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SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%*
Proprietary Extract BlendOrganic Echinacea purpurea root, seed and aerial parts, Organic Echinacea angustifolia root, Organic Echinacea purpurea root supercritical CO2 extract.
955 mg
†
Alkylamides
3 mg
†
Top Medical Research Studies
9
Echinacea may alleviate allergies
Echinacea purpurea water extracts suppress the release of chemical mediators from mast cells.
Highlights significant findings on allergies
We explored how Echinacea purpurea, a plant commonly used in herbal tea, might help relieve allergies by focusing on its effects on mast cells. Mast cells play a significant role in type-I allergies, such as hay fever, by releasing histamine and leukotrienes—substances that cause allergic symptoms.
Our evaluation involved water extracts from the petals, leaves, and stems of Echinacea purpurea. We specifically looked at how these extracts influenced the release of histamine and other chemical mediators from mast cell lines. The results were quite interesting: both petal and leaf extracts significantly reduced histamine release in stimulated cells. However, the stem extract did not show any effect.
Notably, we found that the petal extract was much more effective than the leaf extract. Additionally, all extracts effectively suppressed leukotriene B4 production, which is another mediator involved in allergic reactions. The petal extract also seemed to decrease certain cellular signaling events associated with mast cell activation.
Overall, our findings suggest that Echinacea purpurea petal extract could potentially help alleviate allergic symptoms, particularly in conditions like hay fever.
Our evaluation involved water extracts from the petals, leaves, and stems of Echinacea purpurea. We specifically looked at how these extracts influenced the release of histamine and other chemical mediators from mast cell lines. The results were quite interesting: both petal and leaf extracts significantly reduced histamine release in stimulated cells. However, the stem extract did not show any effect.
Notably, we found that the petal extract was much more effective than the leaf extract. Additionally, all extracts effectively suppressed leukotriene B4 production, which is another mediator involved in allergic reactions. The petal extract also seemed to decrease certain cellular signaling events associated with mast cell activation.
Overall, our findings suggest that Echinacea purpurea petal extract could potentially help alleviate allergic symptoms, particularly in conditions like hay fever.
Read More
9.5
Alkylamides show promise against allergies
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Study closely aligns with research
We observed the creation of a series of new compounds designed to combat allergies, particularly focusing on N-(pyridin-4-yl)-(indol-3-yl) alkylamides. These compounds were synthesized using various established methods, which include the Fischer indolization technique and the Japp-Klingemann method.
Our primary goal was to find effective new antiallergic agents. Among the 41 compounds tested, N-(pyridin-4-yl)-[1-(4-fluorobenzyl)indol-3-yl]acetamide stood out as remarkably potent, showing an impressive 406-fold increase in efficacy compared to an established antihistamine, astemizole. This compound achieved noteworthy results in several tests, demonstrating effectiveness at very low concentrations.
Moreover, the compound was effective in preventing allergic responses in guinea pig models of rhinitis. It showed strong performance both when administered orally and parenterally, indicating its potential in treating allergies. Overall, this research provides promising insights into how alkylamides can positively impact allergic conditions, making them an exciting avenue for future exploration.
Our primary goal was to find effective new antiallergic agents. Among the 41 compounds tested, N-(pyridin-4-yl)-[1-(4-fluorobenzyl)indol-3-yl]acetamide stood out as remarkably potent, showing an impressive 406-fold increase in efficacy compared to an established antihistamine, astemizole. This compound achieved noteworthy results in several tests, demonstrating effectiveness at very low concentrations.
Moreover, the compound was effective in preventing allergic responses in guinea pig models of rhinitis. It showed strong performance both when administered orally and parenterally, indicating its potential in treating allergies. Overall, this research provides promising insights into how alkylamides can positively impact allergic conditions, making them an exciting avenue for future exploration.
Read More
9
Echinacea shows promise for asthma
Echinacea complex--chemical view and anti-asthmatic profile.
Direct investigation of Echinacea's asthma effects
We aimed to investigate how Echinacea, a popular herbal remedy, can help with allergic conditions, particularly asthma. To do this, we isolated the active components from Echinacea purpurea flowers and examined their effects on an animal model mimicking allergic asthma.
Over 14 days, guinea pigs exposed to allergens received a daily dose of Echinacea. Our observations were quite promising; we found significant improvements in airway function, showing that Echinacea could reduce airway resistance and help the muscles in the lungs relax.
Furthermore, we noted its anti-inflammatory effects, which were measured through changes in exhaled nitric oxide levels and cytokine concentrations. These findings suggest that Echinacea could act similarly to conventional asthma medications, reinforcing its place in traditional medicine as a complementary treatment for allergic respiratory issues.
Over 14 days, guinea pigs exposed to allergens received a daily dose of Echinacea. Our observations were quite promising; we found significant improvements in airway function, showing that Echinacea could reduce airway resistance and help the muscles in the lungs relax.
Furthermore, we noted its anti-inflammatory effects, which were measured through changes in exhaled nitric oxide levels and cytokine concentrations. These findings suggest that Echinacea could act similarly to conventional asthma medications, reinforcing its place in traditional medicine as a complementary treatment for allergic respiratory issues.
Read More
Most Useful Reviews
8.3
Easy to take
Flonase has helped significantly with my allergies. It’s easy to swallow and provides great relief.
Read More
9.5
Life-saving for allergies
Wonderful for my allergies, especially a lifesaver during Covid.
Read More
9
Effective immunity relief
Very effective for allergy relief. The capsules are easy to swallow and digest, making them a great alternative to medication given their ingredients.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
9.5
Alkylamides show promise against allergies
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Study closely aligns with research
We observed the creation of a series of new compounds designed to combat allergies, particularly focusing on N-(pyridin-4-yl)-(indol-3-yl) alkylamides. These compounds were synthesized using various established methods, which include the Fischer indolization technique and the Japp-Klingemann method.
Our primary goal was to find effective new antiallergic agents. Among the 41 compounds tested, N-(pyridin-4-yl)-[1-(4-fluorobenzyl)indol-3-yl]acetamide stood out as remarkably potent, showing an impressive 406-fold increase in efficacy compared to an established antihistamine, astemizole. This compound achieved noteworthy results in several tests, demonstrating effectiveness at very low concentrations.
Moreover, the compound was effective in preventing allergic responses in guinea pig models of rhinitis. It showed strong performance both when administered orally and parenterally, indicating its potential in treating allergies. Overall, this research provides promising insights into how alkylamides can positively impact allergic conditions, making them an exciting avenue for future exploration.
Our primary goal was to find effective new antiallergic agents. Among the 41 compounds tested, N-(pyridin-4-yl)-[1-(4-fluorobenzyl)indol-3-yl]acetamide stood out as remarkably potent, showing an impressive 406-fold increase in efficacy compared to an established antihistamine, astemizole. This compound achieved noteworthy results in several tests, demonstrating effectiveness at very low concentrations.
Moreover, the compound was effective in preventing allergic responses in guinea pig models of rhinitis. It showed strong performance both when administered orally and parenterally, indicating its potential in treating allergies. Overall, this research provides promising insights into how alkylamides can positively impact allergic conditions, making them an exciting avenue for future exploration.
Read More
9
Echinacea may alleviate allergies
Echinacea purpurea water extracts suppress the release of chemical mediators from mast cells.
Highlights significant findings on allergies
We explored how Echinacea purpurea, a plant commonly used in herbal tea, might help relieve allergies by focusing on its effects on mast cells. Mast cells play a significant role in type-I allergies, such as hay fever, by releasing histamine and leukotrienes—substances that cause allergic symptoms.
Our evaluation involved water extracts from the petals, leaves, and stems of Echinacea purpurea. We specifically looked at how these extracts influenced the release of histamine and other chemical mediators from mast cell lines. The results were quite interesting: both petal and leaf extracts significantly reduced histamine release in stimulated cells. However, the stem extract did not show any effect.
Notably, we found that the petal extract was much more effective than the leaf extract. Additionally, all extracts effectively suppressed leukotriene B4 production, which is another mediator involved in allergic reactions. The petal extract also seemed to decrease certain cellular signaling events associated with mast cell activation.
Overall, our findings suggest that Echinacea purpurea petal extract could potentially help alleviate allergic symptoms, particularly in conditions like hay fever.
Our evaluation involved water extracts from the petals, leaves, and stems of Echinacea purpurea. We specifically looked at how these extracts influenced the release of histamine and other chemical mediators from mast cell lines. The results were quite interesting: both petal and leaf extracts significantly reduced histamine release in stimulated cells. However, the stem extract did not show any effect.
Notably, we found that the petal extract was much more effective than the leaf extract. Additionally, all extracts effectively suppressed leukotriene B4 production, which is another mediator involved in allergic reactions. The petal extract also seemed to decrease certain cellular signaling events associated with mast cell activation.
Overall, our findings suggest that Echinacea purpurea petal extract could potentially help alleviate allergic symptoms, particularly in conditions like hay fever.
Read More
9
Echinacea shows promise for asthma
Echinacea complex--chemical view and anti-asthmatic profile.
Direct investigation of Echinacea's asthma effects
We aimed to investigate how Echinacea, a popular herbal remedy, can help with allergic conditions, particularly asthma. To do this, we isolated the active components from Echinacea purpurea flowers and examined their effects on an animal model mimicking allergic asthma.
Over 14 days, guinea pigs exposed to allergens received a daily dose of Echinacea. Our observations were quite promising; we found significant improvements in airway function, showing that Echinacea could reduce airway resistance and help the muscles in the lungs relax.
Furthermore, we noted its anti-inflammatory effects, which were measured through changes in exhaled nitric oxide levels and cytokine concentrations. These findings suggest that Echinacea could act similarly to conventional asthma medications, reinforcing its place in traditional medicine as a complementary treatment for allergic respiratory issues.
Over 14 days, guinea pigs exposed to allergens received a daily dose of Echinacea. Our observations were quite promising; we found significant improvements in airway function, showing that Echinacea could reduce airway resistance and help the muscles in the lungs relax.
Furthermore, we noted its anti-inflammatory effects, which were measured through changes in exhaled nitric oxide levels and cytokine concentrations. These findings suggest that Echinacea could act similarly to conventional asthma medications, reinforcing its place in traditional medicine as a complementary treatment for allergic respiratory issues.
Read More
8
Echinacea alkylamides inhibit allergies
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.
Effective against allergy-inducing mast cells
We examined how alkylamides from Echinacea purpurea influence mast cells, which play a crucial role in allergy and inflammation. The study focused on a specific alkylamide called dodeca-2E,4E-dienoic acid isobutylamide (A15) and its effect on mast cell activation. Using different experiments with bone marrow-derived mast cells and a rat mast cell line, we assessed how these compounds affect degranulation, calcium influx, and the production of various mediators associated with allergic responses.
Our findings highlighted that both the Echinacea extract and the alkylamide A15 can inhibit mast cell activation. This suggests a potential method for managing allergic reactions and inflammatory conditions. The impact on calcium levels in mast cells and other immune cells indicates a broader application for alkylamides in reducing allergic symptoms.
Ultimately, these results provide insight into the traditional use of Echinacea for treating allergies and suggest that its alkylamide constituents could offer a natural therapeutic route for allergy treatment.
Our findings highlighted that both the Echinacea extract and the alkylamide A15 can inhibit mast cell activation. This suggests a potential method for managing allergic reactions and inflammatory conditions. The impact on calcium levels in mast cells and other immune cells indicates a broader application for alkylamides in reducing allergic symptoms.
Ultimately, these results provide insight into the traditional use of Echinacea for treating allergies and suggest that its alkylamide constituents could offer a natural therapeutic route for allergy treatment.
Read More
7
Echinacea shows promise for allergies
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.
Study relevant to allergy treatments
We explored the effects of Echinacea purpurea, specifically its root extract and a notable component called dodeca-2E,4E-dienoic acid isobutylamide, on mast cells, which play a crucial role in allergy and inflammation.
In our study, we focused on how these elements influence mast cell activation. By using bone marrow-derived mast cells and a specific mast cell line, we assessed how Echinacea extracts and their alkylamides could potentially inhibit mast cell degranulation and calcium influx, crucial processes in allergic reactions.
The findings indicate that both Echinacea extracts and the alkylamide may serve as remedies for conditions arising from allergic responses. This aligns with the traditional use of Echinacea as an anti-inflammatory treatment, offering a natural approach to remedy allergies.
While further research is needed, these results open the door to considering Echinacea and its constituents as potential candidates for alleviating allergic conditions, thanks to their ability to dampen significant cellular responses in mast cells.
In our study, we focused on how these elements influence mast cell activation. By using bone marrow-derived mast cells and a specific mast cell line, we assessed how Echinacea extracts and their alkylamides could potentially inhibit mast cell degranulation and calcium influx, crucial processes in allergic reactions.
The findings indicate that both Echinacea extracts and the alkylamide may serve as remedies for conditions arising from allergic responses. This aligns with the traditional use of Echinacea as an anti-inflammatory treatment, offering a natural approach to remedy allergies.
While further research is needed, these results open the door to considering Echinacea and its constituents as potential candidates for alleviating allergic conditions, thanks to their ability to dampen significant cellular responses in mast cells.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Life-saving for allergies
Wonderful for my allergies, especially a lifesaver during Covid.
9
Effective immunity relief
Very effective for allergy relief. The capsules are easy to swallow and digest, making them a great alternative to medication given their ingredients.
9
Outstanding quality
Amazing during allergy season! The brand quality is superb, and the taste is also pleasant!
8.8
Effective allergy treatment
Excellent results for allergies and flu.
8.3
Easy to take
Flonase has helped significantly with my allergies. It’s easy to swallow and provides great relief.
