting with healthcare professionals for tailored advice.
The scientific community is actively exploring the role of vitamin B12 in Autism Spectrum Disorder (ASD), with a variety of studies highlighting different aspects of this relationship. Several research pieces indicate that children with ASD often have lower serum levels of vitamin B12 compared to their neurotypical peers, suggesting a potential deficiency that could relate to autism symptoms. For instance, a comprehensive review found significant differences in vitamin B12 levels among 38,000 subjects, indicating a notable deficiency in those diagnosed with ASD [3]. However, while these findings hint at a connection, they stop short of recommending vitamin B12 supplementation as a treatment for autism, due to the complexity of autism's etiology and the need for further exploration [1].
Interestingly, some studies, including one that examined the effects of methylcobalamin (a form of vitamin B12) syrup, reported positive changes in social skills and communication among children with autism after supplementation [5]. Conversely, other research indicates that increased levels of maternal vitamin B12 during pregnancy may correlate with a higher risk of autism in offspring [4]. Overall, while there are encouraging signs that vitamin B12 may impact autism symptoms, the current body of research does not provide a definitive consensus or endorsement for its use as a treatment. Further investigations will be crucial to clarify these effects and establish more robust guidelines for vitamin B12 supplementation in the context of autism.
Based on user reviews, many parents report significant improvements in their children’s symptoms after using methylcobalamin, particularly for those on the autism spectrum. Several users noted enhancements in cognitive function and academic performance; one parent mentioned their son, who began speaking at age 8, showed notable growth in vocabulary and academic skills by age 10, attributing part of this progress to the supplement Read Review. Another reviewer echoed this sentiment, emphasizing the boost in their son's academic abilities, especially in mathematics, after beginning methylcobalamin Read Review.
Additionally, improvements in speech development were highlighted, as one parent shared that their daughter benefited from significant progress with no reported side effects Read Review. Another review mentioned favorable changes in temperament for a nephew who was prescribed the supplement Read Review. Individual results can vary greatly, and one parent noted their son's gradual enhancement in distinct sounds and overall calmness over time, suggesting that consistent use might also be a factor in these improvements Read Review. As with any supplement, it's wise to consult with healthcare professionals for personalized guidance.
Based on user reviews, many parents have reported positive results when combining methylcobalamin with other supplements for managing autism symptoms. One parent highlighted that their son saw improved cognitive function, particularly in mathematics, after being advised by a psychiatrist to use methylcobalamin. This integration of the supplement seems to correlate with his vocabulary expansion, which the parent attributes to the supplement's effects Read Review. Another reviewer echoed similar sentiments regarding their son’s academic progress, reinforcing the idea that such combinations may lead to beneficial outcomes Read Review.
Additionally, another parent noted their daughter’s speech development improved with methylcobalamin, especially considering her limited meat consumption, indicating that the supplement might serve as a dietary complement Read Review. Moreover, the positive temperament changes observed in another child suggest that combining this supplement with an appropriate dietary strategy may enhance emotional well-being Read Review. Lastly, personal anecdotes about improvements in sound articulation and calming effects point towards the potential of combining methylcobalamin with other supplements to address various nutritional gaps Read Review.
Based on user reviews, there appears to be a consensus that methylcobalamin, a form of Vitamin B12, can be beneficial for children with autism, particularly in areas such as speech development and cognitive function. Users report significant improvements in their children's academic performance, particularly in mathematics, after starting methylcobalamin therapy. One user noted that their son, who began speaking at 8, had a marked vocabulary expansion by the age of 10, which they attribute to the supplement (Read Review). Another review echoes this sentiment, emphasizing the positive impact on their son’s cognitive abilities and speech development, reinforcing the notion that the right dosage can lead to meaningful improvements (Read Review).
Users suggest that the effectiveness of B12 for treating autism symptoms, especially for those with dietary constraints, is notable. One parent reported their child, who rarely ate meat, experienced significant speech development improvements without any side effects after taking the supplement. Another review highlighted the calming effect of the product, indicating a potential benefit for behavioral symptoms associated with autism (Read Review). While personal experiences might vary, many parents are finding varying doses of methylcobalamin to be a supportive addition to their children's therapy plans.
9
Improved academic skills
147 people found this helpful
I have bought this product several times and really like it. My son, who has autism and doesn't speak, was advised by a psychiatrist to take methylcobalamin to enhance his cognitive function. Since starting this medication, he has excelled in his studies, particularly in mathematics. Although he began speaking at 8, by 10, his vocabulary had expanded significantly, which I believe is partly thanks to methylcobalamin.
7.5
Enhanced speech development
1 people found this helpful
Excellent product! I am very pleased as my daughter, who has autism and hardly eats meat, has benefited from it. It has significantly supported her speech development with no side effects.
6
Increased clarity
6 people found this helpful
Developmental grey is for slow-speaking children with autism. Since I began taking B12, my son has been making more distinct sounds and has calmed down. Perhaps this is due to time, but I will continue to give it to him. He has an unbalanced diet and doesn’t eat meat, yet he enjoys this berry-flavoured supplement. I also find it helps relieve my own neuralgia, and it refreshes my mind.
9
Academic improvement noted
3 people found this helpful
Once again, I am buying this product as I find it very effective. My son, who has autism and does not speak, was instructed by his psychiatrist to take methylcobalamin for better cognitive function. His skills in academics, especially mathematics, have improved markedly since he started this medication. He began speaking at 8 and by 10, his vocabulary had grown significantly, which I credit partially to methylcobalamin.
7.5
Assisted temperament
This product was recommended for my nephew to aid with his autism symptoms. It has indeed helped improve his temperament.
8
Vitamin B12's impact on autism
Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis.
We delved into the relationship between vitamin B12 levels and autism in children and adolescents by analyzing a comprehensive review of studies on this topic. The review encapsulated 56 studies, including nearly 38,000 participants, and found that those diagnosed with autism spectrum disorders (ASD) had significantly lower vitamin B12 levels compared to the control group. Specifically, the findings revealed a striking difference, with the standardized mean difference indicating a notable deficiency in individuals with ASD.
Moreover, our exploration also pointed to lower vitamin B12 intake in children with autism as compared to those without similar diagnoses. While this suggests a potential link, we noted that no significant differences in vitamin B12 intake were found when comparing children with depression to the control group. However, the study did highlight an encouraging finding: higher vitamin B12 intake appeared to correlate with a reduced risk of depression and behavioral problems.
Overall, the gathered evidence suggests that there may be beneficial effects of ensuring sufficient vitamin B12 levels in children and adolescents, particularly regarding autism and general mental health. This could mean that vitamin B12 deficiency might be a reversible factor involved in some mental health conditions among young individuals.
4
Vitamin B12's impact on autism
Serum interleukin-17 A and homocysteine levels in children with autism.
We explored the connection between vitamin B12 levels and Autism Spectrum Disorder (ASD) symptoms in children. In our research, we compared two groups: 50 children with ASD and 50 healthy children.
We found that children with ASD had lower serum levels of vitamin B12 and higher levels of homocysteine (Hcy) compared to those in the control group. Interestingly, there was a pattern observed; those with more severe autism symptoms had even lower vitamin B12 and folate levels but higher Hcy and IL-17 A levels.
This suggests that low vitamin B12 and high Hcy might be associated with the severity of ASD symptoms. While this study highlights potential links, it does not firmly conclude that vitamin B12 treatment will be effective for managing autism symptoms, as the interaction of various factors still needs consideration.
8
Methylcobalamin improves autism symptoms
Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration.
We examined the potential of a syrup form of methylcobalamin, a type of vitamin B12, in improving the lives of individuals with autism. Over a period of 200 days, 25 children and young adults received a daily dose of 500 µg of this treatment. Throughout this time, both parents and psychologists regularly evaluated the clinical and psychological progress of the participants.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
5
Maternal B12 and autism risk
Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder.
We investigated the connection between maternal serum vitamin B12 levels during early pregnancy and the occurrence of autism spectrum disorders (ASD) in children. In this study, we looked at data from a Finnish national birth cohort, which included 1,558 children diagnosed with ASD between 1987 and 2007. Each of these cases was carefully matched with a control child based on their date of birth, sex, and place of birth.
Our findings revealed that higher levels of maternal vitamin B12, specifically those at or above the 81st percentile, were linked to an increased risk of childhood autism. The adjusted odds ratio was 1.59, indicating a significant association. However, it’s critical to note that there were no significant findings regarding the relationships between maternal vitamin B12 levels and other ASD subtypes, like Asperger's or pervasive developmental disorder (NOS).
This study underscores a potential risk factor associated with higher maternal vitamin B12 levels, yet it does not suggest that vitamin B12 treatment can effectively address autism. In fact, the findings highlight the complexity of autism development and emphasize the need for further research to understand these relationships better.
References
Li H, Dang Y, Yan Y. Serum interleukin-17 A and homocysteine levels in children with autism. BMC Neurosci. 2024;25:17. doi:10.1186/s12868-024-00860-5
Jin T, Huang W, Pang Q, He Z, Yuan L, et al. Inferring the genetic effects of serum homocysteine and vitamin B levels on autism spectral disorder through Mendelian randomization. Eur J Nutr. 2024;63:977. doi:10.1007/s00394-024-03329-7
Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
Sourander A, Silwal S, Surcel HM, Hinkka-Yli-Salomäki S, Upadhyaya S, et al. Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder. Nutrients. 2023;15. doi:10.3390/nu15082009
Čorejová A, Fazekaš T, Jánošíková D, Repiský J, Pospíšilová V, et al. Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration. Nutrients. 2022;14. doi:10.3390/nu14102035
Adams JB, Bhargava A, Coleman DM, Frye RE, Rossignol DA. Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey. J Pers Med. 2021;11. doi:10.3390/jpm11090878
Erden S, Akbaş İleri B, Sadıç Çelikkol Ç, Nalbant K, Kılınç İ, et al. Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism. Int J Psychiatry Clin Pract. 2022;26:8. doi:10.1080/13651501.2021.1906906