Oregano oil enhances diabetic wound healingCellulose nanofibrils reinforced chitosan-gelatin based hydrogel loaded with nanoemulsion of oregano essential oil for diabetic wound healing assisted by low level laser therapy.
Oregano combined with therapies evaluated
We investigated the effectiveness of a special gel, enriched with oregano essential oil, in promoting healing for diabetic foot ulcers. This healing patch was designed using natural polymers such as chitosan and gelatin, combined with a unique nanoemulsion technique to enhance the properties of oregano oil.
To gauge its effectiveness, we assessed the physical properties of the gel and its ability to support cell growth and migration. Our findings revealed that when combined with low-level laser therapy, this duo improved wound healing significantly, achieving up to 100% closure within 48 hours in cell studies.
More impressively, tests on diabetic rats with foot ulcers showed that this combined approach resulted in a 97.5% healing rate, minimal scarring, and faster recovery compared to treatments using only one method. The oregano oil nanoemulsion within the gel played a key role in enhancing healing, demonstrating promising results for managing diabetic ulcers effectively.
Overall, our study suggests that integrating oregano essential oil with advanced therapeutic techniques can be a beneficial strategy for diabetic wound care.
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Carvacrol shows promise for ulcersAnti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Oregano's effects somewhat unclear
We explored the effects of carvacrol, a compound found in oregano oil, on inflammation and ulcers in scientific studies. The research analyzed how carvacrol performed against various agents that induce swelling and gastric ulcers. In these experiments, carvacrol showed promising results in reducing swelling, particularly in models triggered by substances like dextran and histamine.
Carvacrol was especially effective at higher doses, significantly decreasing swelling and ear edema caused by two different irritants. When it came to ulcers, we observed remarkable healing effects, with carvacrol showing up to 91% effectiveness at specific dosages after 14 days of treatment. This suggests that carvacrol may help tackle the issues with gastric lesions that many people experience.
Overall, the findings indicate that carvacrol has the potential to positively influence the healing of ulcers, likely by affecting inflammatory responses in the body. This makes carvacrol, and by extension oregano, an exciting area for further exploration concerning natural treatments for gastric issues.
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Oregano aids pressure ulcer healingTherapeutic potential of Brazilian green propolis and oregano () extracts in collagen hydrogel for pressure ulcer repair: an experimental study in an animal model.
High relevance to ulcer treatment
We investigated the potential of oregano extract in helping heal pressure ulcers by integrating it with collagen hydrogel. In our study, we used 44 mice, dividing them into four distinct groups. These included a control group with no treatment, one group receiving plain collagen hydrogel, and two groups receiving collagen hydrogel with either 1% green propolis extract or 1% oregano extract.
Pressure ulcers were induced on the mice’s backs, and then we evaluated the healing process over a period of 14 days. During this time, we measured various factors such as the area of the wounds, their contraction, and re-epithelialization, as well as the density of dermal collagen and levels of reactive oxygen species and nitrite.
The results were promising and indicated that both oregano and propolis extracts significantly boosted the healing of these ulcers, with oregano being particularly effective in promoting wound contraction. Importantly, these treatments not only helped with the physical aspects of healing, but also led to improvements in skin layer organization and reduction of harmful substances.
Overall, we found that incorporating oregano extract into collagen hydrogels holds significant therapeutic promise for treating pressure ulcers.
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Oregano benefits gut healthHerba Origani alleviated DSS-induced ulcerative colitis in mice through remolding gut microbiota to regulate bile acid and short-chain fatty acid metabolisms.
Moderate relevance to ulcer treatment
We examined how Herba Origani, derived from the oregano plant, can help with ulcerative colitis, a type of gut inflammation. By focusing on its effects on mice with colitis induced by dextran sodium sulfate (DSS), we observed several key benefits from oregano treatment.
The results indicated that oregano helped reduce inflammation and damage in the colon while also enhancing the functioning of the intestinal barrier. Additionally, we found that oregano worked to restore the balance of the gut microbiota, increasing the diversity and abundance of beneficial bacteria. This is crucial for maintaining a healthy gut environment.
Importantly, oregano treatment also appeared to influence the metabolism of bile acids and short-chain fatty acids, which are essential for gut health. By regulating these metabolic processes, oregano may promote better immune function within the intestines.
Overall, our findings suggest that oregano could be a valuable ally in addressing inflammatory gut issues. However, it's important to note that this study primarily focused on the broader condition of ulcerative colitis rather than ulcers alone.
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Our study focused on understanding the effects of marjoram, scientifically known as Origanum majorana, in treating ulcers. We assessed its antiulcerogenic activity using various models of gastric mucosal injury in rats, including stress-induced and chemically induced ulcers.
We discovered that administering the ethanol extract of marjoram at doses of 250 and 500 mg/kg significantly reduced the incidence of ulcers, as well as the overall gastric acid secretion. Interestingly, the marjoram extract not only aided in healing but also replenished the gastric wall mucus and nonprotein sulfhydryls, which were depleted due to ethanol exposure.
Additionally, we noted a decrease in malondialdehyde levels, a marker of lipid damage, highlighting the protective effects of marjoram. These findings were further confirmed by histopathological evaluations, supporting marjoram's role as a potential natural remedy for ulcers. Importantly, an acute toxicity assessment indicated a favorable safety profile for this extract in mice.
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