5/5/2025
Last update
5/5/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 80 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Replenish BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221),Lactobacillus paracasei (SD-5218), Bifidobacterium lactis (SD-5220),Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk)Concentrate, ^Eastern European Wild Kefir Culture containingBifidobacterium lactis, Bifidobacterium longum, Lactobacillusacidophilus, Lactobacillus brevis, Lactobacillus bulgaricus,Lactobacillus casei, Lactobacillus fermentum, Lactobacillushelveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum,Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris,Streptococcus thermophilus, Lactobacillus kefir, Lactobacillusparakefir, Lactobacillus plantarum, Lactococcus lactis biovardiacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides,Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromycesmarxianus, Brettanomyces anomalus, Debaryomyces hansenii,Saccharomyces unisporus, Saccharomyces turicensis,Saccharomyces cerevisiae, Saccharomyces exiguus,Torulaspora delbrueckii
100 Billion CFU¹
+
Protein-Digesting Enzyme BlendProtease, Acid Protease, Protease S
50 mg
+
Eastern European Raw Fruit and Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+
Top Medical Research Studies
8
We investigated the impact of a probiotic ice cream containing engineered bacteria on pollen allergies in mice. After sensitizing the mice, we treated them with this unique ice cream for four weeks. The results were promising! The ice cream significantly lowered serum IgE levels, which are linked to allergic reactions. Additionally, beneficial cytokines increased while the levels of a harmful cytokine decreased. Overall, our findings suggest that this probiotic ice cream could improve allergy responses, particularly with Th1 and Treg involvement.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
Most Useful Reviews
9
Immune response boosted
9 people found this helpful
After two decades of using probiotics and fermented foods, I've finally experienced a good immune response with these. I had food allergies, but after using these for three weeks, my sensitivity has improved, and my nails are stronger. Garden of Life truly delivers quality!
Read More
9
Best probiotics ever
7 people found this helpful
I've struggled with food allergies and IBS for over a decade, trying many probiotics. These are the best by far! They relieve stomach pain and help with frequent bathroom trips. While they are expensive, they're worth it. Just ensure they remain cold during shipping.
Read More
0
Allergy concern
1 people found this helpful
I adore Garden of Life products, yet I am allergic to something in this one. The product appeared fine, but my allergy responses emerged shortly after I began taking it. I selected this due to its variety of probiotics. Sadly, it's not suitable for me. I'm returning to the Garden of Life Doctor Formulated Once Daily Women's. I'm confident it's an excellent product for those without numerous allergies.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 80 Researches
8.2
- All Researches
9.5
We sought to understand if Bifiform Kids, a probiotic, could help prevent respiratory infections in children with recurrent infections and gastrointestinal allergy symptoms. In our controlled trial with 92 children aged 4 to 5, those taking the probiotic showed a significant 3-fold reduction in respiratory infections compared to the control group.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We investigated the effects of Lactobacillus acidophilus on allergies, particularly its peptidoglycan derived from dairy. In a mouse model of β-lactoglobulin allergy, we discovered that this peptidoglycan helped lower IgE production and promoted a healthier immune response. It also appeared to influence specific immune signaling pathways that help manage allergic reactions.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
Read More
9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
9
Lactobacillus acidophilus may reduce allergies
Our study assessed how Lactobacillus acidophilus in probiotic Dahi affects allergies, particularly cow milk allergy in mice. Mice were given two types of probiotic Dahi before being exposed to whey proteins.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immune response boosted
9 people found this helpful
After two decades of using probiotics and fermented foods, I've finally experienced a good immune response with these. I had food allergies, but after using these for three weeks, my sensitivity has improved, and my nails are stronger. Garden of Life truly delivers quality!
Read More
9
Best probiotics ever
7 people found this helpful
I've struggled with food allergies and IBS for over a decade, trying many probiotics. These are the best by far! They relieve stomach pain and help with frequent bathroom trips. While they are expensive, they're worth it. Just ensure they remain cold during shipping.
Read More
0
Allergy concern
1 people found this helpful
I adore Garden of Life products, yet I am allergic to something in this one. The product appeared fine, but my allergy responses emerged shortly after I began taking it. I selected this due to its variety of probiotics. Sadly, it's not suitable for me. I'm returning to the Garden of Life Doctor Formulated Once Daily Women's. I'm confident it's an excellent product for those without numerous allergies.
Read More
Frequently Asked Questions
References
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- Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49:46. 10.1093/ced/llad318
- Li A, Yang J, Zhang C, Chi H, Zhang C, et al. Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a. J Food Biochem. 2021;45:e13662. 10.1111/jfbc.13662
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- Xu H, Duan X, Wang Y, Geng W. Amelioration Effect of ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB/c Mice. Foods. 2024;14. 10.3390/foods14010016
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- Xue J, Liu Z, Xie B, Dong R, Wu J, et al. Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy. Inflamm Res. 2024;73:1919. 10.1007/s00011-024-01940-2
- Puisto R, Gómez-Gallego C, Collado MC, Turta O, Isolauri E, et al. The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Neonatology. 2025;122:84. 10.1159/000540075
- Uberos J, Garcia-Cuesta A, Carrasco-Solis M, Ruiz-López A, Fernandez-Marı N E, et al. Lacticaseibacillus rhamnosus and breastmilk are associated with a decreased risk of atopic dermatitis in very low birth weight premature infants. Benef Microbes. 2023;14:433. 10.1163/18762891-20220144
- Shi J, Dong P, Liu C, Xu Y, Zheng M, et al. Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism. Food Funct. 2023;14:10784. 10.1039/d3fo03321j
- Li L, Wen X, Gong Y, Chen Y, Xu J, et al. HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis. Front Microbiol. 2023;14:1202858. 10.3389/fmicb.2023.1202858
- Vasconcelos JA, Mota AS, Olímpio F, Rosa PC, Damaceno-Rodrigues N, et al. Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome. Probiotics Antimicrob Proteins. 2025;17:588. 10.1007/s12602-023-10167-2
- Tan Lim CSC, Sajo MEJV, Orteza KEMP, Fernandez PBA, Vila MJC. Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis. Pediatr Allergy Immunol. 2023;34:e14022. 10.1111/pai.14022
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. 10.1111/pai.14004
- Hou Y, Zheng S, Zou F, Wang D, Da H, et al. Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. Immunobiology. 2023;228:152712. 10.1016/j.imbio.2023.152712
- Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. 10.33029/0042-8833-2023-92-3-79-86
- Lee JY, Park JY, Jeong Y, Kang CH. Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474. J Microbiol Biotechnol. 2023;33:1039. 10.4014/jmb.2301.01028
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- Feíto-Rodríguez M, Ramírez-Boscà A, Vidal-Asensi S, Fernández-Nieto D, Ros-Cervera G, et al. Randomized double-blind placebo-controlled clinical trial to evaluate the effect of a mixture of probiotic strains on symptom severity and use of corticosteroids in children and adolescents with atopic dermatitis. Clin Exp Dermatol. 2023;48:495. 10.1093/ced/llad007
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- Santos SS, Miranda VC, Trindade LM, Cardoso VN, Reis DC, et al. Bifidobacterium longum subsp. longum 5 Attenuates Signs of Inflammation in a Murine Model of Food Allergy. Probiotics Antimicrob Proteins. 2023;15:63. 10.1007/s12602-021-09846-9
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- Tan-Lim CSC, Esteban-Ipac NAR, Recto MST, Castor MAR, Casis-Hao RJ, et al. Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:1255. 10.1111/pai.13514
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- Di Marzio L, Centi C, Cinque B, Masci S, Giuliani M, et al. Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. Exp Dermatol. 2003;12:615.
- Sandy CM, Guimarães CC, Fonseca VMB, Nicoli JR, Martins FS, et al. Perinatal administration of Saccharomyces cerevisiae UFMG A-905 prevents asthma development in the offspring of mice. Benef Microbes. 2024;16:125. 10.1163/18762891-bja00044
- Singh RG, Garcia-Campayo V, Green JB, Paton N, Saunders JD, et al. Efficacy of a yeast postbiotic on cold/flu symptoms in healthy children: A randomized-controlled trial. Pediatr Res. 2024;96:1739. 10.1038/s41390-024-03331-z
- Calazans APCT, Milani TMS, Prata AS, Clerici MTPS, Nicoli JR, et al. A Functional Bread Fermented with UFMG A-905 Prevents Allergic Asthma in Mice. Curr Dev Nutr. 2024;8:102142. 10.1016/j.cdnut.2024.102142
- Lee MF, Chen YH, Chiang CH, Wu CS, Li MH, et al. Oral Administration of Expressing Mite and Cockroach Major Allergens Alleviates Progression of Atopic March in a Mouse Model. Allergy Asthma Immunol Res. 2024;16:520. 10.4168/aair.2024.16.5.520
- Nakagawa R, Gu W, Mizobuchi H, Kodera S, Takano T, et al. subsp. YRC3780 modifies function of mesenteric lymph node dendritic cells to modulate the balance of T cell differentiation inducing regulatory T cells. Front Immunol. 2024;15:1395380. 10.3389/fimmu.2024.1395380
- Lee MF, Wang NM, Chen YH, Wu CS, Lee MH, et al. An atopic dermatitis-like murine model by skin-brushed cockroach Per a 2 and oral tolerance induction by Lactococcus lactis-derived Per a 2. PLoS One. 2023;18:e0291162. 10.1371/journal.pone.0291162
- Baek J, Kim JH, Kim W. Potential Anti-Allergy and Immunomodulatory Properties of LB 1022 Observed In Vitro and in an Atopic Dermatitis Mouse Model. J Microbiol Biotechnol. 2023;33:823. 10.4014/jmb.2301.01019
- Lee DH, Park HK, Lee HR, Sohn H, Sim S, et al. Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma. Clin Transl Allergy. 2022;12:e12138. 10.1002/clt2.12138
- Lee MF, Chiang CH, Lin SJ, Wu CS, Chen YH. Effectiveness and safety of oral lactococci-based vaccine encoding triple common allergens to prevent airway allergy in mice. PLoS One. 2021;16:e0261333. 10.1371/journal.pone.0261333
- El Mecherfi KE, Lupi R, Cherkaoui M, Albuquerque MAC, Todorov SD, et al. Fermentation of Gluten by Lactococcus lactis LLGKC18 Reduces its Antigenicity and Allergenicity. Probiotics Antimicrob Proteins. 2022;14:779. 10.1007/s12602-021-09808-1
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