5/30/2025
Last update
5/30/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
8
We examined the link between iron deficiency anemia and migraines to understand how iron levels affect migraine symptoms. Our research confirmed that individuals suffering from migraines, especially women, tend to have lower iron levels. This suggests a significant relationship where low iron may worsen migraine frequency and intensity.
Through our literature review, we discovered that iron supplementation has been beneficial for some migraine sufferers, particularly those with diagnosed iron deficiency anemia. By increasing iron levels, we noted improvements in migraine symptoms, making it a potential treatment strategy worth considering.
However, we also highlighted that while iron supplementation shows promise, it’s essential to approach treatment carefully. Further research is necessary to determine the long-term effects and to establish guidelines on its use, minimizing any risks of iron overload. Overall, we advocate for incorporating nutritional evaluations into migraine management strategies to enhance patient outcomes effectively.
Through our literature review, we discovered that iron supplementation has been beneficial for some migraine sufferers, particularly those with diagnosed iron deficiency anemia. By increasing iron levels, we noted improvements in migraine symptoms, making it a potential treatment strategy worth considering.
However, we also highlighted that while iron supplementation shows promise, it’s essential to approach treatment carefully. Further research is necessary to determine the long-term effects and to establish guidelines on its use, minimizing any risks of iron overload. Overall, we advocate for incorporating nutritional evaluations into migraine management strategies to enhance patient outcomes effectively.
Read More
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
Most Useful Reviews
9
Life-changing iron supplement
153 people found this helpful
This product truly saved me. After struggling with anaemia and constant migraines, I began taking these supplements. Instead of stomach issues, I regained energy and clarity. I finished a whole bottle — a first for me! I won’t use any other iron supplement again; this one is exceptional.
Read More
9
Improved energy levels
7 people found this helpful
I rarely write reviews, but this product has truly saved me. After struggling with anaemia for 20 years, I started taking these supplements two months ago when I was utterly exhausted, lightheaded, and suffering from constant migraines. Remarkably, my stomach didn’t react negatively. Within a week, my energy surged, and the brain fog lifted. For the first time, I finished a bottle without issue. I won't use any other iron supplement in future; this product is simply fantastic.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.9
- All Researches
9
We conducted a comprehensive study to explore the effectiveness of vitamin B supplementation, including B12, in reducing migraine occurrences, particularly in women diagnosed with migraines accompanied by aura. Over a period of six months, we administered daily vitamin B supplements to a group of 206 participants, comparing their results to those taking a placebo.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Read More
9
We conducted a thorough investigation into the effects of vitamin B12 supplementation on individuals suffering from migraines, specifically those with aura. Our study focused on how daily doses of a vitamin combination, including B12, influenced migraine symptoms and disability levels over six months. We employed a randomized, double-blind, placebo-controlled trial to ensure the reliability of our findings.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Read More
8
We examined the link between iron deficiency anemia and migraines to understand how iron levels affect migraine symptoms. Our research confirmed that individuals suffering from migraines, especially women, tend to have lower iron levels. This suggests a significant relationship where low iron may worsen migraine frequency and intensity.
Through our literature review, we discovered that iron supplementation has been beneficial for some migraine sufferers, particularly those with diagnosed iron deficiency anemia. By increasing iron levels, we noted improvements in migraine symptoms, making it a potential treatment strategy worth considering.
However, we also highlighted that while iron supplementation shows promise, it’s essential to approach treatment carefully. Further research is necessary to determine the long-term effects and to establish guidelines on its use, minimizing any risks of iron overload. Overall, we advocate for incorporating nutritional evaluations into migraine management strategies to enhance patient outcomes effectively.
Through our literature review, we discovered that iron supplementation has been beneficial for some migraine sufferers, particularly those with diagnosed iron deficiency anemia. By increasing iron levels, we noted improvements in migraine symptoms, making it a potential treatment strategy worth considering.
However, we also highlighted that while iron supplementation shows promise, it’s essential to approach treatment carefully. Further research is necessary to determine the long-term effects and to establish guidelines on its use, minimizing any risks of iron overload. Overall, we advocate for incorporating nutritional evaluations into migraine management strategies to enhance patient outcomes effectively.
Read More
8
We investigated how dietary iron intake and serum ferritin levels relate to severe headaches and migraines in American adults. This research drew on data from 7,880 adults, aged 20 and above, collected between 1999 and 2004 as part of the National Health and Nutrition Examination Surveys (NHANES).
Our findings were particularly interesting for women aged 20 to 50 years, who generally consumed less iron than recommended. We observed that higher dietary iron intake in this group was linked to a lower occurrence of severe headaches or migraines. On the other hand, for women over 50, we discovered that greater serum ferritin levels—essentially a marker of iron storage—seemed to be associated with fewer migraine incidents.
However, for men, we found no significant connection between dietary iron and migraines. This suggests that the link between iron and migraines might be influenced by different biological factors, particularly hormonal changes in women related to menstrual cycles.
Overall, our results highlight the importance of proper dietary iron intake for women, especially those in their childbearing years, as it may help prevent severe headaches. For older women, maintaining higher ferritin levels could provide some protection against migraines as well.
Our findings were particularly interesting for women aged 20 to 50 years, who generally consumed less iron than recommended. We observed that higher dietary iron intake in this group was linked to a lower occurrence of severe headaches or migraines. On the other hand, for women over 50, we discovered that greater serum ferritin levels—essentially a marker of iron storage—seemed to be associated with fewer migraine incidents.
However, for men, we found no significant connection between dietary iron and migraines. This suggests that the link between iron and migraines might be influenced by different biological factors, particularly hormonal changes in women related to menstrual cycles.
Overall, our results highlight the importance of proper dietary iron intake for women, especially those in their childbearing years, as it may help prevent severe headaches. For older women, maintaining higher ferritin levels could provide some protection against migraines as well.
Read More
8
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing iron supplement
153 people found this helpful
This product truly saved me. After struggling with anaemia and constant migraines, I began taking these supplements. Instead of stomach issues, I regained energy and clarity. I finished a whole bottle — a first for me! I won’t use any other iron supplement again; this one is exceptional.
Read More
9
Improved energy levels
7 people found this helpful
I rarely write reviews, but this product has truly saved me. After struggling with anaemia for 20 years, I started taking these supplements two months ago when I was utterly exhausted, lightheaded, and suffering from constant migraines. Remarkably, my stomach didn’t react negatively. Within a week, my energy surged, and the brain fog lifted. For the first time, I finished a bottle without issue. I won't use any other iron supplement in future; this product is simply fantastic.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Birkl C, Filippi V, Steiger R, Frank F, Magnesius S, et al. Dynamic fluctuations in brain iron content during migraine attacks: insights from relaxometry and diffusion tensor imaging. Front Neurol. 2024;15:1422313. 10.3389/fneur.2024.1422313
- Al-Qassab ZM, Ahmed O, Kannan V, Ullah N, Geddada S, et al. Iron Deficiency Anemia and Migraine: A Literature Review of the Prevalence, Pathophysiology, and Therapeutic Potential. Cureus. 2024;16:e69652. 10.7759/cureus.69652
- Meng SH, Zhou HB, Li X, Wang MX, Kang LX, et al. Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine. Front Nutr. 2021;8:685564. 10.3389/fnut.2021.685564
- Tayyebi A, Poursadeghfard M, Nazeri M, Pousadeghfard T. Is There Any Correlation between Migraine Attacks and Iron Deficiency Anemia? A Case-Control Study. Int J Hematol Oncol Stem Cell Res. 2019;13:164.
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. 10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. 10.1590/0004-282X-ANP-2021-0192
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1Â mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
