Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 43 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container:  30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+

Top Medical Research Studies

9
Vitamin D helps reduce migraines
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.

Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.

This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More

Most Useful Reviews

9
Calcium supplement approved
2 people found this helpful
Finally, a calcium supplement that doesn't trigger migraines! Excellent product; every other brand caused migraines for me. As a female in my early 70s, I truly need this.
Read More
9
Migraine-free
This excellent calcium formula maximises absorption and doesn’t trigger migraines for me. As a post-menopausal woman needing calcium due to recent bone density results, I appreciate the easy-to-swallow capsules. Each contains 275 mg of calcium, which allows me to meet my recommended dosage while incorporating supplemental vitamins.
Read More
7.5
Migraine relief
Excellent product; high quality with the right combination of D3, calcium, magnesium, and K. At 46, this has improved my lab work results and alleviated my migraines. No aftertaste, plus fast shipping.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 43 Researches
7.5
  • All Researches
We aimed to understand how vitamin D impacts migraine headaches in children. Through a thorough review of existing literature, we explored the significant association between serum vitamin D levels and the frequency and duration of migraine episodes in the pediatric population.

Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.

It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Read More
We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.

Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.

Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Read More
9
Vitamin D helps reduce migraines
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.

Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.

This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Calcium supplement approved
2 people found this helpful
Finally, a calcium supplement that doesn't trigger migraines! Excellent product; every other brand caused migraines for me. As a female in my early 70s, I truly need this.
Read More
9
Migraine-free
This excellent calcium formula maximises absorption and doesn’t trigger migraines for me. As a post-menopausal woman needing calcium due to recent bone density results, I appreciate the easy-to-swallow capsules. Each contains 275 mg of calcium, which allows me to meet my recommended dosage while incorporating supplemental vitamins.
Read More
7.5
Migraine relief
Excellent product; high quality with the right combination of D3, calcium, magnesium, and K. At 46, this has improved my lab work results and alleviated my migraines. No aftertaste, plus fast shipping.
Read More

Frequently Asked Questions

7.5
Migraine relief
Excellent product; high quality with the right combination of D3, calcium, magnesium, and K. At 46, this has improved my lab work results and alleviated my migraines. No aftertaste, plus fast shipping.
9
Migraine-free
This excellent calcium formula maximises absorption and doesn’t trigger migraines for me. As a post-menopausal woman needing calcium due to recent bone density results, I appreciate the easy-to-swallow capsules. Each contains 275 mg of calcium, which allows me to meet my recommended dosage while incorporating supplemental vitamins.
7
Vitamin D may reduce migraines
We examined how vitamin D affects migraines, drawing from a systematic review and meta-analysis of various dietary supplements. The study brought together evidence from twenty-two trials, focusing on significant outcomes like the frequency and severity of migraine attacks.

Specifically, vitamin D supplementation showed notable benefits. Participants who took vitamin D had a reduction in migraine frequency and the number of monthly migraine days compared to those who received a placebo. This indicates that vitamin D might play a role in alleviating migraines effectively.

Overall, the results suggest that while vitamin D treatment can be beneficial for migraine sufferers, there's still a call for further high-quality clinical trials to solidify our understanding and confirm these findings.
7
Vitamin D linked to migraine relief
Our exploration into the connection between vitamin D levels and migraine prevalence drew on data from the National Health and Nutrition Examination Survey involving over 9,100 participants. The study specifically examined the concentration of vitamin D in the blood and how it relates to self-reported migraine experiences.

We observed that 20.53% of participants reported suffering from migraines, with a clear trend showing that those with lower levels of serum vitamin D tended to experience migraines more frequently. Interestingly, individuals in the highest vitamin D quartile reported a 16% lower incidence of migraines compared to those in the lowest quartile. This finding suggests that sufficient levels of vitamin D might play a role in reducing migraine frequency.

Overall, our analysis indicates a significant negative correlation between serum vitamin D levels and migraine prevalence among American adults. While the precise mechanisms behind this relationship warrant further investigation, our study provides valuable insights into how maintaining adequate vitamin D levels could potentially alleviate migraine symptoms for some individuals.
We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.

Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.

Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
We explored the relationship between vitamin D levels and migraines through a thorough analysis of various studies. Our study aimed to find out how vitamin D affects individuals who suffer from migraines, comparing their vitamin D levels to those who do not have migraines.

By reviewing ten observational studies along with two randomized controlled trials, we found that migraineurs had notably lower levels of serum 25-hydroxy vitamin D compared to nonmigraineurs. Specifically, these levels were about 4.44 ng/mL lower on average. Additionally, we noted that those with low vitamin D levels were significantly more likely to experience migraines.

When it came to vitamin D supplementation, our findings were mixed. We discovered that while taking oral vitamin D did lead to a decrease in how often migraines occurred each month, it did not significantly affect the duration or severity of these headaches. This means that while vitamin D may help reduce the number of migraines one experiences, it does not necessarily make them less intense or shorter in duration.

Overall, our analysis lends support to the idea that maintaining adequate vitamin D levels might be beneficial for those suffering from migraines. However, we must also recognize that vitamin D alone may not be a comprehensive solution for all migraine symptoms.

References

  1. Ilik F, Ertem DH, Ilik MK. [Management of migraine without aura in adolescents: The experience of flunarizine use in a Turkish cohort]. Ideggyogy Sz. 2025;78:122. 10.18071/isz.77.0122
  2. Ma C, Zhu C, Zhang Y, Yu M, Song Y, et al. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion. Phytomedicine. 2024;125:155266. 10.1016/j.phymed.2023.155266
  3. Carcel C, Haghdoost F, Shen J, Nanda P, Bai Y, et al. The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis. Cephalalgia. 2023;43:3331024231183166. 10.1177/03331024231183166
  4. Akif Özdemir FM, Çelik H. Assessment of Micronutrient Levels in Pediatric Migraine Patients. J Child Neurol. 2025. 10.1177/08830738241304868
  5. Hao S, Qian R, Chen Y, Liu J, Xu X, et al. Association between serum vitamin D and severe headache or migraine: A population-based analysis. PLoS One. 2025;20:e0313082. 10.1371/journal.pone.0313082
  6. Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
  7. Tirani SA, Khorvash F, Saneei P, Moradmand Z, Askari G. Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial. BMC Med. 2024;22:457. 10.1186/s12916-024-03684-6
  8. Papasavva M, Vikelis M, Siokas V, Katsarou MS, Dermitzakis EV, et al. Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study. Neurol Int. 2023;15:1117. 10.3390/neurolint15030069
  9. Ioannidou E, Tsakiris C, Goulis DG, Christoforidis A, Zafeiriou D. The association of serum vitamin D concentrations in paediatric migraine. Eur J Paediatr Neurol. 2023;47:60. 10.1016/j.ejpn.2023.09.007
  10. Das S, Roy A, Behera SK, Selvarajan S, Kamalanathan S, et al. Effects of Vitamin D on Migraine: A Meta-Analysis. Neurol India. 2023;71:655. 10.4103/0028-3886.383862
  11. Alipouri M, Amiri E, Hoseini R, Hezarkhani LA. Effects of eight weeks of aerobic exercise and vitamin D supplementation on psychiatric comorbidities in men with migraine and vitamin D insufficiency: A randomized controlled clinical trial. J Affect Disord. 2023;334:12. 10.1016/j.jad.2023.04.108
  12. Niu PP, Wang X, Xu YM. Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study. Front Nutr. 2022;9:907789. 10.3389/fnut.2022.907789
  13. Kotb Elmala M, Suliman HA, Al-Shokary AH, Ibrahim AO, Kamal NM, et al. The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis. J Child Neurol. 2022;37:833. 10.1177/08830738221092882
  14. Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
  15. Canpolat M, Topcu A, Kardas F, Ipekten F, Per H, et al. An assessment of the relation between vitamin D levels and electroencephalogram (EEG) changes in migraine patients. Bratisl Lek Listy. 2022;123:92. 10.4149/BLL_2022_014
  16. Bahrampour N, Mirzababaei A, Yarizadeh H, Barekzai AM, Khorsha F, et al. The relationship between dietary nutrients patterns and intensity and duration of migraine headaches. Br J Nutr. 2022. 10.1017/S0007114522000046
  17. Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. 10.1016/j.ajem.2021.07.062
  18. Sun S, Liu C, Jia Y, Wu J, Li H, et al. Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D. Front Neurol. 2021;12:777721. 10.3389/fneur.2021.777721
  19. Ghorbani Z, Rafiee P, Haghighi S, Razeghi Jahromi S, Djalali M, et al. The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial. J Pharm Health Care Sci. 2021;7:9. 10.1186/s40780-021-00192-0
  20. Bhuya MSI, Saiduzzaman M, Linckon K, Moniruzzaman AHM, Hossain MS, et al. Association of Serum Vitamin D Level in Patients with Migraine. Mymensingh Med J. 2025;34:312.
  21. Zhang YF, Xu ZQ, Zhou HJ, Liu YZ, Jiang XJ. The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies. Clin Neuropharmacol. 2021;44:5. 10.1097/WNF.0000000000000419
  22. Ghorbani Z, Rafiee P, Fotouhi A, Haghighi S, Rasekh Magham R, et al. The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial. J Headache Pain. 2020;21:22. 10.1186/s10194-020-01090-w
  23. Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial. Neurol Sci. 2020;41:1183. 10.1007/s10072-019-04220-8
  24. Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci. 2019;40:2459. 10.1007/s10072-019-04021-z
  25. Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. 10.3390/nu17040725
  26. Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
  27. Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
  28. Gazerani P, Papetti L, Dalkara T, Cook CL, Webster C, et al. The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis. Nutrients. 2024;16. 10.3390/nu16142222
  29. Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
  30. Kurhade PI, Kodape SM, Das A, Bansod PG. Synergistic action of sumatriptan delivery and targeting magnesium deficiency using green, pH-responsive MgO nanoparticles synthesized from mahua flower extracts. Environ Sci Pollut Res Int. 2023. 10.1007/s11356-023-30648-9
  31. Umemoto KK, Tawk K, Mazhari N, Abouzari M, Djalilian HR. Management of Migraine-Associated Vestibulocochlear Disorders. Audiol Res. 2023;13:528. 10.3390/audiolres13040047
  32. Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
  33. Shenoy NN, Gheewala GK, Kedambadi R, Pai S, Zulfikli KM, et al. Can Serum Magnesium Level and Visual Evoked Potentials (P100) be a Predictive in Migraineurs?: Evidence Based Study. Neurol India. 2023;71:463. 10.4103/0028-3886.378668
  34. Frank M, Abouzari M, Djalilian HR. Meniere's disease is a manifestation of migraine. Curr Opin Otolaryngol Head Neck Surg. 2023;31:313. 10.1097/MOO.0000000000000908
  35. Pawar V, Ashraf H, Dorsala S, Mary P, Hameed N, et al. Motorist's Vestibular Disorientation Syndrome (MVDS)-Proposed Diagnostic Criteria. J Pers Med. 2023;13. 10.3390/jpm13050732
  36. Hoshino MT, Bochio MG, Spagnol Bonache J, Ludwig L, Leandro de Campos M, et al. Plasma and erythrocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine. Magnes Res. 2022;35:51. 10.1684/mrh.2022.0502
  37. Mahajan R, Anand KS, Mahajan RK, Garg J, Juneja A. Serum Magnesium Levels During the Ictal and Interictal Phase in Patients of Migraine: A Prospective Observational Study. Neurol India. 2022;70:1852. 10.4103/0028-3886.359247
  38. Bhurat R, Premkumar S, Manokaran RK. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr. 2022;59:623.
  39. Mazza GR, Solorio C, Stek AM, Kalayjian LA, Wilson ML, et al. Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023;308:1749. 10.1007/s00404-022-06872-y
  40. Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, et al. Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain. Int J Mol Sci. 2022;23. 10.3390/ijms23031529
  41. Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
  42. Karim MR, Bhattacharjee M, Islam MS, Banerjee S, Hossain S, et al. Relation between Serum Magnesium Level and Migraine. Mymensingh Med J. 2021;30:301.
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