' 
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
No significant impact evaluated
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
Read More
9.5
Vitamin B12 relieves depressive symptoms
A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
High relevance to treatment effectiveness
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
Vitamin B12's role in stress resilience
Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience.
High relevance for mood disorders
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
Most Useful Reviews
8.8
Improved condition
Let me go; I have been taking it for six months. The blood test didn’t require re-examination the first time, and my depression has improved. Iron is truly important.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7
- All Researches
9.5
Vitamin B12 relieves depressive symptoms
A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
High relevance to treatment effectiveness
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
Vitamin B12's role in stress resilience
Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience.
High relevance for mood disorders
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
9
Vitamin B12 deficiency linked to MDD
Vitamin B12 and homocysteine in patients with major depressive disorder.
Study directly assesses vitamin B12 effects
We explored the relationship between vitamin B12 levels and major depressive disorder (MDD) by examining serum vitamin B12, homocysteine (Hcy), and blood profiles in 59 patients diagnosed with MDD. The severity of depression was evaluated using the HAM-D scale, which allows for a clear understanding of how vitamin B12 might be linked to depressive symptoms.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Read More
8
Folate's role in depression treatment
Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
High relevance to topic
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
8
Chlorzoxazone and folate improve mood
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Folate's role in depression unclear.
We explored how a combination of chlorzoxazone, a medication that activates potassium channels, and folic acid affects anxiety and depression in a mouse model of spinocerebellar ataxia type 3 (SCA3). Specifically, we investigated whether this combination could improve mood and cognitive function in SCA3-84Q mice, which are known to exhibit symptoms linked to cerebellar cognitive affective syndrome.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved condition
Let me go; I have been taking it for six months. The blood test didn’t require re-examination the first time, and my depression has improved. Iron is truly important.
