Last update
3/3/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.6
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Oregano leaf supercritical CO2 extract
230 mg
†
Carvacrol and Thymol
32 mg
†
Top Medical Research Studies
9
We assessed the potential of oregano oil as a treatment for acne, targeting the bacteria often responsible for this common skin condition. Our research involved investigating seven essential oils commonly used in Mediterranean folk medicine, with oregano oil standing out for its remarkable antibacterial properties.
We discovered that oregano oil exhibited strong antimicrobial effects, showing a minimum inhibitory concentration (MIC) of just 0.34 mg/mL against acne-associated bacteria. Notably, it also demonstrated an impressive ability to disrupt biofilms, essential for bacterial survival.
To harness its efficacy, we formulated oregano oil into a nanoemulsion and tested it in a mouse model. The results were promising; this formulation not only promoted healing but also surpassed the conventional antibiotic treatment in combating acne.
Overall, our findings suggest that oregano oil could be a safe and effective natural alternative for treating acne, especially in the face of rising antibiotic resistance.
We discovered that oregano oil exhibited strong antimicrobial effects, showing a minimum inhibitory concentration (MIC) of just 0.34 mg/mL against acne-associated bacteria. Notably, it also demonstrated an impressive ability to disrupt biofilms, essential for bacterial survival.
To harness its efficacy, we formulated oregano oil into a nanoemulsion and tested it in a mouse model. The results were promising; this formulation not only promoted healing but also surpassed the conventional antibiotic treatment in combating acne.
Overall, our findings suggest that oregano oil could be a safe and effective natural alternative for treating acne, especially in the face of rising antibiotic resistance.
Read More
8
We investigated the effects of an ethanolic extract from oregano on acne inflammation, particularly focusing on its ability to suppress inflammatory responses. The study revealed that oregano can be a valuable part of acne treatment due to its significant anti-inflammatory properties.
During our exploration, we found that four potent compounds within the oregano extract, including rosmarinic acid and quercetin, contribute to its strong antioxidant activity. When tested in mouse models, the extract notably reduced inflammation—evidenced by decreased ear thickness and weight.
Additionally, in a laboratory setting using human monocytes, the oregano extract lowered the production of important inflammatory markers like interleukin-8 and tumor necrosis factor-alpha. This suggests that oregano works by interfering with the pathways that activate inflammation, particularly by inhibiting the inflammation-triggering proteins.
Importantly, we noted that the anti-inflammatory effects do not stem from oregano's antimicrobial properties but rather from its ability to combat oxidative stress and inflammation directly. This research positions oregano as a promising natural remedy for managing acne effectively.
During our exploration, we found that four potent compounds within the oregano extract, including rosmarinic acid and quercetin, contribute to its strong antioxidant activity. When tested in mouse models, the extract notably reduced inflammation—evidenced by decreased ear thickness and weight.
Additionally, in a laboratory setting using human monocytes, the oregano extract lowered the production of important inflammatory markers like interleukin-8 and tumor necrosis factor-alpha. This suggests that oregano works by interfering with the pathways that activate inflammation, particularly by inhibiting the inflammation-triggering proteins.
Importantly, we noted that the anti-inflammatory effects do not stem from oregano's antimicrobial properties but rather from its ability to combat oxidative stress and inflammation directly. This research positions oregano as a promising natural remedy for managing acne effectively.
Read More
8
We aimed to explore the effectiveness of oregano oil when combined with finasteride in managing alopecia, particularly focusing on its impact on acne. Our approach involved creating nano-cubosomes that incorporated both finasteride and oregano oil to improve how well the ingredients penetrate the skin. The research employed a thoughtful design to optimize the formulation, with ingredients including phytantriol and alkyl acrylate, which are essential for the production of the cubosomes.
Through our experiments, we discovered that the optimal formulation achieved a particle size of 135 nm with a robust entrapment efficiency of 70%. This means a significant amount of finasteride was successfully encapsulated within the cubosomes. Furthermore, the minimum inhibitory concentration against Propionibacterium acnes indicated that our formulation was effective in combating bacteria often connected to acne.
When we incorporated this optimized nano-cubosome formulation into an aloe ferox gel, we noticed enhanced drug release and skin permeation compared to traditional finasteride formulations. This suggests that the combination of aloe ferox and oregano oil resulted in a synergistic effect, improving both the absorption of finasteride and its efficacy against acne-related bacteria. Overall, our findings support the potential of using oregano oil in topical treatments for hair loss, as it helps boost the delivery of finasteride and provides additional benefits in managing acne.
Through our experiments, we discovered that the optimal formulation achieved a particle size of 135 nm with a robust entrapment efficiency of 70%. This means a significant amount of finasteride was successfully encapsulated within the cubosomes. Furthermore, the minimum inhibitory concentration against Propionibacterium acnes indicated that our formulation was effective in combating bacteria often connected to acne.
When we incorporated this optimized nano-cubosome formulation into an aloe ferox gel, we noticed enhanced drug release and skin permeation compared to traditional finasteride formulations. This suggests that the combination of aloe ferox and oregano oil resulted in a synergistic effect, improving both the absorption of finasteride and its efficacy against acne-related bacteria. Overall, our findings support the potential of using oregano oil in topical treatments for hair loss, as it helps boost the delivery of finasteride and provides additional benefits in managing acne.
Read More
Most Useful Reviews
6
Improved skin radiance
32 people found this helpful
Good recommendation for the protocol against acne. The supplement's composition is commendable, and you can take it for two weeks with a subsequent two-week break. A single package suffices for four courses. Initially, there was a slight rash, but by the end of the second week, my skin appeared more radiant. There was a mild aftertaste from the oregano, yet I feel it works.
Read More
9
Accurate skin treatment
26 people found this helpful
Excellent. This product performed exactly as described. After numerous reviews, I decided to try it due to chronic sinusitis and allergies, alongside itchy skin and acne linked to antibiotics. Within days, my symptoms began to improve and my skin looked clearer. I recommend it for anyone struggling with fungal issues, including acne.
Read More
8
Effective antibiotic
7 people found this helpful
I use oregano oil as a natural antibiotic against cystic acne, and it's highly effective when paired with Sovereign Silver. It benefits gut health and those suffering from SIBO, too. Gaia is reputable for high-grade supplements, and I recommend this product wholeheartedly.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.6
- All Researches
9.5
We explored the potential of oregano essential oil (EO) and probiotics in battling acne. Our study focused on how these natural ingredients could work together to inhibit the growth of bacteria associated with acne vulgaris.
After evaluating several probiotic strains and natural extracts, we found that one specific probiotic, PCB003, was able to effectively inhibit the bacteria responsible for acne. Among the various EOs tested, oregano EO demonstrated the most promising results, especially since it did not harm probiotic growth.
We designed topical patches using alginate and trehalose, finding that these materials effectively preserved the probiotics. When combined with PCB003 and PCB011, the patches not only inhibited bacterial growth significantly but also outperformed standard over-the-counter acne patches.
Notably, when we incorporated oregano EO into the patches, the results were even better. The patches with 30% oregano EO showed an impressive increase in the inhibition zone, achieving substantial inhibition against acne-causing bacteria. Overall, our results suggest that combining probiotics with oregano EO could provide a powerful, natural solution for acne treatment.
After evaluating several probiotic strains and natural extracts, we found that one specific probiotic, PCB003, was able to effectively inhibit the bacteria responsible for acne. Among the various EOs tested, oregano EO demonstrated the most promising results, especially since it did not harm probiotic growth.
We designed topical patches using alginate and trehalose, finding that these materials effectively preserved the probiotics. When combined with PCB003 and PCB011, the patches not only inhibited bacterial growth significantly but also outperformed standard over-the-counter acne patches.
Notably, when we incorporated oregano EO into the patches, the results were even better. The patches with 30% oregano EO showed an impressive increase in the inhibition zone, achieving substantial inhibition against acne-causing bacteria. Overall, our results suggest that combining probiotics with oregano EO could provide a powerful, natural solution for acne treatment.
Read More
9
We assessed the potential of oregano oil as a treatment for acne, targeting the bacteria often responsible for this common skin condition. Our research involved investigating seven essential oils commonly used in Mediterranean folk medicine, with oregano oil standing out for its remarkable antibacterial properties.
We discovered that oregano oil exhibited strong antimicrobial effects, showing a minimum inhibitory concentration (MIC) of just 0.34 mg/mL against acne-associated bacteria. Notably, it also demonstrated an impressive ability to disrupt biofilms, essential for bacterial survival.
To harness its efficacy, we formulated oregano oil into a nanoemulsion and tested it in a mouse model. The results were promising; this formulation not only promoted healing but also surpassed the conventional antibiotic treatment in combating acne.
Overall, our findings suggest that oregano oil could be a safe and effective natural alternative for treating acne, especially in the face of rising antibiotic resistance.
We discovered that oregano oil exhibited strong antimicrobial effects, showing a minimum inhibitory concentration (MIC) of just 0.34 mg/mL against acne-associated bacteria. Notably, it also demonstrated an impressive ability to disrupt biofilms, essential for bacterial survival.
To harness its efficacy, we formulated oregano oil into a nanoemulsion and tested it in a mouse model. The results were promising; this formulation not only promoted healing but also surpassed the conventional antibiotic treatment in combating acne.
Overall, our findings suggest that oregano oil could be a safe and effective natural alternative for treating acne, especially in the face of rising antibiotic resistance.
Read More
8
We aimed to explore the effectiveness of oregano oil when combined with finasteride in managing alopecia, particularly focusing on its impact on acne. Our approach involved creating nano-cubosomes that incorporated both finasteride and oregano oil to improve how well the ingredients penetrate the skin. The research employed a thoughtful design to optimize the formulation, with ingredients including phytantriol and alkyl acrylate, which are essential for the production of the cubosomes.
Through our experiments, we discovered that the optimal formulation achieved a particle size of 135 nm with a robust entrapment efficiency of 70%. This means a significant amount of finasteride was successfully encapsulated within the cubosomes. Furthermore, the minimum inhibitory concentration against Propionibacterium acnes indicated that our formulation was effective in combating bacteria often connected to acne.
When we incorporated this optimized nano-cubosome formulation into an aloe ferox gel, we noticed enhanced drug release and skin permeation compared to traditional finasteride formulations. This suggests that the combination of aloe ferox and oregano oil resulted in a synergistic effect, improving both the absorption of finasteride and its efficacy against acne-related bacteria. Overall, our findings support the potential of using oregano oil in topical treatments for hair loss, as it helps boost the delivery of finasteride and provides additional benefits in managing acne.
Through our experiments, we discovered that the optimal formulation achieved a particle size of 135 nm with a robust entrapment efficiency of 70%. This means a significant amount of finasteride was successfully encapsulated within the cubosomes. Furthermore, the minimum inhibitory concentration against Propionibacterium acnes indicated that our formulation was effective in combating bacteria often connected to acne.
When we incorporated this optimized nano-cubosome formulation into an aloe ferox gel, we noticed enhanced drug release and skin permeation compared to traditional finasteride formulations. This suggests that the combination of aloe ferox and oregano oil resulted in a synergistic effect, improving both the absorption of finasteride and its efficacy against acne-related bacteria. Overall, our findings support the potential of using oregano oil in topical treatments for hair loss, as it helps boost the delivery of finasteride and provides additional benefits in managing acne.
Read More
8
We investigated the effects of an ethanolic extract from oregano on acne inflammation, particularly focusing on its ability to suppress inflammatory responses. The study revealed that oregano can be a valuable part of acne treatment due to its significant anti-inflammatory properties.
During our exploration, we found that four potent compounds within the oregano extract, including rosmarinic acid and quercetin, contribute to its strong antioxidant activity. When tested in mouse models, the extract notably reduced inflammation—evidenced by decreased ear thickness and weight.
Additionally, in a laboratory setting using human monocytes, the oregano extract lowered the production of important inflammatory markers like interleukin-8 and tumor necrosis factor-alpha. This suggests that oregano works by interfering with the pathways that activate inflammation, particularly by inhibiting the inflammation-triggering proteins.
Importantly, we noted that the anti-inflammatory effects do not stem from oregano's antimicrobial properties but rather from its ability to combat oxidative stress and inflammation directly. This research positions oregano as a promising natural remedy for managing acne effectively.
During our exploration, we found that four potent compounds within the oregano extract, including rosmarinic acid and quercetin, contribute to its strong antioxidant activity. When tested in mouse models, the extract notably reduced inflammation—evidenced by decreased ear thickness and weight.
Additionally, in a laboratory setting using human monocytes, the oregano extract lowered the production of important inflammatory markers like interleukin-8 and tumor necrosis factor-alpha. This suggests that oregano works by interfering with the pathways that activate inflammation, particularly by inhibiting the inflammation-triggering proteins.
Importantly, we noted that the anti-inflammatory effects do not stem from oregano's antimicrobial properties but rather from its ability to combat oxidative stress and inflammation directly. This research positions oregano as a promising natural remedy for managing acne effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
6
Improved skin radiance
32 people found this helpful
Good recommendation for the protocol against acne. The supplement's composition is commendable, and you can take it for two weeks with a subsequent two-week break. A single package suffices for four courses. Initially, there was a slight rash, but by the end of the second week, my skin appeared more radiant. There was a mild aftertaste from the oregano, yet I feel it works.
Read More
9
Accurate skin treatment
26 people found this helpful
Excellent. This product performed exactly as described. After numerous reviews, I decided to try it due to chronic sinusitis and allergies, alongside itchy skin and acne linked to antibiotics. Within days, my symptoms began to improve and my skin looked clearer. I recommend it for anyone struggling with fungal issues, including acne.
Read More
8
Effective antibiotic
7 people found this helpful
I use oregano oil as a natural antibiotic against cystic acne, and it's highly effective when paired with Sovereign Silver. It benefits gut health and those suffering from SIBO, too. Gaia is reputable for high-grade supplements, and I recommend this product wholeheartedly.
Read More
7
Skin improvement noted
5 people found this helpful
I purchased this product to combat bad bacteria in my gut, as I've been dealing with acne and candida overgrowth. After taking it for a month at two capsules daily, I've noticed significant improvement in my skin.
Read More
10
Significant acne help
1 people found this helpful
This product helped my acne tremendously! I also take it when I start to feel unwell. I’ve bought it over ten times already.
Read More
Frequently Asked Questions
9
Quick acne improvement
1 people found this helpful
I am extremely enthusiastic about Gaia’s brand. My acne improved noticeably within a brief period, thanks to the quality and purity of the ingredients. No other product has helped me as effectively, and my daily dose of two capsules has proven excellent.
9
We assessed the potential of oregano oil as a treatment for acne, targeting the bacteria often responsible for this common skin condition. Our research involved investigating seven essential oils commonly used in Mediterranean folk medicine, with oregano oil standing out for its remarkable antibacterial properties.
We discovered that oregano oil exhibited strong antimicrobial effects, showing a minimum inhibitory concentration (MIC) of just 0.34 mg/mL against acne-associated bacteria. Notably, it also demonstrated an impressive ability to disrupt biofilms, essential for bacterial survival.
To harness its efficacy, we formulated oregano oil into a nanoemulsion and tested it in a mouse model. The results were promising; this formulation not only promoted healing but also surpassed the conventional antibiotic treatment in combating acne.
Overall, our findings suggest that oregano oil could be a safe and effective natural alternative for treating acne, especially in the face of rising antibiotic resistance.
We discovered that oregano oil exhibited strong antimicrobial effects, showing a minimum inhibitory concentration (MIC) of just 0.34 mg/mL against acne-associated bacteria. Notably, it also demonstrated an impressive ability to disrupt biofilms, essential for bacterial survival.
To harness its efficacy, we formulated oregano oil into a nanoemulsion and tested it in a mouse model. The results were promising; this formulation not only promoted healing but also surpassed the conventional antibiotic treatment in combating acne.
Overall, our findings suggest that oregano oil could be a safe and effective natural alternative for treating acne, especially in the face of rising antibiotic resistance.
9.5
We explored the potential of oregano essential oil (EO) and probiotics in battling acne. Our study focused on how these natural ingredients could work together to inhibit the growth of bacteria associated with acne vulgaris.
After evaluating several probiotic strains and natural extracts, we found that one specific probiotic, PCB003, was able to effectively inhibit the bacteria responsible for acne. Among the various EOs tested, oregano EO demonstrated the most promising results, especially since it did not harm probiotic growth.
We designed topical patches using alginate and trehalose, finding that these materials effectively preserved the probiotics. When combined with PCB003 and PCB011, the patches not only inhibited bacterial growth significantly but also outperformed standard over-the-counter acne patches.
Notably, when we incorporated oregano EO into the patches, the results were even better. The patches with 30% oregano EO showed an impressive increase in the inhibition zone, achieving substantial inhibition against acne-causing bacteria. Overall, our results suggest that combining probiotics with oregano EO could provide a powerful, natural solution for acne treatment.
After evaluating several probiotic strains and natural extracts, we found that one specific probiotic, PCB003, was able to effectively inhibit the bacteria responsible for acne. Among the various EOs tested, oregano EO demonstrated the most promising results, especially since it did not harm probiotic growth.
We designed topical patches using alginate and trehalose, finding that these materials effectively preserved the probiotics. When combined with PCB003 and PCB011, the patches not only inhibited bacterial growth significantly but also outperformed standard over-the-counter acne patches.
Notably, when we incorporated oregano EO into the patches, the results were even better. The patches with 30% oregano EO showed an impressive increase in the inhibition zone, achieving substantial inhibition against acne-causing bacteria. Overall, our results suggest that combining probiotics with oregano EO could provide a powerful, natural solution for acne treatment.
8
We investigated the effects of an ethanolic extract from oregano on acne inflammation, particularly focusing on its ability to suppress inflammatory responses. The study revealed that oregano can be a valuable part of acne treatment due to its significant anti-inflammatory properties.
During our exploration, we found that four potent compounds within the oregano extract, including rosmarinic acid and quercetin, contribute to its strong antioxidant activity. When tested in mouse models, the extract notably reduced inflammation—evidenced by decreased ear thickness and weight.
Additionally, in a laboratory setting using human monocytes, the oregano extract lowered the production of important inflammatory markers like interleukin-8 and tumor necrosis factor-alpha. This suggests that oregano works by interfering with the pathways that activate inflammation, particularly by inhibiting the inflammation-triggering proteins.
Importantly, we noted that the anti-inflammatory effects do not stem from oregano's antimicrobial properties but rather from its ability to combat oxidative stress and inflammation directly. This research positions oregano as a promising natural remedy for managing acne effectively.
During our exploration, we found that four potent compounds within the oregano extract, including rosmarinic acid and quercetin, contribute to its strong antioxidant activity. When tested in mouse models, the extract notably reduced inflammation—evidenced by decreased ear thickness and weight.
Additionally, in a laboratory setting using human monocytes, the oregano extract lowered the production of important inflammatory markers like interleukin-8 and tumor necrosis factor-alpha. This suggests that oregano works by interfering with the pathways that activate inflammation, particularly by inhibiting the inflammation-triggering proteins.
Importantly, we noted that the anti-inflammatory effects do not stem from oregano's antimicrobial properties but rather from its ability to combat oxidative stress and inflammation directly. This research positions oregano as a promising natural remedy for managing acne effectively.
References
- Yong LX, Li W, Conway PL, Loo SCJ. Additive Effects of Natural Plant Extracts/Essential Oils and Probiotics as an Antipathogenic Topical Skin Patch Solution for Acne and Eczema. ACS Appl Bio Mater. 2025;8:1571. 10.1021/acsabm.4c01742
- Hosny KM, Rizg WY, Alfayez E, Elgebaly SS, Alamoudi AJ, et al. Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia. Drug Deliv. 2022;29:284. 10.1080/10717544.2022.2026534
- Taleb MH, Abdeltawab NF, Shamma RN, Abdelgayed SS, Mohamed SS, et al. L. Essential Oil as a Potential Anti-Acne Topical Nanoemulsion-In Vitro and In Vivo Study. Molecules. 2018;23. 10.3390/molecules23092164
- Chuang LT, Tsai TH, Lien TJ, Huang WC, Liu JJ, et al. Ethanolic Extract of Suppresses -Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models. Molecules. 2018;23. 10.3390/molecules23081987
Data last updated:
