Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Thiamin (B1 from culture of S.cerevisiae)
5 mg
417%
Riboflavin (B2 from culture of S. cerevisiae)
10 mg
769%
Niacin (as Niacinamide from culture of S. cerevisiae)
45 mg
281%
Vitamin B6 (from culture of S. cerevisiae)
10 mg
588%
Folate (from culture of S. cerevisiae)
450 mcg DFE
113%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
133 mcg
5542%
Biotin (from culture of S. cerevisiae)
325 mcg
1083%
Pantothenic Acid (from culture of S. cerevisiae)
45 mg
900%
RAW Organic Fruit & Vegetable Blend
360 mg
+
RAW Probiotic & Enzyme Blend
60 mg
+
Top Medical Research Studies
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Read More
8
Niacin shows promise for depression
We investigated how niacin (vitamin B3) impacts depression, particularly through a mouse model using lipopolysaccharide to induce depressive behaviors.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
Read More
Most Useful Reviews
9
Increased vitality
24 people found this helpful
I've been taking this B vitamin complex for two months. Even with a prophylactic dose of one capsule, I've noticed an increase in vitality, endurance against stress, and improved mood. These vitamins are highly effective for me, and I will continue to purchase them.
Read More
9
Herbal remedy
5 people found this helpful
I started using this product for depression, and it has been a wonderful herbal support. I will definitely reorder it and recommend it to others.
Read More
9
Clarity and focus
4 people found this helpful
This is one of my favourite remedies! I notice a clear improvement in my mood and energy shortly after taking a capsule. It helps with anxiety, sleep, and prepares me well for stressful days. I highly recommend this for managing depression.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
- All Researches
9.5
We explored a remarkable case of a 58-year-old cancer patient who exhibited depressive symptoms potentially linked to thiamine deficiency (TD). Initially suspected of having major depressive disorder, her condition transformed dramatically after receiving intravenous thiamine.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Read More
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
8
We explored the effects of a newly developed zinc-acetyl-l-carnitine complex on depression and neuroprotection. This innovative compound showed a remarkable 54% increase in antidepressant activity compared to standard acetyl-l-carnitine.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Read More
8
We explored whether combining antidepressants with low-dose methylfolate could improve outcomes for patients with depressive disorder. In this open-label trial, 44 participants received standard antidepressant treatment along with 800 µg of methylfolate daily for four weeks.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
Read More
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased vitality
24 people found this helpful
I've been taking this B vitamin complex for two months. Even with a prophylactic dose of one capsule, I've noticed an increase in vitality, endurance against stress, and improved mood. These vitamins are highly effective for me, and I will continue to purchase them.
Read More
9
Herbal remedy
5 people found this helpful
I started using this product for depression, and it has been a wonderful herbal support. I will definitely reorder it and recommend it to others.
Read More
9
Clarity and focus
4 people found this helpful
This is one of my favourite remedies! I notice a clear improvement in my mood and energy shortly after taking a capsule. It helps with anxiety, sleep, and prepares me well for stressful days. I highly recommend this for managing depression.
Read More
9
Reduced stress levels
1 people found this helpful
B vitamins help me manage stress; I take them during particularly stressful times. Research shows they can alleviate stress, mental fatigue, and depression. I previously used Solgar B-complex vitamins, but I have learned about these new ones from friends in America. I will continue taking them.
Read More
6
Energy boost
36 people found this helpful
I am extremely pleased with this complex! It truly provides strength and energy. I usually take one capsule, but after a very stressful day, I took another and felt revitalised. There was no fatigue, and my mood was fantastic even after a long workday. The entire family has benefited, and the easily digestible B12 helps prevent depression and supports overall health.
Read More
Frequently Asked Questions
9
Clarity and focus
4 people found this helpful
This is one of my favourite remedies! I notice a clear improvement in my mood and energy shortly after taking a capsule. It helps with anxiety, sleep, and prepares me well for stressful days. I highly recommend this for managing depression.
9
Increased vitality
24 people found this helpful
I've been taking this B vitamin complex for two months. Even with a prophylactic dose of one capsule, I've noticed an increase in vitality, endurance against stress, and improved mood. These vitamins are highly effective for me, and I will continue to purchase them.
7.5
Fatigue reduction
5 people found this helpful
This vitamin B complex has helped alleviate my depression and anxiety. I feel significantly less fatigued, thanks particularly to the methylcobalamin content. Although it is slightly expensive, I prefer natural vitamins and will continue to buy this product.
6
Pain relief
12 people found this helpful
My neuralgia in the hands and feet has greatly improved since starting this product. It has eased my daily pain, and I also find that my depressive feelings have diminished. I'm very grateful for this product.
7.5
Mood improvement
8 people found this helpful
B vitamins have significantly improved my mood and emotional health. I've begun to sleep soundly and wake up refreshed. These vitamins have noticeably supported my cardiovascular and nervous systems. I’m very satisfied and will continue taking them.
9
Herbal remedy
5 people found this helpful
I started using this product for depression, and it has been a wonderful herbal support. I will definitely reorder it and recommend it to others.
6
Energy boost
36 people found this helpful
I am extremely pleased with this complex! It truly provides strength and energy. I usually take one capsule, but after a very stressful day, I took another and felt revitalised. There was no fatigue, and my mood was fantastic even after a long workday. The entire family has benefited, and the easily digestible B12 helps prevent depression and supports overall health.
7.5
Cellular metabolism
4 people found this helpful
This B vitamin complex plays a crucial role in my health. It has enhanced my emotional well-being and helps tackle stress and depression. I feel more resilient and healthier overall since I began taking it.
8
Enhanced emotional health
1 people found this helpful
I liked these vitamins; my well-being and appearance have improved, and I feel more energetic. I intend to order more. It's advisable to take two daily to normalise the nervous and cardiovascular systems, improve skin condition, and support emotional health, particularly in combating stress and depression while boosting the immune system.
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
8
We explored whether combining antidepressants with low-dose methylfolate could improve outcomes for patients with depressive disorder. In this open-label trial, 44 participants received standard antidepressant treatment along with 800 µg of methylfolate daily for four weeks.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
8
We explored the effects of a newly developed zinc-acetyl-l-carnitine complex on depression and neuroprotection. This innovative compound showed a remarkable 54% increase in antidepressant activity compared to standard acetyl-l-carnitine.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
8
We investigated how niacin affects behavior and memory in older rats. Our study included six groups of rats receiving different treatments, including those with D-galactose-induced deficits.
After 14 days of treatment, we found that niacin significantly reduced signs of anxiety and depression, as well as improved memory. It also helped restore balance in various brain chemicals affected by aging.
Overall, niacin shows promise as a treatment for depression and cognitive decline associated with aging.
After 14 days of treatment, we found that niacin significantly reduced signs of anxiety and depression, as well as improved memory. It also helped restore balance in various brain chemicals affected by aging.
Overall, niacin shows promise as a treatment for depression and cognitive decline associated with aging.
8
Niacin shows promise for depression
We investigated how niacin (vitamin B3) impacts depression, particularly through a mouse model using lipopolysaccharide to induce depressive behaviors.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
9.5
We explored a remarkable case of a 58-year-old cancer patient who exhibited depressive symptoms potentially linked to thiamine deficiency (TD). Initially suspected of having major depressive disorder, her condition transformed dramatically after receiving intravenous thiamine.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Caro-Ramírez JY, Bazán LO, Piro OE, Echeverría GA, Jori K, et al. Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection. J Inorg Biochem. 2025;267:112857. doi:10.1016/j.jinorgbio.2025.112857
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. doi:10.1186/s40360-025-00846-x
- Lu J, Mao H, Tan Y, Luo G. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010. Brain Behav. 2024;14:e70128. doi:10.1002/brb3.70128
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. doi:10.1016/j.bcp.2023.115832
- Abdel Rasheed NO, Shiha NA, Mohamed SS, Ibrahim WW. SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice. Int Immunopharmacol. 2023;123:110720. doi:10.1016/j.intimp.2023.110720
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. doi:10.1017/S1478951523001128
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Tuo LJ, Song XY, Zhu YY, He HN, Song YP, et al. Gestational folic acid supplement prevents vitamin D deficiency-induced depression-like behavior by reversing cortical DNA hypomethylation in adult offspring. J Steroid Biochem Mol Biol. 2023;231:106313. doi:10.1016/j.jsbmb.2023.106313
- Pan LA, Segreti AM, Wrobleski J, Shaw A, Hyland K, et al. Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior. Psychol Med. 2023;53:6046. doi:10.1017/S0033291722003233
