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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 13 Reviews
8.7
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
No significant impact evaluated
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
Read More
9.5
Vitamin B12 relieves depressive symptoms
A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
High relevance to treatment effectiveness
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
Vitamin B12's role in stress resilience
Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience.
High relevance for mood disorders
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
Most Useful Reviews
9.5
Strengthens memory
Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders.
Read More
9.5
Improves well-being
This excellent supplement is my second purchase. Vitamin B-12 plays crucial roles in the body, enhancing metabolism and vital functions, including improving cardiovascular health, protecting the central nervous system, reducing depression, and boosting energy. If this review was helpful, please click "like."
Read More
7.5
Helps relieve depression
Excellent! This vitamin is part of the B complex and I believe this active form of B12 (methyl) is the best. After taking it, I noticed a relief in pain and depression. The sublingual gum tastes delightful, but it melted a bit in the heat when I had only a few tablets left.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
9.5
Vitamin B12 relieves depressive symptoms
A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
High relevance to treatment effectiveness
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
Vitamin B12's role in stress resilience
Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience.
High relevance for mood disorders
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
9
Vitamin B12 deficiency linked to MDD
Vitamin B12 and homocysteine in patients with major depressive disorder.
Study directly assesses vitamin B12 effects
We explored the relationship between vitamin B12 levels and major depressive disorder (MDD) by examining serum vitamin B12, homocysteine (Hcy), and blood profiles in 59 patients diagnosed with MDD. The severity of depression was evaluated using the HAM-D scale, which allows for a clear understanding of how vitamin B12 might be linked to depressive symptoms.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Read More
8
Vitamin B12's role in PSD
Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression.
Relevant findings on vitamin B12
We explored the connection between vitamin B12, its transporter genes, and early-onset post-stroke depression (PSD). In a study involving 173 ischemic stroke patients at Xiangya Hospital, we assessed their vitamin B12 and folate levels shortly after their strokes. A notable finding was that 48.6% of participants were diagnosed with PSD two weeks after their strokes.
We observed that those with PSD had significantly lower levels of vitamin B12 compared to those without it. Additionally, a particular genetic variant known as rs1801198 was linked to an increased risk of developing PSD. Specifically, individuals with the GG genotype of this gene had a higher likelihood of experiencing depression after a stroke.
The results suggest that both vitamin B12 levels and genetic factors may play a role in the onset of depression following a stroke. This highlights the potential for vitamin B12 to be included in treatment strategies for PSD, offering new avenues for managing this condition in stroke patients.
We observed that those with PSD had significantly lower levels of vitamin B12 compared to those without it. Additionally, a particular genetic variant known as rs1801198 was linked to an increased risk of developing PSD. Specifically, individuals with the GG genotype of this gene had a higher likelihood of experiencing depression after a stroke.
The results suggest that both vitamin B12 levels and genetic factors may play a role in the onset of depression following a stroke. This highlights the potential for vitamin B12 to be included in treatment strategies for PSD, offering new avenues for managing this condition in stroke patients.
Read More
8
Causal link between vitamin B12 and MDD
Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study.
Highlights potential B12 benefits
We explored the connection between vitamin B12 and depression, focusing on its potential effects on mental health. Utilizing advanced methods like Mendelian randomization and linkage disequilibrium score regression, we aimed to uncover any causal relationships between this essential micronutrient and conditions like major depressive disorder (MDD).
In our analysis, we specifically looked for single nucleotide polymorphisms (SNPs) linked to vitamin B12 that could act as instrumental variables. Our findings suggested a significant association between vitamin B12 and MDD, indicating that higher levels of this vitamin might help alleviate depressive symptoms.
Particularly, we observed a notable negative correlation, meaning that as vitamin B12 levels increased, the severity of depressive symptoms tended to decrease. However, while the results are promising, we advocate for further research to fully understand the biological mechanisms connecting vitamin B12 and mental health.
These findings shine a light on the crucial role that micronutrients like vitamin B12 could play in supporting mental well-being, emphasizing the need for more in-depth studies in this area.
In our analysis, we specifically looked for single nucleotide polymorphisms (SNPs) linked to vitamin B12 that could act as instrumental variables. Our findings suggested a significant association between vitamin B12 and MDD, indicating that higher levels of this vitamin might help alleviate depressive symptoms.
Particularly, we observed a notable negative correlation, meaning that as vitamin B12 levels increased, the severity of depressive symptoms tended to decrease. However, while the results are promising, we advocate for further research to fully understand the biological mechanisms connecting vitamin B12 and mental health.
These findings shine a light on the crucial role that micronutrients like vitamin B12 could play in supporting mental well-being, emphasizing the need for more in-depth studies in this area.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.7
9.5
Strengthens memory
Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders.
Read More
9.5
Improves well-being
This excellent supplement is my second purchase. Vitamin B-12 plays crucial roles in the body, enhancing metabolism and vital functions, including improving cardiovascular health, protecting the central nervous system, reducing depression, and boosting energy. If this review was helpful, please click "like."
Read More
9.5
Instant improvement
This vitamin is one of the best remedies for depression, stress, and anxiety. I've noticed an immediate uplift in my mood after taking it.
8.8
Restores mental health
An effective remedy for restoring the nervous system, this ACTIVE form of vitamin B12 is key for brain function. B12 is hard to absorb from food, which can lead to deficiency. It's vital for addressing issues such as depression, stress, chronic fatigue, and insomnia. I take it alongside folic acid, as they are interrelated vitamins recommended to be taken together.
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8.8
Supports mental health
Excellent! I believe its components are berries, as the taste is clear but light. The quality is high, and I felt its effectiveness after sleeve gastrectomy. It is particularly beneficial for those experiencing numbness or unexplained depression, as B12 significantly impacts the nervous system and metabolism.
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