5/22/2025
Last update
5/22/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
9
We examined the role of magnesium alginate in treating laryngopharyngeal reflux (LPR), which causes symptoms like voice issues, swallowing difficulties, and coughing. In a study involving 100 outpatients, patients were treated with alginate for two months, visiting at the start and then at 15, 30, and 60 days.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
Read More
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
8
We conducted a multicenter crossover study to see if magnesium alginate could alleviate reflux symptoms in infants. A total of 72 infants participated, receiving either magnesium alginate or a thickened formula in alternating phases.
Our findings showed a significant reduction in reflux symptoms across all infant groups. However, there was no significant difference in effectiveness between the two treatments. Importantly, using magnesium alginate also yielded cost savings of about €4.60 per infant compared to the thickened formula.
Thus, magnesium alginate appears to be a cost-effective option without sacrificing symptom relief.
Our findings showed a significant reduction in reflux symptoms across all infant groups. However, there was no significant difference in effectiveness between the two treatments. Importantly, using magnesium alginate also yielded cost savings of about €4.60 per infant compared to the thickened formula.
Thus, magnesium alginate appears to be a cost-effective option without sacrificing symptom relief.
Read More
Most Useful Reviews
9
No reflux issues
5 people found this helpful
I have acid reflux and need to be cautious with certain supplements as they upset my stomach. Fortunately, I have experienced no issues with this calcium and intend to continue taking it!
Read More
9
No reflux found
I experience no reflux with this product, which is wonderful as I struggle to take other types of calcium.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.2
- All Researches
9.5
Gaviscon DA effectively neutralizes acid
We explored how Gaviscon Double Action, a combination of alginate and antacid, affects gastric acid levels. In a carefully designed crossover study, we monitored intragastric pH in healthy volunteers after administering Gaviscon DA versus a placebo.
The results showed a clear advantage for Gaviscon DA, with pH levels reaching 4 or higher nearly 47% of the time, compared to just 5% for the placebo. This confirms that Gaviscon DA effectively neutralizes gastric acid, enhancing the understanding of how its components work together for reflux relief.
The results showed a clear advantage for Gaviscon DA, with pH levels reaching 4 or higher nearly 47% of the time, compared to just 5% for the placebo. This confirms that Gaviscon DA effectively neutralizes gastric acid, enhancing the understanding of how its components work together for reflux relief.
Read More
9
We explored the effects of a multi-herbal Tibetan formula known as Cong zhi 6, which includes calcium carbonate, on individuals suffering from laryngopharyngeal reflux (LPR). Our focus was to understand whether calcium plays a role in alleviating reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
Read More
9
Banxia Houpu Decoction shows promise
We evaluated how Banxia Houpu Decoction, a traditional Chinese remedy, can help patients with refractory gastroesophageal reflux disease (RGERD). In our study involving 89 patients, we compared this decoction to standard Western treatments, including proton pump inhibitors with added magnesium aluminum carbonate.
Results showed that the decoction significantly improved throat burning, swallowing difficulties, and hiccups more effectively than Western treatments. However, the Western medicine group had better relief for heartburn and gastric burning sensations.
Factors like age and gastroesophageal flap valve grade also impacted treatment effectiveness.
Results showed that the decoction significantly improved throat burning, swallowing difficulties, and hiccups more effectively than Western treatments. However, the Western medicine group had better relief for heartburn and gastric burning sensations.
Factors like age and gastroesophageal flap valve grade also impacted treatment effectiveness.
Read More
9
We examined the role of magnesium alginate in treating laryngopharyngeal reflux (LPR), which causes symptoms like voice issues, swallowing difficulties, and coughing. In a study involving 100 outpatients, patients were treated with alginate for two months, visiting at the start and then at 15, 30, and 60 days.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
Read More
9
We aimed to observe how effective Weisu granules are on laryngopharyngeal reflux by randomly assigning 180 patients into three groups.
The experimental group received a combination of Lanqin oral solution and Weisu granules, while the control groups used either Lanqin alone or Esomeprazole with Lanqin.
After four weeks, the experimental group showed a remarkable 91.7% improvement, much higher than the 73.3% in control group A. Although the experimental group differed significantly from control group A, results were similar to control group B, indicating no major advantage over Esomeprazole.
The experimental group received a combination of Lanqin oral solution and Weisu granules, while the control groups used either Lanqin alone or Esomeprazole with Lanqin.
After four weeks, the experimental group showed a remarkable 91.7% improvement, much higher than the 73.3% in control group A. Although the experimental group differed significantly from control group A, results were similar to control group B, indicating no major advantage over Esomeprazole.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
No reflux issues
5 people found this helpful
I have acid reflux and need to be cautious with certain supplements as they upset my stomach. Fortunately, I have experienced no issues with this calcium and intend to continue taking it!
Read More
9
No reflux found
I experience no reflux with this product, which is wonderful as I struggle to take other types of calcium.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Lehner MD, Scheyhing U, Elsässer J. A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro. Sci Rep. 2024;14:22355. 10.1038/s41598-024-74047-7
- Zürcher BF. The Tibetan Formula Cong zhi 6 in the ORL (ENT) Practice: Experiences with Laryngopharyngeal Reflux. Complement Med Res. 2024;31:84. 10.1159/000534212
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. 10.21873/invivo.13056
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. 10.1159/000543367
- Song S, Zhang Y, Zhang J, Jiang Y, Gong A. Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease. Medicine (Baltimore). 2024;103:e38045. 10.1097/MD.0000000000038045
- Pizzorni N, Ambrogi F, Eplite A, Rama S, Robotti C, et al. Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trial. Eur Arch Otorhinolaryngol. 2022;279:2533. 10.1007/s00405-021-07219-0
- Ciprandi G, Damiani V, Passali FM, Crisanti A, Motta G, et al. Magnesium alginate in patients with laryngopharyngeal reflux. J Biol Regul Homeost Agents. 2021;35:61. 10.23812/21-1supp2-12
- Deraman MA, Abdul Hafidz MI, Lawenko RM, Ma ZF, Wong MS, et al. Randomised clinical trial: the effectiveness of Gaviscon Advance vs non-alginate antacid in suppression of acid pocket and post-prandial reflux in obese individuals after late-night supper. Aliment Pharmacol Ther. 2020;51:1014. 10.1111/apt.15746
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. 10.23736/S1121-421X.20.02601-X
- Baldassarre ME, Di Mauro A, Pignatelli MC, Fanelli M, Salvatore S, et al. Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants. Int J Environ Res Public Health. 2019;17. 10.3390/ijerph17010083
- Wilkinson J, Abd-Elaziz K, den Daas I, Wemer J, van Haastert M, et al. Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation (Gaviscon Double Action). Drug Dev Ind Pharm. 2019;45:430. 10.1080/03639045.2018.1546314
- Wilkie MD, Fraser HM, Raja H. Gaviscon® Advance alone versus co-prescription of Gaviscon® Advance and proton pump inhibitors in the treatment of laryngopharyngeal reflux. Eur Arch Otorhinolaryngol. 2018;275:2515. 10.1007/s00405-018-5079-0
- Zhuang XY, Yang HZ, Wang HG, Li CW. [Clinical observation of Weisu granules in treating laryngopharyngeal reflux]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;32:369. 10.13201/j.issn.1001-1781.2018.05.012
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
