Last update
4/1/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Total Carbohydrate
1 g
<1%*
Organic Silactive® Milk Thistle (Silybum marianum) seed extract
750 mg
†
Silymarins
375 mg
†
Top Medical Research Studies
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
Most Useful Reviews
7.5
Improved liver health
11 people found this helpful
The most effective Milk Thistle seed extract I have used. I took it as a liver detox supplement after my blood test showed an elevated fatty liver issue. My doctor advised it wasn't severe enough for a prescription but suggested Milk Thistle instead. I had tried four other cheaper brands, but after deciding to try Gaia Herbs Milk Thistle, I noticed a difference after three months. I have now been taking Milk Thistle extract for over a year.
Read More
7.5
Liver test improvement
Great product that works well. It has helped improve my liver numbers from one blood test to another.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved liver health
11 people found this helpful
The most effective Milk Thistle seed extract I have used. I took it as a liver detox supplement after my blood test showed an elevated fatty liver issue. My doctor advised it wasn't severe enough for a prescription but suggested Milk Thistle instead. I had tried four other cheaper brands, but after deciding to try Gaia Herbs Milk Thistle, I noticed a difference after three months. I have now been taking Milk Thistle extract for over a year.
Read More
7.5
Liver test improvement
Great product that works well. It has helped improve my liver numbers from one blood test to another.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Speciale A, Muscarà C, Molonia MS, Cimino F, Saija A, et al. Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects. Phytother Res. 2021;35:4616. 10.1002/ptr.7107
- Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. 10.1186/s12906-017-1897-7
Data last updated:
