Last update
3/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Vitamin D* (as D3)
25 mcg (1,000 IU)
125%
Women's Probiotic BlendLactobacillus plantarumLactobacillus acidophilusLactobacillus paracaseiLactobacillus rhamnosusLactobacillus gasseriLactobacillus caseiLactobacillus acidophilus NCFM®Lactobacillus reuteriLactobacillus brevisLactobacillus bulgaricusLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
164 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Organic Pacran® Whole Cranberry (fruit)
500 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
439 mg
+
Top Medical Research Studies
9
We investigated the effects of Lactobacillus reuteri on bone health in menopausal mice. Our findings revealed that this probiotic significantly curtails bone loss linked to estrogen deficiency.
Specifically, L. reuteri treatment led to lower levels of bone resorption markers and reduced the factors that promote osteoclast formation, which are responsible for bone deterioration.
These results suggest that L. reuteri not only helps maintain bone density but also positively influences gut health during menopause, showcasing its potential as an accessible method for women to combat post-menopausal bone loss.
Specifically, L. reuteri treatment led to lower levels of bone resorption markers and reduced the factors that promote osteoclast formation, which are responsible for bone deterioration.
These results suggest that L. reuteri not only helps maintain bone density but also positively influences gut health during menopause, showcasing its potential as an accessible method for women to combat post-menopausal bone loss.
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8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
9
Probiotic may stabilize estrogen levels
We examined whether a probiotic containing the strain KABP052 could help stabilize estrogen levels in peri- and postmenopausal women. In a thorough randomized, double-blind study, we compared women taking the probiotic to those given a placebo.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Read More
Most Useful Reviews
7.5
Reduced UTIs
15 people found this helpful
I adore them! Since undergoing surgically induced menopause, I've been using Garden of Life vitamins and probiotics for over two years now. They help prevent recurring UTIs as long as I take them consistently. They're also more affordable on Amazon compared to my local Drug Emporium.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
- All Researches
9
This study explored how MENOLACTO, a form of lactobacillus acidophilus, can help women manage menopausal symptoms. We conducted a rigorous, randomized, double-blinded, placebo-controlled trial with women aged 40 to 60, measuring the effectiveness through various symptom scores and quality of life assessments.
After 12 weeks, we observed a significant decrease in total menopausal symptom scores compared to placebo. Participants also reported improvements across all quality of life metrics. However, we found no notable differences in hormone levels or endometrial thickness between the groups. Overall, MENOLACTO showed promise as a supportive option for alleviating menopause symptoms.
After 12 weeks, we observed a significant decrease in total menopausal symptom scores compared to placebo. Participants also reported improvements across all quality of life metrics. However, we found no notable differences in hormone levels or endometrial thickness between the groups. Overall, MENOLACTO showed promise as a supportive option for alleviating menopause symptoms.
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9
We explored how a combination of ultra-low-dose estriol and lactobacillus in vaginal tablets affects vaginal health in postmenopausal breast cancer survivors taking aromatase inhibitors. Over 28 days, participants showed notable improvements in vaginal microflora and reduced inflammatory markers.
Improvements included higher lactobacillary grades and lower incidences of aerobic vaginitis and leukocytes, which were significant (p < 0.001 for many observations). Although we saw a temporary increase in Candida colonization initially, it quickly returned to baseline. Overall, this combination appears effective and safe for managing severe vaginal issues in this population.
Improvements included higher lactobacillary grades and lower incidences of aerobic vaginitis and leukocytes, which were significant (p < 0.001 for many observations). Although we saw a temporary increase in Candida colonization initially, it quickly returned to baseline. Overall, this combination appears effective and safe for managing severe vaginal issues in this population.
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9
Lactobacillus and estriol resolved vaginal atrophy
We focused on how Lactobacillus acidophilus, combined with ultra-low-dose estriol, affects vaginal atrophy in postmenopausal women undergoing treatment for breast cancer.
In our study, 16 women used a daily vaginal tablet for 28 days and continued with a weekly maintenance schedule.
While estriol levels showed a small, temporary increase, estrogen levels did not rise significantly. Most importantly, vaginal atrophy improved for all participants, and they tolerated the treatment well.
In our study, 16 women used a daily vaginal tablet for 28 days and continued with a weekly maintenance schedule.
While estriol levels showed a small, temporary increase, estrogen levels did not rise significantly. Most importantly, vaginal atrophy improved for all participants, and they tolerated the treatment well.
Read More
9
We examined the effectiveness of an ultra-low-dose vaginal estriol combined with Lactobacillus acidophilus to treat vaginal atrophy in postmenopausal women. This well-structured double-blind, randomized study showed that after just 12 days of treatment, those using the combination saw a significant improvement in their Vaginal Maturation Index compared to those on a placebo.
Even in the long term, maintenance therapy proved effective in keeping symptoms at bay. Our findings indicate that this combination therapy can positively impact vaginal health during menopause, enhancing comfort and wellness.
Even in the long term, maintenance therapy proved effective in keeping symptoms at bay. Our findings indicate that this combination therapy can positively impact vaginal health during menopause, enhancing comfort and wellness.
Read More
9
Probiotic may stabilize estrogen levels
We examined whether a probiotic containing the strain KABP052 could help stabilize estrogen levels in peri- and postmenopausal women. In a thorough randomized, double-blind study, we compared women taking the probiotic to those given a placebo.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced UTIs
15 people found this helpful
I adore them! Since undergoing surgically induced menopause, I've been using Garden of Life vitamins and probiotics for over two years now. They help prevent recurring UTIs as long as I take them consistently. They're also more affordable on Amazon compared to my local Drug Emporium.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31. PubMed
- Binkley N, Sempos CT, Borchardt G, Larsen J, Stacey ML, et al. Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Osteoporos Int. 2025;36:255. 10.1007/s00198-024-07310-2
- Cocetta V, Zorzi M, Bejor S, Cesta MC, De Pizzol M, et al. Retrospective Analysis of the Effect of Postmenopausal Women Medications on SARS-CoV-2 Infection Progression. Life (Basel). 2024;14. 10.3390/life14091107
- Bowles SD, Jacques R, Hill TR, Eastell R, Walsh JS. Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients. 2024;16. 10.3390/nu16172888
- Korkmaz H, Pehlivanoğlu B. Is Vitamin D a Crucial Molecule for Musculoskeletal and Cardiovascular Systems in Postmenopausal Women?. Front Biosci (Landmark Ed). 2024;29:281. 10.31083/j.fbl2908281
- Rusu ME, Bigman G, Ryan AS, Popa DS. Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies. Nutrients. 2024;16. 10.3390/nu16142356
- Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, et al. Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency. Nutrients. 2024;16. 10.3390/nu16111754
- G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. 10.52225/narra.v4i1.452
- Joo NS, Shin SH, Kim KN, Lee SH, Jung S, et al. Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study. Nutrients. 2024;16. 10.3390/nu16081152
- Chiengthong K, Ruanphoo P, Chatsuwan T, Bunyavejchevin S. Effect of vaginal estrogen in postmenopausal women using vaginal pessary for pelvic organ prolapse treatment: a randomized controlled trial. Int Urogynecol J. 2022;33:1833. 10.1007/s00192-021-04821-y
- Lim EY, Lee SY, Shin HS, Lee J, Nam YD, et al. The Effect of YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. J Clin Med. 2020;9. 10.3390/jcm9072173
- Mueck AO, Ruan X, Prasauskas V, Grob P, Ortmann O. Treatment of vaginal atrophy with estriol and lactobacilli combination: a clinical review. Climacteric. 2018;21:140. 10.1080/13697137.2017.1421923
- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. 10.1007/s10096-015-2447-1
- Donders G, Neven P, Moegele M, Lintermans A, Bellen G, et al. Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor(®)) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study. Breast Cancer Res Treat. 2014;145:371. 10.1007/s10549-014-2930-x
- Jaisamrarn U, Triratanachat S, Chaikittisilpa S, Grob P, Prasauskas V, et al. Ultra-low-dose estriol and lactobacilli in the local treatment of postmenopausal vaginal atrophy. Climacteric. 2013;16:347. 10.3109/13697137.2013.769097
- Bhardwaj A, Sapra L, Madan D, Ahuja V, Sharma HP, et al. Gut-resident Tregs (GTregs) play a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions. J Leukoc Biol. 2025. 10.1093/jleuko/qiaf008
- Dabeer S, Tripathi AK, Weiss D, Vikulina T, Ofotokun I, et al. Combined Sequential Antiretroviral Therapy-Induced Immune Reconstitution Bone Loss and Estrogen Deficiency Bone Loss are Cumulative in Mice Models. J Infect Dis. 2024. 10.1093/infdis/jiae643
- Honda S, Tominaga Y, Espadaler-Mazo J, Huedo P, Aguiló M, et al. Supplementation with a Probiotic Formula Having β-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri- and Postmenopausal Women. J Med Food. 2024;27:720. 10.1089/jmf.2023.k.0320
- Vicariotto F, Malfa P, Viciani E, Dell'Atti F, Squarzanti DF, et al. Efficacy of PBS067, subsp. BL050, and LRH020 in the Amelioration of Vaginal Microbiota in Post-Menopausal Women: A Prospective Observational Clinical Trial. Nutrients. 2024;16. 10.3390/nu16030402
- Kwak YK, Daroczy K, Colque P, Kühn I, Möllby R, et al. Persistence of Lactobacilli in Postmenopausal Women - A Double-Blind, Randomized, Pilot Study. Gynecol Obstet Invest. 2017;82:144. 10.1159/000446946
- Bisanz JE, Seney S, McMillan A, Vongsa R, Koenig D, et al. A systems biology approach investigating the effect of probiotics on the vaginal microbiome and host responses in a double blind, placebo-controlled clinical trial of post-menopausal women. PLoS One. 2014;9:e104511. 10.1371/journal.pone.0104511
- Parma M, Dindelli M, Caputo L, Redaelli A, Quaranta L, et al. The role of vaginal Lactobacillus Rhamnosus (Normogin®) in preventing Bacterial Vaginosis in women with history of recurrences, undergoing surgical menopause: a prospective pilot study. Eur Rev Med Pharmacol Sci. 2013;17:1399. PubMed
- Petricevic L, Unger FM, Viernstein H, Kiss H. Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2008;141:54. 10.1016/j.ejogrb.2008.06.003
- Reid G, Burton J, Hammond JA, Bruce AW. Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli. J Med Food. 2004;7:223. PubMed
- Ribeiro JL, Santos TA, Garcia MT, Carvalho BFDC, Esteves JECS, et al. Heat-killed Limosilactobacillus reuteri ATCC PTA 6475 prevents bone loss in ovariectomized mice: A preliminary study. PLoS One. 2024;19:e0304358. 10.1371/journal.pone.0304358
- Rahmani D, Faal B, Zali H, Tackallou SH, Niknam Z. The beneficial effects of simultaneous supplementation of Lactobacillus reuteri and calcium fluoride nanoparticles on ovariectomy-induced osteoporosis. BMC Complement Med Ther. 2023;23:340. 10.1186/s12906-023-04167-6
- Sovijit WN, Sovijit WE, Pu S, Usuda K, Inoue R, et al. Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice. Neurosci Res. 2021;168:76. 10.1016/j.neures.2019.04.005
- Britton RA, Irwin R, Quach D, Schaefer L, Zhang J, et al. Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol. 2014;229:1822. 10.1002/jcp.24636
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