Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.1
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
8
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
9
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
Most Useful Reviews
0
Causes diarrhoea
6 people found this helpful
I ordered several products based on YouTube recommendations, including Kalmac, which has fewer ingredients. However, I've experienced diarrhoea for several days now, which is rather painful, something I’ve never encountered with nutrients before.
Read More
8
No diarrhoea effects
No aftertaste and gentle on the gut. I recently ordered Garden of Life Raw Calcium and began taking it two days ago. It's of high quality, easy on my digestion, and seems to improve my sleep. Previous calcium supplements caused diarrhoea, but so far, this one hasn't. I prefer taking two capsules daily, as the recommended four seems excessive. I'm grateful to iHerb for their timely delivery.
Read More
2
Ongoing diarrhoea
This product does not suit me at all. Originally, I took four pills but realised that it exceeded the recommended daily intake, so I reduced it to two after meals. Unfortunately, I still suffer from diarrhoea and stomach issues on the days I consume it. I think I'd need to reduce the amount further to use it long-term.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
9
We conducted a study to assess the effectiveness of magnesium in treating diarrhea, particularly focusing on its role in extracts from (Wall.) leaves. To evaluate this, we utilized several tests that mimic diarrhea conditions. Our findings showed that while magnesium was mentioned in connection with the extracts, it was administered alongside other treatments. This means we're not entirely sure how much of the anti-diarrheal effect was due to magnesium itself.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
Read More
8
We investigated how extracts from light, medium, and dark roasted coffee beans affect contractions in the ileum, which is part of the intestine. The aim was to see if these coffee extracts could help manage gastrointestinal motility disorders like diarrhea.
During our experiments, we noticed that all coffee extracts reduced spontaneous contractions of rat ileum tissue in a dose-dependent manner. However, it was the light coffee extract that stood out, showing the most significant reduction in ileal contractions, especially at higher concentrations.
Our findings suggested that the antispasmodic effects of light coffee might be linked to its ability to inhibit calcium influx or interfere with calcium signaling pathways, which are crucial in muscle contractions. We found that certain compounds in the light coffee, such as chlorogenic acid and caffeine, likely contributed to this effect. Overall, our study indicates that light-roasted coffee has the potential to help manage conditions related to intestinal spasms and diarrhea.
During our experiments, we noticed that all coffee extracts reduced spontaneous contractions of rat ileum tissue in a dose-dependent manner. However, it was the light coffee extract that stood out, showing the most significant reduction in ileal contractions, especially at higher concentrations.
Our findings suggested that the antispasmodic effects of light coffee might be linked to its ability to inhibit calcium influx or interfere with calcium signaling pathways, which are crucial in muscle contractions. We found that certain compounds in the light coffee, such as chlorogenic acid and caffeine, likely contributed to this effect. Overall, our study indicates that light-roasted coffee has the potential to help manage conditions related to intestinal spasms and diarrhea.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
0
Causes diarrhoea
6 people found this helpful
I ordered several products based on YouTube recommendations, including Kalmac, which has fewer ingredients. However, I've experienced diarrhoea for several days now, which is rather painful, something I’ve never encountered with nutrients before.
Read More
8
No diarrhoea effects
No aftertaste and gentle on the gut. I recently ordered Garden of Life Raw Calcium and began taking it two days ago. It's of high quality, easy on my digestion, and seems to improve my sleep. Previous calcium supplements caused diarrhoea, but so far, this one hasn't. I prefer taking two capsules daily, as the recommended four seems excessive. I'm grateful to iHerb for their timely delivery.
Read More
2
Ongoing diarrhoea
This product does not suit me at all. Originally, I took four pills but realised that it exceeded the recommended daily intake, so I reduced it to two after meals. Unfortunately, I still suffer from diarrhoea and stomach issues on the days I consume it. I think I'd need to reduce the amount further to use it long-term.
Read More
Frequently Asked Questions
0
Causes diarrhoea
6 people found this helpful
I ordered several products based on YouTube recommendations, including Kalmac, which has fewer ingredients. However, I've experienced diarrhoea for several days now, which is rather painful, something I’ve never encountered with nutrients before.
8
No diarrhoea effects
No aftertaste and gentle on the gut. I recently ordered Garden of Life Raw Calcium and began taking it two days ago. It's of high quality, easy on my digestion, and seems to improve my sleep. Previous calcium supplements caused diarrhoea, but so far, this one hasn't. I prefer taking two capsules daily, as the recommended four seems excessive. I'm grateful to iHerb for their timely delivery.
2
Ongoing diarrhoea
This product does not suit me at all. Originally, I took four pills but realised that it exceeded the recommended daily intake, so I reduced it to two after meals. Unfortunately, I still suffer from diarrhoea and stomach issues on the days I consume it. I think I'd need to reduce the amount further to use it long-term.
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
8
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
8
We observed that rotavirus infection predominantly affects mature intestinal cells, leading to severe digestive issues, including diarrhea. This research delved into how 1α,25-hydroxyvitamin D (commonly known as vitamin D) might be influential in mitigating these detrimental effects. Various experiments were conducted with IPEC-J2 cells to analyze the impact of rotavirus on cell death and inflammation.
Our findings revealed that rotavirus not only led to cell death but also induced a specific form of cell death called ferroptosis. This situation was characterized by increased reactive oxygen species and decreased mitochondrial activity, factors that can worsen inflammation and damage gut cells. Interestingly, treatment with vitamin D significantly reduced these harmful effects. It appeared to operate through a specific pathway involving key proteins that protect cells from oxidative stress.
In summary, our study suggests that vitamin D has a protective role and inhibits rotavirus-induced cell damage and ferroptosis. By regulating certain cellular pathways, vitamin D may alleviate the intestinal distress caused by rotavirus, offering a potential therapeutic avenue against diarrhea linked to this virus. Overall, this research supports the consideration of vitamin D as a beneficial treatment in managing rotavirus infections and their associated symptoms.
Our findings revealed that rotavirus not only led to cell death but also induced a specific form of cell death called ferroptosis. This situation was characterized by increased reactive oxygen species and decreased mitochondrial activity, factors that can worsen inflammation and damage gut cells. Interestingly, treatment with vitamin D significantly reduced these harmful effects. It appeared to operate through a specific pathway involving key proteins that protect cells from oxidative stress.
In summary, our study suggests that vitamin D has a protective role and inhibits rotavirus-induced cell damage and ferroptosis. By regulating certain cellular pathways, vitamin D may alleviate the intestinal distress caused by rotavirus, offering a potential therapeutic avenue against diarrhea linked to this virus. Overall, this research supports the consideration of vitamin D as a beneficial treatment in managing rotavirus infections and their associated symptoms.
References
- Duangjai A, Rawangkan A, Yosboonruang A, Ontawong A, Saokaew S, et al. Antispasmodic Activity of Light-Roasted Coffee Extract and Its Potential Use in Gastrointestinal Motility Disorders. Foods. 2024;13. doi:10.3390/foods13152307
- Zhao Y, Zhu X, Lan Q, Wei Z, Shang P, et al. 1α,25-hydroxyvitamin D alleviated rotavirus infection induced ferroptosis in IPEC-J2 cells by regulating the ATF3-SLC7A11-GPX4 axis. Int J Biol Macromol. 2024;283:137484. doi:10.1016/j.ijbiomac.2024.137484
- de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, et al. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024;134. doi:10.1172/JCI171249
- Wang Y, Xiao X, Lin Q, Song R, Wang X, et al. Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia. J Diabetes Investig. 2024;15:121. doi:10.1111/jdi.14084
- Costello R, Rosanoff A, Nielsen F, West C. Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. Adv Nutr. 2023;14:973. doi:10.1016/j.advnut.2023.06.008
- Kamali F, Jamee M, Sayer JA, Sadeghi-Bojd S, Golchehre Z, et al. Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature. CEN Case Rep. 2023;12:413. doi:10.1007/s13730-023-00785-8
- Cao S, Huang K, Wen X, Gao J, Cui B, et al. Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets. Front Microbiol. 2022;13:961989. doi:10.3389/fmicb.2022.961989
- Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
- Sarkar KK, Mitra T, Rahman MA, Raja IM, Aktaruzzaman M, et al. Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes. Biomed Res Int. 2022;2022:1331758. doi:10.1155/2022/1331758
