We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
Most Useful Reviews
9
Works great against flu
I liked it; it’s excellent and works wonderfully against influenza, although the pill is large. I highly recommend it.
Read More
9
Noticeable results
Vitamin C aids my health, providing energy and helping significantly during colds and flu. Thank you for a good product; the results are genuinely noticeable, and the packaging is convenient.
Read More
7.5
Great quality ingredients
1 people found this helpful
The quality and ingredients are excellent. Thankfully, it did not upset my reflux. It’s very effective and tasteless, aiding iron absorption on an empty stomach. The quantity is fantastic for the price.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Works great against flu
I liked it; it’s excellent and works wonderfully against influenza, although the pill is large. I highly recommend it.
Read More
9
Noticeable results
Vitamin C aids my health, providing energy and helping significantly during colds and flu. Thank you for a good product; the results are genuinely noticeable, and the packaging is convenient.
Read More
7.5
Great quality ingredients
1 people found this helpful
The quality and ingredients are excellent. Thankfully, it did not upset my reflux. It’s very effective and tasteless, aiding iron absorption on an empty stomach. The quantity is fantastic for the price.
Read More
7.5
Best for flu
I regard Vitamin C as the best remedy for colds and flu, as well as for sore throat.
Read More
6
Effective against flu
Swallowing it’s a bit large and difficult, but it appears effective for cold and flu susceptibility with the ever-changing weather.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Vitamin C is often touted as a remedy for the common cold and flu, but the scientific evidence supporting its effectiveness is mixed. Some studies suggest that taking Vitamin C may reduce the duration and severity of flu-like symptoms, particularly in people who are under physical stress, such as athletes. However, for the average person, the benefits of high-dose Vitamin C in preventing or treating the flu are not conclusively supported by research. It's generally recommended to maintain an adequate intake of Vitamin C as part of a balanced diet, but relying solely on supplements is not a guaranteed method for preventing the flu.
Incorporating Vitamin C-rich foods, such as citrus fruits, strawberries, and bell peppers, can support your immune system and overall health. It's important to note that while Vitamin C can contribute to your well-being, it should not replace conventional flu prevention measures, like vaccination and good hygiene practices. If you're already experiencing flu symptoms, it's advisable to consult with a healthcare professional for appropriate treatment options.
Based on user reviews, the timeline for seeing results from this supplement when combating flu symptoms can vary. Many users report that they experience noticeable improvements soon after starting the supplement, with several indicating improvements within a few days of use. For instance, one user mentioned that the results are genuinely noticeable, particularly during cold and flu seasons Read Review. Another user emphasized its effectiveness against colds and flu, suggesting that this supplement can significantly aid in susceptibility reduction Read Review.
However, individual experiences may vary based on factors such as overall health, dosage, and regularity in taking the supplement. While some users found it effective immediately, others might take slightly longer to feel the full effects. Therefore, it's generally advisable to be patient and consistent in taking the supplement for the best results.
Vitamin C has garnered scientific attention for its potential role in managing flu symptoms and enhancing immune response. Research indicates that vitamin C supplementation may reduce the incidence of acute respiratory infections, including influenza, by about 4% and can also shorten the duration of flu symptoms by approximately 9% [1]. Furthermore, vitamin C has shown promise in studies examining its effects on immune cell activation, particularly in combination with other substances like red ginseng, which collectively enhance the immune response and reduce lung inflammation during flu infections [3].
Moreover, vitamin C may have direct effects on influenza virus activity, as studies suggest it could inhibit neuraminidase activity—a critical component of the virus's life cycle—though its effectiveness is considered moderate compared to standard antiviral treatments [2]. Additionally, research has explored innovative compounds that combine vitamin C with triterpenes, which exhibit significant anti-influenza properties [4]. Overall, while vitamin C shows promise in the context of flu prevention and management, it is essential to view it as part of a broader strategy, rather than a sole solution.
Based on user reviews, many individuals have reported experiencing significant improvements in symptoms when using Vitamin C as a remedy for colds and the flu. One user praised its effectiveness against influenza, stating that it "works wonderfully" and highly recommended it for those seeking relief Read Review. Another user highlighted the noticeable benefits they felt, noting it provided energy and support during cold and flu episodes, thereby enhancing their overall health Read Review.
Furthermore, some users consider Vitamin C essential for maintaining a robust immune system and preventing common illnesses, indicating it plays a crucial role in their health routines Read Review. However, it's important to acknowledge that individual results do vary, as personal health and adherence to usage can influence effectiveness. While several users found significant relief, experiences may differ based on various factors. Therefore, consistent use is often recommended for optimal results.
Users have reported positive experiences when combining this supplement with other remedies for flu management. Many highlight the effectiveness of Vitamin C in conjunction with their flu remedies, noting that it provides significant support during cold and flu episodes. One user stated that they regard Vitamin C as the best remedy for colds and flu, emphasizing its direct benefits Read Review. Furthermore, another user mentioned that it aids in maintaining a robust immune system, which is vital for warding off illnesses like the flu Read Review.
Additionally, some reviews imply that combining this supplement with Vitamin C can amplify its effectiveness. Users have noted that they experience noticeable improvements in energy and overall health during flu seasons when they use this supplement alongside other vitamins Read Review. Therefore, the consensus among users is that while this supplement works well on its own, integrating it with Vitamin C and maintaining a consistent regimen might yield even better results in flu management.
When it comes to using Vitamin C for treating the flu, research suggests that optimal dosages can significantly impact outcomes. One study highlighted that administering Vitamin C at doses of 125 mg/kg to 250 mg/kg in stressed mice led to a notable reduction in severe pneumonia symptoms caused by the influenza virus. This dosage seemed effective in modulating immune responses and reducing susceptibility to infections [5].
While higher doses in specific contexts showed promising results, the overall consensus is that Vitamin C may not be a standalone solution for combatting flu symptoms. Other studies indicate that Vitamin C can help shorten flu symptom durations by about 9% and can potentially reduce the likelihood of acute respiratory infections by approximately 4% when incorporated into a comprehensive flu management approach [1]. Therefore, while optimal dosages might vary, it’s essential to consider Vitamin C as part of a broader strategy that includes other preventive measures and treatments during flu season.
9
Noticeable results
Vitamin C aids my health, providing energy and helping significantly during colds and flu. Thank you for a good product; the results are genuinely noticeable, and the packaging is convenient.
6
Effective against flu
Swallowing it’s a bit large and difficult, but it appears effective for cold and flu susceptibility with the ever-changing weather.
9
Works great against flu
I liked it; it’s excellent and works wonderfully against influenza, although the pill is large. I highly recommend it.
8
Supports immune system
This is essential for keeping the immune system strong and warding off common colds and flu.
7.5
Best for flu
I regard Vitamin C as the best remedy for colds and flu, as well as for sore throat.
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
References
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. 10.3390/molecules25184248
Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. 10.1111/jphp.12529
Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. 10.1016/j.ejmech.2016.01.005
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. 10.1155/2015/675149