Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
8
We investigated whether vitamin B12 (methylcobalamin) could assist adolescents struggling with persistent sleep-wake schedule disorders. Remarkably, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—saw impressive improvements after taking high doses of B12 daily.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
Read More
8
Vitamin B12 aids sleep-wake disorders
We explored the effects of Vitamin B12 on patients with long-standing sleep-wake rhythm disorders. In one case, a 15-year-old blind girl with a 25-hour sleep cycle improved dramatically after starting a regimen of 1.5 mg of B12 three times a day. Her sleep pattern aligned with the 24-hour cycle, but, after stopping the supplement, her issues returned within two months.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Read More
Most Useful Reviews
7.5
Improved sleep quality
22 people found this helpful
Anemia improved. I’m not vegan and have followed the Fujikawa theory for years, yet my MCV remains high and dizziness persisted. I’ve taken my usual B50 plus B12, dissolving it under my tongue as they are small. Since blood replaces every four months, I take three pills daily. After a month, my dizziness is lessened, and my insomnia has improved, allowing me to sleep easier without melatonin, which was an unexpected benefit. I look forward to my next blood test, as B12 seems to regulate the autonomic nervous system and sleep.
Read More
9
Quick sleep aid
11 people found this helpful
Sleep better! I suffer from insomnia, often taking long to fall asleep. However, after taking one tablet post-dinner, I felt naturally sleepy and fell asleep within 10 minutes. I did feel overly sleepy the next day, so timing and dosage may need adjusting. The taste is delightful and easy to take. I’ll likely repeat once it's finished.
Read More
9
Enhances concentration
Vitamin B12 is vital for brain health, the nervous system, DNA synthesis, and blood cell formation. It aids erythrocyte production, regulates immunity, enhances nerve fiber construction, improves insomnia, and assists with memory and concentration.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
- All Researches
8
We investigated whether vitamin B12 (methylcobalamin) could assist adolescents struggling with persistent sleep-wake schedule disorders. Remarkably, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—saw impressive improvements after taking high doses of B12 daily.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
Read More
8
Vitamin B12 aids sleep-wake disorders
We explored the effects of Vitamin B12 on patients with long-standing sleep-wake rhythm disorders. In one case, a 15-year-old blind girl with a 25-hour sleep cycle improved dramatically after starting a regimen of 1.5 mg of B12 three times a day. Her sleep pattern aligned with the 24-hour cycle, but, after stopping the supplement, her issues returned within two months.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Read More
8
We explored the relationship between vitamin B12 levels and insomnia in a case involving a woman experiencing excessive daytime sleepiness alternating with insomnia. This case fit the criteria for a non-24-hour sleep-wake disorder, where traditional treatments failed to provide relief.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Read More
8
In our exploration of insomnia treatment, we worked with 60 patients diagnosed with the condition. They were split into two groups: one received the Magnesium-melatonin-vitamin B complex, while the other acted as a control. The specific goal was to determine if this combination, which included Vitamin B12, could effectively improve sleep quality over a three-month period.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
Read More
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved sleep quality
22 people found this helpful
Anemia improved. I’m not vegan and have followed the Fujikawa theory for years, yet my MCV remains high and dizziness persisted. I’ve taken my usual B50 plus B12, dissolving it under my tongue as they are small. Since blood replaces every four months, I take three pills daily. After a month, my dizziness is lessened, and my insomnia has improved, allowing me to sleep easier without melatonin, which was an unexpected benefit. I look forward to my next blood test, as B12 seems to regulate the autonomic nervous system and sleep.
Read More
9
Quick sleep aid
11 people found this helpful
Sleep better! I suffer from insomnia, often taking long to fall asleep. However, after taking one tablet post-dinner, I felt naturally sleepy and fell asleep within 10 minutes. I did feel overly sleepy the next day, so timing and dosage may need adjusting. The taste is delightful and easy to take. I’ll likely repeat once it's finished.
Read More
9
Enhances concentration
Vitamin B12 is vital for brain health, the nervous system, DNA synthesis, and blood cell formation. It aids erythrocyte production, regulates immunity, enhances nerve fiber construction, improves insomnia, and assists with memory and concentration.
Read More
9
Avoids insomnia
An excellent quality product with small, easy-to-swallow tablets. It has a pleasant taste and provides substantial energy with an immediate effect. It has no side effects and improves sleep without causing insomnia, aiding metabolism and rejuvenating effects.
Read More
7.5
Calms insomnia
An effective vitamin. The results were visible from the first days of use. It helps with nervous conditions, calms the nervous system, and even aids with insomnia. It's a quality product that gives energy throughout the day. I recommend buying it.
Read More
Frequently Asked Questions
7.5
Calms insomnia
An effective vitamin. The results were visible from the first days of use. It helps with nervous conditions, calms the nervous system, and even aids with insomnia. It's a quality product that gives energy throughout the day. I recommend buying it.
7.5
Improved sleep quality
22 people found this helpful
Anemia improved. I’m not vegan and have followed the Fujikawa theory for years, yet my MCV remains high and dizziness persisted. I’ve taken my usual B50 plus B12, dissolving it under my tongue as they are small. Since blood replaces every four months, I take three pills daily. After a month, my dizziness is lessened, and my insomnia has improved, allowing me to sleep easier without melatonin, which was an unexpected benefit. I look forward to my next blood test, as B12 seems to regulate the autonomic nervous system and sleep.
7.5
Improved sleep
The small, sweet, sublingual pill tastes like strawberries. I bought it due to B12 deficiency and diagnosed autoimmune atrophic gastritis. After several weeks, my sleep has significantly improved, likely aided by exposure to sunlight. However, I believe multiple factors contribute to good health; I consume mostly raw foods while avoiding gluten, milk, and sugar. The product's quality appears excellent as well.
9
Quick sleep aid
11 people found this helpful
Sleep better! I suffer from insomnia, often taking long to fall asleep. However, after taking one tablet post-dinner, I felt naturally sleepy and fell asleep within 10 minutes. I did feel overly sleepy the next day, so timing and dosage may need adjusting. The taste is delightful and easy to take. I’ll likely repeat once it's finished.
9
Avoids insomnia
An excellent quality product with small, easy-to-swallow tablets. It has a pleasant taste and provides substantial energy with an immediate effect. It has no side effects and improves sleep without causing insomnia, aiding metabolism and rejuvenating effects.
9
Enhances concentration
Vitamin B12 is vital for brain health, the nervous system, DNA synthesis, and blood cell formation. It aids erythrocyte production, regulates immunity, enhances nerve fiber construction, improves insomnia, and assists with memory and concentration.
7.5
Stress relief
My favourite, it's necessary for the nervous system's functioning. Excellent for alleviating stress, fatigue, and insomnia. It must be taken with folic acid.
8
We investigated whether vitamin B12 (methylcobalamin) could assist adolescents struggling with persistent sleep-wake schedule disorders. Remarkably, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—saw impressive improvements after taking high doses of B12 daily.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
8
Vitamin B12 aids sleep-wake disorders
We explored the effects of Vitamin B12 on patients with long-standing sleep-wake rhythm disorders. In one case, a 15-year-old blind girl with a 25-hour sleep cycle improved dramatically after starting a regimen of 1.5 mg of B12 three times a day. Her sleep pattern aligned with the 24-hour cycle, but, after stopping the supplement, her issues returned within two months.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
7
We assessed the relationship between vitamin B12 levels and insomnia symptoms in a diverse group of adults visiting primary healthcare clinics in Greece. Our research involved 512 participants, from which we gathered a variety of information including age, weight, and health history. Using standardized scales, we measured excessive daytime sleepiness, insomnia symptoms, and overall sleep quality.
Our findings highlighted that lower vitamin B12 levels, particularly below 342 pg/mL, were linked to increased insomnia symptoms. This association was particularly pronounced in certain groups, such as elderly, non-obese, and female participants. Interestingly, we found that excessive daytime sleepiness connected with low B12 levels only affected obese participants.
However, we did not find a significant connection between vitamin B12 levels and poor overall sleep quality. This indicates that while vitamin B12 may play a role in insomnia for specific individuals, its impact on sleep quality itself remains unclear. Therefore, while our study sheds light on these associations, further research is needed to explore the underlying dynamics between sleep and vitamin B12 more fully.
Our findings highlighted that lower vitamin B12 levels, particularly below 342 pg/mL, were linked to increased insomnia symptoms. This association was particularly pronounced in certain groups, such as elderly, non-obese, and female participants. Interestingly, we found that excessive daytime sleepiness connected with low B12 levels only affected obese participants.
However, we did not find a significant connection between vitamin B12 levels and poor overall sleep quality. This indicates that while vitamin B12 may play a role in insomnia for specific individuals, its impact on sleep quality itself remains unclear. Therefore, while our study sheds light on these associations, further research is needed to explore the underlying dynamics between sleep and vitamin B12 more fully.
7
We aimed to understand the relationship between vitamin B12 levels and insomnia in patients with type 2 diabetes mellitus (T2DM). In our study, we examined 418 individuals living with T2DM, some of whom experienced insomnia and others who did not.
The findings revealed that insomnia was present in about 24% of the participants, and those suffering from insomnia had notably higher levels of vitamin B12 compared to their peers without sleep issues.
Importantly, our analysis indicated that increased vitamin B12 levels could be an independent risk factor for insomnia. We identified a specific cut-off value of 517.50 pg/ml of vitamin B12 that could predict insomnia risk, showcasing its potential significance in managing sleep disturbances among diabetic patients.
Interestingly, the higher vitamin B12 levels in insomniac patients were also linked to the use of mecobalamin, suggesting a possible connection, though further investigation would be needed to fully establish this relationship. Ultimately, our study highlights the complex interplay between vitamin B12 and sleep health in individuals with T2DM, suggesting that elevation in serum vitamin B12 may enhance the risk of insomnia in this population.
The findings revealed that insomnia was present in about 24% of the participants, and those suffering from insomnia had notably higher levels of vitamin B12 compared to their peers without sleep issues.
Importantly, our analysis indicated that increased vitamin B12 levels could be an independent risk factor for insomnia. We identified a specific cut-off value of 517.50 pg/ml of vitamin B12 that could predict insomnia risk, showcasing its potential significance in managing sleep disturbances among diabetic patients.
Interestingly, the higher vitamin B12 levels in insomniac patients were also linked to the use of mecobalamin, suggesting a possible connection, though further investigation would be needed to fully establish this relationship. Ultimately, our study highlights the complex interplay between vitamin B12 and sleep health in individuals with T2DM, suggesting that elevation in serum vitamin B12 may enhance the risk of insomnia in this population.
References
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
- Bouloukaki I, Lampou M, Raouzaiou KM, Lambraki E, Schiza S, et al. Association of Vitamin B12 Levels with Sleep Quality, Insomnia, and Sleepiness in Adult Primary Healthcare Users in Greece. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11233026
- Radlberger RF, Kunz AB. Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Front Neurol. 2023;14:1141835. doi:10.3389/fneur.2023.1141835
- Xiong S, Liu Z, Yao N, Zhang X, Ge Q. The independent association between vitamin B12 and insomnia in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Nutr Diabetes. 2022;12:3. doi:10.1038/s41387-022-00181-8
- Djokic G, Vojvodić P, Korcok D, Agic A, Rankovic A, et al. The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia. Open Access Maced J Med Sci. 2019;7:3101. doi:10.3889/oamjms.2019.771
- Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.
