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SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Highly relevant sleep study
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
9
Vitamin B12 treatment for insomnia
Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12).
Direct focus on insomnia relief
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Read More
8
Vitamin B12 aids sleep disorders
Vitamin B12 treatment for sleep-wake rhythm disorders.
Moderate relevance to treatment effects
We explored how vitamin B12 influences insomnia related to different sleep-wake rhythm disorders. In this study, two patients were treated with vitamin B12 to see if it could help regulate their sleep cycles.
The first patient, a 15-year-old blind girl, battled a free-running sleep-wake rhythm known as hypernychthemeral syndrome for 13 years. Despite several attempts to synchronize her sleep-wake cycle with the typical 24-hour environment, she struggled to do so. After starting a daily regimen of vitamin B12 (1.5 mg taken three times a day), we observed that her sleep-wake rhythm began to align with the 24-hour cycle and remained stable as long as she continued the treatment. However, her free-running rhythm returned within two months after stopping the vitamin B12.
The second patient, a 55-year-old man, had been dealing with delayed sleep phase syndrome since the age of 18. After taking vitamin B12 at the same dosage, he reported an improvement in his sleep-wake disorder that lasted over six months while he remained on the medication.
Although we noted some positive outcomes from vitamin B12 administration, it's essential to acknowledge that the findings are based on a small sample size, which may limit the broader implications of these results.
The first patient, a 15-year-old blind girl, battled a free-running sleep-wake rhythm known as hypernychthemeral syndrome for 13 years. Despite several attempts to synchronize her sleep-wake cycle with the typical 24-hour environment, she struggled to do so. After starting a daily regimen of vitamin B12 (1.5 mg taken three times a day), we observed that her sleep-wake rhythm began to align with the 24-hour cycle and remained stable as long as she continued the treatment. However, her free-running rhythm returned within two months after stopping the vitamin B12.
The second patient, a 55-year-old man, had been dealing with delayed sleep phase syndrome since the age of 18. After taking vitamin B12 at the same dosage, he reported an improvement in his sleep-wake disorder that lasted over six months while he remained on the medication.
Although we noted some positive outcomes from vitamin B12 administration, it's essential to acknowledge that the findings are based on a small sample size, which may limit the broader implications of these results.
Read More
Most Useful Reviews
9.5
Life-changing sleep
This product changed my life. I have various medical conditions that cause insomnia, low energy, and fatigue. Since I started taking this, I've been sleeping better and my energy has increased tremendously. It’s hard to express how grateful I am for this product, which has been working perfectly for nearly four weeks now.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
9
Vitamin B12 treatment for insomnia
Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12).
Direct focus on insomnia relief
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Read More
8
Vitamin B12 and sleep impact
Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report.
Linking vitamin B12 to insomnia
We explored the relationship between vitamin B12 levels and insomnia in a case involving a woman experiencing excessive daytime sleepiness alternating with insomnia. This case fit the criteria for a non-24-hour sleep-wake disorder, where traditional treatments failed to provide relief.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Read More
8
Combined treatment aids insomnia
The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia.
Vitamin B12 part of combination
In our exploration of insomnia treatment, we worked with 60 patients diagnosed with the condition. They were split into two groups: one received the Magnesium-melatonin-vitamin B complex, while the other acted as a control. The specific goal was to determine if this combination, which included Vitamin B12, could effectively improve sleep quality over a three-month period.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
Read More
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Highly relevant sleep study
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
8
Vitamin B12 aids sleep disorders
Vitamin B12 treatment for sleep-wake rhythm disorders.
Moderate relevance to treatment effects
We explored how vitamin B12 influences insomnia related to different sleep-wake rhythm disorders. In this study, two patients were treated with vitamin B12 to see if it could help regulate their sleep cycles.
The first patient, a 15-year-old blind girl, battled a free-running sleep-wake rhythm known as hypernychthemeral syndrome for 13 years. Despite several attempts to synchronize her sleep-wake cycle with the typical 24-hour environment, she struggled to do so. After starting a daily regimen of vitamin B12 (1.5 mg taken three times a day), we observed that her sleep-wake rhythm began to align with the 24-hour cycle and remained stable as long as she continued the treatment. However, her free-running rhythm returned within two months after stopping the vitamin B12.
The second patient, a 55-year-old man, had been dealing with delayed sleep phase syndrome since the age of 18. After taking vitamin B12 at the same dosage, he reported an improvement in his sleep-wake disorder that lasted over six months while he remained on the medication.
Although we noted some positive outcomes from vitamin B12 administration, it's essential to acknowledge that the findings are based on a small sample size, which may limit the broader implications of these results.
The first patient, a 15-year-old blind girl, battled a free-running sleep-wake rhythm known as hypernychthemeral syndrome for 13 years. Despite several attempts to synchronize her sleep-wake cycle with the typical 24-hour environment, she struggled to do so. After starting a daily regimen of vitamin B12 (1.5 mg taken three times a day), we observed that her sleep-wake rhythm began to align with the 24-hour cycle and remained stable as long as she continued the treatment. However, her free-running rhythm returned within two months after stopping the vitamin B12.
The second patient, a 55-year-old man, had been dealing with delayed sleep phase syndrome since the age of 18. After taking vitamin B12 at the same dosage, he reported an improvement in his sleep-wake disorder that lasted over six months while he remained on the medication.
Although we noted some positive outcomes from vitamin B12 administration, it's essential to acknowledge that the findings are based on a small sample size, which may limit the broader implications of these results.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Life-changing sleep
This product changed my life. I have various medical conditions that cause insomnia, low energy, and fatigue. Since I started taking this, I've been sleeping better and my energy has increased tremendously. It’s hard to express how grateful I am for this product, which has been working perfectly for nearly four weeks now.
Read More
