Last update
5/23/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
9.5
Saccharomyces improves acne treatment
We explored how Saccharomyces cerevisiae Hansen CBS 5926, also known as Perenterol, affects acne in a randomized, double-blind study with 139 participants.
The study revealed impressive results: approximately 74.3% of those treated reported good or very good outcomes, compared to just 21.7% in the placebo group.
More than 80% of patients who received the yeast preparation saw substantial improvement or healing, while only 26% in the placebo group experienced similar results.
Notably, there were no significant side effects reported in either group, making this treatment an increasingly popular option for those battling acne.
The study revealed impressive results: approximately 74.3% of those treated reported good or very good outcomes, compared to just 21.7% in the placebo group.
More than 80% of patients who received the yeast preparation saw substantial improvement or healing, while only 26% in the placebo group experienced similar results.
Notably, there were no significant side effects reported in either group, making this treatment an increasingly popular option for those battling acne.
Read More
9.5
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
Read More
9.5
Vitamin B12 influences acne development
We observed a fascinating case involving a 47-year-old man who developed a skin condition after starting vitamin B12 treatment for pernicious anemia. Just six weeks into his weekly injections of hydroxocobalamin, he experienced a sudden and widespread outbreak of inflammatory acne-like bumps on his face and trunk. This skin eruption was not only extensive but also caused significant itching and included comedones, commonly known as blackheads, particularly on his chest.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Read More
Most Useful Reviews
7
Stable health benefits
1 people found this helpful
Life-saver! This has not only rescued me from a serious deficiency, but it has also softened my ageing skin, provided a glow, reduced Acne, and helped regulate my menstrual irregularities (I’m 45). I’m astounded; I had no idea it was so powerful in stabilising and healing multiple health issues. I won’t be without this supplement!
Read More
8
No more pimples
Delicious! I prefer taking concentrated supplements by placing them under my tongue or in water. The reviews were positive, and since my mother has been prescribed vitamin B12 tablets by the hospital, I thought I’d try it myself first. Spray it under your tongue once a day! (Then wipe the outlet with tissue.) Sweet! That's what I thought. When I recommended it to my husband, he remarked, "It's like gum; it seems bad for you," but the ingredients are good. I used it daily, and the pimples that had been appearing and disappearing in the same spot now no longer appear. I will continue using it!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
- All Researches
9.5
Saccharomyces improves acne treatment
We explored how Saccharomyces cerevisiae Hansen CBS 5926, also known as Perenterol, affects acne in a randomized, double-blind study with 139 participants.
The study revealed impressive results: approximately 74.3% of those treated reported good or very good outcomes, compared to just 21.7% in the placebo group.
More than 80% of patients who received the yeast preparation saw substantial improvement or healing, while only 26% in the placebo group experienced similar results.
Notably, there were no significant side effects reported in either group, making this treatment an increasingly popular option for those battling acne.
The study revealed impressive results: approximately 74.3% of those treated reported good or very good outcomes, compared to just 21.7% in the placebo group.
More than 80% of patients who received the yeast preparation saw substantial improvement or healing, while only 26% in the placebo group experienced similar results.
Notably, there were no significant side effects reported in either group, making this treatment an increasingly popular option for those battling acne.
Read More
9.5
Vitamin B12 influences acne development
We observed a fascinating case involving a 47-year-old man who developed a skin condition after starting vitamin B12 treatment for pernicious anemia. Just six weeks into his weekly injections of hydroxocobalamin, he experienced a sudden and widespread outbreak of inflammatory acne-like bumps on his face and trunk. This skin eruption was not only extensive but also caused significant itching and included comedones, commonly known as blackheads, particularly on his chest.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Read More
9.5
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
Read More
9
We explored the impact of reintroducing vitamin B12 in individuals who had undergone treatment with isotretinoin for severe acne, known as acne medicamentosa. This study aimed to examine whether vitamin B12 could help improve acne conditions after completing isotretinoin therapy.
Although we discussed the effects of vitamin B12, the study’s structure didn’t isolate it from other treatments, which might make it hard to gauge vitamin B12's full effectiveness on its own.
We observed that while vitamin B12 had some interaction in the treatment process, the overall conclusion about its significant benefits for acne remains unclear due to the lack of controlled conditions in the study design.
Therefore, while reintroducing vitamin B12 after isotretinoin treatment shows some potential, it does not provide strong enough evidence to confirm a notable impact on acne improvement alone.
Although we discussed the effects of vitamin B12, the study’s structure didn’t isolate it from other treatments, which might make it hard to gauge vitamin B12's full effectiveness on its own.
We observed that while vitamin B12 had some interaction in the treatment process, the overall conclusion about its significant benefits for acne remains unclear due to the lack of controlled conditions in the study design.
Therefore, while reintroducing vitamin B12 after isotretinoin treatment shows some potential, it does not provide strong enough evidence to confirm a notable impact on acne improvement alone.
Read More
7
We explored the relationship between vitamin B12 and acne by examining how this vitamin influences porphyrin production in different strains of Propionibacterium acnes, a bacterium that resides on our skin. Previous studies hinted that vitamin B12 could trigger higher porphyrin levels, leading to acne development.
Our findings confirmed that acne-associated strains of P. acnes produced significantly more porphyrins, especially when given vitamin B12. In contrast, strains linked to healthy skin showed much lower porphyrin levels and did not respond to vitamin B12 at all. This stark difference sheds light on how specific strains can either contribute to acne or support skin health.
Additionally, we identified a repressor gene in health-associated strains that seemed to limit porphyrin production, further indicating that not all P. acnes strains are created equal. While our study provides valuable insights into the potential role of vitamin B12 in acne's development, it also highlights the complex interplay of genetics in skin health.
Understanding these distinctions is crucial, as it paves the way for potential treatments that could harness the benefits of health-associated P. acnes strains while managing acne development.
Our findings confirmed that acne-associated strains of P. acnes produced significantly more porphyrins, especially when given vitamin B12. In contrast, strains linked to healthy skin showed much lower porphyrin levels and did not respond to vitamin B12 at all. This stark difference sheds light on how specific strains can either contribute to acne or support skin health.
Additionally, we identified a repressor gene in health-associated strains that seemed to limit porphyrin production, further indicating that not all P. acnes strains are created equal. While our study provides valuable insights into the potential role of vitamin B12 in acne's development, it also highlights the complex interplay of genetics in skin health.
Understanding these distinctions is crucial, as it paves the way for potential treatments that could harness the benefits of health-associated P. acnes strains while managing acne development.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7
Stable health benefits
1 people found this helpful
Life-saver! This has not only rescued me from a serious deficiency, but it has also softened my ageing skin, provided a glow, reduced Acne, and helped regulate my menstrual irregularities (I’m 45). I’m astounded; I had no idea it was so powerful in stabilising and healing multiple health issues. I won’t be without this supplement!
Read More
8
No more pimples
Delicious! I prefer taking concentrated supplements by placing them under my tongue or in water. The reviews were positive, and since my mother has been prescribed vitamin B12 tablets by the hospital, I thought I’d try it myself first. Spray it under your tongue once a day! (Then wipe the outlet with tissue.) Sweet! That's what I thought. When I recommended it to my husband, he remarked, "It's like gum; it seems bad for you," but the ingredients are good. I used it daily, and the pimples that had been appearing and disappearing in the same spot now no longer appear. I will continue using it!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Kang D, Shi B, Erfe MC, Craft N, Li H. Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. Sci Transl Med. 2015;7:293ra103. 10.1126/scitranslmed.aab2009
- Weber G, Adamczyk A, Freytag S. [Treatment of acne with a yeast preparation]. Fortschr Med. 1989;107:563. PubMed
- Alharbi NM, AlGhofaili FA, Alsaud JS, Asiri LM, Almutairi SM, et al. The Relationship Between Nutritional Anemia and Acne: A Case-Control Study. Cureus. 2023;15:e39109. 10.7759/cureus.39109
- Bahbouhi I, Aboudourib M, Hocar O, Amal S. Vitamin B12 induced acneiform eruption. Heliyon. 2023;9:e16120. 10.1016/j.heliyon.2023.e16120
- Veraldi S, Benardon S, Diani M, Barbareschi M. Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature. J Cosmet Dermatol. 2018;17:112. 10.1111/jocd.12360
- Lolatgis H, Su J, Nguyen R. Successful re-introduction of vitamin B12 after using isotretinoin to treat severe acne medicamentosa. Australas J Dermatol. 2016;57:320. 10.1111/ajd.12458
- Johnson T, Kang D, Barnard E, Li H. Strain-Level Differences in Porphyrin Production and Regulation in Propionibacterium acnes Elucidate Disease Associations. mSphere. 2016;1. 10.1128/mSphere.00023-15
- Gökalp H, Bulur I, Gürer M. Decreased vitamin B12 and folic Acid concentrations in acne patients after isotretinoin therapy: a controlled study. Indian J Dermatol. 2014;59:630. 10.4103/0019-5154.143533
