Garden of Life Oceans Mom Prenatal Fish Oil DHA

ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.

Most Relevant Research

We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.

Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.

Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.

9.5

No allergies experienced

Most Useful Review

I took Raw Prenatal vitamins throughout my pregnancy and experienced no nausea. I had plenty of energy and needed less sleep than before. My baby was born healthy, and I'm currently taking DHA with the vitamins. The child has no allergies and is developing well; the benefits are clear. I highly recommend this to everyone!

High Cholesterol details

SCIENTIFIC SCORE

Possibly Effective

Based on 29 Researches

DHA lowers cholesterol; boosts metabolism

F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol.

Most Relevant Research

We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.

Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.

These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.

9.5

Cholesterol reduction

Most Useful Review

Omega-3 acids cleanse blood vessel walls from excess high cholesterol, helping prevent cholesterol plaques. They improve blood viscosity and normalise blood pressure while increasing the level of "good" cholesterol, HDL, and strengthen blood vessel walls, enhancing their elasticity.

Constipation details

Since I started taking iron, I've had constipation, but this supplement has helped. My stool is now regular. The capsules are small, with a subtle strawberry scent, making them easy to swallow. I highly recommend it! 👍

Depression details

SCIENTIFIC SCORE

Possibly Effective

Based on 31 Researches

DHA shows potential for depression

The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Most Relevant Research

We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.

Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.

Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.

9.5

Depression alleviated

Most Useful Review

Yes! In my first trimester, I experienced severe depression and constant sobbing. Despite taking a vitamin complex for my pregnancy, I found my hormone levels normal. Surprisingly, after one can of Omega, my depressive mood vanished! Hence, I rate it 5 stars! Health!

Heart Disease details

SCIENTIFIC SCORE

Possibly Effective

Based on 32 Researches

Omega-3 lowers coronary risk

A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.

Most Relevant Research

We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.

Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.

This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.

9.5

Organic heart support

Most Useful Review

I highly recommend Garden of Life, Oceans Mom, Strawberry DHA Prenatal for expectant mothers. It helps maintain heart and brain health during pregnancy. The strawberry flavour is enjoyable, and the capsules are easy to swallow with no unpleasant aftertaste. It's organic and free from artificial additives, making it a great choice.

Heartburn details

This probiotic helps with constipation and diarrhoea during pregnancy, easing morning sickness and heartburn while promoting healthy digestion. It is a safe, non-GMO supplement for me and my baby, without major allergens or artificial additives.

Cardiovascular Disease details

SCIENTIFIC SCORE

Possibly Effective

Based on 31 Researches

EPA's role in diabetic heart health

Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.

Most Relevant Research

We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.

In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.

We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.

Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.

9.5

Excellent quality Omega

Most Useful Review

I've taken Omega from this company during pregnancy and lactation. The quality is excellent, and Omega is vital for cardiovascular disease, immunity, vision, and brain health. The dosage is good, and the pleasant taste makes the small capsules easy to swallow without causing a gag reflex. I highly recommend it.

Back Pain details

SCIENTIFIC SCORE

Possibly Effective

Based on 11 Researches

Omega-3s reduce disc degeneration

Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.

Most Relevant Research

We aimed to find out how docosahexaenoic acid (DHA), a key omega-3 fatty acid, could affect intervertebral disc (IVD) degeneration, a common cause of lower back pain. In our study, we used a group of 12 rats, all of whom underwent a procedure to induce disc degeneration.

After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.

We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.

Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.

8.8

Improved immunity

Most Useful Review

My immunity has improved significantly. I was previously concerned about pain in my hands. After taking this for a month, the pain has decreased significantly. I am pleased and hopeful for further improvement.

Nausea details

Dysmenorrhea influences pregnancy nausea

Association of the Verbal Rating Scale-Measured Dysmenorrhea with Nausea and Vomiting in Pregnancy: A Retrospective Cohort Study.

Most Relevant Research

We conducted a retrospective cohort study to investigate the relationship between nausea and vomiting in pregnancy (NVP) and dysmenorrhea measured by a verbal rating scale. Our research included 443 pregnant women, divided into those experiencing NVP and a control group.

From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.

Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.

Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.

Nausea prevention noted

Most Useful Review

These are my favourite omega vitamins. They are the only ones that kept me from being nauseated, and I’ve never experienced a fishy burp after taking them. I continue to take these even now, as I am pleased with how I feel after taking them.