5/7/2025
Last update
5/7/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 45 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Vitamin D* (as D3)
25 mcg (1,000 IU)
125%
Women's Probiotic BlendLactobacillus plantarumLactobacillus acidophilusLactobacillus paracaseiLactobacillus rhamnosusLactobacillus gasseriLactobacillus caseiLactobacillus acidophilus NCFM®Lactobacillus reuteriLactobacillus brevisLactobacillus bulgaricusLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
164 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Organic Pacran® Whole Cranberry (fruit)
500 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
439 mg
+
Top Medical Research Studies
9
We examined the effect of lactic acid bacteria, particularly Lactobacillus gasseri, on the harmful yeast Candida albicans. Our study showed that the metabolites from L. gasseri effectively inhibit the yeast's ability to grow and form biofilms, crucial for its pathogenicity. The research also indicated that these beneficial bacteria can keep C. albicans in a less harmful state by downregulating important genes responsible for its virulence. Overall, L. gasseri appears to be a promising option in the fight against vaginal yeast infections.
Read More
9.5
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
Read More
9
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Read More
Most Useful Reviews
7.5
Big improvement noted
5 people found this helpful
I was struggling with repeated UTIs and yeast infections. This product has helped, as I have been using it for about six weeks and noticed a significant improvement, including in my digestive function.
Read More
9
Most effective probiotic
3 people found this helpful
I take these daily, and compared to other UTI probiotics, I have found them to be the most effective in keeping UTIs and yeast infections away.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 45 Researches
8.2
- All Researches
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9.5
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
Read More
9
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Read More
9
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Big improvement noted
5 people found this helpful
I was struggling with repeated UTIs and yeast infections. This product has helped, as I have been using it for about six weeks and noticed a significant improvement, including in my digestive function.
Read More
9
Most effective probiotic
3 people found this helpful
I take these daily, and compared to other UTI probiotics, I have found them to be the most effective in keeping UTIs and yeast infections away.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Guimarães de Matos G, Barroso de Figueiredo AM, Diniz Gonçalves PH, Luiz de Lima Silva L, Bastista AC, et al. Paracoccidioidesbrasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro. Microb Pathog. 2021;154:104864. 10.1016/j.micpath.2021.104864
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- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. 10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. 10.1128/spectrum.02696-21
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. 10.3906/sag-1709-143
- Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. 10.1007/s00404-016-4235-2
- Matsubara VH, Wang Y, Bandara HMHN, Mayer MPA, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100:6415. 10.1007/s00253-016-7527-3
- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. 10.1007/s10096-015-2447-1
- Vilela SF, Barbosa JO, Rossoni RD, Santos JD, Prata MC, et al. Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella. Virulence. 2015;6:29. 10.4161/21505594.2014.981486
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7:38. 10.1007/s12602-014-9176-0
- Ishikawa KH, Mayer MP, Miyazima TY, Matsubara VH, Silva EG, et al. A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015;24:194. 10.1111/jopr.12198
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. 10.1007/s00284-024-03800-y
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. 10.1038/s41598-020-74027-7
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. 10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. 10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. 10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. 10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. 10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. 10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. 10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. 10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. 10.1016/j.micpath.2017.08.006
- Boahen A, Chew SY, Neela VK, Than LTL. Limosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis. Probiotics Antimicrob Proteins. 2023;15:1681. 10.1007/s12602-023-10050-0
- Kraft-Bodi E, Jørgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015;94:181S. 10.1177/0022034515595950
- Chew SY, Cheah YK, Seow HF, Sandai D, Than LT. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118:1180. 10.1111/jam.12772
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- Martinez RC, Franceschini SA, Patta MC, Quintana SM, Candido RC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl Microbiol. 2009;48:269. 10.1111/j.1472-765X.2008.02477.x
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- Rodríguez-Arias RJ, Guachi-Álvarez BO, Montalvo-Vivero DE, Machado A. Lactobacilli displacement and Candida albicans inhibition on initial adhesion assays: a probiotic analysis. BMC Res Notes. 2022;15:239. 10.1186/s13104-022-06114-z
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- Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K. Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats. Histol Histopathol. 2016;31:689. 10.14670/HH-11-710
- Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, et al. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity. PLoS One. 2015;10:e0131220. 10.1371/journal.pone.0131220
- Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, et al. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93:884.
- Kang CH, Han SH, Kim Y, Paek NS, So JS. In Vitro Probiotic Properties of Lactobacillus salivarius MG242 Isolated from Human Vagina. Probiotics Antimicrob Proteins. 2018;10:343. 10.1007/s12602-017-9323-5
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