5/30/2025
Last update
5/30/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Read More
9
We explored the effectiveness of echinochrome A (Ech A) in treating dry mouth, a common issue during menopause, using ovariectomized rats to simulate this condition. The study involved different groups of rats, including those treated with Ech A.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
Read More
8
We explored how iron treatments can address salivary gland issues that often arise after menopause. By observing ovariectomized rats, we found that using deferoxamine and ferrostatin-1 helped reduce inflammation and reverse some damage to the salivary glands.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Read More
Most Useful Reviews
9
Anemia alleviated
This version of iron has been excellent for those with sensitive stomachs. After being diagnosed as anaemic, I've taken it for years and have not been anaemic since. It digests easily, with no stomach issues, and I will continue using it even though I'm now in menopause and don't experience the monthly issues that caused my anaemia.
Read More
7.5
Fatigue improvement
My physical fatigue has improved! Since entering menopause, my lethargy worsened, despite trying herbal supplements and Chinese medicine. I suspected I lacked basic nutrients, so I tried this iron supplement. Since starting it, I've felt less heavy and lethargic, and my fatigue has improved since premenopause. I’ve always had a weak constitution, so while it's hard to judge supplements, I’m pleased this one is effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.1
- All Researches
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Read More
9
We explored the effectiveness of echinochrome A (Ech A) in treating dry mouth, a common issue during menopause, using ovariectomized rats to simulate this condition. The study involved different groups of rats, including those treated with Ech A.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
Read More
9
Vitamin B12 may aid menopause relief
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
Read More
9
vitamin B12 aids menopause dry eye
We explored the impact of vitamin B12, alongside hyaluronic acid and electrolytes, on menopausal women suffering from moderate dry eye disease. In this study, thirty female participants, aged between 45 to 65, received drops that contained 0.3% sodium hyaluronate, vitamin B12, and other electrolytes for a duration of 30 days.
Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.
The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.
The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Read More
8
We looked into how iron levels affect cognitive performance in women experiencing menopause. Our research involved non-anemic women who had either low or normal iron levels for their age and background. They provided blood samples, underwent MRI scans to assess brain iron levels, and participated in cognitive tasks while we recorded their brain activity through EEG.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Anemia alleviated
This version of iron has been excellent for those with sensitive stomachs. After being diagnosed as anaemic, I've taken it for years and have not been anaemic since. It digests easily, with no stomach issues, and I will continue using it even though I'm now in menopause and don't experience the monthly issues that caused my anaemia.
Read More
7.5
Fatigue improvement
My physical fatigue has improved! Since entering menopause, my lethargy worsened, despite trying herbal supplements and Chinese medicine. I suspected I lacked basic nutrients, so I tried this iron supplement. Since starting it, I've felt less heavy and lethargic, and my fatigue has improved since premenopause. I’ve always had a weak constitution, so while it's hard to judge supplements, I’m pleased this one is effective.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Barnett AL, Wenger MJ, Miles P, Wu D, Isingizwe ZR, et al. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. medRxiv. 2025. 10.1101/2025.01.28.25321122
- Honari N, Sayadi M, Sajjadi SM, Solhjoo S, Sarab GA. Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation. Sci Rep. 2025;15:2449. 10.1038/s41598-025-86333-z
- Barnett AL, Wenger MJ, Miles P, Wu D, Isingizwe ZR, et al. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. Nutrients. 2025;17. 10.3390/nu17050745
- Kastrati L, Groothof D, Quezada-Pinedo HG, Raeisi-Dehkordi H, Bally L, et al. Utility of iron biomarkers in differentiating menopausal status: Findings from CoLaus and PREVEND. Maturitas. 2024;179:107872. 10.1016/j.maturitas.2023.107872
- Xu T, Cai J, Wang L, Xu L, Zhao H, et al. Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition. Elife. 2023;12. 10.7554/eLife.80494
- Cheon YI, Kim JM, Shin SC, Kim HS, Lee JC, et al. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. Aging (Albany NY). 2023;15:2418. 10.18632/aging.204641
- Kim JM, Shin SC, Cheon YI, Kim HS, Park GC, et al. Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats. Mar Drugs. 2022;20. 10.3390/md20120729
- Faramarzi M, Shirmohammadi A, Khorramdel A, Sadighi M, Bargahi E. Effect of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women with chronic periodontitis. J Dent Res Dent Clin Dent Prospects. 2021;15:178. 10.34172/joddd.2021.030
- Liu LL, Liu GW, Liu H, Zhao K, Xu YJ. Iron accumulation deteriorated bone loss in estrogen-deficient rats. J Orthop Surg Res. 2021;16:525. 10.1186/s13018-021-02663-4
- Asadi M, Riazi H, Abbasinazari M, Majd HA, Montazeri A. Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial. J Sex Med. 2023;20:1180. 10.1093/jsxmed/qdad086
- Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. 10.1016/j.jtemb.2022.126942
- Ewies A, Ahmed I, Al-Azzawi F, Pitkin J, Gupta P, et al. Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial. BJOG. 2021;128:2024. 10.1111/1471-0528.16739
- Palacios S, Mustata C, Rizo JM, Regidor PA. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. Eur Rev Med Pharmacol Sci. 2023;27:8180. 10.26355/eurrev_202309_33578
- De-Hita-Cantalejo C, Sánchez-González MC, Silva-Viguera C, GarcÃa-Romera MC, Feria-Mantero R, et al. Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease. Graefes Arch Clin Exp Ophthalmol. 2022;260:529. 10.1007/s00417-021-05415-6
