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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 11 Reviews
8.5
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
8
Vitamin D supports bone health
Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women.
Directly addresses vitamin D effect
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
9
Magnesium aids menopause-related issues
The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.
Strong relevance to menopause research
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
8
Vitamin D critical for fracture prevention
Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study.
Directly addresses menopause and fractures
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
Most Useful Reviews
8.8
Pain relief achieved
I love drinking this supplement after menopause. I dealt with pain issues related to menopause at age 51 and tried various supplements. I switched to this low multivitamin after a year, and it has significantly improved my whole-body pain. My daily life has settled down. If you're apprehensive about supplements, I encourage you to try it. The side effects of medication are daunting, and I believe it's vital to invest in your health.
Read More
9.5
Bone density normalised
I've been taking this supplement for about a year and a half to counteract menopausal hormone deficiency and osteoporosis. Despite not tolerating a prescribed osteoporosis drug, I find this and bone broth effective. I adjusted my intake to prevent magnesium deficiency. After recently measuring my bone density, I'm relieved to see that it's above average for my age group.
Read More
9.3
Effective calcium support
This is possibly the best calcium supplement I’ve found. After searching extensively, I discovered this company’s products have the optimal composition I needed for menopause. Despite the price, the quality justifies it. I take two capsules twice a day and highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
9
Magnesium aids menopause-related issues
The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.
Strong relevance to menopause research
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
9
Magnesium's impact on bone health
Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation.
Study shows mixed magnesium benefits
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
Read More
8
Vitamin D critical for fracture prevention
Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study.
Directly addresses menopause and fractures
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
8
Vitamin D and K for menopause health
Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies.
Moderate relevance due to combined effects
We explored how the combination of vitamins D and K may influence menopausal health in women. Our review incorporated findings from 31 randomized clinical trials, which looked at how these vitamins work together to support bone density and cardiovascular health.
Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.
We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.
Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.
We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.
Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
Read More
8
Vitamin D maintains levels, no menopause impact
Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency.
Relevance score indicates isolated effectiveness
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.5
9.5
Bone density normalised
I've been taking this supplement for about a year and a half to counteract menopausal hormone deficiency and osteoporosis. Despite not tolerating a prescribed osteoporosis drug, I find this and bone broth effective. I adjusted my intake to prevent magnesium deficiency. After recently measuring my bone density, I'm relieved to see that it's above average for my age group.
Read More
9.3
Effective calcium support
This is possibly the best calcium supplement I’ve found. After searching extensively, I discovered this company’s products have the optimal composition I needed for menopause. Despite the price, the quality justifies it. I take two capsules twice a day and highly recommend it!
8.8
Pain relief achieved
I love drinking this supplement after menopause. I dealt with pain issues related to menopause at age 51 and tried various supplements. I switched to this low multivitamin after a year, and it has significantly improved my whole-body pain. My daily life has settled down. If you're apprehensive about supplements, I encourage you to try it. The side effects of medication are daunting, and I believe it's vital to invest in your health.
Read More
8.8
Bone density improved
This product is excellent! My bone density decreased with menopause, and my doctor advised calcium tablets. I chose this supplement for its natural ingredients and comprehensive formula. After two bottles, I no longer experienced constipation, my waist discomfort improved, and my sleep quality has enhanced. I'm eager for my next bone density test results as I believe they will be better. The price is steep, so I hope for more discounts.
Read More
8.8
Improved osteoporosis condition
I was diagnosed with osteoporosis after menopause and initially took Calamet without improvement. Later, I found Garden of Life, which contains natural calcium, magnesium, strontium, boron, and vitamin K. After using it for a year, my osteoporosis condition has improved.
